NECAT Beamline

The Northeastern Collaborative Access Team (NE-CAT) facility at the Advanced Photon Source at Argonne National Laboratory is managed by Cornell University and consists of seven member institutions:

  • Columbia University
  • Cornell University
  • Harvard University
  • Memorial Sloan-Kettering Cancer Center
  • Massachusetts Institute of Technology
  • Rockefeller University
  • Yale University.
  •  

    Primary funding for this project comes from the National Institute of General Medical Sciences (NIGMS) , a division of the National Institutes of Health (NIH). Additional financial support for NE-CAT comes from the member institutions.

    NIGMS at a Glance.

    Supported by:

    National Institutes of Health
    National Institue of General Medical Sciences

    Publications from the Pilatus 6MF Detector

    (funded by grant S10RR029205 from the National Center of Research Resources of the National Institutes of Health)

    2017

    Crochet, R. B., Kim, J. D., Lee, H., Yim, Y. S., Kim, S. G., Neau, D., and Lee, Y. H. (2017) Crystal Structure of Heart 6-Phosphofructo-2-Kinase/Fructose-2,6-Bisphosphatase (PFKFB2) and the Inhibitory Influence of Citrate on Substrate Binding, Proteins 85, 117-124.
    https://www.ncbi.nlm.nih.gov/pubmed/27802586

    Nguyen, L. A., Wang, J., and Steitz, T. A. (2017) Crystal structure of Pistol, a class of self-cleaving ribozyme, Proc Natl Acad Sci U S A.

    https://www.ncbi.nlm.nih.gov/pubmed/28096403

    Ren, Y., Schmiege, P., and Blobel, G. (2017) Structural and biochemical analyses of the DEAD-box ATPase Sub2 in association with THO or Yra1, Elife 6.
    https://www.ncbi.nlm.nih.gov/pubmed/28059701

    2016

    AhYoung, A. P., Koehl, A., Vizcarra, C. L., Cascio, D., and Egea, P. F. (2016) Structure of a Putative Clps N-End Rule Adaptor Protein from the Malaria Pathogen Plasmodium Falciparum, Protein Sci. 25, 689-701.
    http://www.ncbi.nlm.nih.gov/pubmed/26701219

    Ardiccioni, C., Clarke, O. B., Tomasek, D., Issa, H. A., von Alpen, D. C., Pond, H. L., Banerjee, S., Rajashankar, K. R., Liu, Q., Guan, Z., Li, C., Kloss, B., Bruni, R., Kloppmann, E., Rost, B., Manzini, M. C., Shapiro, L., and Mancia, F. (2016) Structure of the Polyisoprenyl-Phosphate Glycosyltransferase Gtrb and Insights into the Mechanism of Catalysis, Nat. Commun. 7, 10175.
    http://www.ncbi.nlm.nih.gov/pubmed/26729507

    Atkison, J. H., Parnham, S., Marcotte, W. R., Jr., and Olsen, S. K. (2016) Crystal Structure of the Nephila clavipes Major Ampullate Spidroin 1A N-terminal Domain Reveals Plasticity at the Dimer Interface, J Biol Chem 291, 19006-19017.
    https://www.ncbi.nlm.nih.gov/pubmed/27445329

    Bale, J. B., Gonen, S., Liu, Y., Sheffler, W., Ellis, D., Thomas, C., Cascio, D., Yeates, T. O., Gonen, T., King, N. P., and Baker, D. (2016) Accurate design of megadalton-scale two-component icosahedral protein complexes, Science 353, 389-394.

    http://www.ncbi.nlm.nih.gov/pubmed/27463675

    Baranovskiy, A. G., Babayeva, N. D., Zhang, Y., Gu, J., Suwa, Y., Pavlov, Y. I., and Tahirov, T. H. (2016) Mechanism of Concerted Rna-DNA Primer Synthesis by the Human Primosome, J. Biol. Chem. 291, 10006-10020.
    http://www.ncbi.nlm.nih.gov/pubmed/26975377

    Bodea, S., Funk, M. A., Balskus, E. P., and Drennan, C. L. (2016) Molecular Basis of C-N Bond Cleavage by the Glycyl Radical Enzyme Choline Trimethylamine-Lyase, Cell Chem Biol [Epub ahead of print].
    https://www.ncbi.nlm.nih.gov/pubmed/27642068

    Blower, T. R., Williamson, B. H., Kerns, R. J., and Berger, J. M. (2016) Crystal Structure and Stability of Gyrase-Fluoroquinolone Cleaved Complexes from Mycobacterium Tuberculosis, Proc. Natl. Acad. Sci. U. S. A. 113, 1706-1713.
    http://www.ncbi.nlm.nih.gov/pubmed/26792525

    Buffalo, C. Z., Bahn-Suh, A. J., Hirakis, S. P., Biswas, T., Amaro, R. E., Nizet, V., and Ghosh, P. (2016) Conserved patterns hidden within group A Streptococcus M protein hypervariability recognize human C4b-binding protein, Nat Microbiol 1, 16155.

    https://www.ncbi.nlm.nih.gov/pubmed/27595425

    Chatterjee, D., Sanchez, A. M., Goldgur, Y., Shuman, S., and Schwer, B. (2016) Transcription of Lncrna Prt, Clustered Prt Rna Sites for Mmi1 Binding, and Rna Polymerase Ii Ctd Phospho-Sites Govern the Repression of Pho1 Gene Expression under Phosphate-Replete Conditions in Fission Yeast, RNA 22, 1011-1025.
    http://www.ncbi.nlm.nih.gov/pubmed/27165520

    Chen, M., Chou, W. K., Al-Lami, N., Faraldos, J. A., Allemann, R. K., Cane, D. E., and Christianson, D. W. (2016) Probing the Role of Active Site Water in the Sesquiterpene Cyclization Reaction Catalyzed by Aristolochene Synthase, Biochemistry 55, 2864-2874.
    http://www.ncbi.nlm.nih.gov/pubmed/27172425

    Cho, J., Lee, C.-J., Zhao, J., Young, H. E., and Zhou, P. (2016) Structure of the essential Haemophilus influenzae UDP-diacylglucosamine pyrophosphohydrolase LpxH in lipid A biosynthesis, Nature Microbiology 1, 16154.

    http://www.nature.com/articles/nmicrobiol2016154

    Chowdhury, C., Chun, S., Sawaya, M. R., Yeates, T. O., and Bobik, T. A. (2016) The Function of the Pduj Microcompartment Shell Protein Is Determined by the Genomic Position of Its Encoding Gene, Mol Microbiol 101, 770-783.
    http://dx.doi.org/10.1111/mmi.13423

    Chung, B. C., Mashalidis, E. H., Tanino, T., Kim, M., Matsuda, A., Hong, J., Ichikawa, S., and Lee, S. Y. (2016) Structural Insights into Inhibition of Lipid I Production in Bacterial Cell Wall Synthesis, Nature 533, 557-5690.
    http://www.ncbi.nlm.nih.gov/pubmed/27088606

    Coleman, J. A., Green, E. M., and Gouaux, E. (2016) X-Ray Structures and Mechanism of the Human Serotonin Transporter, Nature 532, 334-339.
    http://www.ncbi.nlm.nih.gov/pubmed/27049939

    Coloma, J., Jain, R., Rajashankar, Kanagalaghatta R., Garcia-Sastre, A., and Aggarwal, Aneel K. (2016) Structures of NS5 Methyltransferase from Zika Virus, Cell Reports.

    https://www.ncbi.nlm.nih.gov/pubmed/27633330

    Cooper, S. R., Jontes, J. D., and Sotomayor, M. (2016) Structural determinants of adhesion by Protocadherin-19 and implications for its role in epilepsy, Elife 5.
    https://www.ncbi.nlm.nih.gov/pubmed/27787195

    Dharmaiah, S., Bindu, L., Tran, T. H., Gillette, W. K., Frank, P. H., Ghirlando, R., Nissley, D. V., Esposito, D., McCormick, F., Stephen, A. G., and Simanshu, D. K. (2016) Structural basis of recognition of farnesylated and methylated KRAS4b by PDEdelta, Proc Natl Acad Sci U S A 113, E6766-E6775.

    https://www.ncbi.nlm.nih.gov/pubmed/27791178

    Dhakshnamoorthy, B., Rohaim, A., Rui, H., Blachowicz, L., and Roux, B. (2016) Structural and functional characterization of a calcium-activated cation channel from Tsukamurella paurometabola, Nat Commun 7, 12753.
    https://www.ncbi.nlm.nih.gov/pubmed/27678077

    Dhayalan, B., Fitzpatrick, A., Mandal, K., Whittaker, J., Weiss, M., Tokmakoff, A., and Kent, S. (2016) Efficient Total Chemical Synthesis of 13c=18o Isotopomers of Human Insulin for Isotope-Edited Ftir, Chembiochem 17, 415-420.
    http://www.ncbi.nlm.nih.gov/pubmed/26715336

    Doamekpor, S. K., Lee, J. W., Hepowit, N. L., Wu, C., Charenton, C., Leonard, M., Bengtson, M. H., Rajashankar, K. R., Sachs, M. S., Lima, C. D., and Joazeiro, C. A. (2016) Structure and function of the yeast listerin (Ltn1) conserved N-terminal domain in binding to stalled 60S ribosomal subunits, Proc Natl Acad Sci U S A 113, E4151-4160.

    http://www.ncbi.nlm.nih.gov/pubmed/27385828

    Dowling, D. P., Miles, Z. D., Kohrer, C., Maiocco, S. J., Elliott, S. J., Bandarian, V., and Drennan, C. L. (2016) Molecular basis of cobalamin-dependent RNA modification, Nucleic Acids Res.

    https://www.ncbi.nlm.nih.gov/pubmed/27638883

     

    Feliciano, P. R., Drennan, C. L., and Nonato, M. C. (2016) Crystal structure of an Fe-S cluster-containing fumarate hydratase enzyme from Leishmania major reveals a unique protein fold, Proc Natl Acad Sci U S A.

    http://www.ncbi.nlm.nih.gov/pubmed/27528683

    Gagnon, M. G., Lin, J., and Steitz, T. A. (2016) Elongation Factor 4 Remodels the a-Site Trna on the Ribosome, Proc. Natl. Acad. Sci. U. S. A. 113, 4994–4999.
    http://www.ncbi.nlm.nih.gov/pubmed/27092003

    Gagnon, M. G., Roy, R. N., Lomakin, I. B., Florin, T., Mankin, A. S., and Steitz, T. A. (2016) Structures of Proline-Rich Peptides Bound to the Ribosome Reveal a Common Mechanism of Protein Synthesis Inhibition, Nucleic Acids Res. 44, 2439-2450.
    http://www.ncbi.nlm.nih.gov/pubmed/26809677

    Gantt, S. M. F., Decroos, C., Lee, M. S., Gullett, L. E., Bowman, C. M., Christianson, D. W., and Fierke, C. A. (2016) General Base-General Acid Catalysis in Human Histone Deacetylase 8, Biochemistry 55, 820–832.
    http://www.ncbi.nlm.nih.gov/pubmed/26806311

    Gao, P., Yang, H., Rajashankar, K. R., Huang, Z., and Patel, D. J. (2016) Type V CRISPR-Cas Cpf1 endonuclease employs a unique mechanism for crRNA-mediated target DNA recognition,Cell Res 26, 901-913.

    http://www.ncbi.nlm.nih.gov/pubmed/27444870

    Geronimo, I., Denning, C. A., Rogers, W. E., Othman, T., Huxford, T., Heidary, D. K., Glazer, E. C., and Payne, C. M. (2016) Effect of Mutation and Substrate Binding on the Stability of Cytochrome P450bm3 Variants, Biochemistry 55, 3594-3606.
    http://www.ncbi.nlm.nih.gov/pubmed/27267136

    Gibson, M. I., Chen, P. Y., Johnson, A. C., Pierce, E., Can, M., Ragsdale, S. W., and Drennan, C. L. (2016) One-Carbon Chemistry of Oxalate Oxidoreductase Captured by X-Ray Crystallography, Proc. Natl. Acad. Sci. U.S.A. 113, 320-325.
    http://www.ncbi.nlm.nih.gov/pubmed/26712008

    Goodman, Kerry M., Rubinstein, R., Thu, Chan A., Bahna, F., Mannepalli, S., Ahlsén, G., Rittenhouse, C., Maniatis, T., Honig, B., and Shapiro, L. (2016) Structural Basis of Diverse Homophilic Recognition by Clustered α- and β-Protocadherins, Neuron 90, 709-723.
    http://www.ncbi.nlm.nih.gov/pubmed/27161523

    Goodman, K. M., Rubinstein, R., Thu, C. A., Mannepalli, S., Bahna, F., Ahlsen, G., Rittenhouse, C., Maniatis, T., Honig, B., and Shapiro, L. (2016) γ-Protocadherin structural diversity and functional implications, Elife 5.

    https://www.ncbi.nlm.nih.gov/pubmed/27782885

    Gorelik, M., Orlicky, S., Sartori, M. A., Tang, X., Marcon, E., Kurinov, I., Greenblatt, J. F., Tyers, M., Moffat, J., Sicheri, F., and Sidhu, S. S. (2016) Inhibition of Scf Ubiquitin Ligases by Engineered Ubiquitin Variants That Target the Cul1 Binding Site on the Skp1-F-Box Interface, Proc. Natl. Acad. Sci. U.S.A. 113, 3527–3532.
    http://www.ncbi.nlm.nih.gov/pubmed/26976582

    Hayes, R. P., Xiao, Y., Ding, F., van Erp, P. B. G., Rajashankar, K., Bailey, S., Wiedenheft, B., and Ke, A. (2016) Structural Basis for Promiscuous Pam Recognition in Type I–E Cascade from E. Coli, Nature 530, 499-503.
    http://www.ncbi.nlm.nih.gov/pubmed/26863189

    Hicks, K. A., and Ealick, S. E. (2016) Biochemical and Structural Characterization of Klebsiella Pneumoniae Oxamate Amidohydrolase in the Uric Acid Degradation Pathway, Acta Crystallogr D Struct Biol 72, 808-816.
    http://www.ncbi.nlm.nih.gov/pubmed/27303801

    Hicks, K. A., Yuen, M. E., Zhen, W. F., Gerwig, T. J., Story, R. W., Kopp, M. C., and Snider, M. J. (2016) Structural and Biochemical Characterization of 6-Hydroxynicotinic Acid 3-Monooxygenase, a Novel Decarboxylative Hydroxylase Involved in Aerobic Nicotinate Degradation, Biochemistry 55, 3432-3446.
    http://www.ncbi.nlm.nih.gov/pubmed/27218267

    Huang, H., Deng, Z., Vladimirova, O., Wiedmer, A., Lu, F., Lieberman, P. M., and Patel, D. J. (2016) Structural basis underlying viral hijacking of a histone chaperone complex, Nat Commun 7, 12707.
    http://www.ncbi.nlm.nih.gov/pubmed/27581705

    Jorda, J., Leibly, D. J., Thompson, M. C., and Yeates, T. O. (2016) Structure of a Novel 13 Nm Dodecahedral Nanocage Assembled from a Redesigned Bacterial Microcompartment Shell Protein, Chem. Commun. (Camb) 52, 5041-5044.
    http://www.ncbi.nlm.nih.gov/pubmed/26988700

    Kim, M., Sandford, E., Gatica, D., Qiu, Y., Liu, X., Zheng, Y., Schulman, B. A., Xu, J., Semple, I., Ro, S. H., Kim, B., Mavioglu, R. N., Tolun, A., Jipa, A., Takats, S., Karpati, M., Li, J. Z., Yapici, Z., Juhasz, G., Lee, J. H., Klionsky, D. J., and Burmeister, M. (2016) Mutation in Atg5 Reduces Autophagy and Leads to Ataxia with Developmental Delay, Elife 5, e12245.
    http://www.ncbi.nlm.nih.gov/pubmed/26812546

    Kumar, N., Radhakrishnan, A., Su, C. C., Osteryoung, K. W., and Yu, E. W. (2016) Crystal Structure of a Conserved Domain in the Intermembrane Space Region of the Plastid Division Protein Arc6, Protein Sci. 25, 523-529.
    http://www.ncbi.nlm.nih.gov/pubmed/26452626

    Lee, S. J., Ren, F., Zangerl-Plessl, E. M., Heyman, S., Stary-Weinzinger, A., Yuan, P., and Nichols, C. G. (2016) Structural basis of control of inward rectifier Kir2 channel gating by bulk anionic phospholipids, J Gen Physiol 148, 227-237.

    https://www.ncbi.nlm.nih.gov/pubmed/27527100

    Leroy, E., Dusa, A., Colau, Motamedi, A., Cahu, X., Mouton, C., Huang, L. J., Shiau, A. K., and Constantinescu, S. N. (2016) Uncoupling Jak2 V617f Activation from Cytokine-Induced Signalling by Modulation of Jh2 Alphac Helix, Biochem. J. 473, 1579-1591.
    http://www.ncbi.nlm.nih.gov/pubmed/27029346

    Liu, B., Zuo, Y., and Steitz, T. A. (2016) Structures of E. Coli Σs-Transcription Initiation Complexes Provide New Insights into Polymerase Mechanism, Proc. Natl. Acad. Sci. U. S. A. 113, 4051-4056.
     http://www.ncbi.nlm.nih.gov/pubmed/27035955

    Lyubimov, A. Y., Uervirojnangkoorn, M., Zeldin, O. B., Zhou, Q., Zhao, M., Brewster, A. S., Michels-Clark, T., Holton, J. M., Sauter, N. K., Weis, W. I., and Brunger, A. T. (2016) Advances in X-ray free electron laser (XFEL) diffraction data processing applied to the crystal structure of the synaptotagmin-1 / SNARE complex, Elife 5.
    https://www.ncbi.nlm.nih.gov/pubmed/27731796

    Mandal, K., Dhayalan, B., Avital-Shmilovici, M., Tokmakoff, A., and Kent, S. B. H. (2016) Crystallization of Enantiomerically Pure Proteins from Quasi-Racemic Mixtures: Structure Determination by X-Ray Diffraction of Isotope-Labeled Ester Insulin and Human Insulin, ChemBioChem 17, 421-425.
    http://www.ncbi.nlm.nih.gov/pubmed/26707939

    Matsuyama, B. Y., Krasteva, P. V., Baraquet, C., Harwood, C. S., Sondermann, H., and Navarro, M. V. (2016) Mechanistic Insights into C-Di-Gmp-Dependent Control of the Biofilm Regulator Fleq from Pseudomonas Aeruginosa, Proc. Natl. Acad. U. S. A. 113, E209-218.
    http://www.ncbi.nlm.nih.gov/pubmed/26712005

    Matthews, M. M., Thomas, J. M., Zheng, Y., Tran, K., Phelps, K. J., Scott, A. I., Havel, J., Fisher, A. J., and Beal, P. A. (2016) Structures of Human Adar2 Bound to Dsrna Reveal Base-Flipping Mechanism and Basis for Site Selectivity, Nat. Struct. Mol. Biol. 23, 426-433.
    http://www.ncbi.nlm.nih.gov/pubmed/27065196

    McCoy, Jason G., Ren, Z., Stanevich, V., Lee, J., Mitra, S., Levin, Elena J., Poget, S., Quick, M., Im, W., and Zhou, M. (2016) The Structure of a Sugar Transporter of the Glucose Eiic Superfamily Provides Insight into the Elevator Mechanism of Membrane Transport, Structure 24, 956-964.
    http://www.ncbi.nlm.nih.gov/pubmed/27161976

    McLaughlin, M. I., Lanz, N. D., Goldman, P. J., Lee, K. H., Booker, S. J., and Drennan, C. L. (2016) Crystallographic snapshots of sulfur insertion by lipoyl synthase, Proc Natl Acad Sci U S A.

    http://www.ncbi.nlm.nih.gov/pubmed/27506792

    Mansoor, S. E., Lu, W., Oosterheert, W., Shekhar, M., Tajkhorshid, E., and Gouaux, E. (2016) X-ray structures define human P2X3 receptor gating cycle and antagonist action, Nature.

    https://www.ncbi.nlm.nih.gov/pubmed/27626375

    Meisburger, S. P., Taylor, A. B., Khan, C. A., Zhang, S., Fitzpatrick, P. F., and Ando, N. (2016) Domain Movements Upon Activation of Phenylalanine Hydroxylase Characterized by Crystallography and Chromatography-Coupled Small-Angle X-Ray Scattering, J. Am. Chem. Soc. 138, 6506-6516.
    http://www.ncbi.nlm.nih.gov/pubmed/27145334

    Melillo, B., Liang, S., Park, J., Schon, A., Courter, J. R., LaLonde, J. M., Wendler, D. J., Princiotto, A. M., Seaman, M. S., Freire, E., Sodroski, J., Madani, N., Hendrickson, W. A., and Smith, A. B., 3rd. (2016) Small-Molecule Cd4-Mimics: Structure-Based Optimization of Hiv-1 Entry Inhibition, ACS Med. Chem. Lett. 7, 330-334.
    http://www.ncbi.nlm.nih.gov/pubmed/26985324

    Metrick, C. M., and Heldwein, E. E. (2016) Novel Structure and Unexpected Rna-Binding Ability of the C-Terminal Domain of Herpes Simplex Virus 1 Tegument Protein Ul21, J Virol 90, 5759-5769.
    http://www.ncbi.nlm.nih.gov/pubmed/27053559

    Metrick, C. M., and Heldwein, E. E. (2016) The Novel Structure and Unexpected Rna-Binding Ability of the C-Terminal Domain of Hsv-1 Tegument Protein Ul21, J. Virol. 90, 5759-5769.
    http://www.ncbi.nlm.nih.gov/pubmed/27053559

    Morales-Perez, C. L., Noviello, C. M., and Hibbs, R. E. (2016) X-ray structure of the human α4β2 nicotinic receptor, Nature 538, 411-415.

    https://www.ncbi.nlm.nih.gov/pubmed/27698419

    Morgan, J. L., McNamara, J. T., Fischer, M., Rich, J., Chen, H. M., Withers, S. G., and Zimmer, J. (2016) Observing Cellulose Biosynthesis and Membrane Translocation in Crystallo, Nature 531, 329-334.
    http://www.ncbi.nlm.nih.gov/pubmed/26958837

    Murn, J., Teplova, M., Zarnack, K., Shi, Y., and Patel, D. J. (2016) Recognition of Distinct Rna Motifs by the Clustered Ccch Zinc Fingers of Neuronal Protein Unkempt, Nat. Struct. Mol. Biol. 23, 16-23.
    http://www.ncbi.nlm.nih.gov/pubmed/26641712

    Neumann, W., Xu, S., Sarosi, M. B., Scholz, M. S., Crews, B. C., Ghebreselasie, K., Banerjee, S., Marnett, L. J., and Hey-Hawkins, H. C. (2016) Nido-Dicarbaborate Induces Potent and Selective Inhibition of Cyclooxygenase-2, ChemMedChem 11, 175-178.
    http://www.ncbi.nlm.nih.gov/pubmed/26088701

    Nicoludis, J. M., Vogt, B. E., Green, A. G., Scharfe, C. P., Marks, D. S., and Gaudet, R. (2016) Antiparallel protocadherin homodimers use distinct affinity- and specificity-mediating regions in cadherin repeats 1-4, Elife 5.

    http://www.ncbi.nlm.nih.gov/pubmed/27472898

    Oyala, P. H., Ravichandran, K. R., Funk, M. A., Stucky, P. A., Stich, T. A., Drennan, C. L., Britt, R. D., and Stubbe, J. (2016) Biophysical Characterization of Fluorotyrosine Probes Site-Specifically Incorporated into Enzymes: E. coli Ribonucleotide Reductase As an Example, J Am. Chem. Soc. 138, 7951-7964.

    http://www.ncbi.nlm.nih.gov/pubmed/27276098

    Pascolutti, R., Sun, X., Kao, J., Maute, R. L., Ring, A. M., Bowman, G. R., and Kruse, A. C. (2016) Structure and Dynamics of PD-L1 and an Ultra-High-Affinity PD-1 Receptor Mutant, Structure.

    https://www.ncbi.nlm.nih.gov/pubmed/27618663

    Petrou, V. I., Herrera, C. M., Schultz, K. M., Clarke, O. B., Vendome, J., Tomasek, D., Banerjee, S., Rajashankar, K. R., Belcher Dufrisne, M., Kloss, B., Kloppmann, E., Rost, B., Klug, C. S., Trent, M. S., Shapiro, L., and Mancia, F. (2016) Structures of Aminoarabinose Transferase Arnt Suggest a Molecular Basis for Lipid a Glycosylation, Science 351, 608-612.
    http://www.ncbi.nlm.nih.gov/pubmed/26912703

    Pierson, W. E., Hoffer, E. D., Keedy, H. E., Simms, C. L., Dunham, C. M., and Zaher, H. S. (2016) Uniformity of Peptide Release Is Maintained by Methylation of Release Factors, Cell Rep 17, 11-18.

    https://www.ncbi.nlm.nih.gov/pubmed/27681416

    Rechkoblit, O., Gupta, Y. K., Malik, R., Rajashankar, K. R., Johnson, R. E., Prakash, L., Prakash, S., and Aggarwal, A. K. (2016) Structure and mechanism of human PrimPol, a DNA polymerase with primase activity, Sci Adv 2, e1601317.

    https://www.ncbi.nlm.nih.gov/pubmed/27819052

    Ren, A., Vusurovic, N., Gebetsberger, J., Gao, P., Juen, M., Kreutz, C., Micura, R., and Patel, D. J. (2016) Pistol Ribozyme Adopts a Pseudoknot Fold Facilitating Site-Specific in-Line Cleavage, Nat Chem Biol 12, 702-708.
    http://www.ncbi.nlm.nih.gov/pubmed/27398999

    Saotome, K., Singh, A. K., Yelshanskaya, M. V., and Sobolevsky, A. I. (2016) Crystal structure of the epithelial calcium channel TRPV6, Nature 534, 506-511.

    http://www.ncbi.nlm.nih.gov/pubmed/27296226

    Saxton, R. A., Knockenhauer, K. E., Schwartz, T. U., and Sabatini, D. M. (2016) The apo-structure of the leucine sensor Sestrin2 is still elusive, Sci Signal 9, ra92.
    https://www.ncbi.nlm.nih.gov/pubmed/27649739

    Saxton, R. A., Knockenhauer, K. E., Wolfson, R. L., Chantranupong, L., Pacold, M. E., Wang, T., Schwartz, T. U., and Sabatini, D. M. (2016) Structural Basis for Leucine Sensing by the Sestrin2-Mtorc1 Pathway, Science 351, 53-58.
    http://www.ncbi.nlm.nih.gov/pubmed/26586190

    Schmidt, F. I., Lu, A., Chen, J. W., Ruan, J., Tang, C., Wu, H., and Ploegh, H. L. (2016) A Single Domain Antibody Fragment That Recognizes the Adaptor Asc Defines the Role of Asc Domains in Inflammasome Assembly, J. Exp. Med. 213, 771–790.
    http://www.ncbi.nlm.nih.gov/pubmed/27069117

    Schmidt, H. R., Zheng, S., Gurpinar, E., Koehl, A., Manglik, A., and Kruse, A. C. (2016) Crystal Structure of the Human Σ1 Receptor, Nature 532, 527-530.
    http://www.ncbi.nlm.nih.gov/pubmed/27042935

    Schureck, M. A., Repack, A., Miles, S. J., Marquez, J., and Dunham, C. M. (2016) Mechanism of endonuclease cleavage by the HigB toxin, Nucleic Acids Res [Epub ahead of print].
    http://www.ncbi.nlm.nih.gov/pubmed/27378776

    Shao, Y., Huang, H., Qin, D., Li, N. S., Koide, A., Staley, J. P., Koide, S., Kossiakoff, A. A., and Piccirilli, J. A. (2016) Specific Recognition of a Single-stranded RNA Sequence by a Synthetic Antibody Fragment, J Mol Biol.

    https://www.ncbi.nlm.nih.gov/pubmed/27593161

    Shan, C. M., Wang, J., Xu, K., Chen, H., Yue, J. X., Andrews, S., Moresco, J. J., Yates, J. R., Nagy, P. L., Tong, L., and Jia, S. (2016) A histone H3K9M mutation traps histone methyltransferase Clr4 to prevent heterochromatin spreading, Elife 5.
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    Winter, G. E., Buckley, D. L., Paulk, J., Roberts, J. M., Souza, A., Dhe-Paganon, S., and Bradner, J. E. (2015) Phthalimide conjugation as a strategy for in vivo target protein degradation, Science 348, 1376-1381. PubMed

    Winter, J. M., Cascio, D., Dietrich, D., Sato, M., Watanabe, K., Sawaya, M. R., Vederas, J. C., and Tang, Y. (2015) Biochemical and Structural Basis for Controlling Chemical Modularity in Fungal Polyketide Biosynthesis, J. Am. Chem. Soc. 137, 9885–9893. PubMed

    Wojcik, J., Lamontanara, A. J., Grabe, G., Koide, A., Akin, L., Gerig, B., Hantschel, O., and Koide, S. (2016) Allosteric Inhibition of Bcr-Abl Kinase by High-Affinity Monobody Inhibitors Directed to the SH2-Kinase Interface, J. Biol. Chem. [Epub ahead of print]. PubMed

    Xu, K., Chan, Y. P., Bradel-Tretheway, B., Akyol-Ataman, Z., Zhu, Y., Dutta, S., Yan, L., Feng, Y., Wang, L. F., Skiniotis, G., Lee, B., Zhou, Z. H., Broder, C. C., Aguilar, H. C., and Nikolov, D. B. (2015) Crystal Structure of the Pre-fusion Nipah Virus Fusion Glycoprotein Reveals a Novel Hexamer-of-Trimers Assembly, PLoS Pathog. 11, e1005322. PubMed

    Xu, K., Olsen, O., Tzvetkova-Robev, D., Tessier-Lavigne, M., and Nikolov, D. B. (2015) The crystal structure of DR6 in complex with the amyloid precursor protein provides insight into death receptor activation, Genes Dev. 29, 785-790. PubMed

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    Zhang, J., Kiser, P. D., Badiee, M., Palczewska, G., Dong, Z., Golczak, M., Tochtrop, G. P., and Palczewski, K. (2015) Molecular pharmacodynamics of emixustat in protection against retinal degeneration, J. Clin. Invest. 125, 2781-2794. PubMed

    Zhao, C., Rajashankar, K. R., Marcia, M., and Pyle, A. M. (2015) Crystal structure of group II intron domain 1 reveals a template for RNA assembly, Nat. Chem. Biol. 11, 967-972. PubMed

    Zhou, C., Pourmal, S., and Pavletich, N. P. (2015) Dna2 nuclease-helicase structure, mechanism and regulation by Rpa, Elife [Epub ahead of edits]. PubMed

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    2014

    Joh, N. H., Wang, T., Bhate, M. P., Acharya, R., Wu, Y., Grabe, M., Hong, M., Grigoryan, G., and DeGrado, W. F. (2014) De novo design of a transmembrane Zn2+-transporting four-helix bundle, Science 346, 1520-1524. PubMed

    Yamaguchi, M., Yu, S., Qiao, R., Weissmann, F., Miller, D. J., VanderLinden, R., Brown, N. G., Frye, J. J., Peters, J.-M., and Schulman, B. A. (2014) Structure of an APC3-APC16 complex: Insights into assembly of the Anaphase Promoting Complex/Cyclosome, J. Mol. Biol.427, 1748-1764. PubMed

    Bhattacharya, A., Alam, S. L., Fricke, T., Zadrozny, K., Sedzicki, J., Taylor, A. B., Demeler, B., Pornillos, O., Ganser-Pornillos, B. K., Diaz-Griffero, F., Ivanov, D. N., and Yeager, M. (2014) Structural basis of HIV-1 capsid recognition by PF74 and CPSF6, Proc. Nat. Acad. Sci. U.S.A. 111, 18625-18630. PubMed

    Spicer, T. P., Jiang, J., Taylor, A. B., Choi, J. Y., Hart, P. J., Roush, W. R., Fields, G. B., Hodder, P. S., and Minond, D. (2014) Characterization of Selective Exosite-Binding Inhibitors of Matrix Metalloproteinase 13 That Prevent Articular Cartilage Degradation in Vitro, J. Med. Chem. 57, 9598-9611. PubMed

    Ren, A., Kosutic, M., Rajashankar, K. R., Frener, M., Santner, T., Westhof, E., Micura, R., and Patel, D. J. (2014) In-line alignment and Mg2+coordination at the cleavage site of the env22 twister ribozyme, Nat. Commun. 5, 5534. PubMed

    Brohawn, S. G., Campbell, E. B., and MacKinnon, R. (2014) Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel, Nature 516, 126-130. PubMed

    Baranovskiy, A. G., Babayeva, N. D., Suwa, Y., Gu, J., Pavlov, Y. I., and Tahirov, T. H. (2014) Structural basis for inhibition of DNA replication by aphidicolin, Nucleic Acids Res. 42, 14013-1401. PubMed

    Bobik, T. A., Morales, E. J., Shin, A., Cascio, D., Sawaya, M. R., Arbing, M., Yeates, T. O., and Rasche, M. E. (2014) Structure of the methanofuran/methanopterin-biosynthetic enzyme MJ1099 from Methanocaldococcus jannaschii, Acta Crystallogr. F 70, 1472-1479. PubMed

    Guo, L. T., Wang, Y. S., Nakamura, A., Eiler, D., Kavran, J. M., Wong, M., Kiessling, L. L., Steitz, T. A., O'Donoghue, P., and Soll, D. (2014) Polyspecific pyrrolysyl-tRNA synthetases from directed evolution, Proc. Nat. Acad. Sci. U.S.A. 111, 16724-16729. PubMed

    Brown, N. G., Watson, E. R., Weissmann, F., Jarvis, M. A., VanderLinden, R., Grace, C. R., Frye, J. J., Qiao, R., Dube, P., Petzold, G., Cho, S. E., Alsharif, O., Bao, J., Davidson, I. F., Zheng, J. J., Nourse, A., Kurinov, I., Peters, J. M., Stark, H., and Schulman, B. A. (2014) Mechanism of Polyubiquitination by Human Anaphase-Promoting Complex: RING Repurposing for Ubiquitin Chain Assembly, Mol. Cell 56, 246-260. PubMed

    Jacewicz, A., Schwer, B., Smith, P., and Shuman, S. (2014) Crystal structure, mutational analysis and RNA-dependent ATPase activity of the yeast DEAD-box pre-mRNA splicing factor Prp28, Nucleic Acids Res. 42, 12885–12898. PubMed

    Malmirchegini, G. R., Sjodt, M., Shnitkind, S., Sawaya, M. R., Rosinski, J., Newton, S. M., Klebba, P. E., and Clubb, R. T. (2014) Novel mechanism of hemin capture by Hbp2, the hemoglobin-binding hemophore from Listeria monocytogenes, J. Biol. Chem. 289, 34886–34899. PubMed

    Remus, B. S., Jacewicz, A., and Shuman, S. (2014) Structure and mechanism of E. coli RNA 2′,′'-cyclic phosphodiesterase, RNA 20, 1697-1705. PubMed

    Liu, D. S., Nivon, L. G., Richter, F., Goldman, P. J., Deerinck, T. J., Yao, J. Z., Richardson, D., Phipps, W. S., Ye, A. Z., Ellisman, M. H., Drennan, C. L., Baker, D., and Ting, A. Y. (2014) Computational design of a red fluorophore ligase for site-specific protein labeling in living cells, Proc. Nat. Acad. Sci. U.S.A. 111, E4551-4559. PubMed

    Thompson, M. C., Crowley, C. S., Kopstein, J., Bobik, T. A., and Yeates, T. O. (2014) Structure of a bacterial microcompartment shell protein bound to a cobalamin cofactor, Acta Crystallogr. F 70, 1584-1590. PubMed

    Cavalier, M. C., Pierce, A. D., Wilder, P. T., Alasady, M. J., Hartman, K. G., Neau, D. B., Foley, T. L., Jadhav, A., Maloney, D. J., Simeonov, A., Toth, E. A., and Weber, D. J. (2014) Covalent small molecule inhibitors of Ca-bound S100B, Biochemistry 53, 6628-6640. PubMed

    Ayres, C. A., Schormann, N., Senkovich, O., Fry, A., Banerjee, S., Ulett, G. C., and Chattopadhyay, D. (2014) Structure of Streptococcus agalactiae glyceraldehyde-3-phosphate dehydrogenase holoenzyme reveals a novel surface, Acta Crystallogr. F 70, 1333-1339. PubMed

    Polikanov, Y. S., Osterman, I. A., Szal, T., Tashlitsky, V. N., Serebryakova, M. V., Kusochek, P., Bulkley, D., Malanicheva, I. A., Efimenko, T. A., Efremenkova, O. V., Konevega, A. L., Shaw, K. J., Bogdanov, A. A., Rodnina, M. V., Dontsova, O. A., Mankin, A. S., Steitz, T. A., and Sergiev, P. V. (2014) Amicoumacin A Inhibits Translation by Stabilizing mRNA Interaction with the Ribosome, Mol. Cell 56, 531-540. PubMed

    Fagan, C. E., Maehigashi, T., Dunkle, J. A., Miles, S. J., and Dunham, C. M. (2014) Structural insights into translational recoding by frameshift suppressor tRNASufJ, RNA 20, 1944-1954. PubMed

    Polikanov, Y. S., Szal, T., Jiang, F., Gupta, P., Matsuda, R., Shiozuka, M., Steitz, T. A., Vazquez-Laslop, N., and Mankin, A. S. (2014) Negamycin Interferes with Decoding and Translocation by Simultaneous Interaction with rRNA and tRNA, Mol Cell. 56, 541-550. PubMed

    Schmitz, K. R., Carney, D. W., Sello, J. K., and Sauer, R. T. (2014) Crystal structure of Mycobacterium tuberculosis ClpP1P2 suggests a model for peptidase activation by AAA+ partner binding and substrate delivery, Proc. Nat. Acad. Sci. U.S.A. 111, E4587-4595. PubMed

    Robart, A. R., Chan, R. T., Peters, J. K., Rajashankar, K. R., and Toor, N. (2014) Crystal structure of a eukaryotic group II intron lariat, Nature 514, 193-197. PubMed

    Ji, X., Tang, C., Zhao, Q., Wang, W., and Xiong, Y. (2014) Structural basis of cellular dNTP regulation by SAMHD1, Proc. Natl. Acad. Sci. U. S. A .111, E4305–E4314. PubMed

    Baker, B. Y., Shi, W., Wang, B., and Palczewski, K. (2014) High Resolution Crystal Structures of the Photoreceptor Glyceraldehyde 3-Phosphate Dehydrogenase (GAPDH) with Three and Four-bound NAD Molecules, Protein Sci. 23, 1629-1639. PubMed

    Lee, K. S., Liu, J. Y., Wagner, K., Pakhomova, S., Dong, H., Morisseau, C., Fu, S., Yang, J., Wang, P., Ulu, A., Mate, C. A., Nguyen, L. V., Hwang, S. H., Edin, M. L., Mara, A. A., Wulff, H., Newcomer, M. E., Zeldin, D., and Hammock, B. D. (2014) Optimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacy, J. Med. Chem. 28, 7016-7030. PubMed

    Setser, J. W., Heemstra, J. R., Walsh, C. T., and Drennan, C. L. (2014) Crystallographic evidence for drastic conformational changes in the active site of a flavin-dependent N-hydrxylase, Biochemistry 53, 6063–6077. PubMed

    Gao, P., Zillinger, T., Wang, W., Ascano, M., Dai, P., Hartmann, G., Tuschl, T., Deng, L., Barchet, W., and Patel, D. J. (2014) Binding-Pocket and Lid-Region Substitutions Render Human STING Sensitive to the Species-Specific Drug DMXAA, Cell Rep. 8, 1668–1676. PubMed

    Zhang, J., and Ferré-D'Amaré, A. R. (2014) Dramatic Improvement of Crystals of Large RNAs by Cation Replacement and Dehydration, Structure 22, 1363-1371. PubMed

    Grossmann, N., Vakkasoglu, A. S., Hulpke, S., Abele, R., Gaudet, R., and Tampé, R. (2014) Mechanistic determinants of the directionality and energetics of active export by a heterodimeric ABC transporter, Nat. Commun. 5, 5419. PubMed

    Eiler, D., Wang, J., and Steitz, T. A. (2014) Structural basis for the fast self-cleavage reaction catalyzed by the twister ribozyme, Proc. Nat. Acad. Sci. U.S.A. 111, 13028–13033. PubMed

    Sosa, B. A., Demircioglu, F. E., Chen, J. Z., Ingram, J., Ploegh, H., and Schwartz, T. U. (2014) How lamina-associated polypeptide 1 (LAP1) activates Torsin, Elife 3, e03239. PubMed

    Wei, Y., Funk, M. A., Rosado, L. A., Baek, J., Drennan, C. L., and Stubbe, J. (2014) The class III ribonucleotide reductase from Neisseria bacilliformis can utilize thioredoxin as a reductant, Proc. Nat. Acad. Sci. U.S.A. 111, E3756–E3765. PubMed

    Brumshtein, B., Esswein, S. R., Landau, M., Ryan, C. M., Whitelegge, J. P., Phillips, M. L., Cascio, D., Sawaya, M. R., and Eisenberg, D. S. (2014) Formation of Amyloid Fibers by Monomeric Light-chain Variable Domains, J. Biol. Chem. 289, 27513-27525. PubMed

    Polikanov, Y. S., Steitz, T. A., and Innis, C. A. (2014) A proton wire to couple aminoacyl-tRNA accommodation and peptide-bond formation on the ribosome, Nat. Struct. Mol. Biol. 21, 787-793. PubMed

    Maehigashi, T., Dunkle, J. A., Miles, S. J., and Dunham, C. M. (2014) Structural insights into +1 frameshifting promoted by expanded or modification-deficient anticodon stem loops, Proc. Nat. Acad. Sci. U.S.A. 111, 12740–12745. PubMed

    Thompson, M. C., Wheatley, N. M., Jorda, J., Sawaya, M. R., Gidaniyan, S. D., Ahmed, H., Yang, Z., McCarty, K. N., Whitelegge, J. P., and Yeates, T. O. (2014) Identification of a Unique Fe-S Cluster Binding Site in a Glycyl-Radical Type Microcompartment Shell Protein, J. Mol. Biol. 426, 3287–3304. PubMed

    Warner, K. D., Chen, M. C., Song, W., Strack, R. L., Thorn, A., Jaffrey, S. R., and Ferre-D'Amare, A. R. (2014) Structural basis for activity of highly efficient RNA mimics of green fluorescent protein, Nat. Struct. Mol. Biol. 21, 658-663. PubMed

    Leettola, C. N., Knight, M. J., Cascio, D., Hoffman, S., and Bowie, J. U. (2014) Characterization of the SAM domain of the PKD-related protein ANKS6 and its interaction with ANKS3, BMC Struct. Biol. 14, 17. PubMed

    Clayton, G. M., Wang, Y., Crawford, F., Novikov, A., Wimberly, B. T., Kieft, J. S., Falta, M. T., Bowerman, N. A., Marrack, P., Fontenot, A. P., Dai, S., and Kappler, J. W. (2014) Structural basis of chronic beryllium disease: linking allergic hypersensitivity and autoimmunity, Cell 158, 132-142. PubMed

    Huang, H., Levin, E. J., Liu, S., Bai, Y., Lockless, S. W., and Zhou, M. (2014) Structure of a Membrane-Embedded Prenyltransferase Homologous to UBIAD1, PLoS Biol 12, e1001911. PubMed

    Bulkley, D., Brandi, L., Polikanov, Y. S., Fabbretti, A., O'Connor, M., Gualerzi, C. O., and Steitz, T. A.  (2014) The Antibiotics Dityromycin and GE82832 Bind Protein S12 and Block EF-G-Catalyzed Translocation, Cell Reports 6, 357-365. PubMed

    Brown, J. A., Bulkley, D., Wang, J., Valenstein, M. L., Yario, T. A., Steitz, T. A., and Steitz, J. A. (2014) Structural insights into the stabilization of MALAT1 noncoding RNA by a bipartite triple helix, Nat. Struct. Mol. Biol. 21, 633-640. PubMed

    Doamekpor, S. K., Sanchez, A. M., Schwer, B., Shuman, S., and Lima, C. D. (2014) How an mRNA capping enzyme reads distinct RNA polymerase II and Spt5 CTD phosphorylation codes, Genes Dev. 28, 1323-1336. PubMed

    Xu, K., Wu, Z., Renier, N., Antipenko, A., Tzvetkova-Robev, D., Xu, Y., Minchenko, M., Nardi-Dei, V., Rajashankar, K. R., Himanen, J., Tessier-Lavigne, M., and Nikolov, D. B. (2014) Neural migration. Structures of netrin-1 bound to two receptors provide insight into its axon guidance mechanism, Science 344, 1275-1279. PubMed

    Warner, K. D., Homan, P., Weeks, K. M., Smith, A. G., Abell, C., and Ferré-D'Amaré, A. R. (2014) Validating Fragment-Based Drug Discovery for Biological RNAs: Lead Fragments Bind and Remodel the TPP Riboswitch Specifically, Chem. Biol. 21, 591-595. PubMed

    Sciara, G., Clarke, O. B., Tomasek, D., Kloss, B., Tabuso, S., Byfield, R., Cohn, R., Banerjee, S., Rajashankar, K. R., Slavkovic, V., Graziano, J. H., Shapiro, L., and Mancia, F. (2014) Structural basis for catalysis in a CDP-alcohol phosphotransferase, Nat. Commun. 5, 4068. PubMed

    Sinha, S., Cheng, S., Sung, Y. W., McNamara, D. E., Sawaya, M. R., Yeates, T. O., and Bobik, T. A. (2014) Alanine Scanning Mutagenesis Identifies an Asparagine-Arginine-Lysine Triad Essential to Assembly of the Shell of the Pdu Microcompartment. J. Mol. Biol. 426, 2328-2345. PubMed

    Wang, J., and Wing, R. A. (2014) Diamonds in the rough: a strong case for the inclusion of weak-intensity X-ray diffraction data, Acta Crystallogr. D 70, 1491-1497. PubMed

    Dow, B. A., Sukumar, N., Matos, J. O., Choi, M., Schulte, A., Tatulian, S. A., and Davidson, V. L. (2014) The sole tryptophan of amicyanin enhances its thermal stability but does not influence the electronic properties of the type 1 copper site, Arch. Biochem. Biophys. 550-551, 24-27. PubMed

    Hochberg, G. K., Ecroyd, H., Liu, C., Cox, D., Cascio, D., Sawaya, M. R., Collier, M. P., Stroud, J., Carver, J. A., Baldwin, A. J., Robinson, C. V., Eisenberg, D. S., Benesch, J. L., and Laganowsky, A. (2014) The structured core domain of alpha B-crystallin can prevent amyloid fibrillation and associated toxicity, Proc. Nat. Acad. Sci. U.S.A. 11, E1562–E1570. PubMed

    Dunkle, J. A., Vinal, K., Desai, P. M., Zelinskaya, N., Savic, M., West, D. M., Conn, G. L., and Dunham, C. M. (2014) Molecular recognition and modification of the 30S ribosome by the aminoglycoside-resistance methyltransferase NpmA, Proc. Nat. Acad. Sci. U.S.A. 111, 6275-6280. PubMed

    Tu, X., and Palczewski, K. (2014) The macular degeneration-linked C1QTNF5 (S163) mutation causes higher-order structural rearrangements, J. Struct. Biol. 186, 86-94. PubMed

    Cheng, W., and Li, W. (2014) Structural insights into ubiquinone biosynthesis in membranes, Science 343, 878-881. PubMed

    Sui, X., Kiser, P. D., Che, T., Carey, P. R., Golczak, M., Shi, W., Von Lintig, J., and Palczewski, K. (2014) Analysis of carotenoid isomerase activity in a prototypical carotenoid cleavage enzyme, apocarotenoid oxygenase (ACO), J. Biol. Chem. 289, 12286-12289. PubMed

    Ritacco, C. J., Steitz, T. A., and Wang, J. (2014) Exploiting large non-isomorphous differences for phase determination of a G-segment invertase-DNA complex, Acta Crystallogr. D 70, 685-693. PubMed

    Blankenship, E., Vukoti, K., Miyagi, M., and Lodowski, D. T. (2014) Conformational flexibility in the catalytic triad revealed by the high-resolution crystal structure of Streptomyces erythraeus trypsin in an unliganded state, Acta Crystallogr. D 70, 833-840. PubMed

    Kolli, N., and Garman, S. C. (2014) Proteolytic activation of human cathepsin A, J. Biol. Chem. 289, 11592-11600. PubMed

    Lou, X., Toresson, G., Benod, C., Suh, J. H., Philips, K. J., Webb, P., and Gustafsson, J.-A. (2014) Structure of the retinoid X receptor α–liver X receptor β (RXRα–LXRβ) heterodimer on DNA, Nat. Struct. Mol. Biol. 21, 277-281. PubMed

    McNamara, D. E., Cascio, D., Jorda, J., Bustos, C., Wang, T. C., Rasche, M. E., Yeates, T. O., and Bobik, T. A. (2014) Structure of Dihydromethanopterin Reductase: A Cubic Protein Cage for Redox Transfer, J. Biol. Chem. 289, 8852–8864. PubMed

    Singh, H., Arentson, B. W., Becker, D. F., and Tanner, J. J. (2014) Structures of the PutA peripheral membrane flavoenzyme reveal a dynamic substrate-channeling tunnel and the quinone-binding site, Proc. Nat. Acad. Sci. U.S.A. 111, 3389-3394.

    Strunk, R. J., Piemonte, K. M., Petersen, N. M., Koutsioulis, D., Bouriotis, V., Perry, K., and Cole, K. E. (2014) Structure determination of BA0150, a putative polysaccharide deacetylase from Bacillus anthracis, Acta Crystallogr. F 70, 156-159. PubMed

    Huang, H., Zeqiraj, E., Dong, B., Jha, B. K., Duffy, N. M., Orlicky, S., Thevakumaran, N., Talukdar, M., Pillon, M. C., Ceccarelli, D. F., Wan, L. C., Juang, Y. C., Mao, D. Y., Gaughan, C., Brinton, M. A., Perelygin, A. A., Kourinov, I., Guarne, A., Silverman, R. H., and Sicheri, F. (2014) Dimeric Structure of Pseudokinase RNase L Bound to 2-5A Reveals a Basis for Interferon-Induced Antiviral Activity, Mol. Cell 53, 221-234. PubMed

    Luo, Z., Dauter, M., and Dauter, Z. (2014) Phosphates in the Z-DNA dodecamer are flexible, but their P-SAD signal is sufficient for structure solution, Acta Crystallogr. D 70, 1790-1800. PubMed

    Dowling, D. P., Bruender, N. A., Young, A. P., McCarty, R. M., Bandarian, V., and Drennan, C. L. (2014) Radical SAM enzyme QueE defines a new minimal core fold and metal-dependent mechanism, Nat. Chem. Biol. 10, 106-112. PubMed

    Keszei, A. F., Tang, X., McCormick, C., Zeqiraj, E., Rohde, J. R., Tyers, M., and Sicheri, F. (2014) Structure of an SspH1-PKN1 complex reveals the basis for host substrate recognition and mechanism of activation for a bacterial E3 ubiquitin ligase, Mol. Cell Biol. 34, 362-373. PubMed

    Li, L., Fierer, J. O., Rapoport, T. A., and Howarth, M. (2014) Structural Analysis and Optimization of the Covalent Association between SpyCatcher and a Peptide Tag, J. Mol. Biol 426, 309-317. PubMed

    Wheatley, N. M., Sundberg, C. D., Gidaniyan, S. D., Cascio, D., and Yeates, T. O. (2014) Structure and identification of a pterin dehydratase-like protein as a RuBisCO assembly factor in the alpha-carboxysome, J. Biol. Chem. 289, 7973–7981. PubMed

    2013

    Schormann, N., Banerjee, S., Ricciardi, R., and Chattopadhyay, D. (2013) Structure of the uracil complex of Vaccinia virus uracil DNA glycosylase, Acta Crystallogr. F, 1328-1334. PubMed

    Bae, B., Davis, E., Brown, D., Campbell, E. A., Wigneshweraraj, S., and Darst, S. A. (2013) Phage T7 Gp2 inhibition of Escherichia coli RNA polymerase involves misappropriation of σ70 domain 1.1, Proc. Natl. Acad. Sci. U. S. A. 110, 19772–19777. PubMed

    Goldman, P. J., Grove, T. L., Booker, S. J., and Drennan, C. L. (2013) X-ray analysis of butirosin biosynthetic enzyme BtrN redefines structural motifs for AdoMet radical chemistry, Proc. Natl. Acad. Sci. U. S. A. 110, 15949–15954. PubMed

    Penmatsa, A., Wang, K. H., and Gouaux, E. (2013) X-ray structure of dopamine transporter elucidates antidepressant mechanism, Nature 503, 85-90. PubMed

    Kamadurai, H. B., Qiu, Y., Deng, A., Harrison, J. S., Macdonald, C., Actis, M., Rodrigues, P., Miller, D. J., Souphron, J., Lewis, S. M., Kurinov, I., Fujii, N., Hammel, M., Piper, R., Kuhlman, B., and Schulman, B. A. (2013) Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3, Elife 2, e00828. PubMed

    Dang, B., Kubota, T., Mandal, K., Bezanilla, F., and Kent, S. B. H. (2013) Native Chemical Ligation at Asx-Cys, Glx-Cys: Chemical Synthesis and High Resolution X-ray Structure of ShK Toxin by Racemic Protein Crystallography, J. Am. Chem. Soc. 135, 11911−11919. PubMed

    Xu, K., Xu, Y., Rajashankar, Kanagalaghatta R., Robev, D., and Nikolov, Dimitar B. (2013) Crystal Structures of Lgr4 and Its Complex with R-Spondin1, Structure 21, 1683–1689. PubMed

    Nakanishi, K., Ascano, M., Gogakos, T., Ishibe-Murakami, S., Serganov, Artem A., Briskin, D., Morozov, P., Tuschl, T., and Patel, Dinshaw J. (2013) Eukaryote-Specific Insertion Elements Control Human ARGONAUTE Slicer Activity, Cell Rep. 3, 1893-1900. PubMed

    Chen, Y., Rajashankar, K. R., Yang, Y., Agnihothram, S. S., Liu, C., Lin, Y. L., Baric, R. S., and Li, F. (2013) Crystal structure of the receptor-binding domain from newly emerged Middle East respiratory syndrome coronavirus, J. Virol. 87, 10777-10783. PubMed

    Yin, Q., Sester, David P., Tian, Y., Hsiao, Y.-S., Lu, A., Cridland, Jasmyn A., Sagulenko, V., Thygesen, Sara J., Choubey, D., Hornung, V., Walz, T., Stacey, Katryn J., and Wu, H. (2013) Molecular Mechanism for p202-Mediated Specific Inhibition of AIM2 Inflammasome Activation, Cell Rep. 4, 327-339. PubMed

    Lomakin, I. B., and Steitz, T. A. (2013) The initiation of mammalian protein synthesis and mRNA scanning mechanism, Nature 500, 307-311. PubMed

    Andersen, K. R., Onischenko, E., Tang, J. H., Kumar, P., Chen, J. Z., Ulrich, A., Liphardt, J. T., Weis, K., and Schwartz, T. U. (2013) Scaffold nucleoporins Nup188 and Nup192 share structural and functional properties with nuclear transport receptors, eLife 2. e00745. PubMed

    Rivkin, E., Almeida, S. M., Ceccarelli, D. F., Juang, Y. C., Maclean, T. A., Srikumar, T., Huang, H., Dunham, W. H., Fukumura, R., Xie, G., Gondo, Y., Raught, B., Gingras, A. C., Sicheri, F., and Cordes, S. P. (2013) The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis, Nature 498, 318-324. PubMed

    Lavoie, H., Thevakumaran, N., Gavory, G., Li, J. J., Padeganeh, A., Guiral, S., Duchaine, J., Mao, D. Y., Bouvier, M., Sicheri, F., and Therrien, M. (2013) Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization, Nat. Chem. Biol. 9, 428-436. PubMed

    Duda, D. M., Olszewski, J. L., Schuermann, J. P., Kurinov, I., Miller, D. J., Nourse, A., Alpi, A. F., and Schulman, B. A. (2013) Structure of HHARI, a RING-IBR-RING Ubiquitin Ligase: Autoinhibition of an Ariadne-Family E3 and Insights into Ligation Mechanism, Structure 21, 1030-1041. PubMed

    Wang, F., Li, G., Altaf, M., Lu, C., Currie, M. A., Johnson, A., and Moazed, D. (2013) Heterochromatin protein Sir3 induces contacts between the amino terminus of histone H4 and nucleosomal DNA, Proc. Natl. Acad. Sci. U. S. A. 110, 8495–8500. PubMed

    Wheatley, N. M., Gidaniyan, S. D., Liu, Y., Cascio, D., and Yeates, T. O. (2013) Bacterial microcompartment shells of diverse functional types possess pentameric vertex proteins, Protein Sci. 22, 660-665. PubMed

    Hancock, S. P., Ghane, T., Cascio, D., Rohs, R., Di Felice, R., and Johnson, R. C. (2013) Control of DNA minor groove width and Fis protein binding by the purine 2-amino group, Nucleic Acids Res.41, 6750–6760. PubMed

    Sydor, A. M., Jost, M., Ryan, K. S., Turo, K. E., Douglas, C. D., Drennan, C. L., and Zamble, D. B. (2013) Metal-binding Properties of Escherichia coli YjiA, a Member of the Metal Homeostasis-Associated COG0523 Family of GTPases, Biochemistry 52, 1788-1801. PubMed

    Dessau, M., and Modis, Y. (2013) Crystal structure of glycoprotein C from Rift Valley fever virus, Proc. Natl. Acad. Sci. U. S. A. 110, 1696–1701. PubMed

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    Ernst, A., Avvakumov, G., Tong, J., Fan, Y., Zhao, Y., Alberts, P., Persaud, A., Walker, J. R., Neculai, A. M., Neculai, D., Vorobyov, A., Garg, P., Beatty, L., Chan, P. K., Juang, Y. C., Landry, M. C., Yeh, C., Zeqiraj, E., Karamboulas, K., Allali-Hassani, A., Vedadi, M., Tyers, M., Moffat, J., Sicheri, F., Pelletier, L., Durocher, D., Raught, B., Rotin, D., Yang, J., Moran, M. F., Dhe-Paganon, S., and Sidhu, S. S. (2013) A Strategy for Modulation of Enzymes in the Ubiquitin System, Science 339, 590-595. PubMed

    Wu, B., Peisley, A., Richards, C., Yao, H., Zeng, X., Lin, C., Chu, F., Walz, T., and Hur, S. (2013) Structural Basis for dsRNA Recognition, Filament Formation, and Antiviral Signal Activation by MDA5, Cell 152, 276–289. PubMed

    Pecic, S., Pakhomova, S., Newcomer, M. E., Morisseau, C., Hammock, B. D., Zhu, Z., Rinderspacher, A., and Deng, S. X. (2013) Synthesis and structure-activity relationship of piperidine-derived non-urea soluble epoxide hydrolase inhibitors, Bioorg. Med. Chem. Lett. 23, 417-421. PubMed

    Alicea-Velazquez, N. L., Jakoncic, J., and Boggon, T. J. (2013) Structure-guided studies of the SHP-1/JAK1 interaction provide new insights into phosphatase catalytic domain substrate recognition, J. Struct. Biol. 18, 243-251. PubMed

    Arbing, M. A., Chan, S., Harris, L., Kuo, E., Zhou, T. T., Ahn, C. J., Nguyen, L., He, Q., Lu, J., Menchavez, P. T., Shin, A., Holton, T., Sawaya, M. R., Cascio, D., and Eisenberg, D. (2013) Heterologous expression of mycobacterial Esx complexes in Escherichia coli for structural studies is facilitated by the use of maltose binding protein fusions, PLoS One 8, e81753. PubMed

    2012

    Schirle, N. T., and Macrae, I. J. (2012) The Crystal Structure of Human Argonaute2, Science 336, 1037-1040. PubMed

    Luo, M., Arentson, B. W., Srivastava, D., Becker, D. F., and Tanner, J. J. (2012) Crystal Structures and Kinetics of Monofunctional Proline Dehydrogenase Provide Insight into Substrate Recognition and Conformational Changes Associated With Flavin Reduction and Product Release, Biochemistry 51, 10099−10108. PubMed

    Tu, X., and Palczewski, K. (2012) Crystal structure of the globular domain of C1QTNF5: Implications for late-onset retinal macular degeneration, J. Struct. Biol. 180, 439–446. PubMed

    Itsathitphaisarn, O., Wing, R. A., Eliason, W. K., Wang, J., and Steitz, T. A. (2012) The Hexameric Helicase DnaB Adopts a Nonplanar Conformation during Translocation, Cell 151, 267-277. PubMed

    Adachi, M. S., Taylor, A. B., Hart, P. J., and Fitzpatrick, P. F. (2012) Mechanistic and Structural Analyses of the Role of His67 in the Yeast Polyamine Oxidase Fms1: Characterization of N195A and D94N Enzymes, Biochemistry 51, 4888−4897. PubMed

    Kiser, P. D., Farquhar, E. R., Shi, W., Sui, X., Chance, M. R., and Palczewski, K. (2012) Structure of RPE65 isomerase in a lipidic matrix reveals roles for phospholipids and iron in catalysis, Proc. Natl. Acad. Sci. U. S. A. 109, E2747-2756. PubMed

    Lai, R. Y., Huang, S., Fenwick, M. K., Hazra, A. B., Zhang, Y., Rajashankar, K. R., Philmus, B., Kinsland, C., Sanders, J. M., Ealick, S. E., and Begley, T. P. (2012) Thiamin pyrimidine biosynthesis in Candida albicans: a remarkable reaction between histidine and pyridoxal phosphate, J. Am. Chem. Soc. 134, 9157−9159. PubMed

    Wang, H., and Gouaux, E. (2012) Substrate binds in the S1 site of the F253A mutant of LeuT, a neurotransmitter sodium symporter homologue, EMBO Rep.13, 861-866. PubMed

    King, N. P., Sheffler, W., Sawaya, M. R., Vollmar, B. S., Sumida, J. P., Andre, I., Gonen, T., Yeates, T. O., and Baker, D. (2012) Computational design of self-assembling protein nanomaterials with atomic level accuracy, Science 336, 1171-1174. PubMed

    Li, X., Zhang, R., Draheim, K. M., Liu, W., Calderwood, D. A., and Boggon, T. J. (2012) Structural basis for the small G-protein-effector interaction of Ras-related protein 1 (Rap1) and the adaptor protein Krev interaction trapped 1 (KRIT1), J. Biol. Chem. 287, 22317–22327. PubMed