Primary funding for this project comes from the National Institute of General Medical Sciences (NIGMS) , a division of the National Institutes of Health (NIH). Additional financial support for NE-CAT comes from the member institutions.
National Institutes of Health
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The Northeastern Collaborative Access Team (NE-CAT), located at the Advanced Photon Source (APS), is funded by its member institutions and the National Institute of General Medical Sciences (NIGMS). NE-CAT’s mission is to construct and operate synchrotron X-ray beamlines custom-built for technically challenging problems in structural biology.
NE-CAT operates two undulator beamlines, 24-ID-C and 24-ID-E. Both provide exceptionally stable X-ray beams for crystallographic data collection. These beamlines are also available for remote data collection.
The 24-ID-E beamline is a fixed energy microdiffraction beamline delivering X-rays at 12.66 keV, optimized for Se-SAD experiments. It is equipped with a CCD-based ADSC Quantum 315 detector.
August 2, 2016
Jain, R., Coloma, J., Garcia-Sastre, A., and Aggarwal, A. K. (2016) Structure of the NS3 helicase from Zika virus, Nat. Struct. Mol. Biol. [Epub ahead of print]
June 21, 2016
Yao, G., Zhang, S., Mahrhold, S., Lam, K. H., Stern, D., Bagramyan, K., Perry, K., Kalkum, M., Rummel, A., Dong, M., and Jin, R. (2016) N-Linked Glycosylation of Sv2 Is Required for Binding and Uptake of Botulinum Neurotoxin A, Nat. Struct. Mol. Biol. 23, 656-662.
May 26, 2016
Chung, B. C., Mashalidis, E. H., Tanino, T., Kim, M., Matsuda, A., Hong, J., Ichikawa, S., and Lee, S. Y. (2016) Structural insights into inhibition of lipid I production in bacterial cell wall synthesis, Nature 533, 557-5690.
April 28, 2016
Schmidt, H. R., Zheng, S., Gurpinar, E., Koehl, A., Manglik, A., and Kruse, A. C. (2016) Crystal structure of the human σ1 receptor, Nature 532, 527-530.
April 21, 2016
Coleman, J. A., Green, E. M., and Gouaux, E. (2016) X-ray structures and mechanism of the human serotonin transporter, Nature 532, 334-339.
March 17, 2016
Li, L., Park, E., Ling, J., Ingram, J., Ploegh, H., and Rapoport, T. A. (2016) Crystal structure of a substrate-engaged SecY protein-translocation channel, Nature 531, 395-399.
February 25, 2016
Hayes, R. P., Xiao, Y., Ding, F., van Erp, P. B. G., Rajashankar, K., Bailey, S., Wiedenheft, B., and Ke, A. (2016) Structural basis for promiscuous PAM recognition in type I–E Cascade from E. coli, Nature 530, 499-503. PMID: 26863189.
February 18, 2016
Yin, Z., Shi, K., Banerjee, S., Pandey, K. K., Bera, S., Grandgenett, D. P., and Aihara, H. (2016) Crystal structure of the Rous sarcoma virus intasome, Nature 530, 362-366. PMID: 26887497.
February 5, 2016
Petrou, V. I., Herrera, C. M., Schultz, K. M., Clarke, O. B., Vendome, J., Tomasek, D., Banerjee, S., Rajashankar, K. R., Belcher Dufrisne, M., Kloss, B., Kloppmann, E., Rost, B., Klug, C. S., Trent, M. S., Shapiro, L., and Mancia, F. (2016) Structures of aminoarabinose transferase ArnT suggest a molecular basis for lipid A glycosylation, Science 351, 608-612.
January 1, 2016
Saxton, R. A., Knockenhauer, K. E., Wolfson, R. L., Chantranupong, L., Pacold, M. E., Wang, T., Schwartz, T. U., and Sabatini, D. M. (2016) Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway, Science 351, 53-58.
November 12, 2015
Tao, Y., Cheung, L. S., Li, S., Eom, J.-S., Chen, L.-Q., Xu, Y., Perry, K., Frommer, W. B., and Feng, L. (2015) Structure of a eukaryotic SWEET transporter in a homotrimeric complex, Nature 527, 259-263.
October 30, 2015
Jiang, J., Chan, H., Cash, D. D., Miracco, E. J., Ogorzalek Loo, R. R., Upton, H. E., Cascio, D., O'Brien Johnson, R., Collins, K., Loo, J. A., Zhou, Z. H., and Feigon, J. (2015) Structure of Tetrahymena telomerase reveals previously unknown subunits, functions, and interactions, Science 350, aab4070.
October 29, 2015
Wei, J., and Tong, L. (2015) Crystal structure of the 500-kDa yeast acetyl-CoA carboxylase holoenzyme dimer, Nature 526, 723-727.
October 22, 2015
Rubinstein, R., Thu, C. A., Goodman, K. M., Wolcott, H. N., Bahna, F., Mannepalli, S., Ahlsen, G., Chevee, M., Halim, A., Clausen, H., Maniatis, T., Shapiro, L., and Honig, B. (2015) Molecular Logic of Neuronal Self-Recognition through Protocadherin Domain Interactions, Cell 163, 629-642.
Jost, M., Fernandez-Zapata, J., Polanco, M. C., Ortiz-Guerrero, J. M., Chen, P. Y., Kang, G., Padmanabhan, S., Elias-Arnanz, M., and Drennan, C. L. (2015) Structural basis for gene regulation by a B12-dependent photoreceptor, Nature 526, 536–541. PMID: 26416754. 24-ID-C; Pilatus
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