NECAT Beamline

The Northeastern Collaborative Access Team (NE-CAT) facility at the Advanced Photon Source at Argonne National Laboratory is managed by Cornell University and consists of seven member institutions:

  • Columbia University
  • Cornell University
  • Harvard University
  • Memorial Sloan-Kettering Cancer Center
  • Massachusetts Institute of Technology
  • Rockefeller University
  • Yale University.
  •  

    Primary funding for this project comes from the National Institute of General Medical Sciences (NIGMS) , a division of the National Institutes of Health (NIH). Additional financial support for NE-CAT comes from the member institutions.

    NIGMS at a Glance.

    Supported by:

    National Institutes of Health
    National Institue of General Medical Sciences

    Publications based in part upon data collected at the NE-CAT beamlines at the Advanced Photon Source.

    2016

    AhYoung, A. P., Koehl, A., Vizcarra, C. L., Cascio, D., and Egea, P. F. (2016) Structure of a Putative Clps N-End Rule Adaptor Protein from the Malaria Pathogen Plasmodium Falciparum, Protein Sci. 25, 689-701.
    http://www.ncbi.nlm.nih.gov/pubmed/26701219

    Araya-Secchi, R., Neel, B. L., and Sotomayor, M. (2016) An Elastic Element in the Protocadherin-15 Tip Link of the Inner Ear, Nat Commun 7, 13458.
    https://www.ncbi.nlm.nih.gov/pubmed/27857071

    Ardiccioni, C., Clarke, O. B., Tomasek, D., Issa, H. A., von Alpen, D. C., Pond, H. L., Banerjee, S., Rajashankar, K. R., Liu, Q., Guan, Z., Li, C., Kloss, B., Bruni, R., Kloppmann, E., Rost, B., Manzini, M. C., Shapiro, L., and Mancia, F. (2016) Structure of the Polyisoprenyl-Phosphate Glycosyltransferase Gtrb and Insights into the Mechanism of Catalysis, Nat. Commun. 7, 10175.
    http://www.ncbi.nlm.nih.gov/pubmed/26729507

    Atkison, J. H., Parnham, S., Marcotte, W. R., Jr., and Olsen, S. K. (2016) Crystal Structure of the Nephila Clavipes Major Ampullate Spidroin 1a N-Terminal Domain Reveals Plasticity at the Dimer Interface, J Biol Chem 291, 19006-19017.
    https://www.ncbi.nlm.nih.gov/pubmed/27445329

    Bajaj, R. A., Arbing, M. A., Shin, A., Cascio, D., and Miallau, L. (2016) Crystal Structure of the Toxin Msmeg_6760, the Structural Homolog of Mycobacterium Tuberculosis Rv2035, a Novel Type Ii Toxin Involved in the Hypoxic Response, Acta Crystallogr F Struct Biol Commun 72, 863-869.
    https://www.ncbi.nlm.nih.gov/pubmed/27917833

    Bale, J. B., Gonen, S., Liu, Y., Sheffler, W., Ellis, D., Thomas, C., Cascio, D., Yeates, T. O., Gonen, T., King, N. P., and Baker, D. (2016) Accurate Design of Megadalton-Scale Two-Component Icosahedral Protein Complexes, Science 353, 389-394.
    http://www.ncbi.nlm.nih.gov/pubmed/27463675

    Baranovskiy, A. G., Babayeva, N. D., Zhang, Y., Gu, J., Suwa, Y., Pavlov, Y. I., and Tahirov, T. H. (2016) Mechanism of Concerted Rna-DNA Primer Synthesis by the Human Primosome, J. Biol. Chem. 291, 10006-10020.
    http://www.ncbi.nlm.nih.gov/pubmed/26975377

    Baskin, J. M., Wu, X., Christiano, R., Oh, M. S., Schauder, C. M., Gazzerro, E., Messa, M., Baldassari, S., Assereto, S., Biancheri, R., Zara, F., Minetti, C., Raimondi, A., Simons, M., Walther, T. C., Reinisch, K. M., and De Camilli, P. (2016) The Leukodystrophy Protein Fam126a (Hyccin) Regulates Ptdins(4)P Synthesis at the Plasma Membrane, Nat. Cell Biol. 18, 132-138.
    http://www.ncbi.nlm.nih.gov/pubmed/26571211

    Baytshtok, V., Fei, X., Grant, R. A., Baker, T. A., and Sauer, R. T. (2016) A Structurally Dynamic Region of the Hslu Intermediate Domain Controls Protein Degradation and Atp Hydrolysis, Structure 24, 1766-1777.
    https://www.ncbi.nlm.nih.gov/pubmed/27667691

    Bekes, M., van der Heden van Noort, G. J., Ekkebus, R., Ovaa, H., Huang, T. T., and Lima, C. D. (2016) Recognition of Lys48-Linked Di-Ubiquitin and Deubiquitinating Activities of the Sars Coronavirus Papain-Like Protease, Mol. Cell 62, 572-585.
    http://www.ncbi.nlm.nih.gov/pubmed/27203180

    Blower, T. R., Williamson, B. H., Kerns, R. J., and Berger, J. M. (2016) Crystal Structure and Stability of Gyrase-Fluoroquinolone Cleaved Complexes from Mycobacterium Tuberculosis, Proc. Natl. Acad. Sci. U. S. A. 113, 1706-1713.
    http://www.ncbi.nlm.nih.gov/pubmed/26792525

    Bodea, S., Funk, M. A., Balskus, E. P., and Drennan, C. L. (2016) Molecular Basis of C-N Bond Cleavage by the Glycyl Radical Enzyme Choline Trimethylamine-Lyase, Cell Chem Biol 23, 1206-1216.
    https://www.ncbi.nlm.nih.gov/pubmed/27642068

    Bozzi, A. T., Bane, L. B., Weihofen, W. A., Singharoy, A., Guillen, E. R., Ploegh, H. L., Schulten, K., and Gaudet, R. (2016) Crystal Structure and Conformational Change Mechanism of a Bacterial Nramp-Family Divalent Metal Transporter, Structure 24, 2102-2114.
    https://www.ncbi.nlm.nih.gov/pubmed/27839948

    Bradley, T., Fera, D., Bhiman, J., Eslamizar, L., Lu, X., Anasti, K., Zhang, R., Sutherland, Laura L., Scearce, Richard M., Bowman, Cindy M., Stolarchuk, C., Lloyd, Krissey E., Parks, R., Eaton, A., Foulger, A., Nie, X., Karim, Salim S. A., Barnett, S., Kelsoe, G., Kepler, Thomas B., Alam, S. M., Montefiori, David C., Moody, M. A., Liao, H.-X., Morris, L., Santra, S., Harrison, Stephen C., and Haynes, Barton F. (2016) Structural Constraints of Vaccine-Induced Tier-2 Autologous Hiv Neutralizing Antibodies Targeting the Receptor-Binding Site, Cell Reports 14, 43-54.
    http://www.ncbi.nlm.nih.gov/pubmed/26725118

    Bridwell-Rabb, J., Kang, G., Zhong, A., Liu, H. W., and Drennan, C. L. (2016) An Hd Domain Phosphohydrolase Active Site Tailored for Oxetanocin-a Biosynthesis, Proc Natl Acad Sci U S A 113, 13750-13755.
    https://www.ncbi.nlm.nih.gov/pubmed/27849620

    Brown, N. G., VanderLinden, R., Watson, E. R., Weissmann, F., Ordureau, A., Wu, K. P., Zhang, W., Yu, S., Mercredi, P. Y., Harrison, J. S., Davidson, I. F., Qiao, R., Lu, Y., Dube, P., Brunner, M. R., Grace, C. R., Miller, D. J., Haselbach, D., Jarvis, M. A., Yamaguchi, M., Yanishevski, D., Petzold, G., Sidhu, S. S., Kuhlman, B., Kirschner, M. W., Harper, J. W., Peters, J. M., Stark, H., and Schulman, B. A. (2016) Dual Ring E3 Architectures Regulate Multiubiquitination and Ubiquitin Chain Elongation by Apc/C, Cell 165, 1440-1453.
    http://www.ncbi.nlm.nih.gov/pubmed/27259151

    Buffalo, C. Z., Bahn-Suh, A. J., Hirakis, S. P., Biswas, T., Amaro, R. E., Nizet, V., and Ghosh, P. (2016) Conserved Patterns Hidden within Group a Streptococcus M Protein Hypervariability Recognize Human C4b-Binding Protein, Nat Microbiol 1, 16155.
    https://www.ncbi.nlm.nih.gov/pubmed/27595425

    Callahan, S. J., Luyten, Y. A., Gupta, Y. K., Wilson, G. G., Roberts, R. J., Morgan, R. D., and Aggarwal, A. K. (2016) Structure of Type Iil Restriction-Modification Enzyme Mmei in Complex with DNA Has Implications for Engineering New Specificities, PLoS Biol 14, e1002442.
    http://www.ncbi.nlm.nih.gov/pubmed/27082731

    Cavalier, M. C., Ansari, M. I., Pierce, A. D., Wilder, P. T., McKnight, L. E., Raman, E. P., Neau, D. B., Bezawada, P., Alasady, M. J., Charpentier, T. H., Varney, K., Toth, E. A., MacKerell, A. D., Coop, A., and Weber, D. J. (2016) Small Molecule Inhibitors of Ca2+-S100b Reveal Two Protein Conformations, J. Med. Chem. 59, 592-608.
    http://www.ncbi.nlm.nih.gov/pubmed/26727270

    Chatterjee, D., Sanchez, A. M., Goldgur, Y., Shuman, S., and Schwer, B. (2016) Transcription of Lncrna Prt, Clustered Prt Rna Sites for Mmi1 Binding, and Rna Polymerase Ii Ctd Phospho-Sites Govern the Repression of Pho1 Gene Expression under Phosphate-Replete Conditions in Fission Yeast, RNA 22, 1011-1025.
    http://www.ncbi.nlm.nih.gov/pubmed/27165520

    Chattopadhyay, D., Swingle, M. R., Salter, E. A., Wood, E., D'Arcy, B., Zivanov, C., Abney, K., Musiyenko, A., Rusin, S. F., Kettenbach, A., Yet, L., Schroeder, C. E., Golden, J. E., Dunham, W. H., Gingras, A. C., Banerjee, S., Forbes, D., Wierzbicki, A., and Honkanen, R. E. (2016) Crystal Structures and Mutagenesis of Ppp-Family Ser/Thr Protein Phosphatases Elucidate the Selectivity of Cantharidin and Novel Norcantharidin-Based Inhibitors of Pp5c, Biochem. Pharmacol. 109, 14-26.
    http://www.ncbi.nlm.nih.gov/pubmed/27002182

    Chen, M. (2016), Terpene Synthases: One Fold, Many Products, University of Pennsylvania, Philadelphia, Pennsylvania.

    Chen, M., Chou, W. K., Al-Lami, N., Faraldos, J. A., Allemann, R. K., Cane, D. E., and Christianson, D. W. (2016) Probing the Role of Active Site Water in the Sesquiterpene Cyclization Reaction Catalyzed by Aristolochene Synthase, Biochemistry 55, 2864-2874.
    http://www.ncbi.nlm.nih.gov/pubmed/27172425

    Chen, M., Chou, W. K., Toyomasu, T., Cane, D. E., and Christianson, D. W. (2016) Structure and Function of Fusicoccadiene Synthase, a Hexameric Bifunctional Diterpene Synthase, ACS Chem. Biol. 11, 889-899.
    http://www.ncbi.nlm.nih.gov/pubmed/26734760

    Chen, X., Randles, L., Shi, K., Tarasov, S. G., Aihara, H., and Walters, K. J. (2016) Structures of Rpn1 T1:Rad23 and Hrpn13:Hplic2 Reveal Distinct Binding Mechanisms between Substrate Receptors and Shuttle Factors of the Proteasome, Structure 24, 1257-1270.
    http://www.ncbi.nlm.nih.gov/pubmed/27396824

    Chen, Y., Seepersaud, R., Bensing, B. A., Sullam, P. M., and Rapoport, T. A. (2016) Mechanism of a Cytosolic O-Glycosyltransferase Essential for the Synthesis of a Bacterial Adhesion Protein, Proc. Natl. Acad. Sci. U.S.A. 113, E1190–E1199.
    http://www.ncbi.nlm.nih.gov/pubmed/26884191

    Cho, J., Lee, C.-J., Zhao, J., Young, H. E., and Zhou, P. (2016) Structure of the Essential Haemophilus Influenzae Udp-Diacylglucosamine Pyrophosphohydrolase Lpxh in Lipid a Biosynthesis, Nature Microbiology 1, 16154.
    http://www.nature.com/articles/nmicrobiol2016154

    Choi, P. H., Jo, J., Lin, Y. C., Lin, M. H., Chou, C. Y., Dietrich, L. E., and Tong, L. (2016) A Distinct Holoenzyme Organization for Two-Subunit Pyruvate Carboxylase, Nat Commun 7, 12713.
    https://www.ncbi.nlm.nih.gov/pubmed/27708276

    Chowdhury, C., Chun, S., Sawaya, M. R., Yeates, T. O., and Bobik, T. A. (2016) The Function of the Pduj Microcompartment Shell Protein Is Determined by the Genomic Position of Its Encoding Gene, Mol Microbiol 101, 770-783.
    http://www.ncbi.nlm.nih.gov/pubmed/27561553

    Chung, B. C., Mashalidis, E. H., Tanino, T., Kim, M., Matsuda, A., Hong, J., Ichikawa, S., and Lee, S. Y. (2016) Structural Insights into Inhibition of Lipid I Production in Bacterial Cell Wall Synthesis, Nature 533, 557-5690.
    http://www.ncbi.nlm.nih.gov/pubmed/27088606

    Clark, K. M., Jenkins, J. L., Fedoriw, N., and Dumont, M. E. (2016) Human Caax Protease Zmpste24 Expressed in Yeast: Structure and Inhibition by Hiv Protease Inhibitors, Protein Sci.
    https://www.ncbi.nlm.nih.gov/pubmed/27774687

    Clark, N. E., Katolik, A., Roberts, K. M., Taylor, A. B., Holloway, S. P., Schuermann, J. P., Montemayor, E. J., Stevens, S. W., Fitzpatrick, P. F., Damha, M. J., and Hart, P. J. (2016) Metal Dependence and Branched Rna Cocrystal Structures of the Rna Lariat Debranching Enzyme Dbr1, Proc Natl Acad Sci U S A 113, 14727-14732.
    https://www.ncbi.nlm.nih.gov/pubmed/27930312

    Coleman, J. A., Green, E. M., and Gouaux, E. (2016) X-Ray Structures and Mechanism of the Human Serotonin Transporter, Nature 532, 334-339.
    http://www.ncbi.nlm.nih.gov/pubmed/27049939

    Coloma, J., Jain, R., Rajashankar, Kanagalaghatta R., Garcia-Sastre, A., and Aggarwal, Aneel K. (2016) Structures of Ns5 Methyltransferase from Zika Virus, Cell Rep 16, 3097-3102.
    https://www.ncbi.nlm.nih.gov/pubmed/27633330

    Conrad, K. S., Hurley, J. M., Widom, J., Ringelberg, C. S., Loros, J. J., Dunlap, J. C., and Crane, B. R. (2016) Structure of the Frequency-Interacting Rna Helicase: A Protein Interaction Hub for the Circadian Clock, EMBO J 35, 1707-1719.
    http://www.ncbi.nlm.nih.gov/pubmed/27340124

    Cooper, S. R., Jontes, J. D., and Sotomayor, M. (2016) Structural Determinants of Adhesion by Protocadherin-19 and Implications for Its Role in Epilepsy, Elife 5.
    https://www.ncbi.nlm.nih.gov/pubmed/27787195

    Dang, B., Kubota, T., Mandal, K., Correa, A. M., Bezanilla, F., and Kent, S. B. (2016) Elucidation of the Covalent and Tertiary Structures of Biologically Active Ts3 Toxin, Angew Chem Int Ed Engl 55, 8639-8642.
    https://www.ncbi.nlm.nih.gov/pubmed/27244051

    Demircioglu, F. E., Sosa, B. A., Ingram, J., Ploegh, H. L., and Schwartz, T. U. (2016) Structures of Torsina and Its Disease-Mutant Complexed with an Activator Reveal the Molecular Basis for Primary Dystonia, Elife 5.
    https://www.ncbi.nlm.nih.gov/pubmed/27490483

    Dhakshnamoorthy, B., Rohaim, A., Rui, H., Blachowicz, L., and Roux, B. (2016) Structural and Functional Characterization of a Calcium-Activated Cation Channel from Tsukamurella Paurometabola, Nat Commun 7, 12753.
    https://www.ncbi.nlm.nih.gov/pubmed/27678077

    Dharmaiah, S., Bindu, L., Tran, T. H., Gillette, W. K., Frank, P. H., Ghirlando, R., Nissley, D. V., Esposito, D., McCormick, F., Stephen, A. G., and Simanshu, D. K. (2016) Structural Basis of Recognition of Farnesylated and Methylated Kras4b by Pdeδ, Proc Natl Acad Sci U S A 113, E6766-E6775.
    https://www.ncbi.nlm.nih.gov/pubmed/27791178

    Dhayalan, B., Fitzpatrick, A., Mandal, K., Whittaker, J., Weiss, M., Tokmakoff, A., and Kent, S. (2016) Efficient Total Chemical Synthesis of 13c=18o Isotopomers of Human Insulin for Isotope-Edited Ftir, ChemBioChem 17, 415-420.
    http://www.ncbi.nlm.nih.gov/pubmed/26715336

    Dhindwal, S., Gomez-Gil, L., Neau, D. B., Pham, T. T., Sylvestre, M., Eltis, L. D., Bolin, J. T., and Kumar, P. (2016) Structural Basis of the Enhanced Pollutant-Degrading Capabilities of an Engineered Biphenyl Dioxygenase, J. Bacteriol. 198, 1499-1512.
    http://www.ncbi.nlm.nih.gov/pubmed/26953337

    Dimitrova, Yoana N., Jenni, S., Valverde, R., Khin, Y., and Harrison, Stephen C. (2016) Structure of the Mind Complex Defines a Regulatory Focus for Yeast Kinetochore Assembly, Cell 167, 1014-1027 e1012.
    https://www.ncbi.nlm.nih.gov/pubmed/27881300

    Dippel, A. B., Olenginski, G. M., Maurici, N., Liskov, M. T., Brewer, S. H., and Phillips-Piro, C. M. (2016) Probing the Effectiveness of Spectroscopic Reporter Unnatural Amino Acids: A Structural Study, Acta Crystallogr D Struct Biol 72, 121-130.
    http://www.ncbi.nlm.nih.gov/pubmed/26894540

    Doamekpor, S. K., Lee, J. W., Hepowit, N. L., Wu, C., Charenton, C., Leonard, M., Bengtson, M. H., Rajashankar, K. R., Sachs, M. S., Lima, C. D., and Joazeiro, C. A. (2016) Structure and Function of the Yeast Listerin (Ltn1) Conserved N-Terminal Domain in Binding to Stalled 60s Ribosomal Subunits, Proc Natl Acad Sci U S A 113, E4151-4160.
    http://www.ncbi.nlm.nih.gov/pubmed/27385828

    Dowling, D. P., Kung, Y., Croft, A. K., Taghizadeh, K., Kelly, W. L., Walsh, C. T., and Drennan, C. L. (2016) Structural Elements of an Nrps Cyclization Domain and Its Intermodule Docking Domain, Proc Natl Acad Sci U S A 113, 12432-12437.
    https://www.ncbi.nlm.nih.gov/pubmed/27791103

    Dowling, D. P., Miles, Z. D., Kohrer, C., Maiocco, S. J., Elliott, S. J., Bandarian, V., and Drennan, C. L. (2016) Molecular Basis of Cobalamin-Dependent Rna Modification, Nucleic Acids Res 44, 9965-9976.
    https://www.ncbi.nlm.nih.gov/pubmed/27638883

    Eser, B. E., Zhang, X., Chanani, P. K., Begley, T. P., and Ealick, S. E. (2016) From Suicide Enzyme to Catalyst: The Iron-Dependent Sulfide Transfer in Methanococcus Jannaschii Thiamin Thiazole Biosynthesis, J. Am. Chem. Soc. 138, 3639-3642.
    http://www.ncbi.nlm.nih.gov/pubmed/26928142

    Feliciano, P. R., Drennan, C. L., and Nonato, M. C. (2016) Crystal Structure of an Fe-S Cluster-Containing Fumarate Hydratase Enzyme from Leishmania Major Reveals a Unique Protein Fold, Proc Natl Acad Sci U S A 113, 9804-9809.
    https://www.ncbi.nlm.nih.gov/pubmed/27528683

    Fenwick, M. K., and Ealick, S. E. (2016) Crystal Structures of the Iron-Sulfur Cluster-Dependent Quinolinate Synthase in Complex with Dihydroxyacetone Phosphate, Iminoaspartate Analogues, and Quinolinate, Biochemistry 55, 4135-4139.
    http://www.ncbi.nlm.nih.gov/pubmed/27404889

    Fenwick, M. K., Philmus, B., Begley, T. P., and Ealick, S. E. (2016) Burkholderia Glumae Toxa Is a Dual Specificity Methyltransferase That Catalyzes the Last Two Steps of Toxoflavin Biosynthesis, Biochemistry 55, 2748-2759.
    http://www.ncbi.nlm.nih.gov/pubmed/27070241

    Fu, T. M., Li, Y., Lu, A., Li, Z., Vajjhala, P. R., Cruz, A. C., Srivastava, D. B., DiMaio, F., Penczek, P. A., Siegel, R. M., Stacey, K. J., Egelman, E. H., and Wu, H. (2016) Cryo-Em Structure of Caspase-8 Tandem Ded Filament Reveals Assembly and Regulation Mechanisms of the Death-Inducing Signaling Complex, Mol Cell 64, 236-250.
    https://www.ncbi.nlm.nih.gov/pubmed/27746017

    Gagnon, M. G., Lin, J., and Steitz, T. A. (2016) Elongation Factor 4 Remodels the a-Site Trna on the Ribosome, Proc. Natl. Acad. Sci. U. S. A. 113, 4994–4999.
    http://www.ncbi.nlm.nih.gov/pubmed/27092003

    Gagnon, M. G., Roy, R. N., Lomakin, I. B., Florin, T., Mankin, A. S., and Steitz, T. A. (2016) Structures of Proline-Rich Peptides Bound to the Ribosome Reveal a Common Mechanism of Protein Synthesis Inhibition, Nucleic Acids Res. 44, 2439-2450.
    http://www.ncbi.nlm.nih.gov/pubmed/26809677

    Gantt, S. M. F., Decroos, C., Lee, M. S., Gullett, L. E., Bowman, C. M., Christianson, D. W., and Fierke, C. A. (2016) General Base-General Acid Catalysis in Human Histone Deacetylase 8, Biochemistry 55, 820–832.
    http://www.ncbi.nlm.nih.gov/pubmed/26806311

    Gao, P., Yang, H., Rajashankar, K. R., Huang, Z., and Patel, D. J. (2016) Type V Crispr-Cas Cpf1 Endonuclease Employs a Unique Mechanism for Crrna-Mediated Target DNA Recognition, Cell Res 26, 901-913.
    http://www.ncbi.nlm.nih.gov/pubmed/27444870

    Geng, Y., Mosyak, L., Kurinov, I., Zuo, H., Sturchler, E., Cheng, T. C., Subramanyam, P., Brown, A. P., Brennan, S. C., Mun, H. C., Bush, M., Chen, Y., Nguyen, T. X., Cao, B., Chang, D. D., Quick, M., Conigrave, A. D., Colecraft, H. M., McDonald, P., and Fan, Q. R. (2016) Structural Mechanism of Ligand Activation in Human Calcium-Sensing Receptor, Elife 5.
    https://www.ncbi.nlm.nih.gov/pubmed/27434672

    Geronimo, I., Denning, C. A., Rogers, W. E., Othman, T., Huxford, T., Heidary, D. K., Glazer, E. C., and Payne, C. M. (2016) Effect of Mutation and Substrate Binding on the Stability of Cytochrome P450bm3 Variants, Biochemistry 55, 3594-3606.
    http://www.ncbi.nlm.nih.gov/pubmed/27267136

    Gibson, M. I., Chen, P. Y., Johnson, A. C., Pierce, E., Can, M., Ragsdale, S. W., and Drennan, C. L. (2016) One-Carbon Chemistry of Oxalate Oxidoreductase Captured by X-Ray Crystallography, Proc. Natl. Acad. Sci. U.S.A. 113, 320-325.
    http://www.ncbi.nlm.nih.gov/pubmed/26712008

    Girish, T. S., McGinty, R. K., and Tan, S. (2016) Multivalent Interactions by the Set8 Histone Methyltransferase with Its Nucleosome Substrate, J. Mol. Biol. 428, 1531-1543.
    http://www.ncbi.nlm.nih.gov/pubmed/26953260

    Golani, L. K., Wallace-Povirk, A., Deis, S. M., Wong, J., Ke, J., Gu, X., Raghavan, S., Wilson, M. R., Li, X., Polin, L., de Waal, P. W., White, K., Kushner, J., O'Connor, C., Hou, Z., Xu, H. E., Melcher, K., Dann, C. E., 3rd, Matherly, L. H., and Gangjee, A. (2016) Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-D] Pyrimidine Antifolates with Heteroatom Bridge Substitutions Via Cellular Uptake by Folate Receptor Alpha and the Proton-Coupled Folate Transporter and Inhibition of De Novo Purine Nucleotide Biosynthesis, J Med Chem 59, 7856-7876.
    https://www.ncbi.nlm.nih.gov/pubmed/27458733

    Goodman, Kerry M., Rubinstein, R., Thu, Chan A., Bahna, F., Mannepalli, S., Ahlsén, G., Rittenhouse, C., Maniatis, T., Honig, B., and Shapiro, L. (2016) Structural Basis of Diverse Homophilic Recognition by Clustered Α- and Β-Protocadherins, Neuron 90, 709-723.
    http://www.ncbi.nlm.nih.gov/pubmed/27161523

    Goodman, K. M., Rubinstein, R., Thu, C. A., Mannepalli, S., Bahna, F., Ahlsen, G., Rittenhouse, C., Maniatis, T., Honig, B., and Shapiro, L. (2016) Γ-Protocadherin Structural Diversity and Functional Implications, Elife 5.
    https://www.ncbi.nlm.nih.gov/pubmed/27782885

    Goodman, K. M., Yamagata, M., Jin, X., Mannepalli, S., Katsamba, P. S., Ahlsen, G., Sergeeva, A. P., Honig, B., Sanes, J. R., and Shapiro, L. (2016) Molecular Basis of Sidekick-Mediated Cell-Cell Adhesion and Specificity, Elife 5.
    https://www.ncbi.nlm.nih.gov/pubmed/27644106

    Gorelik, M., Orlicky, S., Sartori, M. A., Tang, X., Marcon, E., Kurinov, I., Greenblatt, J. F., Tyers, M., Moffat, J., Sicheri, F., and Sidhu, S. S. (2016) Inhibition of Scf Ubiquitin Ligases by Engineered Ubiquitin Variants That Target the Cul1 Binding Site on the Skp1-F-Box Interface, Proc. Natl. Acad. Sci. U.S.A. 113, 3527–3532.
    http://www.ncbi.nlm.nih.gov/pubmed/26976582

    Grasso, M., Estrada, M. A., Ventocilla, C., Samanta, M., Maksimoska, J., Villanueva, J., Winkler, J. D., and Marmorstein, R. (2016) Chemically Linked Vemurafenib Inhibitors Promote an Inactive Brafv600e Conformation, ACS Chem Biol 11, 2876-2888.
    https://www.ncbi.nlm.nih.gov/pubmed/27571413

    Hai, Y. (2016), Structure and Function of Metallohydrolases in the Arginase-Deacetylase Family, University of Pennsylvania, Philadelphia, Pennsylvania.

    Hai, Y., and Christianson, D. W. (2016) Histone Deacetylase 6 Structure and Molecular Basis of Catalysis and Inhibition, Nat Chem Biol 12, 741-747.
    https://www.ncbi.nlm.nih.gov/pubmed/27454933

    Hamill, S., Lou, H. J., Turk, B. E., and Boggon, T. J. (2016) Structural Basis for Noncanonical Substrate Recognition of Cofilin/Adf Proteins by Lim Kinases, Mol. Cell 62, 397-408.
    http://www.ncbi.nlm.nih.gov/pubmed/27153537

    Hancock, S. P., Stella, S., Cascio, D., and Johnson, R. C. (2016) DNA Sequence Determinants Controlling Affinity, Stability and Shape of DNA Complexes Bound by the Nucleoid Protein Fis, PLoS One 11, e0150189.
    http://www.ncbi.nlm.nih.gov/pubmed/26959646

    Hanke, L., Knockenhauer, K. E., Brewer, R. C., van Diest, E., Schmidt, F. I., Schwartz, T. U., and Ploegh, H. L. (2016) The Antiviral Mechanism of an Influenza a Virus Nucleoprotein-Specific Single-Domain Antibody Fragment, MBio 7.
    https://www.ncbi.nlm.nih.gov/pubmed/27965447

    Harrison, O. J., Brasch, J., Lasso, G., Katsamba, P. S., Ahlsen, G., Honig, B., and Shapiro, L. (2016) Structural Basis of Adhesive Binding by Desmocollins and Desmogleins, Proc. Natl. Acad. Sci. U S A 113, 7160-7165.
    http://www.ncbi.nlm.nih.gov/pubmed/27298358

    Hayes, R. P., Xiao, Y., Ding, F., van Erp, P. B. G., Rajashankar, K., Bailey, S., Wiedenheft, B., and Ke, A. (2016) Structural Basis for Promiscuous Pam Recognition in Type I–E Cascade from E. Coli, Nature 530, 499-503.
    http://www.ncbi.nlm.nih.gov/pubmed/26863189

    Hicks, K. A., and Ealick, S. E. (2016) Biochemical and Structural Characterization of Klebsiella Pneumoniae Oxamate Amidohydrolase in the Uric Acid Degradation Pathway, Acta Crystallogr D Struct Biol 72, 808-816.
    http://www.ncbi.nlm.nih.gov/pubmed/27303801

    Hicks, K. A., Yuen, M. E., Zhen, W. F., Gerwig, T. J., Story, R. W., Kopp, M. C., and Snider, M. J. (2016) Structural and Biochemical Characterization of 6-Hydroxynicotinic Acid 3-Monooxygenase, a Novel Decarboxylative Hydroxylase Involved in Aerobic Nicotinate Degradation, Biochemistry 55, 3432-3446.
    http://www.ncbi.nlm.nih.gov/pubmed/27218267

    Hill, M. E., MacPherson, D. J., Wu, P., Julien, O., Wells, J. A., and Hardy, J. A. (2016) Reprogramming Caspase-7 Specificity by Regio-Specific Mutations and Selection Provides Alternate Solutions for Substrate Recognition, ACS Chem. Biol. 11, 1603-1612.
    http://www.ncbi.nlm.nih.gov/pubmed/27032039

    Hofmann, L., Tsybovsky, Y., Alexander, N. S., Babino, D., Leung, N. Y., Montell, C., Banerjee, S., von Lintig, J., and Palczewski, K. (2016) Structural Insights into the Drosophila Melanogaster Retinol Dehydrogenase, a Member of the Short-Chain Dehydrogenase/Reductase Family, Biochemistry 55, 6545-6557.
    https://www.ncbi.nlm.nih.gov/pubmed/27809489

    Huang, H., Deng, Z., Vladimirova, O., Wiedmer, A., Lu, F., Lieberman, P. M., and Patel, D. J. (2016) Structural Basis Underlying Viral Hijacking of a Histone Chaperone Complex, Nat Commun 7, 12707.
    https://www.ncbi.nlm.nih.gov/pubmed/27581705

    Jain, R., Coloma, J., Garcia-Sastre, A., and Aggarwal, A. K. (2016) Structure of the Ns3 Helicase from Zika Virus, Nat Struct Mol Biol 23, 752-754.
    http://www.ncbi.nlm.nih.gov/pubmed/27399257

    Jorda, J., Leibly, D. J., Thompson, M. C., and Yeates, T. O. (2016) Structure of a Novel 13 Nm Dodecahedral Nanocage Assembled from a Redesigned Bacterial Microcompartment Shell Protein, Chem. Commun. (Camb) 52, 5041-5044.
    http://www.ncbi.nlm.nih.gov/pubmed/26988700

    Kane Dickson, V. (2016) Phasing and Structure of Bestrophin-1: A Case Study in the Use of Heavy-Atom Cluster Compounds with Multi-Subunit Transmembrane Proteins, Acta Crystallogr D Struct Biol 72, 319-325.
    http://www.ncbi.nlm.nih.gov/pubmed/26960119

    Kattke, M. D., Chan, A. H., Duong, A., Sexton, D. L., Sawaya, M. R., Cascio, D., Elliot, M. A., and Clubb, R. T. (2016) Crystal Structure of the Streptomyces Coelicolor Sortase E1 Transpeptidase Provides Insight into the Binding Mode of the Novel Class E Sorting Signal, PLoS One 11, e0167763.
    https://www.ncbi.nlm.nih.gov/pubmed/27936128

    Kim, K. H., Ko, D. K., Kim, Y. T., Kim, N. H., Paul, J., Zhang, S. Q., Murray, C. B., Acharya, R., DeGrado, W. F., Kim, Y. H., and Grigoryan, G. (2016) Protein-Directed Self-Assembly of a Fullerene Crystal, Nat. Commun. 7, 11429.
    http://www.ncbi.nlm.nih.gov/pubmed/27113637

    Kim, M., Sandford, E., Gatica, D., Qiu, Y., Liu, X., Zheng, Y., Schulman, B. A., Xu, J., Semple, I., Ro, S. H., Kim, B., Mavioglu, R. N., Tolun, A., Jipa, A., Takats, S., Karpati, M., Li, J. Z., Yapici, Z., Juhasz, G., Lee, J. H., Klionsky, D. J., and Burmeister, M. (2016) Mutation in Atg5 Reduces Autophagy and Leads to Ataxia with Developmental Delay, Elife 5, e12245.
    http://www.ncbi.nlm.nih.gov/pubmed/26812546

    Kuk, A. C., Mashalidis, E. H., and Lee, S. Y. (2016) Crystal Structure of the Mop Flippase Murj in an Inward-Facing Conformation, Nat Struct Mol Biol.
    https://www.ncbi.nlm.nih.gov/pubmed/28024149

    Kumar, N., Radhakrishnan, A., Su, C. C., Osteryoung, K. W., and Yu, E. W. (2016) Crystal Structure of a Conserved Domain in the Intermembrane Space Region of the Plastid Division Protein Arc6, Protein Sci. 25, 523-529.
    http://www.ncbi.nlm.nih.gov/pubmed/26452626

    LaRochelle, J. R., Fodor, M., Xu, X., Durzynska, I., Fan, L., Stams, T., Chan, H. M., LaMarche, M. J., Chopra, R., Wang, P., Fortin, P. D., Acker, M. G., and Blacklow, S. C. (2016) Structural and Functional Consequences of Three Cancer-Associated Mutations of the Oncogenic Phosphatase Shp2, Biochemistry 55, 2269-2277.
    http://www.ncbi.nlm.nih.gov/pubmed/27030275

    Lee, S. J., Ren, F., Zangerl-Plessl, E. M., Heyman, S., Stary-Weinzinger, A., Yuan, P., and Nichols, C. G. (2016) Structural Basis of Control of Inward Rectifier Kir2 Channel Gating by Bulk Anionic Phospholipids, J Gen Physiol 148, 227-237.
    https://www.ncbi.nlm.nih.gov/pubmed/27527100

    Leroy, E., Dusa, A., Colau, Motamedi, A., Cahu, X., Mouton, C., Huang, L. J., Shiau, A. K., and Constantinescu, S. N. (2016) Uncoupling Jak2 V617f Activation from Cytokine-Induced Signalling by Modulation of Jh2 Alphac Helix, Biochem. J. 473, 1579-1591.
    http://www.ncbi.nlm.nih.gov/pubmed/27029346

    Levsh, O., Chiang, Y. C., Tung, C. F., Noel, J. P., Wang, Y., and Weng, J. K. (2016) Dynamic Conformational States Dictate Selectivity toward the Native Substrate in a Substrate-Permissive Acyltransferase, Biochemistry 55, 6314-6326.
    https://www.ncbi.nlm.nih.gov/pubmed/27805809

    Li, H., Hwang, Y., Perry, K., Bushman, F., and Van Duyne, G. D. (2016) Structure and Metal Binding Properties of a Poxvirus Resolvase, J. Biol. Chem. 291, 11094-11104.
    http://www.ncbi.nlm.nih.gov/pubmed/27013661

    Li, L., Park, E., Ling, J., Ingram, J., Ploegh, H., and Rapoport, T. A. (2016) Crystal Structure of a Substrate-Engaged Secy Protein-Translocation Channel, Nature 531, 395-399.
    http://www.ncbi.nlm.nih.gov/pubmed/26950603

    Li, X., Saha, P., Li, J., Blobel, G., and Pfeffer, S. R. (2016) Clues to the Mechanism of Cholesterol Transfer from the Structure of Npc1 Middle Lumenal Domain Bound to Npc2, Proc Natl Acad Sci U S A 113, 10079-10084.
    https://www.ncbi.nlm.nih.gov/pubmed/27551080

    Li, X., Wang, J., Coutavas, E., Shi, H., Hao, Q., and Blobel, G. (2016) Structure of Human Niemann-Pick C1 Protein, Proc Natl Acad Sci U S A 113, 8212-8217.
    http://www.ncbi.nlm.nih.gov/pubmed/27307437

    Lim, D. Y., Shin, S. H., Lee, M. H., Malakhova, M., Kurinov, I., Wu, Q., Xu, J., Jiang, Y., Dong, Z., Liu, K., Lee, K. Y., Bae, K. B., Choi, B. Y., Deng, Y., Bode, A., and Dong, Z. (2016) A Natural Small Molecule, Catechol, Induces C-Myc Degradation by Directly Targeting Erk2 in Lung Cancer, Oncotarget 7, 35001-35014.
    http://www.ncbi.nlm.nih.gov/pubmed/27167001

    Liu, B., and Steitz, T. A. (2016) Structural Insights into Nusg Regulating Transcription Elongation, Nucleic Acids Res.
    https://www.ncbi.nlm.nih.gov/pubmed/27899640

    Liu, B., Zuo, Y., and Steitz, T. A. (2016) Structures of E. Coli Σs-Transcription Initiation Complexes Provide New Insights into Polymerase Mechanism, Proc. Natl. Acad. Sci. U. S. A. 113, 4051-4056.
     http://www.ncbi.nlm.nih.gov/pubmed/27035955

    Lyubimov, A. Y., Uervirojnangkoorn, M., Zeldin, O. B., Zhou, Q., Zhao, M., Brewster, A. S., Michels-Clark, T., Holton, J. M., Sauter, N. K., Weis, W. I., and Brunger, A. T. (2016) Advances in X-Ray Free Electron Laser (Xfel) Diffraction Data Processing Applied to the Crystal Structure of the Synaptotagmin-1 / Snare Complex, Elife 5.
    https://www.ncbi.nlm.nih.gov/pubmed/27731796

    Ma, W., and Goldberg, J. (2016) Tango1/Ctage5 Receptor as a Polyvalent Template for Assembly of Large Copii Coats, Proc Natl Acad Sci U S A 113, 10061-10066.
    https://www.ncbi.nlm.nih.gov/pubmed/27551091

    Mandal, K., Dhayalan, B., Avital-Shmilovici, M., Tokmakoff, A., and Kent, S. B. H. (2016) Crystallization of Enantiomerically Pure Proteins from Quasi-Racemic Mixtures: Structure Determination by X-Ray Diffraction of Isotope-Labeled Ester Insulin and Human Insulin, ChemBioChem 17, 421-425.
    http://www.ncbi.nlm.nih.gov/pubmed/26707939

    Mansoor, S. E., Lu, W., Oosterheert, W., Shekhar, M., Tajkhorshid, E., and Gouaux, E. (2016) X-Ray Structures Define Human P2x3 Receptor Gating Cycle and Antagonist Action, Nature 538, 66-71.
    https://www.ncbi.nlm.nih.gov/pubmed/27626375

    Matsuyama, B. Y., Krasteva, P. V., Baraquet, C., Harwood, C. S., Sondermann, H., and Navarro, M. V. (2016) Mechanistic Insights into C-Di-Gmp-Dependent Control of the Biofilm Regulator Fleq from Pseudomonas Aeruginosa, Proc. Natl. Acad. U. S. A. 113, E209-218.
    http://www.ncbi.nlm.nih.gov/pubmed/26712005

    Matthews, M. M., Thomas, J. M., Zheng, Y., Tran, K., Phelps, K. J., Scott, A. I., Havel, J., Fisher, A. J., and Beal, P. A. (2016) Structures of Human Adar2 Bound to Dsrna Reveal Base-Flipping Mechanism and Basis for Site Selectivity, Nat. Struct. Mol. Biol. 23, 426-433.
    http://www.ncbi.nlm.nih.gov/pubmed/27065196

    McCoy, Jason G., Ren, Z., Stanevich, V., Lee, J., Mitra, S., Levin, Elena J., Poget, S., Quick, M., Im, W., and Zhou, M. (2016) The Structure of a Sugar Transporter of the Glucose Eiic Superfamily Provides Insight into the Elevator Mechanism of Membrane Transport, Structure 24, 956-964.
    http://www.ncbi.nlm.nih.gov/pubmed/27161976

    McKinney, B., Meyer, P. A., Crosas, M., and Sliz, P. (2016) Extension of Research Data Repository System to Support Direct Compute Access to Biomedical Datasets: Enhancing Dataverse to Support Large Datasets, Ann N Y Acad Sci.
    https://www.ncbi.nlm.nih.gov/pubmed/27862010

    McLaughlin, M. I., Lanz, N. D., Goldman, P. J., Lee, K. H., Booker, S. J., and Drennan, C. L. (2016) Crystallographic Snapshots of Sulfur Insertion by Lipoyl Synthase, Proc Natl Acad Sci U S A 113, 9446-9450.
    https://www.ncbi.nlm.nih.gov/pubmed/27506792

    McMillan, B. J., Tibbe, C., Jeon, H., Drabek, A. A., Klein, T., and Blacklow, S. C. (2016) Electrostatic Interactions between Elongated Monomers Drive Filamentation of Drosophila Shrub, a Metazoan Escrt-Iii Protein, Cell Rep 16, 1211-1217.
    http://www.ncbi.nlm.nih.gov/pubmed/27452459

    McNally, R., Toms, A. V., and Eck, M. J. (2016) Crystal Structure of the Ferm-Sh2 Module of Human Jak2, PLoS One 11, e0156218.
    http://www.ncbi.nlm.nih.gov/pubmed/27227461

    Meisburger, S. P., Taylor, A. B., Khan, C. A., Zhang, S., Fitzpatrick, P. F., and Ando, N. (2016) Domain Movements Upon Activation of Phenylalanine Hydroxylase Characterized by Crystallography and Chromatography-Coupled Small-Angle X-Ray Scattering, J. Am. Chem. Soc. 138, 6506-6516.
    http://www.ncbi.nlm.nih.gov/pubmed/27145334

    Melillo, B., Liang, S., Park, J., Schon, A., Courter, J. R., LaLonde, J. M., Wendler, D. J., Princiotto, A. M., Seaman, M. S., Freire, E., Sodroski, J., Madani, N., Hendrickson, W. A., and Smith, A. B., 3rd. (2016) Small-Molecule Cd4-Mimics: Structure-Based Optimization of Hiv-1 Entry Inhibition, ACS Med. Chem. Lett. 7, 330-334.
    http://www.ncbi.nlm.nih.gov/pubmed/26985324

    Melnikov, S. V., Soll, D., Steitz, T. A., and Polikanov, Y. S. (2016) Insights into Rna Binding by the Anticancer Drug Cisplatin from the Crystal Structure of Cisplatin-Modified Ribosome, Nucleic Acids Res. 44, 4978-4987.
    http://www.ncbi.nlm.nih.gov/pubmed/27079977

    Metrick, C. M., and Heldwein, E. E. (2016) Novel Structure and Unexpected Rna-Binding Ability of the C-Terminal Domain of Herpes Simplex Virus 1 Tegument Protein Ul21, J Virol 90, 5759-5769.
    http://www.ncbi.nlm.nih.gov/pubmed/27053559

    Meyer, P. A., Socias, S., Key, J., Ransey, E., Tjon, E. C., Buschiazzo, A., Lei, M., Botka, C., Withrow, J., Neau, D., Rajashankar, K., Anderson, K. S., Baxter, R. H., Blacklow, S. C., Boggon, T. J., Bonvin, A. M., Borek, D., Brett, T. J., Caflisch, A., Chang, C. I., Chazin, W. J., Corbett, K. D., Cosgrove, M. S., Crosson, S., Dhe-Paganon, S., Di Cera, E., Drennan, C. L., Eck, M. J., Eichman, B. F., Fan, Q. R., Ferre-D'Amare, A. R., Christopher Fromme, J., Garcia, K. C., Gaudet, R., Gong, P., Harrison, S. C., Heldwein, E. E., Jia, Z., Keenan, R. J., Kruse, A. C., Kvansakul, M., McLellan, J. S., Modis, Y., Nam, Y., Otwinowski, Z., Pai, E. F., Pereira, P. J., Petosa, C., Raman, C. S., Rapoport, T. A., Roll-Mecak, A., Rosen, M. K., Rudenko, G., Schlessinger, J., Schwartz, T. U., Shamoo, Y., Sondermann, H., Tao, Y. J., Tolia, N. H., Tsodikov, O. V., Westover, K. D., Wu, H., Foster, I., Fraser, J. S., Maia, F. R., Gonen, T., Kirchhausen, T., Diederichs, K., Crosas, M., and Sliz, P. (2016) Data Publication with the Structural Biology Data Grid Supports Live Analysis, Nat. Commun. 7, 10882.
    http://www.ncbi.nlm.nih.gov/pubmed/26947396

    Morales-Perez, C. L., Noviello, C. M., and Hibbs, R. E. (2016) X-Ray Structure of the Human Α4β2 Nicotinic Receptor, Nature 538, 411-415.
    https://www.ncbi.nlm.nih.gov/pubmed/27698419

    Morgan, J. L., McNamara, J. T., Fischer, M., Rich, J., Chen, H. M., Withers, S. G., and Zimmer, J. (2016) Observing Cellulose Biosynthesis and Membrane Translocation in Crystallo, Nature 531, 329-334.
    http://www.ncbi.nlm.nih.gov/pubmed/26958837

    Murn, J., Teplova, M., Zarnack, K., Shi, Y., and Patel, D. J. (2016) Recognition of Distinct Rna Motifs by the Clustered Ccch Zinc Fingers of Neuronal Protein Unkempt, Nat. Struct. Mol. Biol. 23, 16-23.
    http://www.ncbi.nlm.nih.gov/pubmed/26641712

    Neumann, W., Xu, S., Sarosi, M. B., Scholz, M. S., Crews, B. C., Ghebreselasie, K., Banerjee, S., Marnett, L. J., and Hey-Hawkins, H. C. (2016) Nido-Dicarbaborate Induces Potent and Selective Inhibition of Cyclooxygenase-2, ChemMedChem 11, 175-178.
    http://www.ncbi.nlm.nih.gov/pubmed/26088701

    Nicoludis, J. M., Vogt, B. E., Green, A. G., Scharfe, C. P., Marks, D. S., and Gaudet, R. (2016) Antiparallel Protocadherin Homodimers Use Distinct Affinity- and Specificity-Mediating Regions in Cadherin Repeats 1-4, Elife 5.
    https://www.ncbi.nlm.nih.gov/pubmed/27472898

    Oliveira, T., Sharkey, M. A., Engel, P. C., and Khan, A. R. (2016) Crystal Structure of a Chimaeric Bacterial Glutamate Dehydrogenase, Acta Crystallogr F Struct Biol Commun 72, 462-466.
    https://www.ncbi.nlm.nih.gov/pubmed/27303899

    Orlova, N., Gerding, M., Ivashkiv, O., Olinares, P. D., Chait, B. T., Waldor, M. K., and Jeruzalmi, D. (2016) The Replication Initiator of the Cholera Pathogen's Second Chromosome Shows Structural Similarity to Plasmid Initiators, Nucleic Acids Res.
    https://www.ncbi.nlm.nih.gov/pubmed/28031373

    Oyala, P. H., Ravichandran, K. R., Funk, M. A., Stucky, P. A., Stich, T. A., Drennan, C. L., Britt, R. D., and Stubbe, J. (2016) Biophysical Characterization of Fluorotyrosine Probes Site-Specifically Incorporated into Enzymes: E. Coli Ribonucleotide Reductase as an Example, J Am. Chem. Soc. 138, 7951-7964.
    http://www.ncbi.nlm.nih.gov/pubmed/27276098

    Pascolutti, R., Sun, X., Kao, J., Maute, R. L., Ring, A. M., Bowman, G. R., and Kruse, A. C. (2016) Structure and Dynamics of Pd-L1 and an Ultra-High-Affinity Pd-1 Receptor Mutant, Structure 24, 1719-1728.
    https://www.ncbi.nlm.nih.gov/pubmed/27618663

    Petrou, V. I., Herrera, C. M., Schultz, K. M., Clarke, O. B., Vendome, J., Tomasek, D., Banerjee, S., Rajashankar, K. R., Belcher Dufrisne, M., Kloss, B., Kloppmann, E., Rost, B., Klug, C. S., Trent, M. S., Shapiro, L., and Mancia, F. (2016) Structures of Aminoarabinose Transferase Arnt Suggest a Molecular Basis for Lipid a Glycosylation, Science 351, 608-612.
    https://www.ncbi.nlm.nih.gov/pubmed/26912703

    Pierson, W. E., Hoffer, E. D., Keedy, H. E., Simms, C. L., Dunham, C. M., and Zaher, H. S. (2016) Uniformity of Peptide Release Is Maintained by Methylation of Release Factors, Cell Rep 17, 11-18.
    https://www.ncbi.nlm.nih.gov/pubmed/27681416

    Porter, N. J., Christianson, N. H., Decroos, C., and Christianson, D. W. (2016) Structural and Functional Influence of the Glycine-Rich Loop G302gggy on the Catalytic Tyrosine of Histone Deacetylase 8, Biochemistry 55, 6718-6729.
    https://www.ncbi.nlm.nih.gov/pubmed/27933794

    Raymond, D. D., Stewart, S. M., Lee, J., Ferdman, J., Bajic, G., Do, K. T., Ernandes, M. J., Suphaphiphat, P., Settembre, E. C., Dormitzer, P. R., Del Giudice, G., Finco, O., Kang, T. H., Ippolito, G. C., Georgiou, G., Kepler, T. B., Haynes, B. F., Moody, M. A., Liao, H. X., Schmidt, A. G., and Harrison, S. C. (2016) Influenza Immunization Elicits Antibodies Specific for an Egg-Adapted Vaccine Strain, Nat Med 22, 1465-1469.
    https://www.ncbi.nlm.nih.gov/pubmed/27820604

    Rechkoblit, O., Gupta, Y. K., Malik, R., Rajashankar, K. R., Johnson, R. E., Prakash, L., Prakash, S., and Aggarwal, A. K. (2016) Structure and Mechanism of Human Primpol, a DNA Polymerase with Primase Activity, Sci Adv 2, e1601317.
    https://www.ncbi.nlm.nih.gov/pubmed/27819052

    Ren, A., Vusurovic, N., Gebetsberger, J., Gao, P., Juen, M., Kreutz, C., Micura, R., and Patel, D. J. (2016) Pistol Ribozyme Adopts a Pseudoknot Fold Facilitating Site-Specific in-Line Cleavage, Nat Chem Biol 12, 702-708.
    https://www.ncbi.nlm.nih.gov/pubmed/27398999

    Rudolph, M. J., Vance, D. J., Cassidy, M. S., Rong, Y., and Mantis, N. J. (2016) Structural Analysis of Single Domain Antibodies Bound to a Second Neutralizing Hot Spot on Ricin Toxin's Enzymatic Subunit, J Biol Chem.
    https://www.ncbi.nlm.nih.gov/pubmed/27903650

    Rudolph, M. J., Vance, D. J., Cassidy, M. S., Rong, Y., Shoemaker, C. B., and Mantis, N. J. (2016) Structural Analysis of Nested Neutralizing and Non-Neutralizing B Cell Epitopes on Ricin Toxin's Enzymatic Subunit, Proteins 84, 1162-1172.
    http://www.ncbi.nlm.nih.gov/pubmed/27159829

    Saotome, K., Singh, A. K., Yelshanskaya, M. V., and Sobolevsky, A. I. (2016) Crystal Structure of the Epithelial Calcium Channel Trpv6, Nature 534, 506-511.
    http://www.ncbi.nlm.nih.gov/pubmed/27296226

    Saredi, G., Huang, H., Hammond, C. M., Alabert, C., Bekker-Jensen, S., Forne, I., Reveron-Gomez, N., Foster, B. M., Mlejnkova, L., Bartke, T., Cejka, P., Mailand, N., Imhof, A., Patel, D. J., and Groth, A. (2016) H4k20me0 Marks Post-Replicative Chromatin and Recruits the Tonsl-Mms22l DNA Repair Complex, Nature 534, 714-718.
    http://www.ncbi.nlm.nih.gov/pubmed/27338793

    Saxton, R. A., Chantranupong, L., Knockenhauer, K. E., Schwartz, T. U., and Sabatini, D. M. (2016) Mechanism of Arginine Sensing by Castor1 Upstream of Mtorc1, Nature 536, 229-233.
    http://www.ncbi.nlm.nih.gov/pubmed/27487210

    Saxton, R. A., Knockenhauer, K. E., Schwartz, T. U., and Sabatini, D. M. (2016) The Apo-Structure of the Leucine Sensor Sestrin2 Is Still Elusive, Sci Signal 9, ra92.
    https://www.ncbi.nlm.nih.gov/pubmed/27649739

    Saxton, R. A., Knockenhauer, K. E., Wolfson, R. L., Chantranupong, L., Pacold, M. E., Wang, T., Schwartz, T. U., and Sabatini, D. M. (2016) Structural Basis for Leucine Sensing by the Sestrin2-Mtorc1 Pathway, Science 351, 53-58.
    http://www.ncbi.nlm.nih.gov/pubmed/26586190

    Schmidt, F. I., Lu, A., Chen, J. W., Ruan, J., Tang, C., Wu, H., and Ploegh, H. L. (2016) A Single Domain Antibody Fragment That Recognizes the Adaptor Asc Defines the Role of Asc Domains in Inflammasome Assembly, J. Exp. Med. 213, 771–790.
    http://www.ncbi.nlm.nih.gov/pubmed/27069117

    Schmidt, H. R., Zheng, S., Gurpinar, E., Koehl, A., Manglik, A., and Kruse, A. C. (2016) Crystal Structure of the Human Σ1 Receptor, Nature 532, 527-530.
    http://www.ncbi.nlm.nih.gov/pubmed/27042935

    Schormann, N., Zhukovskaya, N., Bedwell, G., Nuth, M., Gillilan, R., Prevelige, P. E., Ricciardi, R. P., Banerjee, S., and Chattopadhyay, D. (2016) Poxvirus Uracil-DNA Glycosylase - an Unusual Member of the Family I Uracil-DNA Glycosylases, Protein Sci 25, 2113-2131.
    https://www.ncbi.nlm.nih.gov/pubmed/27684934

    Schureck, M. A. (2016), Structural and Functional Studies of a Toxin-Antitoxin System Involved in Translational Inhibition, Emory University, Atlanta, Georgia.

    Schureck, M. A., Maehigashi, T., Miles, S. J., Marquez, J., and Dunham, C. M. (2016) Mrna Bound to the 30s Subunit Is a Higb Toxin Substrate, RNA 22, 1261-1270.
    http://www.ncbi.nlm.nih.gov/pubmed/27307497

    Schureck, M. A., Repack, A., Miles, S. J., Marquez, J., and Dunham, C. M. (2016) Mechanism of Endonuclease Cleavage by the Higb Toxin, Nucleic Acids Res 44, 7944-7953.
    https://www.ncbi.nlm.nih.gov/pubmed/27378776

    Shaban, N. M., Shi, K., Li, M., Aihara, H., and Harris, R. S. (2016) 1.92 Angstrom Zinc-Free Apobec3f Catalytic Domain Crystal Structure, J. Mol. Biol. 428, 2307-2316.
    http://www.ncbi.nlm.nih.gov/pubmed/27139641

    Shan, C. M., Wang, J., Xu, K., Chen, H., Yue, J. X., Andrews, S., Moresco, J. J., Yates, J. R., Nagy, P. L., Tong, L., and Jia, S. (2016) A Histone H3k9m Mutation Traps Histone Methyltransferase Clr4 to Prevent Heterochromatin Spreading, Elife 5.
    https://www.ncbi.nlm.nih.gov/pubmed/27648579

    Shao, Y., Huang, H., Qin, D., Li, N. S., Koide, A., Staley, J. P., Koide, S., Kossiakoff, A. A., and Piccirilli, J. A. (2016) Specific Recognition of a Single-Stranded Rna Sequence by a Synthetic Antibody Fragment, J Mol Biol 428, 4100-4114.
    https://www.ncbi.nlm.nih.gov/pubmed/27593161

    Shelton, C. L., Conrady, D. G., and Herr, A. B. (2016) Functional Consequences of B-Repeat Sequence Variation in the Staphylococcal Biofilm Protein Aap: Deciphering the Assembly Code, Biochem J.
    https://www.ncbi.nlm.nih.gov/pubmed/27872164

    Shi, K., Carpenter, M. A., Banerjee, S., Shaban, N. M., Kurahashi, K., Salamango, D. J., McCann, J. L., Starrett, G. J., Duffy, J. V., Demir, O., Amaro, R. E., Harki, D. A., Harris, R. S., and Aihara, H. (2016) Structural Basis for Targeted DNA Cytosine Deamination and Mutagenesis by Apobec3a and Apobec3b, Nat Struct Mol Biol.
    https://www.ncbi.nlm.nih.gov/pubmed/27991903

    Silvaroli, J. A., Arne, J. M., Chelstowska, S., Kiser, P. D., Banerjee, S., and Golczak, M. (2016) Ligand Binding Induces Conformational Changes in Human Cellular Retinol-Binding Protein 1 (Crbp1) Revealed by Atomic Resolution Crystal Structures, J. Biol. Chem. 291, 8528-8540.
    http://www.ncbi.nlm.nih.gov/pubmed/26900151

    Silvers, M. A., Pakhomova, S., Neau, D. B., Silvers, W. C., Anzalone, N., Taylor, C. M., and Waldrop, G. L. (2016) Crystal Structure of Carboxyltransferase from Staphylococcus Aureus Bound to the Antibacterial Agent Moiramide B, Biochemistry 55, 4666-4674.
    https://www.ncbi.nlm.nih.gov/pubmed/27471863

    Soragni, A., Janzen, D. M., Johnson, L. M., Lindgren, A. G., Thai-Quynh Nguyen, A., Tiourin, E., Soriaga, A. B., Lu, J., Jiang, L., Faull, K. F., Pellegrini, M., Memarzadeh, S., and Eisenberg, D. S. (2016) A Designed Inhibitor of P53 Aggregation Rescues P53 Tumor Suppression in Ovarian Carcinomas, Cancer Cell 29, 90-103.
    http://www.ncbi.nlm.nih.gov/pubmed/26748848

    Soriaga, A. B., Sangwan, S., Macdonald, R., Sawaya, M. R., and Eisenberg, D. (2016) Crystal Structures of Iapp Amyloidogenic Segments Reveal a Novel Packing Motif of out-of-Register Beta Sheets, J Phys Chem B 120, 5810-5816.
    http://www.ncbi.nlm.nih.gov/pubmed/26629790

    Stein, B. J., Grant, R. A., Sauer, R. T., and Baker, T. A. (2016) Structural Basis of an N-Degron Adaptor with More Stringent Specificity, Structure 24, 232-242.
    http://www.ncbi.nlm.nih.gov/pubmed/26805523

    Streich, F. C., Jr., and Lima, C. D. (2016) Capturing a Substrate in an Activated Ring E3/E2-Sumo Complex, Nature 536, 304-308.
    https://www.ncbi.nlm.nih.gov/pubmed/27509863

    Sui, X., Zhang, J., Golczak, M., Palczewski, K., and Kiser, P. D. (2016) Key Residues for Catalytic Function and Metal Coordination in a Carotenoid Cleavage Dioxygenase, J Biol Chem 291, 19401-19412.
    https://www.ncbi.nlm.nih.gov/pubmed/27453555

    Taabazuing, C. Y., Fermann, J., Garman, S., and Knapp, M. J. (2016) Substrate Promotes Productive Gas Binding in the Α-Ketoglutarate-Dependent Oxygenase Fih, Biochemistry 55, 277-286.
    http://www.ncbi.nlm.nih.gov/pubmed/26727884

    Tabackman, A. A., Frankson, R., Marsan, E. S., Perry, K., and Cole, K. E. (2016) Structure of 'Linkerless' Hydroxamic Acid Inhibitor-Hdac8 Complex Confirms the Formation of an Isoform-Specific Subpocket, J Struct. Biol. 195, 373-378.
    http://www.ncbi.nlm.nih.gov/pubmed/27374062

    Tanaka, M., Roberts, J. M., Seo, H. S., Souza, A., Paulk, J., Scott, T. G., DeAngelo, S. L., Dhe-Paganon, S., and Bradner, J. E. (2016) Design and Characterization of Bivalent Bet Inhibitors, Nat Chem Biol 12, 1089-1096.
    https://www.ncbi.nlm.nih.gov/pubmed/27775715

    Taylor, N. D., Garruss, A. S., Moretti, R., Chan, S., Arbing, M. A., Cascio, D., Rogers, J. K., Isaacs, F. J., Kosuri, S., Baker, D., Fields, S., Church, G. M., and Raman, S. (2016) Engineering an Allosteric Transcription Factor to Respond to New Ligands, Nat. Methods 13, 177-183.
    http://www.ncbi.nlm.nih.gov/pubmed/26689263

    Thomaston, J. L., and DeGrado, W. F. (2016) Crystal Structure of the Drug-Resistant S31n Influenza M2 Proton Channel, Protein Sci. 25, 1551-1554.
    http://www.ncbi.nlm.nih.gov/pubmed/27082171

    Tripathi, S., and Paukstelis, P. J. (2016) Structural Implications of Homopyrimidine Base Pairs in the Parallel-Stranded D(Yga) Motif, ChemBioChem 17, 1177-1183.
    http://www.ncbi.nlm.nih.gov/pubmed/26629965

    Truttmann, M. C., Cruz, V. E., Guo, X., Engert, C., Schwartz, T. U., and Ploegh, H. L. (2016) The Caenorhabditis Elegans Protein Fic-1 Is an Ampylase That Covalently Modifies Heat-Shock 70 Family Proteins, Translation Elongation Factors and Histones, PLoS Genet 12, e1006023.
    http://www.ncbi.nlm.nih.gov/pubmed/27138431

    Uddin, M. J., Crews, B. C., Xu, S., Ghebreselasie, K., Daniel, C. K., Kingsley, P. J., Banerjee, S., and Marnett, L. J. (2016) Antitumor Activity of Cytotoxic Cyclooxygenase-2 Inhibitors, ACS Chem Biol 11, 3052-3060.
    https://www.ncbi.nlm.nih.gov/pubmed/27588346

    Uljon, S., Xu, X., Durzynska, I., Stein, S., Adelmant, G., Marto, J. A., Pear, W. S., and Blacklow, S. C. (2016) Structural Basis for Substrate Selectivity of the E3 Ligase Cop1, Structure 24, 687-696.
    http://www.ncbi.nlm.nih.gov/pubmed/27041596

    Unciuleac, M. C., Smith, P. C., and Shuman, S. (2016) Crystal Structure and Biochemical Characterization of a Mycobacterium Smegmatis Aaa-Type Nucleoside Triphosphatase Phosphohydrolase (Msm0858), J. Bacteriol. 198, 1521-1533.
    http://www.ncbi.nlm.nih.gov/pubmed/26953339

    Uppalapati, M., Lee, D. J., Mandal, K., Li, H., Miranda, L. P., Lowitz, J., Kenney, J., Adams, J. J., Ault-Riche, D., Kent, S. B., and Sidhu, S. S. (2016) A Potent D-Protein Antagonist of Vegf-a Is Nonimmunogenic, Metabolically Stable and Longer-Circulating in Vivo, ACS Chem. Biol. 11, 1058-1065.
    http://www.ncbi.nlm.nih.gov/pubmed/26745345

    Vaisey, G., Miller, A. N., and Long, S. B. (2016) Distinct Regions That Control Ion Selectivity and Calcium-Dependent Activation in the Bestrophin Ion Channel, Proc Natl Acad Sci U S A 113, E7399-E7408.
    https://www.ncbi.nlm.nih.gov/pubmed/27821745

    Valverde, R., Ingram, J., and Harrison, S. C. (2016) Conserved Tetramer Junction in the Kinetochore Ndc80 Complex, Cell Rep 17, 1915-1922.
    https://www.ncbi.nlm.nih.gov/pubmed/27851957

    Wagner, F. F., Bishop, J. A., Gale, J. P., Shi, X., Walk, M., Ketterman, J., Patnaik, D., Barker, D., Walpita, D., Campbell, A. J., Nguyen, S., Lewis, M., Ross, L., Weiwer, M., An, W. F., Germain, A. R., Nag, P. P., Metkar, S., Kaya, T., Dandapani, S., Olson, D. E., Barbe, A. L., Lazzaro, F., Sacher, J. R., Cheah, J. H., Fei, D., Perez, J., Munoz, B., Palmer, M., Stegmaier, K., Schreiber, S. L., Scolnick, E., Zhang, Y. L., Haggarty, S. J., Holson, E. B., and Pan, J. Q. (2016) Inhibitors of Glycogen Synthase Kinase 3 with Exquisite Kinome-Wide Selectivity and Their Functional Effects, ACS Chem. Biol. 11, 1952-1963.
    http://www.ncbi.nlm.nih.gov/pubmed/27128528

    Wagner, J. M., Chan, S., Evans, T. J., Kahng, S., Kim, J., Arbing, M. A., Eisenberg, D., and Korotkov, K. V. (2016) Structures of Eccb1 and Eccd1 from the Core Complex of the Mycobacterial Esx-1 Type Vii Secretion System, BMC Struct. Biol. 16, 5.
    http://www.ncbi.nlm.nih.gov/pubmed/26922638

    Wan, L. C., Pillon, M. C., Thevakumaran, N., Sun, Y., Chakrabartty, A., Guarne, A., Kurinov, I., Durocher, D., and Sicheri, F. (2016) Structural and Functional Characterization of Keops Dimerization by Pcc1 and Its Role in T6a Biosynthesis, Nucleic Acids Res 44, 6971-6980.
    http://www.ncbi.nlm.nih.gov/pubmed/27302132

    Wang, Y., Roose, B. W., Philbin, J. P., Doman, J. L., and Dmochowski, I. J. (2016) Programming a Molecular Relay for Ultrasensitive Biodetection through (129)Xe Nmr, Angew Chem Int Ed Engl 55, 1733-1736.
    http://www.ncbi.nlm.nih.gov/pubmed/26692420

    Wang, Y., Roose, B. W., Philbin, J. P., Doman, J. L., and Dmochowski, I. J. (2016) Programming a Molecular Relay for Ultrasensitive Biodetection through Xe Nmr, Angew. Chem. Int. Ed. Engl. 55, 1733-1736.
    http://www.ncbi.nlm.nih.gov/pubmed/26692420

    Wei, J., Zhang, Y., Yu, T. Y., Sadre-Bazzaz, K., Rudolph, M. J., Amodeo, G. A., Symington, L. S., Walz, T., and Tong, L. (2016) A Unified Molecular Mechanism for the Regulation of Acetyl-Coa Carboxylase by Phosphorylation, Cell Discov 2, 16044.
    https://www.ncbi.nlm.nih.gov/pubmed/27990296

    Wheatley, N. M., Eden, K. D., Ngo, J., Rosinski, J. S., Sawaya, M. R., Cascio, D., Collazo, M., Hoveida, H., Hubbell, W. L., and Yeates, T. O. (2016) A Pii-Like Protein Regulated by Bicarbonate: Structural and Biochemical Studies of the Carboxysome-Associated Cpii Protein, J Mol Biol 428, 4013-4030.
    http://www.ncbi.nlm.nih.gov/pubmed/27464895

    Wittenborn, E. C., Jost, M., Wei, Y., Stubbe, J., and Drennan, C. L. (2016) Structure of the Catalytic Domain of the Class I Polyhydroxybutyrate Synthase from Cupriavidus Necator, J Biol Chem 291, 25264-25277.
    https://www.ncbi.nlm.nih.gov/pubmed/27742839

    Wojcik, J., Lamontanara, A. J., Grabe, G., Koide, A., Akin, L., Gerig, B., Hantschel, O., and Koide, S. (2016) Allosteric Inhibition of Bcr-Abl Kinase by High-Affinity Monobody Inhibitors Directed to the Sh2-Kinase Interface, J. Biol. Chem. 291, 8836-8847.
    http://www.ncbi.nlm.nih.gov/pubmed/26912659

    Wong, E. V., Cao, W., Vörös, J., Merchant, M., Modis, Y., Hackney, D. D., Montpetit, B., and De La Cruz, E. M. (2016) Pi Release Limits the Intrinsic and Rna-Stimulated Atpase Cycles of Dead-Box Protein 5 (Dbp5), J. Mol. Biol. 428, 592-508.
    http://www.ncbi.nlm.nih.gov/pubmed/26730886

    Wong, S. J., Gearhart, M. D., Taylor, A. B., Nanyes, D. R., Ha, D. J., Robinson, A. K., Artigas, J. A., Lee, O. J., Demeler, B., Hart, P. J., Bardwell, V. J., and Kim, C. A. (2016) Kdm2b Recruitment of the Polycomb Group Complex, Prc1.1, Requires Cooperation between Pcgf1 and Bcorl1, Structure 24, 1795-1801.
    https://www.ncbi.nlm.nih.gov/pubmed/27568929

    Wu, H., Hu, C., Wang, A., Weisberg, E. L., Chen, Y., Yun, C. H., Wang, W., Liu, Y., Liu, X., Tian, B., Wang, J., Zhao, Z., Liang, Y., Li, B., Wang, L., Wang, B., Chen, C., Buhrlage, S. J., Qi, Z., Zou, F., Nonami, A., Li, Y., Fernandes, S. M., Adamia, S., Stone, R. M., Galinsky, I. A., Wang, X., Yang, G., Griffin, J. D., Brown, J. R., Eck, M. J., Liu, J., Gray, N. S., and Liu, Q. (2016) Discovery of a Btk/Mnk Dual Inhibitor for Lymphoma and Leukemia, Leukemia 30, 173-181.
    http://www.ncbi.nlm.nih.gov/pubmed/26165234

    Yang, H., Gao, P., Rajashankar, K. R., and Patel, D. J. (2016) Pam-Dependent Target DNA Recognition and Cleavage by C2c1 Crispr-Cas Endonuclease, Cell 167, 1814-1828 e1812.
    https://www.ncbi.nlm.nih.gov/pubmed/27984729

    Yao, G., Zhang, S., Mahrhold, S., Lam, K. H., Stern, D., Bagramyan, K., Perry, K., Kalkum, M., Rummel, A., Dong, M., and Jin, R. (2016) N-Linked Glycosylation of Sv2 Is Required for Binding and Uptake of Botulinum Neurotoxin A, Nat. Struct. Mol. Biol. 23, 656-662.
    https://www.ncbi.nlm.nih.gov/pubmed/27294781

    Ye, Q., Ur, S. N., Su, T. Y., and Corbett, K. D. (2016) Structure of the Saccharomyces Cerevisiae Hrr25:Mam1 Monopolin Subcomplex Reveals a Novel Kinase Regulator, EMBO J 35, 2139-2151.
    https://www.ncbi.nlm.nih.gov/pubmed/27491543

    Yelshanskaya, M. V., Singh, A. K., Sampson, J. M., Narangoda, C., Kurnikova, M., and Sobolevsky, A. I. (2016) Structural Bases of Noncompetitive Inhibition of Ampa-Subtype Ionotropic Glutamate Receptors by Antiepileptic Drugs, Neuron 91, 1305-1315.
    https://www.ncbi.nlm.nih.gov/pubmed/27618672

    Yin, Z., Shi, K., Banerjee, S., Pandey, K. K., Bera, S., Grandgenett, D. P., and Aihara, H. (2016) Crystal Structure of the Rous Sarcoma Virus Intasome, Nature 530, 362-366.
    http://www.ncbi.nlm.nih.gov/pubmed/26887497

    Zhang, W., Wu, K.-P., Sartori, Maria A., Kamadurai, Hari B., Ordureau, A., Jiang, C., Mercredi, Peter Y., Murchie, R., Hu, J., Persaud, A., Mukherjee, M., Li, N., Doye, A., Walker, John R., Sheng, Y., Hao, Z., Li, Y., Brown, Kevin R., Lemichez, E., Chen, J., Tong, Y., Harper, J. W., Moffat, J., Rotin, D., Schulman, Brenda A., and Sidhu, Sachdev S. (2016) System-Wide Modulation of Hect E3 Ligases with Selective Ubiquitin Variant Probes, Mol. Cell 62, 121-136.
    http://www.ncbi.nlm.nih.gov/pubmed/26949039

    Zhang, X., Eser, B. E., Chanani, P. K., Begley, T. P., and Ealick, S. E. (2016) Structural Basis for Iron-Mediated Sulfur Transfer in Archael and Yeast Thiazole Synthases, Biochemistry 55, 1826-1838.
    http://www.ncbi.nlm.nih.gov/pubmed/26919468

    Zhao, C., and Pyle, A. M. (2016) Crystal Structures of a Group Ii Intron Maturase Reveal a Missing Link in Spliceosome Evolution, Nat. Struct. Mol. Biol. 23, 558-565.
    http://www.ncbi.nlm.nih.gov/pubmed/27136328

    Zhou, L., Hinerman, J. M., Blaszczyk, M., Miller, J. L., Conrady, D. G., Barrow, A. D., Chirgadze, D. Y., Bihan, D., Farndale, R. W., and Herr, A. B. (2016) Structural Basis for Collagen Recognition by the Immune Receptor Oscar, Blood 127, 529-537.
    http://www.ncbi.nlm.nih.gov/pubmed/26552697

    Zimanyi, C. M., Chen, P. Y., Kang, G., Funk, M. A., and Drennan, C. L. (2016) Molecular Basis for Allosteric Specificity Regulation in Class Ia Ribonucleotide Reductase from Escherichia Coli, Elife 5, e07141.
    http://www.ncbi.nlm.nih.gov/pubmed/26754917

    Zinder, J. C., Wasmuth, E. V., and Lima, C. D. (2016) Nuclear Rna Exosome at 3.1 a Reveals Substrate Specificities, Rna Paths, and Allosteric Inhibition of Rrp44/Dis3, Mol Cell 64, 734-745.
    https://www.ncbi.nlm.nih.gov/pubmed/27818140

    2015

    Ah Young, A. P., Koehl, A., Cascio, D., and Egea, P. F. (2015) Structural mapping of the ClpB ATPases of Plasmodium falciparum: Targeting protein folding and secretion for antimalarial drug design, Protein Sci. 24, 1508-1520. PubMed

    Ahmad, M. F., Huff, S. E., Pink, J., Alam, I., Zhang, A., Perry, K., Harris, M. E., Misko, T., Porwal, S. K., Oleinick, N. L., Miyagi, M., Viswanathan, R., and Dealwis, C. G. (2015) Identification of non-nucleoside human ribonucleotide reductase modulators, J. Med. Chem. 58, 9498−9509. PubMed

    Ahmed, M., Cheng, M., Zhao, Q., Goldgur, Y., Cheal, S. M., Guo, H. F., Larson, S. M., and Cheung, N. V. (2015) Humanized Affinity-Matured Monoclonal Antibody 8H9 Has Potent Anti-Tumor Activity and Binds to FG Loop of B7-H3, J. Biol. Chem. 290, 30018–30029. PubMed

    Bae, B., Feklistov, A., Lass-Napiorkowska, A., Landick, R., and Darst, S. A. (2015) Structure of a bacterial RNA polymerase holoenzyme open promoter complex, Elife 4, e08504. PubMed

    Bai, Y., McCoy, J. G., Levin, E. J., Sobrado, P., Rajashankar, K. R., Fox, B. G., and Zhou, M. (2015) X-ray structure of a mammalian stearoyl-CoA desaturase, Nature 524, 252–256. PubMed

    Baker, B. Y., Gulati, S., Shi, W., Wang, B., Stewart, P. L., and Palczewski, K. (2015) Crystallization of Proteins from Crude Bovine Rod Outer Segments, in Methods Enzymol., Academic Press. PubMed

    Bale, J. B., Park, R. U., Liu, Y., Gonen, S., Gonen, T., Cascio, D., King, N. P., Yeates, T. O., and Baker, D. (2015) Structure of a designed tetrahedral protein assembly variant engineered to have improved soluble expression, Protein Sci. 24, 1695-1701. PubMed

    Baranovskiy, A. G., Zhang, Y., Suwa, Y., Babayeva, N. D., Gu, J., Pavlov, Y. I., and Tahirov, T. H. (2015) Crystal Structure of the Human Primase, J. Biol. Chem. 290, 5635–5646. PubMed

    Becker, A., Kannan, T. R., Taylor, A. B., Pakhomova, O. N., Zhang, Y., Somarajan, S. R., Galaleldeen, A., Holloway, S. P., Baseman, J. B., and Hart, P. J. (2015) Structure of CARDS toxin, a unique ADP-ribosylating and vacuolating cytotoxin from Mycoplasma pneumoniae, Proc. Natl. Acad. Sci. U.S.A. 112, 5165-5170. PubMed

    Begley, M. J., Yun, C. H., Gewinner, C. A., Asara, J. M., Johnson, J. L., Coyle, A. J., Eck, M. J., Apostolou, I., and Cantley, L. C. (2015) EGF-receptor specificity for phosphotyrosine-primed substrates provides signal integration with Src, Nat. Struct. Mol. Biol. 22, 983–990. PubMed

    Bigalke, J. M., and Heldwein, E. E. (2015) Structural basis of membrane budding by the nuclear egress complex of herpesviruses, EMBO J. 34, 2921-29369. PubMed

    Blankenship, E., Vahedi-Faridi, A., and Lodowski, David T. (2015) The High-Resolution Structure of Activated Opsin Reveals a Conserved Solvent Network in the Transmembrane Region Essential for Activation, Structure 23, 2358-2364. PubMed

    Blobaum, A. L., Xu, S., Rowlinson, S. W., Duggan, K. C., Banerjee, S., Kudalkar, S. N., Birmingham, W. R., Ghebreselasie, K., and Marnett, L. J. (2015) Action at a Distance: Mutations of Peripheral Residues Transform Rapid Reversible Inhibitors to Slow, Tight Binders of Cyclooxygenase-2, J. Biol. Chem. 290, 12793–12803. PubMed

    Bolla, J. R., Su, C. C., Delmar, J. A., Radhakrishnan, A., Kumar, N., Chou, T. H., Long, F., Rajashankar, K. R., and Yu, E. W. (2015) Crystal structure of the Alcanivorax borkumensis YdaH transporter reveals an unusual topology, Nat. Commun. 6, 6874. PubMed

    Borowska, Marta T., Dominik, Pawel K., Anghel, S. A., Kossiakoff, Anthony A., and Keenan, Robert J. (2015) A YidC-like Protein in the Archaeal Plasma Membrane, Structure 23, 1715-1724. PubMed

    Brown, N. G., VanderLinden, R., Watson, E. R., Qiao, R., Grace, C. R. R., Yamaguchi, M., Weissmann, F., Frye, J. J., Dube, P., Ei Cho, S., Actis, M. L., Rodrigues, P., Fujii, N., Peters, J.-M., Stark, H., and Schulman, B. A. (2015) RING E3 mechanism for ubiquitin ligation to a disordered substrate visualized for human anaphase-promoting complex, Proc. Natl. Acad. Sci. U.S.A. 112, 5272-5279. PubMed

    Broussard, T., Pakhomova, S., Neau, D. B., Bonnot, R., and Waldrop, G. L. (2015) Structural Analysis of Substrate, Reaction Intermediate and Product Binding in Haemophilus influenzae Biotin Carboxylase, Biochemistry 54, 3860-3870. PubMed

    Brumshtein, B., Esswein, S. R., Salwinski, L., Phillips, M. L., Ly, A. T., Cascio, D., Sawaya, M. R., and Eisenberg, D. S. (2015) Inhibition by small-molecule ligands of formation of amyloid fibrils of an immunoglobulin light chain variable domain, Elife 4, e10935. PubMed

    Bunker, R. D., Mandal, K., Bashiri, G., Chaston, J. J., Pentelute, B. L., Lott, J. S., Kent, S. B. H., and Baker, E. N. (2015) A functional role of Rv1738 in Mycobacterium tuberculosis persistence suggested by racemic protein crystallography, Proc. Natl. Acad. Sci. U.S.A. 112, 4310-4315. PubMed

    Burke, H. G., and Heldwein, E. E. (2015) Crystal Structure of the Human Cytomegalovirus Glycoprotein B, PLoS Pathog 11, e1005227. PubMed

    Calmettes, C., Ing, C., Buckwalter, C. M., El Bakkouri, M., Chieh-Lin Lai, C., Pogoutse, A., Gray-Owen, S. D., Pomes, R., and Moraes, T. F. (2015) The molecular mechanism of Zinc acquisition by the neisserial outer-membrane transporter ZnuD, Nat. Commun. 6, 7996. PubMed

    Cappadocia, L., Pichler, A., and Lima, C. D. (2015) Structural basis for catalytic activation by the human ZNF451 SUMO E3 ligase, Nat. Struct. Mol. Biol. 22, 968–975. PubMed

    Chauleau, M., Jacewicz, A., and Shuman, S. (2015) DNA3'pp5'G de-capping activity of aprataxin: effect of cap nucleoside analogs and structural basis for guanosine recognition, Nucleic Acids Res. 43, 6075-6083. PubMed

    Chen, Y., Bauer, B. W., Rapoport, T. A., and Gumbart, J. C. Conformational changes of the clamp of the protein translocation ATPase SecA, J. Mol. Biol. 427, 2348-2359. PubMed

    Chen, S., Rufiange, A., Huang, H., Rajashankar, K. R., Nourani, A., and Patel, D. J. (2015) Structure-function studies of histone H3/H4 tetramer maintenance during transcription by chaperone Spt2, Genes Dev. 29, 1326-1340. PubMed

    Chen, S., Yang, Z., Wilkinson, A. W., Deshpande, A. J., Sidoli, S., Krajewski, K., Strahl, B. D., Garcia, B. A., Armstrong, S. A., Patel, D. J., and Gozani, O. (2015) The PZP Domain of AF10 Senses Unmodified H3K27 to Regulate DOT1L-Mediated Methylation of H3K79, Mol. Cell 60, 319-327. PubMed

    Chou, T. H., Delmar, J. A., Wright, C. C., Kumar, N., Radhakrishnan, A., Doh, J. K., Licon, M. H., Reddy Bolla, J., Lei, H. T., Rajashankar, K. R., Su, C. C., Purdy, G. E., and Yu, E. W. (2015) Crystal structure of the Mycobacterium tuberculosis transcriptional regulator Rv0302, Protein Sci. 24, 1942-1955. PubMed

    Chowdhury, C., Chun, S., Pang, A., Sawaya, M. R., Sinha, S., Yeates, T. O., and Bobik, T. A. (2015) Selective molecular transport through the protein shell of a bacterial microcompartment organelle, Proc. Natl. Acad. Sci. U.S.A. 112, 2990-2995. PubMed

    Clarke, O. B., Tomasek, D., Jorge, C. D., Dufrisne, M. B., Kim, M., Banerjee, S., Rajashankar, K. R., Shapiro, L., Hendrickson, W. A., Santos, H., and Mancia, F. (2015) Structural basis for phosphatidylinositol-phosphate biosynthesis, Nat. Commun. 6, 8505. PubMed

    Dai, Q., Ren, A., Westholm, J. O., Duan, H., Patel, D. J., and Lai, E. C. (2015) Common and distinct DNA-binding and regulatory activities of the BEN-solo transcription factor family, Genes Dev. 29, 48-62. PubMed

    Decroos, C., and Christianson, D. W. (2015) Design, Synthesis, and Evaluation of Polyamine Deacetylase Inhibitors, and High-Resolution Crystal Structures of Their Complexes with Acetylpolyamine Amidohydrolase, Biochemistry 54, 4692-4703. PubMed

    Delmar, J. A., Chou, T. H., Wright, C. C., Licon, M. H., Doh, J. K., Radhakrishnan, A., Kumar, N., Lei, H. T., Bolla, J. R., Rajashankar, K. R., Su, C. C., Purdy, G. E., and Yu, E. W. (2015) Structural Basis for the Regulation of the MmpL Transporters of Mycobacterium tuberculosis, J. Biol. Chem. 290, 28559-28574. PubMed

    Dhatwalia, R., Singh, H., Reilly, T. J., and Tanner, J. J. (2015) Crystal Structure and Tartrate Inhibition of Legionella pneumophila Histidine Acid Phosphatase, Arch. Biochem. Biophys.528, 32-38. PubMed

    Diao, J., Liu, R., Rong, Y., Zhao, M., Zhang, J., Lai, Y., Zhou, Q., Wilz, L. M., Li, J., Vivona, S., Pfuetzner, R. A., Brunger, A. T., and Zhong, Q. (2015) ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes, Nature 520, 563-566. PubMed

    Doamekpor, S. K., Schwer, B., Sanchez, A. M., Shuman, S., and Lima, C. D. (2015) Fission yeast RNA triphosphatase reads an Spt5 CTD code, RNA 21, 113-123. PubMed

    Dong, C., Mao, Y., Tempel, W., Qin, S., Li, L., Loppnau, P., Huang, R., and Min, J. (2015) Structural basis for substrate recognition by the human N-terminal methyltransferase 1, Genes Dev. 29, 2343-2348. PubMed

    Draheim, K. M., Li, X., Zhang, R., Fisher, O. S., Villari, G., Boggon, T. J., and Calderwood, D. A. (2015) CCM2-CCM3 interaction stabilizes their protein expression and permits endothelial network formation, J. Cell Biology 208, 987-1001. PubMed

    Dziedzic, P., Cisneros, J. A., Robertson, M. J., Hare, A. A., Danford, N. E., Baxter, R. H., and Jorgensen, W. L. (2015) Design, synthesis, and protein crystallography of biaryltriazoles as potent tautomerase inhibitors of macrophage migration inhibitory factor, J. Am. Chem. Soc. 137, 2996-3003. PubMed

    Englert, M., Nakamura, A., Wang, Y. S., Eiler, D., Soll, D., and Guo, L. T. (2015) Probing the active site tryptophan of Staphylococcus aureus thioredoxin with an analog, Nucleic Acids Res. 43, 11061-11067. PubMed

    Fan, H., Hahm, J., Diggs, S., Perry, J. J., and Blaha, G. (2015) Structural and Functional Analysis of BipA, a Regulator of Virulence in enteropathogenic Escherichia coli, J. Biol. Chem. 290, 20857-20. PubMed

    Fenwick, M. K., Mehta, A. P., Zhang, Y., Abdelwahed, S. H., Begley, T. P., and Ealick, S. E. (2015) Non-canonical active site architecture of the radical SAM thiamin pyrimidine synthase, Nat. Commun. 6. PubMed

    Fisher, O. S., Deng, H., Liu, D., Zhang, Y., Wei, R., Deng, Y., Zhang, F., Louvi, A., Turk, B. E., Boggon, T. J., and Su, B. (2015) Structure and vascular function of MEKK3-cerebral cavernous malformations 2 complex, Nat. Commun. 6, 7937. PubMed

    Fisher, O. S., Liu, W., Zhang, R., Stiegler, A. L., Ghedia, S., Weber, J. L., and Boggon, T. J. (2015) Structural basis for the disruption of the Cerebral Cavernous Malformations 2 (CCM2) interaction with Krev Interaction Trapped 1 (KRIT1) by disease-associated mutations, J. Biol. Chem. 290, 2842-2853. PubMed

    Funk, M. A. (2015), Structural Studies of Radical Enzymes in Bacterial Central Metabolism, Massachusetts Institute of Technology, Cambridge, Massachusetts.

    Gagnon, D. M., Brophy, M. B., Bowman, S. E., Stich, T. A., Drennan, C. L., Britt, R. D., and Nolan, E. M. (2015) Manganese Binding Properties of Human Calprotectin Under Conditions of High and Low Calcium: X-ray Crystallographic and Advanced EPR Spectroscopic Analysis, J. Am. Chem. Soc. 137, 3004-3016. PubMed

    Garnham, C. P., Vemu, A., Wilson-Kubalek, E. M., Yu, I., Szyk, A., Lander, G. C., Milligan, R. A., and Roll-Mecak, A. (2015) Multivalent Microtubule Recognition by Tubulin Tyrosine Ligase-like Family Glutamylases, Cell 161, 1112-1123. PubMed

    Gibson, M. I. (2015), Structures of Oxalate Oxidoreductase: C[2] Activation by a Microbial Tpp-Dependent Ferredoxin Oxidoreductase, Massachusetts Institute of Technology, Cambridge, Massachusetts.

    Gibson, M. I., Brignole, E. J., Pierce, E., Can, M., Ragsdale, S. W., and Drennan, C. L. (2015) Structure of an oxalate oxidoreductase provides insight into microbial 2-oxoacid metabolism, Biochemistry 54, 4112-4120. PubMed

    Golczak, M., Sears, A. E., Kiser, P. D., and Palczewski, K. (2015) LRAT-specific domain facilitates vitamin A metabolism by domain swapping in HRASLS3, Nat. Chem. Biol. 11, 26-32. PubMed

    Gupta, Y. K., Chan, S. H., Xu, S. Y., and Aggarwal, A. K. (2015) Structural basis of asymmetric DNA methylation and ATP-triggered long-range diffusion by EcoP15I, Nat. Commun. 6, 7363. PubMed

    Ha, B. H., Simpson, M. A., Koleske, A. J., and Boggon, T. J. (2015) Structure of the ABL2/ARG kinase in complex with dasatinib, Acta Crystallogr. F 71, 443-448. PubMed

    Harris, G. G., Lombardi, P. M., Pemberton, T. A., Matsui, T., Weiss, T. M., Cole, K. E., Koksal, M., Murphy, F. V. t., Vedula, L. S., Chou, W. K., Cane, D. E., and Christianson, D. W. (2015) Structural Studies of Geosmin Synthase, a Bifunctional Sesquiterpene Synthase with αα Domain Architecture That Catalyzes a Unique Cyclization-Fragmentation Reaction Sequence, Biochemistry 54, 7142–7155. PubMed

    Hernandez, A. R., Shao, Y., Hoshika, S., Yang, Z., Shelke, S. A., Herrou, J., Kim, H. J., Kim, M. J., Piccirilli, J. A., and Benner, S. A. (2015) A Crystal Structure of a Functional RNA Molecule Containing an Artificial Nucleobase Pair, Angew. Chem. Int. Ed. Engl. 54, 9853-9856. PubMed

    Hinshaw, S. M., Makrantoni, V., Kerr, A., Marston, A. L., and Harrison, S. C. (2015) Structural evidence for Scc4-dependent localization of cohesin loading, 4, e06057. PubMed

    Horenkamp, F. A., Kauffman, K. J., Kohler, L. J., Sherwood, R. K., Krueger, K. P., Shteyn, V., Roy, C. R., Melia, T. J., and Reinisch, K. M. (2015) The Legionella Anti-autophagy Effector RavZ Targets the Autophagosome via PI3P- and Curvature-Sensing Motifs, Dev. Cell 34, 569-576. PubMed

    Huang, H., Stromme, C. B., Saredi, G., Hodl, M., Strandsby, A., Gonzalez-Aguilera, C., Chen, S., Groth, A., and Patel, D. J. (2015) A unique binding mode enables MCM2 to chaperone histones H3-H4 at replication forks, Nat. Struct. Mol. Biol. 22, 618-626. PubMed

    Ingram, J. R., Knockenhauer, K. E., Markus, B. M., Mandelbaum, J., Ramek, A., Shan, Y., Shaw, D. E., Schwartz, T. U., Ploegh, H. L., and Lourido, S. (2015) Allosteric activation of apicomplexan calcium-dependent protein kinases, Proc. Natl. Acad. Sci. U.S.A. 112, E4975–E4984. PubMed

    Jenni, S., Goyal, Y., von Grotthuss, M., Shvartsman, Stanislav Y., and Klein, Daryl E. Structural Basis of Neurohormone Perception by the Receptor Tyrosine Kinase Torso, Molecular Cell 60, 941–952. PubMed

    Jensen, J. L., Balbo, A., Neau, D. B., Chakravarthy, S., Zhao, H., Sinha, S. C., and Colbert, C. L. (2015) Mechanistic implications of the unique structural features and dimerization of the cytoplasmic domain of the Pseudomonas sigma regulator, PupR, Biochemistry 54, 5867-5877. PubMed

    Jensen, J. L., Indurthi, V. S., Neau, D. B., Vetter, S. W., and Colbert, C. L. (2015) Structural insights into the binding of the human receptor for advanced glycation end products (RAGE) by S100B, as revealed by an S100B-RAGE-derived peptide complex, Acta Crystallogr. D, 1176-1183. PubMed

    Jiang, J., Chan, H., Cash, D. D., Miracco, E. J., Ogorzalek Loo, R. R., Upton, H. E., Cascio, D., O'Brien Johnson, R., Collins, K., Loo, J. A., Zhou, Z. H., and Feigon, J. (2015) Structure of Tetrahymena telomerase reveals previously unknown subunits, functions, and interactions, Science 350, aab4070. PubMed

    Jin, N., Wang, Y., Crawford, F., White, J., Marrack, P., Dai, S., and Kappler, J. W. (2015) N-terminal additions to the WE14 peptide of chromogranin A create strong autoantigen agonists in type 1 diabetes, Proc. Natl. Acad. Sci. U.S.A.112, 13318–13323. PubMed

    Jost, M., Born, D. A., Cracan, V., Banerjee, R., and Drennan, C. L. (2015) Structural Basis for Substrate Specificity in Adenosylcobalamin-Dependent Isobutyryl-CoA Mutase and Related Acyl-CoA Mutases, J. Biol. Chem. 290, 26882-22698. PubMed

    Jost, M., Cracan, V., Hubbard, P. A., Banerjee, R., and Drennan, C. L. (2015) Visualization of a radical B12 enzyme with its G-protein chaperone, Proc. Natl. Acad. Sci. U.S.A. 112, 2419-2424. PubMed

    Jost, M., Fernandez-Zapata, J., Polanco, M. C., Ortiz-Guerrero, J. M., Chen, P. Y., Kang, G., Padmanabhan, S., Elias-Arnanz, M., and Drennan, C. L. (2015) Structural basis for gene regulation by a B12-dependent photoreceptor, Nature 526, 536–541. PubMed

    Jurgenson, C. T., and Pollard, T. D. (2015) Crystals of the Arp2/3 complex in two new space groups with structural information about actin-related protein 2 and potential WASP binding sites, Acta Crystallogr. F 71, 1161-1168. PubMed

    Kelley, K., Knockenhauer, K. E., Kabachinski, G., and Schwartz, T. U. (2015) Atomic structure of the Y complex of the nuclear pore, Nat. Struct. Mol. Biol. 22, 425-431. PubMed

    Kiser, P. D., Zhang, J., Badiee, M., Li, Q., Shi, W., Sui, X., Golczak, M., Tochtrop, G. P., and Palczewski, K. (2015) Catalytic mechanism of a retinoid isomerase essential for vertebrate vision, Nat. Chem. Biol. 11, 409-415. PubMed

    Knockenhauer, K. E., and Schwartz, T. U. (2015) Structural Characterization of Bardet-Biedl Syndrome 9 Protein (BBS9), J. Biol. Chem. 290, 19569-19583. PubMed

    Kosutic, M., Neuner, S., Ren, A., Flur, S., Wunderlich, C., Mairhofer, E., Vusurovic, N., Seikowski, J., Breuker, K., Hobartner, C., Patel, D. J., Kreutz, C., and Micura, R. (2015) A Mini-Twister Variant and Impact of Residues/Cations on the Phosphodiester Cleavage of this Ribozyme Class, Angew. Chem. Int. Ed. Engl. 54, 15128-15133. PubMed

    Kudalkar, S. N., Nikas, S. P., Kingsley, P. J., Xu, S., Galligan, J. J., Rouzer, C. A., Banerjee, S., Ji, L., Eno, M. R., Makriyannis, A., and Marnett, L. J. (2015) 13-methylarachidonic acid is a positive allosteric modulator of endocannabinoid oxygenation by cyclooxygenase, J. Biol. Chem. 290, 7897–7909. PubMed

    Kumar, S., Krishnamoorthy, K., Mudeppa, D. G., and Rathod, P. K. (2015) Structure of Plasmodium falciparum orotate phosphoribosyltransferase with autologous inhibitory protein-protein interactions, Acta Crystallogr. F 71, 600-608. PubMed

    Lai, Y. T., Jiang, L., Chen, W., and Yeates, T. O. (2015) On the predictability of the orientation of protein domains joined by a spanning alpha-helical linker, Protein. Eng. Des. Sel. 28, 491-500. PubMed

    Lall, P., Lindsay, A., Hanscom, S., Kecman, T., Taglauer, E. S., McVeigh, U. M., Franklin, E., McCaffrey, M. W., and Khan, A. R. (2015) Structure-Function Analyses of the Interactions Between Rab11 and Rab14 Small GTPases with their Shared Effector Rab Coupling Protein (RCP), J. Biol. Chem. 290, 18817–18832. PubMed

    Lee, W.-G., Frey, K. M., Gallardo-Macias, R., Spasov, K. A., Chan, A. H., Anderson, K. S., and Jorgensen, W. L. (2015) Discovery and crystallography of bicyclic arylaminoazines as potent inhibitors of HIV-1 reverse transcriptase, Bioorg. Med. Chem. Lett. 25, 4824-4827. PubMed

    Lee, K., Lam, K.-H., Kruel, A.-M., Mahrhold, S., Perry, K., Cheng, L. W., Rummel, A., and Jin, R. (2015) Inhibiting oral intoxication of botulinum neurotoxin A complex by carbohydrate receptor mimics, Toxicon 107, Part A, 43-49. PubMed

    Lee, S., Greenlee, E. B., Amick, J. R., Ligon, G. F., Lillquist, J. S., Natoli, E. J., Hadari, Y., Alvarado, D., and Schlessinger, J. (2015) Inhibition of ErbB3 by a monoclonal antibody that locks the extracellular domain in an inactive configuration, Proc. Natl. Acad. Sci. U.S.A.112, 13225–13230. PubMed

    Leibly, David J., Arbing, Mark A., Pashkov, I., DeVore, N., Waldo, Geoffrey S., Terwilliger, Thomas C., and Yeates, Todd O. (2015) A Suite of Engineered GFP Molecules for Oligomeric Scaffolding, Structure 23, 1754-1768. PubMed

    Leung, J. H., Schurig-Briccio, L. A., Yamaguchi, M., Moeller, A., Speir, J. A., Gennis, R. B., and Stout, C. D. (2015) Structural biology. Division of labor in transhydrogenase by alternating proton translocation and hydride transfer, Science 347, 178-181. PubMed

    Li, X., Roberti, R., and Blobel, G. (2015) Structure of an integral membrane sterol reductase from Methylomicrobium alcaliphilum, Nature 517, 104-107. PubMed

    Lin, D. Y., Huang, S., and Chen, J. (2015) Crystal structures of a polypeptide processing and secretion transporter, Nature 523, 425-430. PubMed

    Lin, J., Gagnon, M. G., Bulkley, D., and Steitz, T. A. (2015) Conformational Changes of Elongation Factor G on the Ribosome during tRNA Translocation, Cell 160, 219-227. PubMed

    Luo, M., and Tanner, J. J. (2015) Structural Basis of Substrate Recognition by Aldehyde Dehydrogenase 7A1, Biochemistry 54, 5513-5522. PubMed

    Lye, M. F., Sharma, M., El Omari, K., Filman, D. J., Schuermann, J. P., Hogle, J. M., and Coen, D. M. (2015) Unexpected features and mechanism of heterodimer formation of a herpesvirus nuclear egress complex, EMBO J. 34, 2937-2952. PubMed

    Mahmutovic, S., Clark, L., Levis, S. C., Briggiler, A. M., Enria, D. A., Harrison, S. C., and Abraham, J. (2015) Molecular Basis for Antibody-Mediated Neutralization of New World Hemorrhagic Fever Mammarenaviruses, Cell Host Microbe 18, 705-713. PubMed

    Matarlo, J. S., Evans, C. E., Sharma, I., Lavaud, L. J., Ngo, S. C., Shek, R., Rajashankar, K. R., French, J. B., Tan, D. S., and Tonge, P. J. (2015) Mechanism of MenE Inhibition by Acyl-Adenylate Analogues and Discovery of Novel Antibacterial Agents, Biochemistry 54, 6514–6524. PubMed

    Mateja, A., Paduch, M., Chang, H. Y., Szydlowska, A., Kossiakoff, A. A., Hegde, R. S., and Keenan, R. J. (2015) Protein targeting. Structure of the Get3 targeting factor in complex with its membrane protein cargo, Science 347, 1152-1155. PubMed

    McMillan, B. J., Schnute, B., Ohlenhard, N., Zimmerman, B., Miles, L., Beglova, N., Klein, T., and Blacklow, S. C. (2015) A tail of two sites: a bipartite mechanism for recognition of notch ligands by mind bomb e3 ligases, Mol. Cell 57, 912-924. PubMed

    McNamara, D. E., Senese, S., Yeates, T. O., and Torres, J. Z. (2015) Structures of potent anticancer compounds bound to tubulin, Protein Sci. 24, 1164-1172. PubMed

    Mi, L.-Z., Brown, C. T., Gao, Y., Tian, Y., Le, V. Q., Walz, T., and Springer, T. A. (2015) Structure of bone morphogenetic protein 9 procomplex, Proc. Natl. Acad. Sci. U.S.A. 12, 3710-3715. PMID: 25751889 PubMed

    Mir, A., Chen, J., Robinson, K., Lendy, E., Goodman, J., Neau, D. B., and Golden, B. L. (2015) Two divalent metal ions and conformational changes play roles in the hammerhead ribozyme cleavage reaction, Biochemistry 54, 6369−6381. PubMed

    Murphy, M. W., Lee, J. K., Rojo, S., Gearhart, M. D., Kurahashi, K., Banerjee, S., Loeuille, G. A., Bashamboo, A., McElreavey, K., Zarkower, D., Aihara, H., and Bardwell, V. J. (2015) An ancient protein-DNA interaction underlying metazoan sex determination, Nat. Struct. Mol. Biol. 22, 442-451. PubMed

    Nicoludis, John M., Lau, S.-Y., Schärfe, Charlotta P. I., Marks, Debora S., Weihofen, Wilhelm A., and Gaudet, R. Structure and Sequence Analyses of Clustered Protocadherins Reveal Antiparallel Interactions that Mediate Homophilic Specificity, Structure 23, 2087-2098. PubMed

    Nocula-Nocula-Lugowska, M., Lugowski, M., Salgia, R., and Kossiakoff, A. A. (2015) Engineering synthetic antibody inhibitors specific for LD2 or LD4 motifs of paxillin, J. Mol. Biol. 427, 2532–2547. PubMed

    Noey, E. L., Tibrewal, N., Jimenez-Oses, G., Osuna, S., Park, J., Bond, C. M., Cascio, D., Liang, J., Zhang, X., Huisman, G. W., Tang, Y., and Houk, K. N. (2015) Origins of stereoselectivity in evolved ketoreductases, Proc. Natl. Acad. Sci. U.S.A. 112, E7065-E7072. PubMed

    Noh, K.-M., Wang, H., Kim, Hyunjae R., Wenderski, W., Fang, F., Li, Charles H., Dewell, S., Hughes, Stephen H., Melnick, Ari M., Patel, Dinshaw J., Li, H., and Allis, C. D. (2015) Engineering of a Histone-Recognition Domain in Dnmt3a Alters the Epigenetic Landscape and Phenotypic Features of Mouse ESCs, Mol. Cell 59, 89-103. PubMed

    Park, E., Kim, N., Ficarro, S. B., Zhang, Y., Lee, B. I., Cho, A., Kim, K., Park, A. K., Park, W. Y., Murray, B., Meyerson, M., Beroukhim, R., Marto, J. A., Cho, J., and Eck, M. J. (2015) Structure and mechanism of activity-based inhibition of the EGF receptor by Mig6, Nat. Struct. Mol. Biol. 22, 703-711. PubMed

    Park, E., Graziano, B. R., Zheng, W., Garabedian, M., Goode, B. L., and Eck, M. J. (2015) Structure of a Bud6/Actin Complex Reveals a Novel WH2-like Actin Monomer Recruitment Motif, Structure 23, 1492-1499. PubMed

    Peng, M., Cascio, D., and Egea, P. F. (2015) Crystal structure and solution characterization of the thioredoxin-2 from Plasmodium falciparum, a constituent of an essential parasitic protein export complex, Biochem. Biophys. Res. Commun. 456, 403-409. PubMed

    Penmatsa, A., Wang, K. H., and Gouaux, E. (2015) X-ray structures of Drosophila dopamine transporter in complex with nisoxetine and reboxetine, Nat. Struct. Mol. Biol. 22, 506-508. PubMed

    Polikanov, Y. S., Melnikov, S. V., Soll, D., and Steitz, T. A. (2015) Structural insights into the role of rRNA modifications in protein synthesis and ribosome assembly, Nat. Struct. Mol. Biol. 22, 342-344. PubMed

    Polikanov, Y. S., and Moore, P. B. (2015) Acoustic vibrations contribute to the diffuse scatter produced by ribosome crystals, Acta Crystallogr. D Biol. Crystallogr. 71, 2021-2031. PubMed

    Polikanov, Y. S., Starosta, A. L., Juette, M. F., Altman, R. B., Terry, D. S., Lu, W., Burnett, B. J., Dinos, G., Reynolds, K. A., Blanchard, S. C., Steitz, T. A., and Wilson, D. N. (2015) Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A, Mol. Cell 58, 832–844. PubMed

    Price, I. R., Gaballa, A., Ding, F., Helmann, J. D., and Ke, A. (2015) Mn2+-Sensing Mechanisms of yybP-ykoY Orphan Riboswitches, Mol. Cell 57, 1110-1123. PubMed

    Qian, W. J., Park, J. E., Grant, R., Lai, C. C., Kelley, J. A., Yaffe, M. B., Lee, K. S., and Burke, T. R. (2015) Neighbor-directed Histidine N(τ)-Alkylation: A Route to Imidazolium-containing Phosphopeptide Macrocycles, Biopolymers 104, 1161-1168. PubMed

    Ren, A., Rajashankar, K. R., and Patel, D. J. (2015) Global RNA Fold and Molecular Recognition for a pfl Riboswitch Bound to ZMP, a Master Regulator of One-Carbon Metabolism, Structure 23, 1375-1381. PubMed

    Ren, A., Wang, Xin C., Kellenberger, Colleen A., Rajashankar, Kanagalaghatta R., Jones, Roger A., Hammond, Ming C., and Patel, Dinshaw J. (2015) Structural Basis for Molecular Discrimination by a 3′,3′-cGAMP Sensing Riboswitch, Cell Reports 11, 1-12. PubMed

    Ren, A., Xue, Y., Peselis, A., Serganov, A., Al-Hashimi, Hashim M., and Patel, Dinshaw J. (2015) Structural and Dynamic Basis for Low-Affinity, High-Selectivity Binding of L-Glutamine by the Glutamine Riboswitch, Cell Reports 13, 1800-1813. PubMed

    Robinson, R., Qureshi, I. A., Klancher, C. A., Rodriguez, P. J., Tanner, J. J., and Sobrado, P. (2015) Contribution to catalysis of ornithine binding residues in ornithine N5-monooxygenase, Arch. Biochem. Biophys. 585, 25-31. PubMed

    Rodriguez, J. A., Ivanova, M. I., Sawaya, M. R., Cascio, D., Reyes, F. E., Shi, D., Sangwan, S., Guenther, E. L., Johnson, L. M., Zhang, M., Jiang, L., Arbing, M. A., Nannenga, B. L., Hattne, J., Whitelegge, J., Brewster, A. S., Messerschmidt, M., Boutet, S., Sauter, N. K., Gonen, T., and Eisenberg, D. S. (2015) Structure of the toxic core of α-synuclein from invisible crystals, Nature 525, 486-490. PubMed

    Rosenberg, O. S., Dovala, D., Li, X., Connolly, L., Bendebury, A., Finer-Moore, J., Holton, J., Cheng, Y., Stroud, R. M., and Cox, J. S. (2015) Substrates Control Multimerization and Activation of the Multi-Domain ATPase Motor of Type VII Secretion, Cell 161, 501-512. PubMed

    Roy, R. N., Lomakin, I. B., Gagnon, M. G., and Steitz, T. A. (2015) The mechanism of inhibition of protein synthesis by the proline-rich peptide oncocin, Nat. Struct. Mol. Biol. 22, 466-469. PubMed

    Rubinstein, R., Thu, C. A., Goodman, K. M., Wolcott, H. N., Bahna, F., Mannepalli, S., Ahlsen, G., Chevee, M., Halim, A., Clausen, H., Maniatis, T., Shapiro, L., and Honig, B. (2015) Molecular Logic of Neuronal Self-Recognition through Protocadherin Domain Interactions, Cell 163, 629-642. PubMed

    Saelices, L., Johnson, L. M., Liang, W. Y., Sawaya, M. R., Cascio, D., Ruchala, P., Whitelegge, J., Jiang, L., Riek, R., and Eisenberg, D. S. (2015) Uncovering the Mechanism of Aggregation of Human Transthyretin, J. Biol. Chem. 290, 28932-28943. PubMed

    Saoji, M., and Paukstelis, P. J. (2015) Sequence-dependent structural changes in a self-assembling DNA oligonucleotide, Acta Crystallographica D 71, 2471-2478. PubMed

    Saoji, M., Zhang, D., and Paukstelis, P. J. (2015) Probing the role of sequence in the assembly of three-dimensional DNA crystals, Biopolymers 103, 618-626. PubMed

    Schirle, N. T., Sheu-Gruttadauria, J., Chandradoss, S. D., Joo, C., and MacRae, I. J. (2015) Water-mediated recognition of t1-adenosine anchors Argonaute2 to microRNA targets, Elife 4, e07646. PubMed

    Schmandt, N., Velisetty, P., Chalamalasetti, S. V., Stein, R. A., Bonner, R., Talley, L., Parker, M. D., McHaourab, H. S., Yee, V. C., Lodowski, D. T., and Chakrapani, S. (2015) A chimeric prokaryotic pentameric ligand-gated channel reveals distinct pathways of activation, J. Gen. Physiol. 146, 323-340. PubMed

    Schmidt, A. G., Therkelsen, M. D., Stewart, S., Kepler, T. B., Liao, H. X., Moody, M. A., Haynes, B. F., and Harrison, S. C. (2015) Viral Receptor-Binding Site Antibodies with Diverse Germline Origins, Cell 161, 1026–1034. PubMed

    Schormann, N., Banerjee, S., Ricciardi, R., and Chattopadhyay, D. (2015) Binding of undamaged double stranded DNA to vaccinia virus uracil-DNA Glycosylase, BMC Struct. Biol. 15, 10. PubMed

    Schureck, M. A., Dunkle, J. A., Maehigashi, T., Miles, S. J., and Dunham, C. M. (2015) Defining the mRNA recognition signature of a bacterial toxin protein, Proc. Natl. Acad. Sci. U.S.A. 112, 13862-13867. PubMed

    Schwer, B., Ghosh, A., Sanchez, A. M., Lima, C. D., and Shuman, S. (2015) Genetic and structural analysis of the essential fission yeast RNA polymerase II CTD phosphatase Fcp1, RNA 21, 1135–1146. PubMed

    Sekiyama, N., Arthanari, H., Papadopoulos, E., Rodriguez-Mias, R. A., Wagner, G., and Leger-Abraham, M. (2015) Molecular mechanism of the dual activity of 4EGI-1: Dissociating eIF4G from eIF4E but stabilizing the binding of unphosphorylated 4E-BP1, Proc. Natl. Acad. Sci. U.S.A. 112, E4036–E4045. PubMed

    Shi, K., Carpenter, M. A., Kurahashi, K., Harris, R. S., and Aihara, H. (2015) Crystal Structure of the DNA Deaminase APOBEC3B Catalytic Domain, J. Biol. Chem. 290, 28120-28130. PubMed

    Singh, M., Wang, Z., Cascio, D., and Feigon, J. (2015) Structure and interactions of the CS domain of human H/ACA RNP assembly protein Shq1, J. Mol. Biol. 427, 807-823. PubMed

    Sit, B., Crowley, S. M., Bhullar, K., Lai, C. C., Tang, C., Hooda, Y., Calmettes, C., Khambati, H., Ma, C., Brumell, J. H., Schryvers, A. B., Vallance, B. A., and Moraes, T. F. (2015) Active Transport of Phosphorylated Carbohydrates Promotes Intestinal Colonization and Transmission of a Bacterial Pathogen, PLoS Pathog. 11, e1005107. PubMed

    Soragni, A., Yousefi, S., Stoeckle, C., Soriaga, A. B., Sawaya, M. R., Kozlowski, E., Schmid, I., Radonjic-Hoesli, S., Boutet, S., Williams, G. J., Messerschmidt, M., Seibert, M. M., Cascio, D., Zatsepin, N. A., Burghammer, M., Riekel, C., Colletier, J. P., Riek, R., Eisenberg, D. S., and Simon, H. U. (2015) Toxicity of Eosinophil MBP Is Repressed by Intracellular Crystallization and Promoted by Extracellular Aggregation, Mol. Cell 57, 1011-1021. PubMed

    Su, C.-C., Bolla, Jani R., Kumar, N., Radhakrishnan, A., Long, F., Delmar, Jared A., Chou, T.-H., Rajashankar, Kanagalaghatta R., Shafer, William M., and Yu, Edward W. (2015) Structure and Function of Neisseria gonorrhoeae MtrF Illuminates a Class of Antimetabolite Efflux Pumps, Cell Reports 11, 61-70. PubMed

    Sue, A. C., Mannige, R. V., Deng, H., Cao, D., Wang, C., Gandara, F., Stoddart, J. F., Whitelam, S., and Yaghi, O. M. (2015) Heterogeneity of functional groups in a metal-organic framework displays magic number ratios, Proc. Natl. Acad. Sci. U.S.A. 112, 5591-5596. PubMed

    Sui, X., Golczak, M., Zhang, J., Kleinberg, K. A., von Lintig, J., Palczewski, K., and Kiser, P. D. (2015) Utilization of Dioxygen by Carotenoid Cleavage Oxygenases, J. Biol. Chem. 290, 30212-30223. PubMed

    Suslov, N. B., DasGupta, S., Huang, H., Fuller, J. R., Lilley, D. M., Rice, P. A., and Piccirilli, J. A. (2015) Crystal structure of the Varkud satellite ribozyme, Nat. Chem. Biol. 11, 840-846. PubMed

    Suwa, Y., Gu, J., Baranovskiy, A. G., Babayeva, N. D., Pavlov, Y. I., and Tahirov, T. H. (2015) Crystal Structure of the Human Pol alpha B Subunit in Complex with the C-terminal Domain of the Catalytic Subunit, J. Biol. Chem. 290, 14328–14337. PubMed

    Sysoeva, T. A., Bane, L. B., Xiao, D. Y., Bose, B., Chilton, S. S., Gaudet, R., and Burton, B. M. (2014) Structural characterization of the late competence protein ComFB from Bacillus subtilis, Biosci. Rep.35, art:e00183. PubMed

    Szulik, M. W., Pallan, P. S., Nocek, B., Voehler, M., Banerjee, S., Brooks, S., Joachimiak, A., Egli, M., Eichman, B. F., and Stone, M. P. (2015) Differential stabilities and sequence-dependent base pair opening dynamics of watson-crick base pairs with 5-hydroxymethylcytosine, 5-formylcytosine, or 5-carboxylcytosine, Biochemistry 54, 1294-1305. PubMed

    Tago, N., Katolik, A., Clark, N. E., Montemayor, E. J., Seio, K., Sekine, M., Hart, P. J., and Damha, M. J. (2015) Design, Synthesis, and Properties of Phosphoramidate 2',5'-Linked Branched RNA: Toward the Rational Design of Inhibitors of the RNA Lariat Debranching Enzyme, J. Org. Chem. 80, 10108-10118. PubMed

    Tan, L., Akahane, K., McNally, R., Reyskens, K. M., Ficarro, S. B., Liu, S., Herter-Sprie, G. S., Koyama, S., Pattison, M. J., Labella, K. M., Johannessen, L., Akbay, E. A., Wong, K. K., Frank, D. A., Marto, J. A., Look, A. T., Arthur, S., Eck, M. J., and Gray, N. S. (2015) Development of Selective Covalent JAK3 Inhibitors, J. Med. Chem. 58, 6589-6606. PubMed

    Tang, C., Ji, X., Wu, L., and Xiong, Y. (2015) Impaired dNTPase Activity of SAMHD1 by Phosphomimetic Mutation of T592, J. Biol. Chem. 290, 26352-26359. PubMed

    Tao, Y., Cheung, L. S., Li, S., Eom, J.-S., Chen, L.-Q., Xu, Y., Perry, K., Frommer, W. B., and Feng, L. (2015) Structure of a eukaryotic SWEET transporter in a homotrimeric complex, Nature 527, 259-263. PubMed

    Taylor, A. B., Pica-Mattoccia, L., Polcaro, C. M., Donati, E., Cao, X., Basso, A., Guidi, A., Rugel, A. R., Holloway, S. P., Anderson, T. J., Hart, P. J., Cioli, D., and LoVerde, P. T. (2015) Structural and Functional Characterization of the Enantiomers of the Antischistosomal Drug Oxamniquine, PLoS Negl. Trop. Dis. 9, e0004132. PubMed

    Thompson, M. C., Cascio, D., Leibly, D. J., and Yeates, T. O. (2015) An allosteric model for control of pore opening by substrate binding in the EutL microcompartment shell protein, Protein Sci. 24, 956-975. PubMed

    Tookmanian, E. M., Phillips-Piro, C. M., Fenlon, E. E., and Brewer, S. H. (2015) Azidoethoxyphenylalanine as a Vibrational Reporter and Click Chemistry Partner in Proteins, Chem. Eur. J. 21, 19096-19103. PubMed

    Tripathi, S., Zhang, D., and Paukstelis, P. J. (2015) An intercalation-locked parallel-stranded DNA tetraplex, Nucleic Acids Res. 43, 1937-1944. PubMed

    Unciuleac, M. C., Goldgur, Y., and Shuman, S. (2015) Structure and two-metal mechanism of a eukaryal nick-sealing RNA ligase, Proc. Natl. Acad. Sci. U.S.A. 112, 13868–13873. PubMed

    Vasilyev, N., Polonskaia, A., Darnell, J. C., Darnell, R. B., Patel, D. J., and Serganov, A. (2015) Crystal structure reveals specific recognition of a G-quadruplex RNA by a β-turn in the RGG motif of FMRP, Proc. Natl. Acad. Sci. U.S.A. 112, E5391–E5400. PubMed

    Vinokur, J. M., Korman, T. P., Sawaya, M. R., Collazo, M., Cascio, D., and Bowie, J. U. (2015) Structural Analysis of Mevalonate-3-Kinase Provides Insight Into The Mechanisms of Isoprenoid Pathway Decarboxylases, Protein Sci. 24, 212-220. PubMed

    Wang, K. H., Penmatsa, A., and Gouaux, E. (2015) Neurotransmitter and psychostimulant recognition by the dopamine transporter, Nature 521, 322-327. PubMed

    Wang, L., Lee, S. J., and Verdine, G. (2015) Structural Basis for Avoidance of Promutagenic DNA Repair by MutY Adenine DNA Glycosylase, J. Biol. Chem. 290, 17096–17105. PubMed

    Wei, J., and Tong, L. (2015) Crystal structure of the 500-kDa yeast acetyl-CoA carboxylase holoenzyme dimer, Nature 526, 723-727.

    Winter, G. E., Buckley, D. L., Paulk, J., Roberts, J. M., Souza, A., Dhe-Paganon, S., and Bradner, J. E. (2015) Phthalimide conjugation as a strategy for in vivo target protein degradation, Science 348, 1376-1381. PubMed

    Winter, J. M., Cascio, D., Dietrich, D., Sato, M., Watanabe, K., Sawaya, M. R., Vederas, J. C., and Tang, Y. (2015) Biochemical and Structural Basis for Controlling Chemical Modularity in Fungal Polyketide Biosynthesis, J. Am. Chem. Soc. 137, 9885–9893. PubMed

    Wong, Y. L., Anzola, J. V., Davis, R. L., Yoon, M., Motamedi, A., Kroll, A., Seo, C. P., Hsia, J. E., Kim, S. K., Mitchell, J. W., Mitchell, B. J., Desai, A., Gahman, T. C., Shiau, A. K., and Oegema, K. (2015) Reversible centriole depletion with an inhibitor of Polo-like kinase 4, Science 348, 1155-1160. PubMed

    Xu, K., Chan, Y. P., Bradel-Tretheway, B., Akyol-Ataman, Z., Zhu, Y., Dutta, S., Yan, L., Feng, Y., Wang, L. F., Skiniotis, G., Lee, B., Zhou, Z. H., Broder, C. C., Aguilar, H. C., and Nikolov, D. B. (2015) Crystal Structure of the Pre-fusion Nipah Virus Fusion Glycoprotein Reveals a Novel Hexamer-of-Trimers Assembly, PLoS Pathog. 11, e1005322. PubMed

    Xu, K., Olsen, O., Tzvetkova-Robev, D., Tessier-Lavigne, M., and Nikolov, D. B. (2015) The crystal structure of DR6 in complex with the amyloid precursor protein provides insight into death receptor activation, Genes Dev. 29, 785-790. PubMed

    Xu, X., Choi, S. H., Hu, T., Tiyanont, K., Habets, R., Groot, A. J., Vooijs, M., Aster, J. C., Chopra, R., Fryer, C., and Blacklow, S. C. (2015) Insights into Autoregulation of Notch3 from Structural and Functional Studies of Its Negative Regulatory Region, Structure 23, 1227–1235. PubMed

    Yamaguchi, M., Yu, S., Qiao, R., Weissmann, F., Miller, D. J., VanderLinden, R., Brown, N. G., Frye, J. J., Peters, J.-M., and Schulman, B. A. (2014) Structure of an APC3-APC16 complex: Insights into assembly of the Anaphase Promoting Complex/Cyclosome, J. Mol. Biol.427, 1748-1764. PubMed

    Ye, Q., Rosenberg, S. C., Moeller, A., Speir, J. A., Su, T. Y., and Corbett, K. D. (2015) TRIP13 is a protein-remodeling AAA+ ATPase that catalyzes MAD2 conformation switching, Elife 4. eLife.07367. PubMed

    Yudina, Z., Roa, A., Johnson, R., Biris, N., de Souza Aranha Vieira, D. A., Tsiperson, V., Reszka, N., Taylor, A. B., Hart, P. J., Demeler, B., Diaz-Griffero, F., and Ivanov, D. N. (2015) RING Dimerization Links Higher-Order Assembly of TRIM5α to Synthesis of K63-Linked Polyubiquitin, Cell Rep. 12, 788-797. PubMed

    Zeqiraj, E., Tian, L., Piggott, C. A., Pillon, M. C., Duffy, N. M., Ceccarelli, D. F., Keszei, A. F., Lorenzen, K., Kurinov, I., Orlicky, S., Gish, G. D., Heck, A. J., Guarne, A., Greenberg, R. A., and Sicheri, F. (2015) Higher-Order Assembly of BRCC36-KIAA0157 Is Required for DUB Activity and Biological Function, Mol. Cell 59, 970-983. PubMed

    Zhang, J., and Ferre-D'Amare, A. R. (2015) Post-crystallization Improvement of RNA Crystal Diffraction Quality, Methods Mol. Biol. 1316, 13-24. PubMed

    Zhang, J., Kiser, P. D., Badiee, M., Palczewska, G., Dong, Z., Golczak, M., Tochtrop, G. P., and Palczewski, K. (2015) Molecular pharmacodynamics of emixustat in protection against retinal degeneration, J. Clin. Invest. 125, 2781-2794. PubMed

    Zhang, R., Li, X., and Boggon, T. J. Structural analysis of the KRIT1 ankyrin repeat and FERM domains reveals a conformationally stable ARD-FERM interface, J. Struct. Biol. 192, 449–456. PubMed

    Zhang, Z. M., Rothbart, S. B., Allison, D. F., Cai, Q., Harrison, J. S., Li, L., Wang, Y., Strahl, B. D., Wang, G. G., and Song, J. (2015) An Allosteric Interaction Links USP7 to Deubiquitination and Chromatin Targeting of UHRF1, Cell Rep. 12, 1400-1406. PubMed

    Zhao, C., Rajashankar, K. R., Marcia, M., and Pyle, A. M. (2015) Crystal structure of group II intron domain 1 reveals a template for RNA assembly, Nat. Chem. Biol. 11, 967-972. PubMed

    Zhou, C., Pourmal, S., and Pavletich, N. P. (2015) Dna2 nuclease-helicase structure, mechanism and regulation by Rpa, Elife 4. e09832. PubMed

    Zhou, Q., Lai, Y., Bacaj, T., Zhao, M., Lyubimov, A. Y., Uervirojnangkoorn, M., Zeldin, O. B., Brewster, A. S., Sauter, N. K., Cohen, A. E., Soltis, S. M., Alonso-Mori, R., Chollet, M., Lemke, H. T., Pfuetzner, R. A., Choi, U. B., Weis, W. I., Diao, J., Sudhof, T. C., and Brunger, A. T. (2015) Architecture of the synaptotagmin-SNARE machinery for neuronal exocytosis, Nature 525, 62-67. PubMed

    2014

    Albright, R. A., Ornstein, D. L., Cao, W., Chang, W. C., Robert, D., Tehan, M., Hoyer, D., Liu, L., Stabach, P., Yang, G., De La Cruz, E. M., and Braddock, D. T. (2014) The Molecular Basis of Purinergic Signal Metabolism by Ecto-Nucleotide Pyrophosphatase/Phosphodiesterases 4 and 1 and Implications in Stroke, J. Biol. Chem. 289, 3294-3306. PubMed

    Althoff, T., Hibbs, R. E., Banerjee, S., and Gouaux, E. (2014) X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors, Nature 512, 333-337. PubMed

    Ayres, C. A., Schormann, N., Senkovich, O., Fry, A., Banerjee, S., Ulett, G. C., and Chattopadhyay, D. (2014) Structure of Streptococcus agalactiae glyceraldehyde-3-phosphate dehydrogenase holoenzyme reveals a novel surface, Acta Crystallogr. F 70, 1333-1339. PubMed

    Baker, B. Y., Shi, W., Wang, B., and Palczewski, K. (2014) High Resolution Crystal Structures of the Photoreceptor Glyceraldehyde 3-Phosphate Dehydrogenase (GAPDH) with Three and Four-bound NAD Molecules, Protein Sci. 23, 1629-1639. PubMed

    Baranovskiy, A. G., Babayeva, N. D., Suwa, Y., Gu, J., Pavlov, Y. I., and Tahirov, T. H. (2014) Structural basis for inhibition of DNA replication by aphidicolin, Nucleic Acids Res. 42, 14013-1401. PubMed

    Baranovskiy, A. G., Gu, J., Babayeva, N. D., Agarkar, V. B., Suwa, Y., and Tahirov, T. H. (2014) Crystallization and preliminary X-ray diffraction analysis of human DNA primase, Acta Crystallogr. F 70, 206-210. PubMed

    Bhattacharya, A., Alam, S. L., Fricke, T., Zadrozny, K., Sedzicki, J., Taylor, A. B., Demeler, B., Pornillos, O., Ganser-Pornillos, B. K., Diaz-Griffero, F., Ivanov, D. N., and Yeager, M. (2014) Structural basis of HIV-1 capsid recognition by PF74 and CPSF6, Proc. Nat. Acad. Sci. U.S.A. 111, 18625-18630. PubMed

    Bhattacharya, S., Lou, X., Hwang, P., Rajashankar, K. R., Wang, X., Gustafsson, J. A., Fletterick, R. J., Jacobson, R. H., and Webb, P. (2014) Structural and functional insight into TAF1-TAF7, a subcomplex of transcription factor II D, Proc. Nat. Acad. Sci. U.S.A. 111, 9103-9108. PubMed

    Blankenship, E., Vukoti, K., Miyagi, M., and Lodowski, D. T. (2014) Conformational flexibility in the catalytic triad revealed by the high-resolution crystal structure of Streptomyces erythraeus trypsin in an unliganded state, Acta Crystallogr. D 70, 833-840. PubMed

    Bobik, T. A., Morales, E. J., Shin, A., Cascio, D., Sawaya, M. R., Arbing, M., Yeates, T. O., and Rasche, M. E. (2014) Structure of the methanofuran/methanopterin-biosynthetic enzyme MJ1099 from Methanocaldococcus jannaschii, Acta Crystallogr. F 70, 1472-1479. PubMed

    Bolla, J. R., Su, C. C., Do, S. V., Radhakrishnan, A., Kumar, N., Long, F., Chou, T. H., Delmar, J. A., Lei, H. T., Rajashankar, K. R., Shafer, W. M., and Yu, E. W. (2014) Crystal Structure of the Neisseria gonorrhoeae MtrD Inner Membrane Multidrug Efflux Pump, PLoS One 9, e97903. PubMed

    Brohawn, S. G., Campbell, E. B., and MacKinnon, R. (2014) Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel, Nature 516, 126-130. PubMed

    Brown, J. A., Bulkley, D., Wang, J., Valenstein, M. L., Yario, T. A., Steitz, T. A., and Steitz, J. A. (2014) Structural insights into the stabilization of MALAT1 noncoding RNA by a bipartite triple helix, Nat. Struct. Mol. Biol. 21, 633-640. PubMed

    Brown, N. G., Watson, E. R., Weissmann, F., Jarvis, M. A., VanderLinden, R., Grace, C. R., Frye, J. J., Qiao, R., Dube, P., Petzold, G., Cho, S. E., Alsharif, O., Bao, J., Davidson, I. F., Zheng, J. J., Nourse, A., Kurinov, I., Peters, J. M., Stark, H., and Schulman, B. A. (2014) Mechanism of Polyubiquitination by Human Anaphase-Promoting Complex: RING Repurposing for Ubiquitin Chain Assembly, Mol. Cell 56, 246-260. PubMed

    Brumshtein, B., Esswein, S. R., Landau, M., Ryan, C. M., Whitelegge, J. P., Phillips, M. L., Cascio, D., Sawaya, M. R., and Eisenberg, D. S. (2014) Formation of Amyloid Fibers by Monomeric Light-chain Variable Domains, J. Biol. Chem. 289, 27513-27525. PubMed

    Bulkley, D., Brandi, L., Polikanov, Yury S., Fabbretti, A., O'Connor, M., Gualerzi, Claudio O., and Steitz, Thomas A. The Antibiotics Dityromycin and GE82832 Bind Protein S12 and Block EF-G-Catalyzed Translocation, Cell Reports 6, 357-365. PubMed

    Cai, Y., Deng, Y., Horenkamp, F., Reinisch, K. M., and Burd, C. G. (2014) Sac1-Vps74 structure reveals a mechanism to terminate phosphoinositide signaling in the Golgi apparatus, J. Cell. Biol. 206, 485-491. PubMed

    Cavalier, M. C., Pierce, A. D., Wilder, P. T., Alasady, M. J., Hartman, K. G., Neau, D. B., Foley, T. L., Jadhav, A., Maloney, D. J., Simeonov, A., Toth, E. A., and Weber, D. J. (2014) Covalent small molecule inhibitors of Ca-bound S100B, Biochemistry 53, 6628-6640. PubMed

    Chen, C., Ha, B. H., Thevenin, A. F., Lou, H. J., Zhang, R., Yip, K. Y., Peterson, J. R., Gerstein, M., Kim, P. M., Filippakopoulos, P., Knapp, S., Boggon, T. J., and Turk, B. E. (2014) Identification of a Major Determinant for Serine-Threonine Kinase Phosphoacceptor Specificity, Mol. Cell 53, 140-147. PubMed

    Chen, W., Zhang, L., Zheng, G., Fu, Y., Ji, Q., Liu, F., Chen, H., and He, C. (2014) Crystal structure of the RNA demethylase ALKBH5 from zebrafish, FEBS Lett. 588, 892-898. PubMed

    Cheng, W., and Li, W. (2014) Structural insights into ubiquinone biosynthesis in membranes, Science 343, 878-881. PubMed

    Cheng, Z., Cheung, P., Kuo, A. J., Yukl, E. T., Wilmot, C. M., Gozani, O., and Patel, D. J. (2014) A molecular threading mechanism underlies Jumonji lysine demethylase KDM2A regulation of methylated H3K36, Genes Dev 28, 1758-1771. PubMed

    Clayton, G. M., Wang, Y., Crawford, F., Novikov, A., Wimberly, B. T., Kieft, J. S., Falta, M. T., Bowerman, N. A., Marrack, P., Fontenot, A. P., Dai, S., and Kappler, J. W. (2014) Structural basis of chronic beryllium disease: linking allergic hypersensitivity and autoimmunity, Cell 158, 132-142. PubMed

    Da Fonseca, I., Qureshi, I. A., Mehra-Chaudhary, R., Kizjakina, K., Tanner, J. J., and Sobrado, P. (2014) Contributions of Unique Active Site Residues of Eukaryotic UDP-Galactopyranose Mutases to Substrate Recognition and Active Site Dynamics, Biochemistry 53, 7794−7804. PubMed

    Demirci, H., Murphy, F. V. t., Murphy, E. L., Connetti, J. L., Dahlberg, A. E., Jogl, G., and Gregory, S. T. (2014) A structural analysis of base substitutions in Thermus thermophilus 16S ribosomal RNA conferring streptomycin resistance, Antimicrob. Agents Chemother. 58, 4308-4317. PubMed

    Dickson, V. K., Pedi, L., and Long, S. B. (2014) Structure and insights into the function of a Ca2+-activated Cl- channel, Nature 516, 213-218. PubMed

    Do, T. D., LaPointe, N. E., Sangwan, S., Teplow, D. B., Feinstein, S. C., Sawaya, M. R., Eisenberg, D., and Bowers, M. T. (2014) Factors that Drive Peptide Assembly from Native to Amyloid Structures: Experimental and Theoretical Analysis of [Leu-5]-Enkephalin Mutants, J. Phys. Chem. B 118, 7247-7256. PubMed

    Doamekpor, S. K., Sanchez, A. M., Schwer, B., Shuman, S., and Lima, C. D. (2014) How an mRNA capping enzyme reads distinct RNA polymerase II and Spt5 CTD phosphorylation codes, Genes Dev. 28, 1323-1336. PubMed

    Dow, B. A., Sukumar, N., Matos, J. O., Choi, M., Schulte, A., Tatulian, S. A., and Davidson, V. L. (2014) The sole tryptophan of amicyanin enhances its thermal stability but does not influence the electronic properties of the type 1 copper site, Arch. Biochem. Biophys. 550-551, 24-27. PubMed

    Dowling, D. P., Bruender, N. A., Young, A. P., McCarty, R. M., Bandarian, V., and Drennan, C. L. (2014) Radical SAM enzyme QueE defines a new minimal core fold and metal-dependent mechanism, Nat. Chem. Biol. 10, 106-112. PubMed

    Du, J., Johnson, L. M., Groth, M., Feng, S., Hale, C. J., Li, S., Vashisht, A. A., Gallego-Bartolome, J., Wohlschlegel, J. A., Patel, D. J., and Jacobsen, S. E. (2014) Mechanism of DNA Methylation-Directed Histone Methylation by KRYPTONITE, Mol. Cell 55, 495-504. PubMed

    Dunkle, J. A., Vinal, K., Desai, P. M., Zelinskaya, N., Savic, M., West, D. M., Conn, G. L., and Dunham, C. M. (2014) Molecular recognition and modification of the 30S ribosome by the aminoglycoside-resistance methyltransferase NpmA, Proc. Nat. Acad. Sci. U.S.A. 111, 6275-6280. PubMed

    Dürr, Katharina L., Chen, L., Stein, Richard A., De Zorzi, R., Folea, I. M., Walz, T., McHaourab, Hassane S., and Gouaux, E. (2014) Structure and Dynamics of AMPA Receptor GluA2 in Resting, Pre-Open, and Desensitized States, Cell 158, 778-792. PubMed

    Eiler, D., Wang, J., and Steitz, T. A. (2014) Structural basis for the fast self-cleavage reaction catalyzed by the twister ribozyme, Proc. Nat. Acad. Sci. U.S.A. 111, 13028–13033. PubMed

    Fagan, C. E., Maehigashi, T., Dunkle, J. A., Miles, S. J., and Dunham, C. M. (2014) Structural insights into translational recoding by frameshift suppressor tRNASufJ, RNA 20, 1944-1954. PubMed

    Fei, X., Ye, X., LaRonde, N. A., and Lorimer, G. H. (2014) Formation and structures of GroEL:GroES2 chaperonin footballs, the protein-folding functional form, Proc. Nat. Acad. Sci. U.S.A. 111, 12775–12780. PubMed

    Fera, D., Schmidt, A. G., Haynes, B. F., Gao, F., Liao, H. X., Kepler, T. B., and Harrison, S. C. (2014) Affinity maturation in an HIV broadly neutralizing B-cell lineage through reorientation of variable domains, Proc. Nat. Acad. Sci. U.S.A. 111, 10275-10280. PubMed

    Ferreira-Cerca, S., Kiburu, I., Thomson, E., LaRonde, N., and Hurt, E. (2014) Dominant Rio1 kinase/ATPase catalytic mutant induces trapping of late pre-40S biogenesis factors in 80S-like ribosomes, Nucleic Acids Res. 42, 8635–8647. PubMed

    Fribourgh, Jennifer L., Nguyen, Henry C., Matreyek, Kenneth A., Alvarez, Frances Joan D., Summers, Brady J., Dewdney, Tamaria G., Aiken, C., Zhang, P., Engelman, A., and Xiong, Y. (2014) Structural Insight into HIV-1 Restriction by MxB, Cell Host & Microbe 16, 627–638. PubMed

    Funk, M. A., Judd, E. T., Marsh, E. N., Elliott, S. J., and Drennan, C. L. (2014) Structures of benzylsuccinate synthase elucidate roles of accessory subunits in glycyl radical enzyme activation and activity, Proc. Nat. Acad. Sci. U.S.A. 111, 10161-10166. PubMed

    Gagnon, M. G., Lin, J., Bulkley, D., and Steitz, T. A. (2014) Crystal structure of elongation factor 4 bound to a clockwise ratcheted ribosome, Science 345, 684-687. PubMed

    Gándara, F., Furukawa, H., Lee, S., and Yaghi, O. M. (2014) High Methane Storage Capacity in Aluminum Metal-Organic Frameworks, J. Am. Chem. Soc. 136, 5271-5274. PubMed

    Gao, A., and Serganov, A. (2014) Structural insights into recognition of c-di-AMP by the ydaO riboswitch, Nat. Chem. Biol. 10, 787-792. PubMed

    Gao, P., Zillinger, T., Wang, W., Ascano, M., Dai, P., Hartmann, G., Tuschl, T., Deng, L., Barchet, W., and Patel, D. J. (2014) Binding-Pocket and Lid-Region Substitutions Render Human STING Sensitive to the Species-Specific Drug DMXAA, Cell Rep. 8, 1668–1676. PubMed

    Gleason, J. E., Galaleldeen, A., Peterson, R. L., Taylor, A. B., Holloway, S. P., Waninger-Saroni, J., Cormack, B. P., Cabelli, D. E., Hart, P. J., and Culotta, V. C. (2014) Candida albicans SOD5 represents the prototype of an unprecedented class of Cu-only superoxide dismutases required for pathogen defense, Proc. Nat. Acad. Sci. U.S.A. 11, 5866-5871. PubMed

    Goldgur, Y., Susi, P., Karelehto, E., Sanmark, H., Lamminmaki, U., Oricchio, E., Wendel, H. G., Nikolov, D. B., and Himanen, J. P. (2014) Generation and characterization of a single-chain anti-EphA2 antibody, Growth Factors 32, 214-222. PubMed

    Grossmann, N., Vakkasoglu, A. S., Hulpke, S., Abele, R., Gaudet, R., and Tampé, R. (2014) Mechanistic determinants of the directionality and energetics of active export by a heterodimeric ABC transporter, Nat. Commun. 5, 5419. PubMed

    Gu, J., Babayeva, N. D., Suwa, Y., Baranovskiy, A. G., Price, D. H., and Tahirov, T. H. (2014) Crystal structure of HIV-1 Tat complexed with human P-TEFb and AFF4, Cell Cycle 13, 1788-1797. PubMed

    Guo, L. T., Wang, Y. S., Nakamura, A., Eiler, D., Kavran, J. M., Wong, M., Kiessling, L. L., Steitz, T. A., O'Donoghue, P., and Soll, D. (2014) Polyspecific pyrrolysyl-tRNA synthetases from directed evolution, Proc. Nat. Acad. Sci. U.S.A. 111, 16724-16729. PubMed

    Han, S., Le, B. V., Hajare, H. S., Baxter, R. H., and Miller, S. J. (2014) X-ray Crystal Structure of Teicoplanin A-2 Bound to a Catalytic Peptide Sequence via the Carrier Protein Strategy, J. Org. Chem.79, 8550-8556. PubMed

    Hochberg, G. K., Ecroyd, H., Liu, C., Cox, D., Cascio, D., Sawaya, M. R., Collier, M. P., Stroud, J., Carver, J. A., Baldwin, A. J., Robinson, C. V., Eisenberg, D. S., Benesch, J. L., and Laganowsky, A. (2014) The structured core domain of alphaB-crystallin can prevent amyloid fibrillation and associated toxicity, Proc. Nat. Acad. Sci. U.S.A. 11, E1562–E1570. PubMed

    Horenkamp, F. A., Mukherjee, S., Alix, E., Schauder, C. M., Hubber, A. M., Roy, C. R., and Reinisch, K. M. (2014) Legionella pneumophila subversion of host vesicular transport by SidC effector proteins, Traffic 15, 488-499. PubMed

    Horton, J. R., Nugent, R. L., Li, A., Mabuchi, M. Y., Fomenkov, A., Cohen-Karni, D., Griggs, R. M., Zhang, X., Wilson, G. G., Zheng, Y., Xu, S.-y., and Cheng, X. (2014) Structure and mutagenesis of the DNA modification-dependent restriction endonuclease AspBHI, Sci. Rep. 4. PubMed

    Huang, H., Ceccarelli, D. F., Orlicky, S., St-Cyr, D. J., Ziemba, A., Garg, P., Plamondon, S., Auer, M., Sidhu, S., Marinier, A., Kleiger, G., Tyers, M., and Sicheri, F. (2014) E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin, Nat. Chem. Biol. 10, 156-163. PubMed

    Huang, H., Levin, E. J., Liu, S., Bai, Y., Lockless, S. W., and Zhou, M. (2014) Structure of a Membrane-Embedded Prenyltransferase Homologous to UBIAD1, PLoS Biol 12, e1001911. PubMed

    Huang, H., Suslov, N. B., Li, N.-S., Shelke, S. A., Evans, M. E., Koldobskaya, Y., Rice, P. A., and Piccirilli, J. A. (2014) A G-quadruplex–containing RNA activates fluorescence in a GFP-like fluorophore, Nat. Chem. Biol. 10, 686-691. PubMed

    Huang, H., Zeqiraj, E., Dong, B., Jha, B. K., Duffy, N. M., Orlicky, S., Thevakumaran, N., Talukdar, M., Pillon, M. C., Ceccarelli, D. F., Wan, L. C., Juang, Y. C., Mao, D. Y., Gaughan, C., Brinton, M. A., Perelygin, A. A., Kourinov, I., Guarne, A., Silverman, R. H., and Sicheri, F. (2014) Dimeric Structure of Pseudokinase RNase L Bound to 2-5A Reveals a Basis for Interferon-Induced Antiviral Activity, Mol. Cell 53, 221-234. PubMed

    Huo, Y., Nam, K. H., Ding, F., Lee, H., Wu, L., Xiao, Y., Farchione, M. D., Jr., Zhou, S., Rajashankar, K., Kurinov, I., Zhang, R., and Ke, A. (2014) Structures of CRISPR Cas3 offer mechanistic insights into Cascade-activated DNA unwinding and degradation, Nat. Struct. Mol. Biol. 21, 771-777. PubMed

    Ivanova, M. I., Sievers, S. A., Guenther, E. L., Johnson, L. M., Winkler, D. D., Galaleldeen, A., Sawaya, M. R., Hart, P. J., and Eisenberg, D. S. (2014) Aggregation-triggering segments of SOD1 fibril formation support a common pathway for familial and sporadic ALS, Proc. Natl. Acad. Sci. U. S. A. 111, 197-201. PubMed

    Jacewicz, A., Schwer, B., Smith, P., and Shuman, S. (2014) Crystal structure, mutational analysis and RNA-dependent ATPase activity of the yeast DEAD-box pre-mRNA splicing factor Prp28, Nucleic Acids Res. 42, 12885–12898. PubMed

    Jacobitz, A. W., Wereszczynski, J., Yi, S. W., Amer, B. R., Huang, G. L., Nguyen, A. V., Sawaya, M. R., Jung, M. E., McCammon, J. A., and Clubb, R. T. (2014) Structural and computational studies of the Staphylococcus aureus Sortase B-substrate complex reveal a substrate-stabilized oxyanion hole, J. Biol. Chem. 289, 8891–8902. PubMed

    Jain, R., Rajashankar, K. R., Buku, A., Johnson, R. E., Prakash, L., Prakash, S., and Aggarwal, A. K. (2014) Crystal Structure of Yeast DNA Polymerase & Catalytic Domain, PLoS ONE 9, e94835. PubMed

    Ji, X., Tang, C., Zhao, Q., Wang, W., and Xiong, Y. (2014) Structural basis of cellular dNTP regulation by SAMHD1, Proc. Natl. Acad. Sci. U. S. A .111, E4305–E4314. PubMed

    Jia, X., Weber, E., Tokarev, A., Lewinski, M., Rizk, M., Suarez, M., Guatelli, J., and Xiong, Y. (2014) Structural basis of HIV-1 Vpu-mediated BST2 antagonism via hijacking of the clathrin adaptor protein complex 1, Elife 3, e02362. PubMed

    Jimenez-Oses, G., Osuna, S., Gao, X., Sawaya, M. R., Gilson, L., Collier, S. J., Huisman, G. W., Yeates, T. O., Tang, Y., and Houk, K. N. (2014) The role of distant mutations and allosteric regulation on LovD active site dynamics, Nat. Chem. Biol. 10, 431-436. PubMed

    Joh, N. H., Wang, T., Bhate, M. P., Acharya, R., Wu, Y., Grabe, M., Hong, M., Grigoryan, G., and DeGrado, W. F. (2014) De novo design of a transmembrane Zn2+-transporting four-helix bundle, Science 346, 1520-1524. PubMed

    Johnson, Z. L., Lee, J. H., Lee, K., Lee, M., Kwon, D. Y., Hong, J., and Lee, S. Y. (2014) Structural basis of nucleoside and nucleoside drug selectivity by concentrative nucleoside transporters, Elife 3, e03604. PubMed

    Keszei, A. F., Tang, X., McCormick, C., Zeqiraj, E., Rohde, J. R., Tyers, M., and Sicheri, F. (2014) Structure of an SspH1-PKN1 complex reveals the basis for host substrate recognition and mechanism of activation for a bacterial E3 ubiquitin ligase, Mol. Cell Biol. 34, 362-373. PubMed

    Kim, Y., Rosenberg, Scott C., Kugel, Christine L., Kostow, N., Rog, O., Davydov, V., Su, Tiffany Y., Dernburg, Abby F., and Corbett, Kevin D. The Chromosome Axis Controls Meiotic Events through a Hierarchical Assembly of HORMA Domain Proteins, Dev. Cell 31, 487-502. PubMed

    King, N. P., Bale, J. B., Sheffler, W., McNamara, D. E., Gonen, S., Gonen, T., Yeates, T. O., and Baker, D. (2014) Accurate design of co-assembling multi-component protein nanomaterials, Nature 510, 103-108. PubMed

    Kobe, M. J., Neau, D. B., Mitchell, C. E., Bartlett, S. G., and Newcomer, M. E. (2014) The Structure of Human 15-Lipoxygenase-2 with a Substrate Mimic, J. Biol. Chem. 289, 8562–8569. PubMed

    Kolli, N., and Garman, S. C. (2014) Proteolytic activation of human cathepsin A, J. Biol. Chem. 289, 11592-11600. PubMed

    Kumar, N., Radhakrishnan, A., Wright, C. C., Chou, T. H., Lei, H. T., Bolla, J. R., Tringides, M. L., Rajashankar, K. R., Su, C. C., Purdy, G. E., and Yu, E. W. (2014) Crystal Structure of the transcriptional regulator Rv1219c of Mycobacterium tuberculosis, Protein Sci. 23, 423-432. PubMed

    Lai, Y. T., Reading, E., Hura, G. L., Tsai, K. L., Laganowsky, A., Asturias, F. J., Tainer, J. A., Robinson, C. V., and Yeates, T. O. (2014) Structure of a designed protein cage that self-assembles into a highly porous cube, Nat. Chem. 6, 1065-1071. PubMed

    Lee, K., Lam, K.-H., Kruel, A. M., Perry, K., Rummel, A., and Jin, R. (2014) High-resolution crystal structure of HA33 of botulinum neurotoxin type B progenitor toxin complex, Biochem. Biophys. Res. Commun. 446, 568-573. PubMed

    Lee, K., Zhong, X., Gu, S., Kruel, A. M., Dorner, M. B., Perry, K., Rummel, A., Dong, M., and Jin, R. (2014) Molecular basis for disruption of E-cadherin adhesion by botulinum neurotoxin A complex, Science 344, 1405-1410. PubMed

    Lee, K. S., Liu, J. Y., Wagner, K., Pakhomova, S., Dong, H., Morisseau, C., Fu, S., Yang, J., Wang, P., Ulu, A., Mate, C. A., Nguyen, L. V., Hwang, S. H., Edin, M. L., Mara, A. A., Wulff, H., Newcomer, M. E., Zeldin, D., and Hammock, B. D. (2014) Optimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacy, J. Med. Chem. 28, 7016-7030. PubMed

    Leettola, C. N., Knight, M. J., Cascio, D., Hoffman, S., and Bowie, J. U. (2014) Characterization of the SAM domain of the PKD-related protein ANKS6 and its interaction with ANKS3, BMC Struct. Biol. 14, 17. PubMed

    Lei, H.-T., Bolla, J. R., Su, C.-C., and Yu, E. W. (2014) Crystal structures of CusC review conformational changes accompanying folding and transmembrane channel formation, J. Mol. Biol 426, 403-411. PubMed

    Lei, H. T., Chou, T. H., Su, C. C., Bolla, J. R., Kumar, N., Radhakrishnan, A., Long, F., Delmar, J. A., Do, S. V., Rajashankar, K. R., Shafer, W. M., and Yu, E. W. (2014) Crystal Structure of the Open State of the Neisseria gonorrhoeae MtrE Outer Membrane Channel, PLoS One 9, e97475. PubMed

    Li, L., Fierer, J. O., Rapoport, T. A., and Howarth, M. (2014) Structural Analysis and Optimization of the Covalent Association between SpyCatcher and a Peptide Tag, J. Mol. Biol 426, 309-317. PubMed

    Li, R., Chou, W. K. W., Himmelberger, J. A., Litwin, K. M., Harris, G. G., Cane, D. E., and Christianson, D. W. (2014) Reprogramming the Chemodiversity of Terpenoid Cyclization by Remolding the Active Site Contour of epi-Isozizaene Synthase, Biochemistry 53, 1155-1168. PubMed

    Li, Q., Wanderling, S., Paduch, M., Medovoy, D., Singharoy, A., McGreevy, R., Villalba-Galea, C. A., Hulse, R. E., Roux, B., Schulten, K., Kossiakoff, A., and Perozo, E. (2014) Structural mchanism of voltage-dependent gating in an isolated voltage-sensing domain, Nat. Struct. Mol. Biol. 21, 244-252. PubMed

    Liu, D. S., Nivon, L. G., Richter, F., Goldman, P. J., Deerinck, T. J., Yao, J. Z., Richardson, D., Phipps, W. S., Ye, A. Z., Ellisman, M. H., Drennan, C. L., Baker, D., and Ting, A. Y. (2014) Computational design of a red fluorophore ligase for site-specific protein labeling in living cells, Proc. Nat. Acad. Sci. U.S.A. 111, E4551-4559. PubMed

    Liu, S., Cheng, W., Fowle Grider, R., Shen, G., and Li, W. (2014) Structures of an intramembrane vitamin K epoxide reductase homolog reveal control mechanisms for electron transfer, Nat. Commun. 5, 3110. PubMed

    Liu, Z., Frutos, S., Bick, M. J., Vila-Perelló, M., Debelouchina, G. T., Darst, S. A., and Muir, T. W. (2014) Structure of the branched intermediate in protein splicing, Proc. Nat. Acad. Sci. U.S.A. 111, 8422-8427. PubMed

    Lohse, M. B., Rosenberg, O. S., Cox, J. S., Stroud, R. M., Finer-Moore, J. S., and Johnson, A. D. (2014) Structure of a new DNA-binding domain which regulates pathogenesis in a wide variety of fungi, Proc. Nat. Acad. Sci. U.S.A. 111, 10404-10410. PubMed

    Lou, X., Toresson, G., Benod, C., Suh, J. H., Philips, K. J., Webb, P., and Gustafsson, J.-A. (2014) Structure of the retinoid X receptor α–liver X receptor β (RXRα–LXRβ) heterodimer on DNA, Nat. Struct. Mol. Biol. 21, 277-281. PubMed

    Luo, Z., Dauter, M., and Dauter, Z. (2014) Phosphates in the Z-DNA dodecamer are flexible, but their P-SAD signal is sufficient for structure solution, Acta Crystallogr. D 70, 1790-1800. PubMed

    Luo, Z., Rajashankar, K., and Dauter, Z. (2014) Weak data do not make a free lunch, only a cheap meal, Acta Crystallogr. D 70, 253-260. PubMed

    Maehigashi, T., Dunkle, J. A., Miles, S. J., and Dunham, C. M. (2014) Structural insights into +1 frameshifting promoted by expanded or modification-deficient anticodon stem loops, Proc. Nat. Acad. Sci. U.S.A. 111, 12740–12745. PubMed

    Malmirchegini, G. R., Sjodt, M., Shnitkind, S., Sawaya, M. R., Rosinski, J., Newton, S. M., Klebba, P. E., and Clubb, R. T. (2014) Novel mechanism of hemin capture by Hbp2, the hemoglobin-binding hemophore from Listeria monocytogenes, J. Biol. Chem. 289, 34886–34899. PubMed

    McGinty, R. K., Henrici, R. C., and Tan, S. (2014) Crystal structure of the PRC1 ubiquitylation module bound to the nucleosome, Nature 514, 591-596. PubMed

    McKeown, M. R., Shaw, D. L., Fu, H., Liu, S., Xu, X., Marineau, J. J., Huang, Y., Zhang, X., Buckley, D. L., Kadam, A., Zhang, Z., Blacklow, S. C., Qi, J., Zhang, W., and Bradner, J. E. (2014) Biased multicomponent reactions to develop novel bromodomain inhibitors, J. Med. Chem. 57, 9019-9027. PubMed

    McNamara, D. E., Cascio, D., Jorda, J., Bustos, C., Wang, T. C., Rasche, M. E., Yeates, T. O., and Bobik, T. A. (2014) Structure of Dihydromethanopterin Reductase: A Cubic Protein Cage for Redox Transfer, J. Biol. Chem. 289, 8852–8864. PubMed

    Montemayor, E. J., Katolik, A., Clark, N. E., Taylor, A. B., Schuermann, J. P., Combs, D. J., Johnsson, R., Holloway, S. P., Stevens, S. W., Damha, M. J., and Hart, P. J. (2014) Structural basis of lariat RNA recognition by the intron debranching enzyme Dbr1, Nucleic Acids Res. 42, 10845–10855. PubMed

    Neau, D. B., Bender, G., Boeglin, W. E., Bartlett, S. G., Brash, A. R., and Newcomer, M. E. (2014) Crystal Structure of a Lipoxygenase in Complex with Substrate: the Arachidonic Acid Binding Site of 8R-Lipoxygenase, J. Biol. Chem. 289, 31905-31913. PubMed

    Okamoto, R., Mandal, K., Sawaya, M. R., Kajihara, Y., Yeates, T. O., and Kent, S. B. (2014) (Quasi-)Racemic X-ray Structures of Glycosylated and Non-Glycosylated Forms of the Chemokine Ser-CCL1 Prepared by Total Chemical Synthesis, Angew. Chem. Int. Ed. Engl. 53, 5194-5198. PubMed

    Papadopoulos, E., Jenni, S., Kabha, E., Takrouri, K. J., Yi, T., Salvi, N., Luna, R. E., Gavathiotis, E., Mahalingam, P., Arthanari, H., Rodriguez-Mias, R., Yefidoff-Freedman, R., Aktas, B. H., Chorev, M., Halperin, J. A., and Wagner, G. (2014) Structure of the eukaryotic translation initiation factor eIF4E in complex with 4EGI-1 reveals an allosteric mechanism for dissociating eIF4G, Proc. Nat. Acad. Sci. U.S.A. 111, E3187-3195. PubMed

    Pavone, V., Zhang, S. Q., Merlino, A., Lombardi, A., Wu, Y., and Degrado, W. F. (2014) Crystal structure of an amphiphilic foldamer reveals a 48-mer assembly comprising a hollow truncated octahedron, Nat. Commun. 5, 3581. PubMed

    Peisley, A., Wu, B., Xu, H., Chen, Z. J., and Hur, S. (2014) Structural basis for ubiquitin-mediated antiviral signal activation by RIG-I, Nature 509, 110-114. PubMed

    Pemberton, T. A., Srivastava, D., Sanyal, N., Henzl, M. T., Becker, D. F., and Tanner, J. J. (2014) Structural Studies of Yeast Δ1-pyrroline-5-carboxylate Dehydrogenase (aka ALDH4A1): Active Site Flexibility and Oligomeric State, Biochemistry 53, 1350-1359. PubMed

    Piatkevich, Kiryl D., English, Brian P., Malashkevich, Vladimir N., Xiao, H., Almo, Steven C., Singer, Robert H., and Verkhusha, Vladislav V. (2014) Photoswitchable Red Fluorescent Protein with a Large Stokes Shift, Chem. Biol. 21, 1402-1414. PubMed

    Polikanov, Y. S., Osterman, I. A., Szal, T., Tashlitsky, V. N., Serebryakova, M. V., Kusochek, P., Bulkley, D., Malanicheva, I. A., Efimenko, T. A., Efremenkova, O. V., Konevega, A. L., Shaw, K. J., Bogdanov, A. A., Rodnina, M. V., Dontsova, O. A., Mankin, A. S., Steitz, T. A., and Sergiev, P. V. (2014) Amicoumacin A Inhibits Translation by Stabilizing mRNA Interaction with the Ribosome, Mol. Cell 56, 531-540. PubMed

    Polikanov, Y. S., Steitz, T. A., and Innis, C. A. (2014) A proton wire to couple aminoacyl-tRNA accommodation and peptide-bond formation on the ribosome, Nat. Struct. Mol. Biol. 21, 787-793. PubMed

    Polikanov, Y. S., Szal, T., Jiang, F., Gupta, P., Matsuda, R., Shiozuka, M., Steitz, T. A., Vazquez-Laslop, N., and Mankin, A. S. (2014) Negamycin Interferes with Decoding and Translocation by Simultaneous Interaction with rRNA and tRNA, Mol Cell. 56, 541-550. PubMed

    Poor, C. B., Andorfer, M. C., and Lewis, J. C. (2014) Improving the Stability and Catalyst Lifetime of the Halogenase RebH By Directed Evolution, Chembiochem 15, 1286-1289. PubMed

    Poor, C. B., Wegner, S. V., Li, H., Dlouhy, A. C., Schuermann, J. P., Sanishvili, R., Hinshaw, J. R., Riggs-Gelasco, P. J., Outten, C. E., and He, C. (2014) Molecular mechanism and structure of the Saccharomyces cerevisiae iron regulator Aft2, Proc. Nat. Acad. Sci. U.S.A. 111, 4043-4048. PubMed

    Quan, B., Seo, H.-S., Blobel, G., and Ren, Y. (2014) Vesiculoviral matrix (M) protein occupies nucleic acid binding site at nucleoporin pair (Rae1•Nup98), Proc. Nat. Acad. Sci. U.S.A.111, 9127-9132. PubMed

    Radhakrishnan, A., Kumar, N., Wright, C. C., Chou, T. H., Tringides, M. L., Bolla, J. R., Lei, H. T., Rajashankar, K., Su, C. C., Purdy, G. E., and Yu, E. W. (2014) Crystal structure of the transcriptional regulator Rv0678 of Mycobacterium tuberculosis, J. Biol. Chem. 289, 16526-16540. PubMed

    Rajashankar, K., and Dauter, Z. (2014) Data collection for crystallographic structure determination, Methods Mol. Biol. 1140, 211-237. PubMed

    Remus, B. S., Jacewicz, A., and Shuman, S. (2014) Structure and mechanism of E. coli RNA 2',3'-cyclic phosphodiesterase, RNA 20, 1697-1705. PubMed

    Ren, A., and Patel, D. J. (2014) c-di-AMP binds the ydaO riboswitch in two pseudo-symmetry-related pockets, Nat. Chem. Biol.10, 780-786. PubMed

    Ren, A., Kosutic, M., Rajashankar, K. R., Frener, M., Santner, T., Westhof, E., Micura, R., and Patel, D. J. (2014) In-line alignment and Mg2+ coordination at the cleavage site of the env22 twister ribozyme, Nat. Commun. 5, 5534. PubMed

    Ritacco, C. J., Steitz, T. A., and Wang, J. (2014) Exploiting large non-isomorphous differences for phase determination of a G-segment invertase-DNA complex, Acta Crystallogr. D 70, 685-693. PubMed

    Robart, A. R., Chan, R. T., Peters, J. K., Rajashankar, K. R., and Toor, N. (2014) Crystal structure of a eukaryotic group II intron lariat, Nature 514, 193-197. PubMed

    Ruangprasert, A., Maehigashi, T., Miles, S. J., Giridharan, N., Liu, J. X., and Dunham, C. M. (2014) Mechanisms of Toxin Inhibition and Transcriptional Repression by E. coli DinJ-YafQ, J. Biol. Chem. 289, 20559-20569. PubMed

    Sanches, M., Duffy, N. M., Talukdar, M., Thevakumaran, N., Chiovitti, D., Canny, M. D., Lee, K., Kurinov, I., Uehling, D., Al-Awar, R., Poda, G., Prakesch, M., Wilson, B., Tam, V., Schweitzer, C., Toro, A., Lucas, J. L., Vuga, D., Lehmann, L., Durocher, D., Zeng, Q., Patterson, J. B., and Sicheri, F. (2014) Structure and mechanism of action of the hydroxy-aryl-aldehyde class of IRE1 endoribonuclease inhibitors, Nat. Commun. 5, 4202. PubMed

    Sandstrom, A., Peigné, C.-M., Léger, A., Crooks, James E., Konczak, F., Gesnel, M.-C., Breathnach, R., Bonneville, M., Scotet, E., and Adams, Erin J. (2014) The Intracellular B30.2 Domain of Butyrophilin 3A1 Binds Phosphoantigens to Mediate Activation of Human Vγ9Vδ2 T Cells, Immunity 40, 490-500. PubMed

    Sasaki, E., Zhang, X., Sun, H. G., Lu, M. Y., Liu, T. L., Ou, A., Li, J. Y., Chen, Y. H., Ealick, S. E., and Liu, H. W. (2014) Co-opting sulphur-carrier proteins from primary metabolic pathways for 2-thiosugar biosynthesis, Nature 510, 427-431. PubMed

    Sawaya, M. R., Cascio, D., Gingery, M., Rodriguez, J., Goldschmidt, L., Colletier, J. P., Messerschmidt, M. M., Boutet, S., Koglin, J. E., Williams, G. J., Brewster, A. S., Nass, K., Hattne, J., Botha, S., Doak, R. B., Shoeman, R. L., DePonte, D. P., Park, H. W., Federici, B. A., Sauter, N. K., Schlichting, I., and Eisenberg, D. S. (2014) Protein crystal structure obtained at 2.9 Å resolution from injecting bacterial cells into an X-ray free-electron laser beam, Proc. Nat. Acad. Sci. U.S.A. 111, 12769–12774. PubMed

    Schauder, C. M., Wu, X., Saheki, Y., Narayanaswamy, P., Torta, F., Wenk, M. R., De Camilli, P., and Reinisch, K. M. (2014) Structure of a lipid-bound extended synaptotagmin indicates a role in lipid transfer, Nature 510, 552-555. PubMed

    Schirle, N. T., Sheu-Gruttadauria, J., and MacRae, I. J. (2014) Structural basis for microRNA targeting, Science 346, 608-613. PubMed

    Schmitz, K. R., Carney, D. W., Sello, J. K., and Sauer, R. T. (2014) Crystal structure of Mycobacterium tuberculosis ClpP1P2 suggests a model for peptidase activation by AAA+ partner binding and substrate delivery, Proc. Nat. Acad. Sci. U.S.A. 111, E4587-4595. PubMed

    Schureck, M. A., Maehigashi, T., Miles, S. J., Marquez, J., Ei Cho, S., Erdman, R., and Dunham, C. M. (2014) Structure of the P. vulgaris HigB-(HigA)2-HigB toxin-antitoxin complex, J. Biol. Chem 289, 1060-1070. PubMed

    Sciara, G., Clarke, O. B., Tomasek, D., Kloss, B., Tabuso, S., Byfield, R., Cohn, R., Banerjee, S., Rajashankar, K. R., Slavkovic, V., Graziano, J. H., Shapiro, L., and Mancia, F. (2014) Structural basis for catalysis in a CDP-alcohol phosphotransferase, Nat. Commun. 5, 4068. PubMed

    Scott, Daniel C., Sviderskiy, Vladislav O., Monda, Julie K., Lydeard, John R., Cho, Shein E., Harper, J. W., and Schulman, Brenda A. (2014) Structure of a RING E3 Trapped in Action Reveals Ligation Mechanism for the Ubiquitin-like Protein NEDD8, Cell 157, 1671-1684. PubMed

    Seo, M., and Lee, Y.-H. (2014) PFKFB3 regulates oxidative stress homeostasis via its S-glutathionylation in cancer, J. Mol. Biol. 426, 830-842. PubMed

    Setser, J. W., Heemstra, J. R., Walsh, C. T., and Drennan, C. L. (2014) Crystallographic evidence for drastic conformational changes in the active site of a flavin-dependent N-hydrxylase, Biochemistry 53, 6063–6077. PubMed

    Sheng, G., Zhao, H., Wang, J., Rao, Y., Tian, W., Swarts, D. C., van der Oost, J., Patel, D. J., and Wang, Y. (2014) Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage, Proc. Natl. Acad. Sci. U. S. A. 111, 652-657. PubMed

    Sherman, D. J., Lazarus, M. B., Murphy, L., Liu, C., Walker, S., Ruiz, N., and Kahne, D. (2014) Decoupling catalytic activity from biological function of the ATPase that powers lipopolysaccharide transport, Proc. Nat. Acad. Sci. U.S.A. 111, 4982-4987. PubMed

    Shrivastava, T., Mino, K., Babayeva, N. D., Baranovskaya, O. I., Rizzino, A., and Tahirov, T. H. (2014) Structural basis of Ets1 activation by Runx1, Leukemia 28, 2040-2048. PubMed

    Simanshu, D. K., Zhai, X., Munch, D., Hofius, D., Markham, J. E., Bielawski, J., Bielawska, A., Malinina, L., Molotkovsky, J. G., Mundy, J. W., Patel, D. J., and Brown, R. E. (2014) Arabidopsis Accelerated Cell Death 11, ACD11, Is a Ceramide-1-Phosphate Transfer Protein and Intermediary Regulator of Phytoceramide Levels, Cell Rep. 6, 388-399. PubMed

    Singh, H., Arentson, B. W., Becker, D. F., and Tanner, J. J. (2014) Structures of the PutA peripheral membrane flavoenzyme reveal a dynamic substrate-channeling tunnel and the quinone-binding site, Proc. Nat. Acad. Sci. U.S.A. 111, 3389-3394.

    Sinha, S., Cheng, S., Sung, Y. W., McNamara, D. E., Sawaya, M. R., Yeates, T. O., and Bobik, T. A. (2014) Alanine Scanning Mutagenesis Identifies an Asparagine-Arginine-Lysine Triad Essential to Assembly of the Shell of the Pdu Microcompartment. J. Mol. Biol. 426, 2328-2345. PubMed

    Song, G., and Springer, T. A. (2014) Structures of the Toxoplasma gliding motility adhesin, Proc. Nat. Acad. Sci. U.S.A. 111, 4862-4867. PubMed

    Sosa, B. A., Demircioglu, F. E., Chen, J. Z., Ingram, J., Ploegh, H., and Schwartz, T. U. (2014) How lamina-associated polypeptide 1 (LAP1) activates Torsin, Elife 3, e03239. PubMed

    Spicer, T. P., Jiang, J., Taylor, A. B., Choi, J. Y., Hart, P. J., Roush, W. R., Fields, G. B., Hodder, P. S., and Minond, D. (2014) Characterization of Selective Exosite-Binding Inhibitors of Matrix Metalloproteinase 13 That Prevent Articular Cartilage Degradation in Vitro, J. Med. Chem. 57, 9598-9611. PubMed

    Stiegler, A. L., Zhang, R., Liu, W., and Boggon, T. J. (2014) Structural determinants for binding of Sorting Nexin 17 (SNX17) to the cytoplasmic adaptor protein Krev Interaction Trapped 1 (KRIT1), J. Biol. Chem. 289, 25362-25373. PubMed

    Strunk, R. J., Piemonte, K. M., Petersen, N. M., Koutsioulis, D., Bouriotis, V., Perry, K., and Cole, K. E. (2014) Structure determination of BA0150, a putative polysaccharide deacetylase from Bacillus anthracis, Acta Crystallogr. F 70, 156-159. PubMed

    Su, C. C., Radhakrishnan, A., Kumar, N., Long, F., Bolla, J. R., Lei, H. T., Delmar, J. A., Do, S. V., Chou, T. H., Rajashankar, K. R., Zhang, Q., and Yu, E. W. (2014) Crystal structure of the Campylobacter jejuni CmeC outer membrane channel, Protein Sci. 23, 954-961. PubMed

    Sui, X., Kiser, P. D., Che, T., Carey, P. R., Golczak, M., Shi, W., Von Lintig, J., and Palczewski, K. (2014) Analysis of carotenoid isomerase activity in a prototypical carotenoid cleavage enzyme, apocarotenoid oxygenase (ACO), J. Biol. Chem. 289, 12286-12289. PubMed

    Tao, Z., Fusco, A., Huang, D. B., Gupta, K., Young Kim, D., Ware, C. F., Van Duyne, G. D., and Ghosh, G. (2014) p100/IκBδ sequesters and inhibits NF-κB through κBsome formation, Proc. Nat. Acad. Sci. U.S.A. 111, 15946-15951. PubMed

    Thompson, M. C., Crowley, C. S., Kopstein, J., Bobik, T. A., and Yeates, T. O. (2014) Structure of a bacterial microcompartment shell protein bound to a cobalamin cofactor, Acta Crystallogr. F 70, 1584-1590. PubMed

    Thompson, M. C., Wheatley, N. M., Jorda, J., Sawaya, M. R., Gidaniyan, S. D., Ahmed, H., Yang, Z., McCarty, K. N., Whitelegge, J. P., and Yeates, T. O. Identification of a Unique Fe-S Cluster Binding Site in a Glycyl-Radical Type Microcompartment Shell Protein, J. Mol. Biol. 426, 3287–3304. PubMed

    Tian, Y., Simanshu, D. K., Ma, J. B., Park, J. E., Heo, I., Kim, V. N., and Patel, D. J. (2014) A Phosphate-Binding Pocket within the Platform-PAZ-Connector Helix Cassette of Human Dicer, Mol. Cell 53, 606-616. PubMed

    Tu, X., and Palczewski, K. (2014) The macular degeneration-linked C1QTNF5 (S163) mutation causes higher-order structural rearrangements, J. Struct. Biol. 186, 86-94. PubMed

    Wang, C., Chung, B. C., Yan, H., Wang, H. G., Lee, S. Y., and Pitt, G. S. (2014) Structural analyses of Ca2+/CaM interaction with NaV channel C-termini reveal mechanisms of calcium-dependent regulation, Nat. Commun. 5, 4896. PubMed

    Wang, R., Persky, N. S., Yoo, B., Ouerfelli, O., Smogorzewska, A., Elledge, S. J., and Pavletich, N. P. (2014) DNA repair. Mechanism of DNA interstrand cross-link processing by repair nuclease FAN1, Science 346, 1127-1130. PubMed

    Wang, J., and Wing, R. A. (2014) Diamonds in the rough: a strong case for the inclusion of weak-intensity X-ray diffraction data, Acta Crystallogr. D 70, 1491-1497. PubMed

    Warner, K. D., Chen, M. C., Song, W., Strack, R. L., Thorn, A., Jaffrey, S. R., and Ferre-D'Amare, A. R. (2014) Structural basis for activity of highly efficient RNA mimics of green fluorescent protein, Nat. Struct. Mol. Biol. 21, 658-663. PubMed

    Warner, K. D., and Ferre-D'Amare, A. R. (2014) Crystallographic Analysis of TPP Riboswitch Binding by Small-Molecule Ligands Discovered Through Fragment-Based Drug Discovery Approaches, Methods Enzymol. 549, 221-233. PubMed

    Warner, Katherine D., Homan, P., Weeks, Kevin M., Smith, Alison G., Abell, C., and Ferré-D'Amaré, Adrian R. (2014) Validating Fragment-Based Drug Discovery for Biological RNAs: Lead Fragments Bind and Remodel the TPP Riboswitch Specifically, Chem. Biol. 21, 591-595. PubMed

    Washington, A. Z., Benicewicz, D. B., Canzoneri, J. C., Fagan, C. E., Mwakwari, S. C., Maehigashi, T., Dunham, C., and Oyelere, A. K. (2014) Macrolide-Peptide Conjugates as Probes of the Path of Travel of the Nascent Peptides through the Ribosome, ACS Chem. Biol. 9, 2621-2631. PubMed

    Wasmuth, E. V., Januszyk, K., and Lima, C. D. (2014) Structure of an Rrp6-RNA exosome complex bound to poly(A) RNA, Nature 511, 435-439. PubMed

    Wei, Y., Funk, M. A., Rosado, L. A., Baek, J., Drennan, C. L., and Stubbe, J. (2014) The class III ribonucleotide reductase from Neisseria bacilliformis can utilize thioredoxin as a reductant, Proc. Nat. Acad. Sci. U.S.A. 111, E3756–E3765. PubMed

    Wheatley, N. M., Sundberg, C. D., Gidaniyan, S. D., Cascio, D., and Yeates, T. O. (2014) Structure and identification of a pterin dehydratase-like protein as a RuBisCO assembly factor in the alpha-carboxysome, J. Biol. Chem. 289, 7973–7981. PubMed

    Wu, X., Chi, R. J., Baskin, J. M., Lucast, L., Burd, C. G., De Camilli, P., and Reinisch, K. M. (2014) Structural Insights into Assembly and Regulation of the Plasma Membrane Phosphatidylinositol 4-Kinase Complex, Dev. Cell 28, 19-29. PubMed

    Xia, S., and Konigsberg, W. H. (2014) Mispairs with Watson-Crick Base-pair Geometry Observed in Ternary Complexes of an RB69 DNA Polymerase Variant, Protein Sci. 23, 508-513. PubMed

    Xia, W., and Springer, T. A. (2014) Metal ion and ligand binding of integrin α5β1 , Proc. Nat. Acad. Sci. U.S.A. 111, 17863–17868. PubMed

    Xu, S., Hermanson, D. J., Banerjee, S., Ghebreselasie, K., Clayton, G. M., Garavito, R. M., and Marnett, L. J. (2014) Oxicams Bind in a Novel Mode to the Cyclooxygenase Active Site via a Two-water-mediated H-bonding Network, J. Biol. Chem. 289, 6799-6808. PubMed

    Xu, Y., Tao, Y., Cheung, L. S., Fan, C., Chen, L.-Q., Xu, S., Perry, K., Frommer, W. B., and Feng, L. (2014) Structures of bacterial homologues of SWEET transporters in two distinct conformations, Nature 515, 448-452. PubMed

    Xu, K., Wu, Z., Renier, N., Antipenko, A., Tzvetkova-Robev, D., Xu, Y., Minchenko, M., Nardi-Dei, V., Rajashankar, K. R., Himanen, J., Tessier-Lavigne, M., and Nikolov, D. B. (2014) Structures of netrin-1 bound to two receptors provide insight into its axon guidance mechanism, Science 344, 1275-1279. PubMed

    Yang, G., Fu, Y., Malakhova, M., Kurinov, I., Zhu, F., Yao, K., Li, H., Chen, H., Li, W., Lim, D. Y., Sheng, Y., Bode, A. M., Dong, Z., and Dong, Z. (2014) Caffeic acid directly targets ERK1/2 to attenuate solar UV-induced skin carcinogenesis, Cancer Prev. Res. (Phila) 7, 1056-1066. PubMed

    Yang, T., Liu, Q., Kloss, B., Bruni, R., Kalathur, R. C., Guo, Y., Kloppmann, E., Rost, B., Colecraft, H. M., and Hendrickson, W. A. (2014) Structure and selectivity in bestrophin ion channels, Science 346, 355-359. PubMed

    Yasui, N., Findlay, G. M., Gish, G. D., Hsiung, M. S., Huang, J., Tucholska, M., Taylor, L., Smith, L., Boldridge, W. C., Koide, A., Pawson, T., and Koide, S. (2014) Directed network wiring identifies a key protein interaction in embryonic stem cell differentiation, Mol. Cell 54, 1034-1041. PubMed

    Ye, W., Paul, D., Gao, L., Seckute, J., Sangaiah, R., Jayaraj, K., Zhang, Z., Kaminski, P. A., Ealick, S. E., Gold, A., and Ball, L. M. (2014) Ethenoguanines Undergo Glycosylation by Nucleoside 2'-Deoxyribosyltransferases at Non-Natural Sites, PLoS One 9, e115082. PubMed

    Yelshanskaya, M. V., Li, M., and Sobolevsky, A. I. (2014) Structure of an agonist-bound ionotropic glutamate receptor, Science 345, 1070-1074. PubMed

    Zeqiraj, E., Tang, X., Hunter, R. W., Garcia-Rocha, M., Judd, A., Deak, M., von Wilamowitz-Moellendorff, A., Kurinov, I., Guinovart, J. J., Tyers, M., Sakamoto, K., and Sicheri, F. (2014) Structural basis for the recruitment of glycogen synthase by glycogenin, Proc. Nat. Acad. Sci. U.S.A. 111, E2831-E2840. PubMed

    Zhang, J., and Ferré-D'Amaré, Adrian R. (2014) Dramatic Improvement of Crystals of Large RNAs by Cation Replacement and Dehydration, Structure 22, 1363-1371. PubMed

    Zhang, Z., Liu, Q., and Hendrickson, W. A. (2014) Crystal Structures of Apparent Saccharide Sensors from Histidine Kinase Receptors Prevalent in a Human Gut Symbiont, FEBS J. 281, 4263–4279. PubMed

    Zhao, Q., Saro, D., Sachpatzidis, A., Singh, T. R., Schlingman, D., Zheng, X.-F., Mack, A., Tsai, M.-S., Mochrie, S., Regan, L., Meetei, A. R., Sung, P., and Xiong, Y. (2014) The MHF complex senses branched DNA by binding a pair of crossover DNA duplexes, Nat. Commun. 5, 2987. PubMed

    Zhao, Q., Xue, X., Longerich, S., Sung, P., and Xiong, Y. (2014) Structural insights into 5' flap DNA unwinding and incision by the human FAN1 dimer, Nat. Commun. 5, 5726. PubMed

    Zhong, X., Du, J., Hale, C. J., Gallego-Bartolome, J., Feng, S., Vashisht, A. A., Chory, J., Wohlschlegel, J. A., Patel, D. J., and Jacobsen, S. E. (2014) Molecular Mechanism of Action of Plant DRM De Novo DNA Methyltransferases, Cell 157, 1050-1060. PubMed

    Zhou, L., Bosscher, M., Zhang, C., Özçubukçu, S., Zhang, L., Zhang, W., Li, C. J., Liu, J., Jensen, M. P., Lai, L., and He, C. (2014) A protein engineered to bind uranyl selectively and with femtomolar affinity, Nat. Chem. 6, 236-241. PubMed

    Zhou, X., Levin, E. J., Pan, Y., McCoy, J. G., Sharma, R., Kloss, B., Bruni, R., Quick, M., and Zhou, M. (2014) Structural basis of the alternating-access mechanism in a bile acid transporter, Nature 505, 569-573. PubMed

    2013

    Ahmed, M., Goldgur, Y., Hu, J., Guo, H. F., and Cheung, N. K. (2013) In silico driven redesign of a clinically relevant antibody for the treatment of GD2 positive tumors, PLoS One 8, e63359. PubMed

    Alicea-Velazquez, N. L., Jakoncic, J., and Boggon, T. J. (2013) Structure-guided studies of the SHP-1/JAK1 interaction provide new insights into phosphatase catalytic domain substrate recognition, J. Struct. Biol. 18, 243-251. PubMed

    Andersen, K. R., Onischenko, E., Tang, J. H., Kumar, P., Chen, J. Z., Ulrich, A., Liphardt, J. T., Weis, K., and Schwartz, T. U. (2013) Scaffold nucleoporins Nup188 and Nup192 share structural and functional properties with nuclear transport receptors, eLife 2. e00745. PubMed

    Apostol, M. I., Perry, K., and Surewicz, W. K. (2013) Crystal structure of human prion protein fragment reveals a motif for oligomer formation, J. Am. Chem. Soc. 135, 10202−10205. PubMed

    Arbing, M. A., Chan, S., Harris, L., Kuo, E., Zhou, T. T., Ahn, C. J., Nguyen, L., He, Q., Lu, J., Menchavez, P. T., Shin, A., Holton, T., Sawaya, M. R., Cascio, D., and Eisenberg, D. (2013) Heterologous expression of mycobacterial Esx complexes in Escherichia coli for structural studies is facilitated by the use of maltose binding protein fusions, PLoS One 8, e81753. PubMed

    Avital-Shmilovici, M., Mandal, K., Gates, Z. P., Phillips, N., Weiss, M. A., and Kent, S. B. (2013) Fully Convergent Chemical Synthesis of Ester Insulin: Determination of the High Resolution X-ray Structure by Racemic Protein Crystallography, J. Am. Chem. Soc. 135, 3173–3185. PubMed

    Bae, B., Davis, E., Brown, D., Campbell, E. A., Wigneshweraraj, S., and Darst, S. A. (2013) Phage T7 Gp2 inhibition of Escherichia coli RNA polymerase involves misappropriation of σ70 domain 1.1, Proc. Natl. Acad. Sci. U. S. A. 110, 19772–19777. PubMed

    Bilokapic, S., and Schwartz, T. U. (2013) Structural and Functional Studies of the 252 kDa Nucleoporin ELYS Reveal Distinct Roles for Its Three Tethered Domains, Structure 21, 572-580. PubMed

    Broussard, T. C., Kobe, M. J., Pakhomova, S., Neau, D. B., Price, A. E., Champion, T. S., and Waldrop, G. L. (2013) The Three-Dimensional Structure of the Biotin Carboxylase-Biotin Carboxyl Carrier Protein Complex of E. coli Acetyl-CoA Carboxylase, Structure 21, 650-657. PubMed

    Bryk, R., Arango, N., Maksymiuk, C., Balakrishnan, A., Wu, Y. T., Wong, C. H., Masquelin, T., Hipskind, P. A., Lima, C. D., and Nathan, C. (2013) Lipoamide channel-binding sulfonamides selectively inhibit mycobacterial lipoamide dehydrogenase, Biochemistry 52, 9375−9384. PubMed

    Cantara, W. A., Murphy, F. V. t., Demirci, H., and Agris, P. F. (2013) Expanded use of sense codons is regulated by modified cytidines in tRNA, Proc. Natl. Acad. Sci. U. S. A. 110, 10964–10969. PubMed

    Cao, Y., Pan, Y., Huang, H., Jin, X., Levin, E. J., Kloss, B., and Zhou, M. (2013) Gating of the TrkH ion channel by its associated RCK protein TrkA, Nature 496, 317-322. PubMed

    Chae, P. S., Rana, R. R., Gotfryd, K., Rasmussen, S. G., Kruse, A. C., Cho, K. H., Capaldi, S., Carlsson, E., Kobilka, B., Loland, C. J., Gether, U., Banerjee, S., Byrne, B., Lee, J. K., and Gellman, S. H. (2013) Glucose-Neopentyl Glycol (GNG) amphiphiles for membrane protein study, Chem. Commun. (Camb.) 49, 2261-2372. PubMed

    Chen, L., Shi, K., Yin, Z., and Aihara, H. (2013) Structural asymmetry in the Thermus thermophilus RuvC dimer suggests a basis for sequential strand cleavages during Holliday junction resolution, Nucleic Acids Res. 41, 648-656. PubMed

    Chen, Y., Rajashankar, K. R., Yang, Y., Agnihothram, S. S., Liu, C., Lin, Y. L., Baric, R. S., and Li, F. (2013) Crystal structure of the receptor-binding domain from newly emerged Middle East respiratory syndrome coronavirus, J. Virol. 87, 10777-10783. PubMed

    Chen, S., Oldham, M. L., Davidson, A. L., and Chen, J. (2013) Carbon catabolite repression of the maltose transporter revealed by X-ray crystallography, Nature 499, 364-368. PubMed

    Chen, Q., Sun, X., Zhou, X. H., Liu, J. H., Wu, J., Zhang, Y., and Wang, J. H. (2013) N-terminal horseshoe conformation of DCC is functionally required for axon guidance and might be shared by other neural receptors, J. Cell. Sci. 126, 186-195. PubMed

    Chung, B. C., Zhao, J., Gillespie, R. A., Kwon, D. Y., Guan, Z., Hong, J., Zhou, P., and Lee, S. Y. (2013) Crystal structure of MraY, an essential membrane enzyme for bacterial cell wall synthesis, Science 341, 1012-1016. PubMed

    Conrady, D. G., Wilson, J. J., and Herr, A. B. (2013) Structural basis for Zn2+-dependent intercellular adhesion in staphylococcal biofilms, Proc. Natl. Acad. Sci. U. S. A. 110, E202-E211. PubMed

    Dang, B., Kubota, T., Mandal, K., Bezanilla, F., and Kent, S. B. H. (2013) Native Chemical Ligation at Asx-Cys, Glx-Cys: Chemical Synthesis and High Resolution X-ray Structure of ShK Toxin by Racemic Protein Crystallography, J. Am. Chem. Soc. 135, 11911−11919. PubMed

    Davis, M. J., Ha, B. H., Holman, E. C., Halaban, R., Schlessinger, J., and Boggon, T. J. (2013) RAC1P29S is a spontaneously activating cancer-associated GTPase, Proc. Natl. Acad. Sci. U. S. A. 110, 912-917. PubMed

    Demirci, H., Murphy IV, F., Murphy, E., Gregory, S. T., Dahlberg, A. E., and Jogl, G. (2013) A structural basis for streptomycin-induced misreading of the genetic code, Nat. Commun. 4, 1355. PubMed

    Demirci, H., Wang, L., Murphy, F. V. t., Murphy, E. L., Carr, J. F., Blanchard, S. C., Jogl, G., Dahlberg, A. E., and Gregory, S. T. (2013) The central role of protein S12 in organizing the structure of the decoding site of the ribosome, RNA 19, 1791-1801. PubMed

    Dessau, M., and Modis, Y. (2013) Crystal structure of glycoprotein C from Rift Valley fever virus, Proc. Natl. Acad. Sci. U. S. A. 110, 1696–1701. PubMed

    Dhakshnamoorthy, B., Ziervogel, B. K., Blachowicz, L., and Roux, B. (2013) A structural study of ion permeation in OmpF porin from anomalous X-ray diffraction and molecular dynamics simulations, J. Am. Chem. Soc.135, 16561−16568. PubMed

    Duda, D. M., Olszewski, J. L., Schuermann, J. P., Kurinov, I., Miller, D. J., Nourse, A., Alpi, A. F., and Schulman, B. A. (2013) Structure of HHARI, a RING-IBR-RING Ubiquitin Ligase: Autoinhibition of an Ariadne-Family E3 and Insights into Ligation Mechanism, Structure 21, 1030-1041. PubMed

    Economou, N. J., Zentner, I. J., Lazo, E., Jakoncic, J., Stojanoff, V., Weeks, S. D., Grasty, K. C., Cocklin, S., and Loll, P. J. (2013) Structure of the complex between teicoplanin and a bacterial cell-wall peptide: use of a carrier-protein approach, Acta Crystallogr. D 69, 520-533. PubMed

    Eiler, D., Lin, J., Simonetti, A., Klaholz, B. P., and Steitz, T. A. (2013) Initiation factor 2 crystal structure reveals a different domain organization from eukaryotic initiation factor 5B and mechanism among translational GTPases, Proc. Natl. Acad. Sci. U. S. A.110, 15662-15667. PubMed

    Ernst, A., Avvakumov, G., Tong, J., Fan, Y., Zhao, Y., Alberts, P., Persaud, A., Walker, J. R., Neculai, A. M., Neculai, D., Vorobyov, A., Garg, P., Beatty, L., Chan, P. K., Juang, Y. C., Landry, M. C., Yeh, C., Zeqiraj, E., Karamboulas, K., Allali-Hassani, A., Vedadi, M., Tyers, M., Moffat, J., Sicheri, F., Pelletier, L., Durocher, D., Raught, B., Rotin, D., Yang, J., Moran, M. F., Dhe-Paganon, S., and Sidhu, S. S. (2013) A Strategy for Modulation of Enzymes in the Ubiquitin System, Science 339, 590-595. PubMed

    Fagan, C. E., Dunkle, J. A., Maehigashi, T., Dang, M. N., Devaraj, A., Miles, S. J., Qin, D., Fredrick, K., and Dunham, C. M. (2013) Reorganization of an intersubunit bridge induced by disparate 16S ribosomal ambiguity mutations mimics an EF-Tu-bound state, Proc. Natl. Acad. Sci. U. S. A. 110, 9716–9721. PubMed

    Fei, X., Yang, D., Laronde-Leblanc, N., and Lorimer, G. H. (2013) Crystal structure of a GroEL-ADP complex in the relaxed allosteric state at 2.7 Å resolution, Proc. Natl. Acad. Sci. U. S. A. 110, E2958–E2966. PubMed

    Feklistov, A., and Darst, S. A. (2013) Crystallographic analysis of an RNA polymerase [sigma]-subunit fragment complexed with -10 promoter element ssDNA: quadruplex formation as a possible tool for engineering crystal contacts in protein-ssDNA complexes, Acta Crystallogr. F 69, 950-955. PubMed

    Fisher, O. S., Zhang, R., Li, X., Murphy, J. W., Demeler, B., and Boggon, T. J. (2013) Structural studies of cerebral cavernous malformations 2 (CCM2) reveal a folded helical domain at its C-terminus, FEBS Lett. 587, 272-277. PubMed

    Galaleldeen, A., Taylor, A. B., Chen, D., Schuermann, J. P., Holloway, S. P., Hou, S., Gong, S., Zhong, G., and Hart, P. J. (2013) Structure of the Chlamydia trachomatis Immunodominant Antigen Pgp3, J. Biol. Chem. 288, 22068–22079. PubMed

    Gao, J., Ha, B. H., Lou, H. J., Morse, E. M., Zhang, R., Calderwood, D. A., Turk, B. E., and Boggon, T. J. (2013) Substrate and Inhibitor Specificity of the Type II p21-Activated Kinase, PAK6, PLoS One 8, e77818. PubMed

    Gao, P., Ascano, M., Wu, Y., Barchet, W., Gaffney, B. L., Zillinger, T., Serganov, A. A., Liu, Y., Jones, R. A., Hartmann, G., Tuschl, T., and Patel, D. J. (2013) Cyclic [G(2',5')pA(3',5')p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase, Cell 53, 1094–1107. PubMed

    Gao, P., Ascano, M., Zillinger, T., Wang, W., Dai, P., Serganov, A. A., Gaffney, B. L., Shuman, S., Jones, R. A., Deng, L., Hartmann, G., Barchet, W., Tuschl, T., and Patel, D. J. (2013) Structure-Function Analysis of STING Activation by c[G(2',5')pA(3',5')p] and Targeting by Antiviral DMXAA, Cell 153, 1094-1107. PubMed

    Geng, Y., Bush, M., Mosyak, L., Wang, F., and Fan, Q. R. (2013) Structural mechanism of ligand activation in human GABAB receptor, Nature 504, 254-259. PubMed

    Goldman, P. J., Grove, T. L., Booker, S. J., and Drennan, C. L. (2013) X-ray analysis of butirosin biosynthetic enzyme BtrN redefines structural motifs for AdoMet radical chemistry, Proc. Natl. Acad. Sci. U. S. A. 110, 15949–15954. PubMed

    Goldman, P. J., Grove, T. L., Sites, L. A., McLaughlin, M. I., Booker, S. J., and Drennan, C. L. (2013) X-ray structure of an AdoMet radical activase reveals an anaerobic solution for formylglycine posttranslational modification, Proc. Natl. Acad. Sci. U. S. A. 110, 8519–8524. PubMed

    Grigg, Jason C., and Ke, A. (2013) Determinants for Geometry and Information Decoding of tRNA by T Box Leader RNA, Structure 21, 2025-2032. PubMed

    Hancock, S. P., Ghane, T., Cascio, D., Rohs, R., Di Felice, R., and Johnson, R. C. (2013) Control of DNA minor groove width and Fis protein binding by the purine 2-amino group, Nucleic Acids Res.41, 6750–6760. PubMed

    Hicks, K. A., O'Leary, S. E., Begley, T. P., and Ealick, S. E. (2013) Structural and Mechanistic Studies of HpxO, a Novel FAD-dependent Urate Oxidase from Klebsiella pneumoniae, Biochemistry 52, 477-487. PubMed

    Hinshaw, S. M., and Harrison, S. C. (2013) An Iml3-Chl4 Heterodimer Links the Core Centromere to Factors Required for Accurate Chromosome Segregation, Cell Rep. 5, 29-36. PubMed

    Hitosugi, T., Zhou, L., Fan, J., Elf, S., Zhang, L., Xie, J., Wang, Y., Gu, T.-L., Aleckovic, M., LeRoy, G., Kang, Y., Kang, H.-B., Seo, J.-H., Shan, C., Jin, P., Gong, W., Lonial, S., Arellano, M. L., Khoury, H. J., Chen, G. Z., Shin, D. M., Khuri, F. R., Boggon, T. J., Kang, S., He, C., and Chen, J. (2013) Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation, Nat. Commun. 4, 1790. PubMed

    Huang, J., Chen, S., Zhang, J. J., and Huang, X. Y. (2013) Crystal structure of oligomeric β1-adrenergic G protein-coupled receptors in ligand-free basal state, Nat. Struct. Mol. Biol. 20, 419-425. PubMed

    Ji, X., Wu, Y., Yan, J., Mehrens, J., Yang, H., DeLucia, M., Hao, C., Gronenborn, A. M., Skowronski, J., Ahn, J., and Xiong, Y. (2013) Mechanism of allosteric activation of SAMHD1 by dGTP, Nat. Struct. Mol. Biol.20, 1304-1309. PubMed

    Ji, Q., Zhang, L., Jones, M. B., Sun, F., Deng, X., Liang, H., Cho, H., Brugarolas, P., Gao, Y. N., Peterson, S. N., Lan, L., Bae, T., and He, C. (2013) Molecular mechanism of quinone signaling mediated through S-quinonization of a YodB family repressor QsrR, Proc. Natl. Acad. Sci. U. S. A. 110, 5010-5015. PubMed

    Kamadurai, H. B., Qiu, Y., Deng, A., Harrison, J. S., Macdonald, C., Actis, M., Rodrigues, P., Miller, D. J., Souphron, J., Lewis, S. M., Kurinov, I., Fujii, N., Hammel, M., Piper, R., Kuhlman, B., and Schulman, B. A. (2013) Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3, Elife 2, e00828. PubMed

    Ketkar, A., Zafar, M. K., Maddukuri, L., Yamanaka, K., Banerjee, S., Egli, M., Choi, J. Y., Lloyd, R. S., and Eoff, R. L. (2013) Leukotriene Biosynthesis Inhibitor MK886 Impedes DNA Polymerase Activity, Chem. Res. Toxicol. 26, 221-232. PubMed

    Kirouac, K. N., Basu, A. K., and Ling, H. (2013) Replication of a carcinogenic nitropyrene DNA lesion by human Y-family DNA polymerase, Nucleic Acids Res. 41, 2060-2071. PubMed

    Kirouac, K. N., Basu, A. K., and Ling, H. (2013) Structural mechanism of replication stalling on a bulky amino-policyclic aromatic hydrocarbon DNA adduct by a Y family DNA polymerase, J. Mol Biol. 425, 4167–4176. PubMed

    Klein, D. E., Choi, J. L., and Harrison, S. C. (2013) Structure of a dengue envelope protein late-stage fusion intermediate, J. Virol. 87, 2287-2293. PubMed

    Kohlway, A., Luo, D., Rawling, D. C., Ding, S. C., and Pyle, A. M. (2013) Defining the functional determinants for RNA surveillance by RIG-I, EMBO Rep. 14, 772-779. PubMed

    Korman, T. P., Sahachartsiri, B., Charbonneau, D. M., Huang, G. L., Beauregard, M., and Bowie, J. U. (2013) Dieselzymes: development of a stable and methanol tolerant lipase for biodiesel production by directed evolution, Biotechnol. Biofuels 6, 70. PubMed

    Krishnan, V., Dwivedi, P., Kim, B. J., Samal, A., Macon, K., Ma, X., Mishra, A., Doran, K. S., Ton-That, H., and Narayana, S. V. (2013) Structure of Streptococcus agalactiae tip pilin GBS104: a model for GBS pili assembly and host interactions, Acta Crystallogr. D 69, 1073-1089. PubMed

    Lai, Y.-T., Tsai, K.-L., Sawaya, M. R., Asturias, F. J., and Yeates, T. O. (2013) Structure and Flexibility of Nanoscale Protein Cages Designed by Symmetric Self-Assembly, J. Am. Chem. Soc. 135, 7738–7743. PubMed

    Lall, P., Horgan, C. P., Oda, S., Franklin, E., Sultana, A., Hanscom, S. R., McCaffrey, M. W., and Khan, A. R. (2013) Structural and functional analysis of FIP2 binding to the endosome-localised Rab25 GTPase, Biochimi. Biophys. Acta 1834, 2679–2690. PubMed

    Lalonde, J. M., Le-Khac, M., Jones, D. M., Courter, J. R., Park, J., Schon, A., Princiotto, A. M., Wu, X., Mascola, J. R., Freire, E., Sodroski, J., Madani, N., Hendrickson, W. A., and Smith, A. B., 3rd. (2013) Structure-Based Design and Synthesis of an HIV-1 Entry Inhibitor Exploiting X-Ray and Thermodynamic Characterization, ACS Med. Chem. Lett. 4, 338-343. PubMed

    Lavoie, H., Thevakumaran, N., Gavory, G., Li, J. J., Padeganeh, A., Guiral, S., Duchaine, J., Mao, D. Y., Bouvier, M., Sicheri, F., and Therrien, M. (2013) Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization, Nat. Chem. Biol. 9, 428-436. PubMed

    Law, J. A., Du, J., Hale, C. J., Feng, S., Krajewski, K., Palanca, A. M. S., Strahl, B. D., Patel, D. J., and Jacobsen, S. E. (2013) Polymerase IV occupancy at RNA-directed DNA methylation sites requires SHH1, Nature 498, 385-389. PubMed

    Lee, K., Gu, S., Jin, L., Le, T. T. N., Cheng, L. W., Strotmeier, J., Kruel, A. M., Yao, G., Perry, K., Rummel, A., and Jin, R. (2013) Structure of a Bimodular Botulinum Neurotoxin Complex Provides Insights into Its Oral Toxicity, PLoS Pathog. 9, e1003690. PubMed

    Li, Y., Wang, J., Kanai, R., and Modis, Y. (2013) Crystal structure of glycoprotein E2 from bovine viral diarrhea virus, Proc. Natl. Acad. Sci. U. S. A. 110, 6805-6810. PubMed

    Liebschner, D., Dauter, M., Brzuszkiewicz, A., and Dauter, Z. (2013) On the reproducibility of protein crystal structures: five atomic resolution structures of trypsin, Acta Crystallogr. D 69, 1447-1462. PubMed

    Lim, D., Gold, D. A., Julien, L., Rosowski, E. E., Niedelman, W., Yaffe, M. B., and Saeij, J. P. (2013) Structure of the Toxoplasma gondii ROP18 kinase domain reveals a second ligand binding pocket required for acute virulence, J. Biol. Chem. 288, 34968-34980. PubMed

    Liu, W., Draheim, K. M., Zhang, R., Calderwood, D. A., and Boggon, T. J. (2013) Mechanism for KRIT1 Release of ICAP1-Mediated Suppression of Integrin Activation, Mol. Cell 49, 719-729. PubMed

    Liu, B., Eliason, W. K., and Steitz, T. A. (2013) Structure of a helicase–helicase loader complex reveals insights into the mechanism of bacterial primosome assembly, Nat. Commun. 4. 2495. PubMed

    Liu, X., and Ladias, J. A. A. (2013) Structural Basis for the BRCA1 BRCT Interaction with the Proteins ATRIP and BAAT1, Biochemistry 52, 7618-7627. PubMed

    Lomakin, I. B., and Steitz, T. A. (2013) The initiation of mammalian protein synthesis and mRNA scanning mechanism, Nature 500, 307-311. PubMed

    Ma, W., and Goldberg, J. (2013) Rules for the recognition of dilysine retrieval motifs by coatomer, EMBO J. 32, 926–937. PubMed

    Makde, R. D., and Tan, S. Strategies for crystallizing a chromatin protein in complex with the nucleosome core particle, Anal. Biochem. 442, 138-145. PubMed

    Marcia, M., Humphris-Narayanan, E., Keating, K. S., Somarowthu, S., Rajashankar, K., and Pyle, A. M. (2013) Solving nucleic acid structures by molecular replacement: examples from group II intron studies, Acta Crystallogr. D 69, 2174-2185. PubMed

    Marcia, M., Somarowthu, S., and Pyle, A. M. (2013) Now on display: a gallery of group II intron structures at different stages of catalysis, Mob. DNA 4, 14. PubMed

    McCarthy, K. R., Schmidt, A. G., Kirmaier, A., Wyand, A. L., Newman, R. M., and Johnson, W. E. (2013) Gain-of-Sensitivity Mutations in a Trim5-Resistant Primary Isolate of Pathogenic SIV Identify Two Independent Conserved Determinants of Trim5α Specificity, PLoS Pathog. 9, e1003352. PubMed

    Miallau, L., Jain, P., Arbing, M. A., Cascio, D., Phan, T., Ahn, C. J., Chan, S., Chernishof, I., Maxson, M., Chiang, J., Jacobs, W. R., Jr., and Eisenberg, D. S. (2013) Comparative Proteomics Identifies the Cell-Associated Lethality of M. tuberculosis RelBE-like Toxin-Antitoxin Complexes, Structure 21, 627-632. PubMed

    Mielecki, M., Krawiec, K., Kiburu, I., Grzelak, K., Zagorski, W., Kierdaszuk, B., Kowa, K., Fokt, I., Szymanski, S., Swierk, P., Szeja, W., Priebe, W., Lesyng, B., and Laronde-Leblanc, N. (2013) Development of novel molecular probes of the Rio1 atypical protein kinase, Biochim. Biophys. Acta 1834, 1292–1301. PubMed

    Monda, J. K., Scott, D. C., Miller, D. J., Lydeard, J., King, D., Harper, J. W., Bennett, E. J., and Schulman, B. A. (2013) Structural Conservation of Distinctive N-terminal Acetylation-Dependent Interactions across a Family of Mammalian NEDD8 Ligation Enzymes, Structure 21, 42-53. PubMed

    Morrison, E., Kantz, A., Gassner, G. T., and Sazinsky, M. H. (2013) Structure and Mechanism of Styrene Monooxygenase Reductase: New Insight into the FAD-Transfer Reaction, Biochemistry 52, 6063-6075. PubMed

    Nakanishi, K., Ascano, M., Gogakos, T., Ishibe-Murakami, S., Serganov, Artem A., Briskin, D., Morozov, P., Tuschl, T., and Patel, Dinshaw J. (2013) Eukaryote-Specific Insertion Elements Control Human ARGONAUTE Slicer Activity, Cell Rep. 3, 1893-1900. PubMed

    Nguyen, Jennifer B., Pool, Christopher D., Wong, Christina Y. B., Treger, Rebecca S., Williams, David L., Cappello, M., Lea, Wendy A., Simeonov, A., Vermeire, Jon J., and Modis, Y. (2013) Peroxiredoxin-1 from the Human Hookworm Ancylostoma ceylanicum Forms a Stable Oxidized Decamer and Is Covalently Inhibited by Conoidin A, Chemistry & Biology 20, 991-1001. PubMed

    Oh, Y. S., Gao, P., Lee, K. W., Ceglia, I., Seo, J. S., Zhang, X., Ahn, J. H., Chait, B. T., Patel, D. J., Kim, Y., and Greengard, P. (2013) SMARCA3, a Chromatin-Remodeling Factor, Is Required for p11-Dependent Antidepressant Action, Cell 152, 831-843. PubMed

    Olsen, S. K., and Lima, C. D. (2013) Structure of a Ubiquitin E1-E2 Complex: Insights to E1-E2 Thioester Transfer, Mol. Cell 49, 884-896. PubMed

    Pecic, S., Pakhomova, S., Newcomer, M. E., Morisseau, C., Hammock, B. D., Zhu, Z., Rinderspacher, A., and Deng, S. X. (2013) Synthesis and structure-activity relationship of piperidine-derived non-urea soluble epoxide hydrolase inhibitors, Bioorg. Med. Chem. Lett. 23, 417-421. PubMed

    Penmatsa, A., Wang, K. H., and Gouaux, E. (2013) X-ray structure of dopamine transporter elucidates antidepressant mechanism, Nature 503, 85-90. PubMed

    Polley, S., Huang, D. B., Hauenstein, A. V., Fusco, A. J., Zhong, X., Vu, D., Schrofelbauer, B., Kim, Y., Hoffmann, A., Verma, I. M., Ghosh, G., and Huxford, T. (2013) A Structural Basis for IκB Kinase 2 Activation Via Oligomerization-Dependent Trans Auto-Phosphorylation, PLoS Biol. 11, e1001581. PubMed

    Rajagopalan, S., Teter, S. J., Zwart, P. H., Brennan, R. G., Phillips, K. J., and Kiley, P. J. (2013) Studies of IscR reveal a unique mechanism for metal-dependent regulation of DNA binding specificity, Nat. Struct. Mol. Biol. 20, 740-747. PubMed

    Red Brewer, M., Yun, C. H., Lai, D., Lemmon, M. A., Eck, M. J., and Pao, W. (2013) Mechanism for activation of mutated epidermal growth factor receptors in lung cancer, Proc. Natl. Acad. Sci. U. S. A. 110, E3595–E3604. PubMed

    Ritacco, C. J., Kamtekar, S., Wang, J., and Steitz, T. A. (2013) Crystal structure of an intermediate of rotating dimers within the synaptic tetramer of the G-segment invertase, Nucleic Acids Res. 41, 2673-2682. PubMed

    Rivkin, E., Almeida, S. M., Ceccarelli, D. F., Juang, Y. C., Maclean, T. A., Srikumar, T., Huang, H., Dunham, W. H., Fukumura, R., Xie, G., Gondo, Y., Raught, B., Gingras, A. C., Sicheri, F., and Cordes, S. P. (2013) The linear ubiquitin-specific deubiquitinase gumby regulates angiogenesis, Nature 498, 318-324. PubMed

    Rutherford, K., Yuan, P., Perry, K., Sharp, R., and Van Duyne, G. D. (2013) Attachment site recognition and regulation of directionality by the serine integrases, Nucleic Acids Res. 41, 8341-8356. PubMed

    Salom, D., Padayatti, P. S., and Palczewski, K. (2013) Chapter 24 - Crystallization of G Protein-Coupled Receptors, in Methods in Cell Biology (Conn, P. M., Ed.), pp 451-468, Academic Press. PubMed

    Sana, B., Johnson, E., Le Magueres, P., Criswell, A., Cascio, D., and Lim, S. (2013) The role of non-conserved residues of Archaeoglobus fulgidus ferritin on its unique structure and biophysical properties, J. Biol. Chem. 288, 32663-32672. PubMed

    Sartmatova, D., Nash, T., Schormann, N., Nuth, M., Ricciardi, R., Banerjee, S., and Chattopadhyay, D. (2013) Crystallization and preliminary X-ray diffraction analysis of three recombinant mutants of Vaccinia virus uracil DNA glycosylase, Acta Crystallogr. F 69, 295-301. PubMed

    Schmidt, A. G., Xu, H., Khan, A. R., O'Donnell, T., Khurana, S., King, L. R., Manischewitz, J., Golding, H., Suphaphiphat, P., Carfi, A., Settembre, E. C., Dormitzer, P. R., Kepler, T. B., Zhang, R., Moody, M. A., Haynes, B. F., Liao, H. X., Shaw, D. E., and Harrison, S. C. (2013) Preconfiguration of the antigen-binding site during affinity maturation of a broadly neutralizing influenza virus antibody, Proc. Natl. Acad. Sci. U. S. A. 110, 264-269. PubMed

    Schormann, N., Banerjee, S., Ricciardi, R., and Chattopadhyay, D. (2013) Structure of the uracil complex of Vaccinia virus uracil DNA glycosylase, Acta Crystallogr. F, 1328-1334. PubMed

    Sethi, D. K., Gordo, S., Schubert, D. A., and Wucherpfennig, K. W. (2013) Crossreactivity of a human autoimmune TCR is dominated by a single TCR loop, Nat . Commun. 4, 2623. PubMed

    Sha, F., Gencer, E. B., Georgeon, S., Koide, A., Yasui, N., Koide, S., and Hantschel, O. (2013) Dissection of the BCR-ABL signaling network using highly specific monobody inhibitors to the SHP2 SH2 domains, Proc. Natl. Acad. Sci. U. S. A.110, 14924–14929. PubMed

    Shanmugam, G., Minko, I. G., Banerjee, S., Christov, P. P., Kozekov, I. D., Rizzo, C. J., Lloyd, R. S., Egli, M., and Stone, M. P. (2013) Ring-Opening of the γ-OH-PdG Adduct Promotes Error-Free Bypass by the Sulfolobus solfataricus DNA Polymerase Dpo4, Chem. Res. Toxicol. 26, 1348-1360. PubMed

    Sharkey, M. A., Oliveira, T. F., Engel, P. C., and Khan, A. R. (2013) Structure of NADP -dependent glutamate dehydrogenase from Escherichia coli: Reflections on the basis of coenzyme specificity in the family of glutamate dehydrogenases, FEBS J. 280, 4681–4692. PubMed

    Shi, K., Huang, W. M., and Aihara, H. (2013) An enzyme-catalyzed multistep DNA refolding mechanism in hairpin telomere formation, PLoS Biol. 11, e1001472. PubMed

    Shi, K., Pandey, K. K., Bera, S., Vora, A. C., Grandgenett, D. P., and Aihara, H. (2013) A possible role for the asymmetric C-terminal domain dimer of rous sarcoma virus integrase in viral DNA binding, PLoS One 8, e56892. PubMed

    Shnitsar, V., Li, J., Li, X., Calmettes, C., Basu, A., Casey, J. R., Moraes, T. F., and Reithmeier, R. A. (2013) A Substrate Access Tunnel in the Cytosolic Domain is not an Essential Feature of the SLC4 Family of Bicarbonate Transporters, J. Biol. Chem. 288, 33848-33860. PubMed

    Sikowitz, M. D., Cooper, L. E., Begley, T. P., Kaminski, P. A., and Ealick, S. E. (2013) Reversal of Substrate Specificity of CMP N-glycosidase to dCMP, Biochemistry 52, 4037–4047. PubMed

    Sikowitz, M. D., Shome, B., Zhang, Y., Begley, T. P., and Ealick, S. E. (2013) Structure of a Clostridium botulinum C143S thiaminase I/thiamin complex reveals active site architecture, Biochemistry 52,7830−7839. PubMed

    Simanshu, D. K., Kamlekar, R. K., Wijesinghe, D. S., Zou, X., Zhai, X., Mishra, S. K., Molotkovsky, J. G., Malinina, L., Hinchcliffe, E. H., Chalfant, C. E., Brown, R. E., and Patel, D. J. (2013) Non-vesicular trafficking by a ceramide-1-phosphate transfer protein regulates eicosanoids, Nature 500, 463-467. PubMed

    Simanshu, Dhirendra K., Yamaguchi, Y., Park, J.-H., Inouye, M., and Patel, Dinshaw J. Structural Basis of mRNA Recognition and Cleavage by Toxin MazF and Its Regulation by Antitoxin MazE in Bacillus subtilis, Mol. Cell 52, 447-458.. PubMed

    Siu, K. K., Sultana, A., Azimi, F. C., and Lee, J. E. (2013) Structural determinants of HIV-1 Vif susceptibility and DNA binding in APOBEC3F, Nat. Commun. 4, 2593. PubMed

    Soriano, E. V., Zhang, Y., Colabroy, K. L., Sanders, J. M., Settembre, E. C., Dorrestein, P. C., Begley, T. P., and Ealick, S. E. (2013) Active-site models for complexes of quinolinate synthase with substrates and intermediates, Acta Crystallogr. D 69, 1685-1696. PubMed

    Stinson, Benjamin M., Nager, Andrew R., Glynn, Steven E., Schmitz, Karl R., Baker, Tania A., and Sauer, Robert T. (2013) Nucleotide Binding and Conformational Switching in the Hexameric Ring of a AAA+ Machine, Cell 153, 628-639. PubMed

    Strugatsky, D., McNulty, R., Munson, K., Chen, C. K., Soltis, S. M., Sachs, G., and Luecke, H. (2013) Structure of the proton-gated urea channel from the gastric pathogen Helicobacter pylori, Nature 493, 255–258. PubMed

    Subramanian, R., Ti, S.-C., Tan, L., Darst, S. A., and Kapoor, T. M. (2013) Marking and Measuring Single Microtubules by PRC1 and Kinesin-4, Cell 154, 377-390. PubMed

    Sukumar, N. (2013) Crystallographic studies on B12 binding proteins in eukaryotes and prokaryotes, Biochimie 95, 976-988. PubMed

    Sun, X.-J., Wang, Z., Wang, L., Jiang, Y., Kost, N., Soong, T. D., Chen, W.-Y., Tang, Z., Nakadai, T., Elemento, O., Fischle, W., Melnick, A., Patel, D. J., Nimer, S. D., and Roeder, R. G. (2013) A stable transcription factor complex nucleated by oligomeric AML1-ETO controls leukaemogenesis, Nature 500, 93-97. PubMed

    Sung, R. J., Zhang, M., Qi, Y., and Verdine, G. L. (2013) Structural and biochemical analysis of DNA helix-invasion by the bacterial 8-oxoguanine DNA glycosylase MutM, J. Biol. Chem.288, 10012-10023. PubMed

    Sydor, A. M., Jost, M., Ryan, K. S., Turo, K. E., Douglas, C. D., Drennan, C. L., and Zamble, D. B. (2013) Metal-binding Properties of Escherichia coli YjiA, a Member of the Metal Homeostasis-Associated COG0523 Family of GTPases, Biochemistry 52, 1788-1801. PubMed

    Teplova, M., Hafner, M., Teplov, D., Essig, K., Tuschl, T., and Patel, D. J. (2013) Structure-function studies of STAR family Quaking proteins bound to their in vivo RNA target sites, Genes Dev. 27, 928-940. PubMed

    Toms, A. V., Deshpande, A., McNally, R., Jeong, Y., Rogers, J. M., Kim, C. U., Gruner, S. M., Ficarro, S. B., Marto, J. A., Sattler, M., Griffin, J. D., and Eck, M. J. (2013) Structure of a pseudokinase-domain switch that controls oncogenic activation of Jak kinases, Nat. Struct. Mol. Biol. 20, 1221-1223. PubMed

    Tu, D., Zhu, Z., Zhou, A., Yun, C.-h., Lee, K.-E., Toms, A., Li, Y., Dunn, G., Chan, E., Thai, T., Yang, S., Ficarro, S., Marto, J., Jeon, H., Hahn, W., Barbie, D., and Eck, M. (2013) Structure and Ubiquitination-Dependent Activation of TANK-Binding Kinase 1, Cell Rep. 3, 747-758. PubMed

    Vigdorovich, V., Ramagopal, U. A., Lazar-Molnar, E., Sylvestre, E., Lee, J. S., Hofmeyer, K. A., 583036. Zang, X., Nathenson, S. G., and Almo, S. C. (2013) Structure and T Cell Inhibition Properties of B7 Family Member, B7-H3, Structure 21, 707-717. PubMed

    Wan, L. C., Mao, D. Y., Neculai, D., Strecker, J., Chiovitti, D., Kurinov, I., Poda, G., Thevakumaran, N., Yuan, F., Szilard, R. K., Lissina, E., Nislow, C., Caudy, A. A., Durocher, D., and Sicheri, F. (2013) Reconstitution and characterization of eukaryotic N6-threonylcarbamoylation of tRNA using a minimal enzyme system, Nucleic Acids Res. 41, 6332-6346. PubMed

    Wang, F., Li, G., Altaf, M., Lu, C., Currie, M. A., Johnson, A., and Moazed, D. (2013) Heterochromatin protein Sir3 induces contacts between the amino terminus of histone H4 and nucleosomal DNA, Proc. Natl. Acad. Sci. U. S. A. 110, 8495–8500. PubMed

    Wang, H., Goehring, A., Wang, K. H., Penmatsa, A., Ressler, R., and Gouaux, E. (2013) Structural basis for action by diverse antidepressants on biogenic amine transporters, Nature 503, 141-145. PubMed

    Wang, P., Bashiri, G., Gao, X., Sawaya, M. R., and Tang, Y. (2013) Uncovering the Enzymes that Catalyze the Final Steps in Oxytetracycline Biosynthesis, J. Am. Chem. Soc. 135, 7138-7141. PubMed

    Weixlbaumer, A., Leon, K., Landick, R., and Darst, S. A. (2013) Structural Basis of Transcriptional Pausing in Bacteria, Cell 152, 431-441. PubMed

    Wheatley, N. M., Gidaniyan, S. D., Liu, Y., Cascio, D., and Yeates, T. O. (2013) Bacterial microcompartment shells of diverse functional types possess pentameric vertex proteins, Protein Sci. 22, 660-665. PubMed

    Windsor, M. A., Valk, P. L., Xu, S., Banerjee, S., and Marnett, L. J. (2013) Exploring the molecular determinants of substrate-selective inhibition of cyclooxygenase-2 by lumiracoxib, Bioorg. Med. Chem. Lett. 23, 5860–5864. PubMed

    Wu, B., Peisley, A., Richards, C., Yao, H., Zeng, X., Lin, C., Chu, F., Walz, T., and Hur, S. (2013) Structural Basis for dsRNA Recognition, Filament Formation, and Antiviral Signal Activation by MDA5, Cell 152, 276–289. PubMed

    Xia, S., Wang, J., and Konigsberg, W. H. (2013) DNA Mismatch Synthesis Complexes Provide Insights into Base Selectivity of a B Family DNA Polymerase, J. Am. Chem. Soc. 9, 193-202. PubMed

    Xia, S., Wood, M., Bradley, M. J., De La Cruz, E. M., and Konigsberg, W. H. (2013) Alteration in the cavity size adjacent to the active site of RB69 DNA polymerase changes its conformational dynamics, Nucleic Acids Res. 41, 4167–4176. PubMed

    Xu, K., Rockx, B., Xie, Y., Debuysscher, B. L., Fusco, D. L., Zhu, Z., Chan, Y. P., Xu, Y., Luu, T., Cer, R. Z., Feldmann, H., Mokashi, V., Dimitrov, D. S., Bishop-Lilly, K. A., Broder, C. C., and Nikolov, D. B. (2013) Crystal structure of the hendra virus attachment g glycoprotein bound to a potent cross-reactive neutralizing human monoclonal antibody, PLoS Pathog. 9, e1003684. PubMed

    Xu, K., Tzvetkova-Robev, D., Xu, Y., Goldgur, Y., Chan, Y. P., Himanen, J. P., and Nikolov, D. B. (2013) Insights into Eph receptor tyrosine kinase activation from crystal structures of the EphA4 ectodomain and its complex with ephrin-A5, Proc. Natl. Acad. Sci. U. S. A.110, 14634–14639. PubMed

    Xu, K., Xu, Y., Rajashankar, Kanagalaghatta R., Robev, D., and Nikolov, Dimitar B. (2013) Crystal Structures of Lgr4 and Its Complex with R-Spondin1, Structure 21, 1683–1689. PubMed

    Yang, H., Rudge, D. G., Koos, J. D., Vaidialingam, B., Yang, H. J., and Pavletich, N. P. (2013) mTOR kinase structure, mechanism and regulation, Nature 497, 217-223. PubMed

    Yasuda, H., Park, E., Yun, C. H., Sng, N. J., Lucena-Araujo, A. R., Yeo, W. L., Huberman, M. S., Cohen, D. W., Nakayama, S., Ishioka, K., Yamaguchi, N., Hanna, M., Oxnard, G. R., Lathan, C. S., Moran, T., Sequist, L. V., Chaft, J. E., Riely, G. J., Arcila, M. E., Soo, R. A., Meyerson, M., Eck, M. J., Kobayashi, S. S., and Costa, D. B. (2013) Structural, Biochemical, and Clinical Characterization of Epidermal Growth Factor Receptor (EGFR) Exon 20 Insertion Mutations in Lung Cancer, Sc. Transl. Med. 5, 216ra177. PubMed

    Yildiz, M., Ghosh, S., Bell, J. A., Sherman, W., and Hardy, J. A. (2013) Allosteric Inhibition of the NS2B-NS3 Protease from Dengue Virus, ACS Chem Biol. 8, 2744−2752. PubMed

    Yin, Q., Sester, David P., Tian, Y., Hsiao, Y.-S., Lu, A., Cridland, Jasmyn A., Sagulenko, V., Thygesen, Sara J., Choubey, D., Hornung, V., Walz, T., Stacey, Katryn J., and Wu, H. (2013) Molecular Mechanism for p202-Mediated Specific Inhibition of AIM2 Inflammasome Activation, Cell Rep. 4, 327-339. PubMed

    Yu, X., Seegar, T. C., Dalton, A. C., Tzvetkova-Robev, D., Goldgur, Y., Rajashankar, K. R., Nikolov, D. B., and Barton, W. A. (2013) Structural basis for angiopoietin-1-mediated signaling initiation, Proc. Natl. Acad. Sci. U. S. A. 110, 7205-7210. PubMed

    Yu, Y., Zhu, J., Huang, P. S., Wang, J. H., Pullen, N., and Springer, T. A. (2013) Domain 1 of Mucosal Addressin Cell Adhesion Molecule has an I1-set Fold and a Flexible Integrin-Binding Loop, J. Biol. Chem. 288, 6284–6294. PubMed

    Zhang, J., and Ferre-D'Amare, A. R. (2013) Co-crystal structure of a T-box riboswitch stem I domain in complex with its cognate tRNA, Nature 500, 363-366. PubMed Also, highlighted in News and Views

    Zheng, C., Page, R. C., Das, V., Nix, J. C., Wigren, E., Misra, S., and Zhang, B. (2013) Structural characterization of carbohydrate binding by LMAN1 provides new insight into the endoplasmic reticulum export of FV and FVIII, J. Biol. Chem. 288, 20499-20509. PubMed

    Zhu, W., Haile, A. M., Singh, R., Larson, J. D., Smithen, D., Chan, J. Y., Tanner, J. J., and Becker, D. F. (2013) Involvement of the β3-α3 loop of the Proline Dehydrogenase Domain in Allosteric Regulation of Membrane Association of Proline Utilization A, Biochemistry 52, 4482−4491. PubMed

    Ziervogel, B. K., and Roux, B. (2013) The Binding of Antibiotics in OmpF Porin, Structure 21, 76-87. PubMed

    2012

    Adachi, M. S., Taylor, A. B., Hart, P. J., and Fitzpatrick, P. F. (2012) Mechanistic and Structural Analyses of the Role of His67 in the Yeast Polyamine Oxidase Fms1, Biochemistry 51, 4888−4897. PubMed

    Adachi, M. S., Taylor, A. B., Hart, P. J., and Fitzpatrick, P. F. (2012) Mechanistic and Structural Analyses of the Roles of Active Site Residues in the Yeast Polyamine Oxidase Fms1: Characterization of the N195A and D94N Enzymes, Biochemistry 51, 8690-8697. PubMed

    Ahmad, M. F., Kaushal, P. S., Wan, Q., Wijerathna, S. R., An, X., Huang, M., and Dealwis, C. G. (2012) Role of arginine-293 and glutamine-288 in communication between catalytic and allosteric sites in yeast ribonucleotide reductase, J. Mol. Biol. 419, 315-329. PubMed

    Ahmad, M. F., Wan, Q., Jha, S., Motea, E., Berdis, A., and Dealwis, C. (2012) Evaluating the therapeutic potential of a non-natural nucleotide that inhibits human ribonucleotide reductase, Mol. Cancer Ther. 11, 2077-2086. PubMed

    Arbing, M. A., Chan, S., Shin, A., Phan, T., Ahn, C. J., Rohlin, L., and Gunsalus, R. P. (2012) Structure of the surface layer of the methanogenic archaean Methanosarcina acetivorans, Proc. Natl. Acad. Sci. U. S. A. 109, 11812–11817. PubMed

    Armstrong, A. A., Mohideen, F., and Lima, C. D. (2012) Recognition of SUMO-modified PCNA requires tandem receptor motifs in Srs2, Nature 483, 59-63. PubMed

    Ausin, I., Greenberg, M. V., Simanshu, D. K., Hale, C. J., Vashisht, A. A., Simon, S. A., Lee, T. F., Feng, S., Espanola, S. D., Meyers, B. C., Wohlschlegel, J. A., Patel, D. J., and Jacobsen, S. E. (2012) INVOLVED IN DE NOVO 2-containing complex involved in RNA-directed DNA methylation in Arabidopsis, Proc. Natl. Acad. Sci. U. S. A. 109, 8374-8381. PubMed

    Babayeva, N. D., Baranovskaya, O. I., and Tahirov, T. H. (2012) Structural basis of Ets1 cooperative binding to widely separated sites on promoter DNA, PLoS One 7, e33698. PubMed

    Baconguis, I., and Gouaux, E. (2012) Structural plasticity and dynamic selectivity of acid-sensing ion channel-spider toxin complexes, Nature 89, 400-405. PubMed

    Bilokapic, S., and Schwartz, T. U. (2012) Molecular basis for Nup37 and ELY5/ELYS recruitment to the nuclear pore complex, Proc. Natl. Acad. Sci. U. S. A. 109, 15241–15246. PubMed

    Bolla, J. R., Do, S. V., Long, F., Dai, L., Su, C. C., Lei, H. T., Chen, X., Gerkey, J. E., Murphy, D. C., Rajashankar, K. R., Zhang, Q., and Yu, E. W. (2012) Structural and functional analysis of the transcriptional regulator Rv3066 of Mycobacterium tuberculosis, Nucleic Acids Res. 40, 9340-9355. PubMed

    Brohawn, S. G., del Marmol, J., and MacKinnon, R. (2012) Crystal structure of the human K2P TRAAK, a lipid- and mechano-sensitive K+ ion channel, Science 335, 436-441. PubMed

    Brugarolas, P., Movahedzadeh, F., Wang, Y., Zhang, N., Bartek, I. L., Gao, Y. N., Voskuil, M. I., Franzblau, S. G., and He, C. (2012) The oxidation-sensing regulator (MosR) is a new redox dependent transcription factor in Mycobacterium tuberculosis, J. Biol. Chem. 287, 37703–37712. PubMed

    Buss, J. M., McTamney, P. M., and Rokita, S. E. (2012) Expression of a soluble form of iodotyrosine deiodinase for active site characterization by engineering the native membrane protein from Mus musculus, Protein Sci. 21, 351-361. PubMed

    Calmettes, C., Alcantara, J., Yu, R. H., Schryvers, A. B., and Moraes, T. F. (2012) The structural basis of transferrin sequestration by transferrin-binding protein B, Nat. Struct. Mol. Biol.19, 358-360. PubMed

    Cao, Z., and Bowie, J. U. (2012) Shifting hydrogen bonds may produce flexible transmembrane helices, Proc. Natl. Acad. Sci. U. S. A. 109, 8121-8126. PubMed

    Cavalier, M. C., Kim, S. G., Neau, D., and Lee, Y. H. (2012) Molecular basis of the fructose-2,6-bisphosphatase reaction of PFKFB3: Transition state and the C-terminal function, Proteins 80, 1143-1153. PubMed

    Cavalier, M. C., Yim, Y. S., Asamizu, S., Neau, D., Almabruk, K. H., Mahmud, T., and Lee, Y. H. (2012) Mechanistic Insights into Validoxylamine A 7'-Phosphate Synthesis by VldE Using the Structure of the Entire Product Complex, PLoS One 7, e44934. PubMed

    Chan, R. T., Robart, A. R., Rajashankar, K. R., Pyle, A. M., and Toor, N. (2012) Crystal structure of a group II intron in the pre-catalytic state, Nat. Struct. Mol. Biol. 19, 555-557. PubMed

    Chen, L., Lin, Y. L., Peng, G., and Li, F. (2012) Structural basis for multifunctional roles of mammalian aminopeptidase N, Proc. Natl. Acad. Sci. U. S. A. 109, 17966–17971. PubMed

    Chen, M., Drury, J. E., Christianson, D. W., and Penning, T. M. (2012) Conversion of human steroid 5β-reductase (AKR1D1) into a 3β-hydroxysteroid dehydrogenase by a single-point mutation E120H; an example of perfect enzyme-engineering, J. Biol. Chem. 287, 16609-16620. PubMed

    Chen, Y., Farquhar, E. R., Chance, M. R., Palczewski, K., and Kiser, P. D. (2012) Insights into substrate specificity and metal activation of mammalian tetrahedral aspartyl aminopeptidase, J. Biol. Chem. 287, 13356-13370. PubMed

    Cheng, P. N., Liu, C., Zhao, M., Eisenberg, D., and Nowick, J. S. (2012) Amyloid β-sheet mimics that antagonize protein aggregation and reduce amyloid toxicity, Nat. Chem. 4, 927-933. PubMed

    Cho, U. S., and Harrison, S. C. (2012) Ndc10 is a platform for inner kinetochore assembly in budding yeast, Nat. Struct. Mol. Biol. 19, 48-55. PubMed

    Chuenchor, W., Doukov, T. I., Resto, M., Chang, A., and Gerratana, B. (2012) Regulation of the intersubunit ammonia tunnel in Mycobacterium tuberculosis glutamine-dependent NAD+ synthetase, Biochem J. 443, 417-426. PubMed

    Corbett, K. D., and Harrison, S. C. (2012) Molecular Architecture of the Yeast Monopolin Complex, Cell Rep. 1, 583-589. PubMed

    Coskun, A., Hmadeh, M., Barin, G., Gándara, F., Li, Q., Choi, E., Strutt, N. L., Cordes, D. B., Slawin, A. M., Stoddart, J. F., Sauvage, J. P., and Yaghi, O. M. (2012) Metal-organic frameworks incorporating copper-complexed rotaxanes, Angew Chem. Int. Ed. Engl. 51, 2160-2163. PubMed

    Crenshaw, C. M., Nam, K., Oo, K., Kutchukian, P. S., Bowman, B. R., Karplus, M., and Verdine, G. L. (2012) Enforced presentation of an extrahelical guanine to the lesion-recognition pocket of the human 8-oxoguanine DNA glycosylase, hOGG1, J. Biol. Chem. 287, 24916–24928. PubMed

    De Ioannes, P., Malu, S., Cortes, P., and Aggarwal, A. K. (2012) Structural Basis of DNA Ligase IV-Artemis Interaction in Nonhomologous End-Joining, Cell Rep. 2, 1505–1512. P PubMed

    Dessanti, P., Zhang, Y., Allegrini, S., Tozzi, M. G., Sgarrella, F., and Ealick, S. E. (2012) Structural basis of the substrate specificity of Bacillus cereus adenosine phosphorylase, Acta Crystallogr. D 68, 239-248. PubMed

    Dhatwalia, R., Singh, H., Oppenheimer, M., Karr, D. B., Nix, J. C., Sobrado, P., and Tanner, J. J. (2012) Crystal structures and small-angle X-ray scattering analysis of UDP-galactopyranose mutase from the pathogenic fungus Aspergillus fumigatus, J. Biol. Chem. 287, 9041-9051. PubMed

    Dhatwalia, R., Singh, H., Oppenheimer, M., Sobrado, P., and Tanner, J. J. (2012) Crystal Structures of Trypanosoma cruzi UDP-Galactopyranose Mutase Implicate Flexibility of the Histidine Loop in Enzyme Activation, Biochemistry 51, 4968−4979. PubMed

    Dhatwalia, R., Singh, H., Solano, L. M., Oppenheimer, M., Robinson, R. M., Ellerbrock, J. F., Sobrado, P., and Tanner, J. J. (2012) Identification of the NAD(P)H Binding Site of Eukaryotic UDP-Galactopyranose Mutase, J. Am. Chem. Soc. 134, 18132−18138. PubMed

    Didovyk, A., and Verdine, G. L. (2012) Structural origins of DNA target selection and nucleobase extrusion by a DNA cytosine methyltransferase, J. Biol. Chem.287, 40099–40105. PubMed

    Dong, N., Zhu, Y., Lu, Q., Hu, L., Zheng, Y., and Shao, F. (2012) Structurally Distinct Bacterial TBC-like GAPs Link Arf GTPase to Rab1 Inactivation to Counteract Host Defenses, Cell 150, 1029-1041. PubMed

    Doud, M. B., Koksal, A. C., Mi, L. Z., Song, G., Lu, C., and Springer, T. A. (2012) Unexpected fold in the circumsporozoite protein target of malaria vaccines, Proc. Natl. Acad. Sci. U. S. A. 109, 7817-7822. PubMed

    Du, J., Kelly, A. E., Funabiki, H., and Patel, D. J. (2012) Structural Basis for Recognition of H3T3ph and Smac/DIABLO N-terminal Peptides by Human Survivin, Structure 20, 185-195. PubMed

    Du, J., Zhong, X., Bernatavichute, Y. V., Stroud, H., Feng, S., Caro, E., Vashisht, A. A., Terragni, J., Chin, H. G., Tu, A., Hetzel, J., Wohlschlegel, J. A., Pradhan, S., Patel, D. J., and Jacobsen, S. E. (2012) Dual Binding of Chromomethylase Domains to H3K9me2-Containing Nucleosomes Directs DNA Methylation in Plants, Cell 151, 167-180. PubMed

    Duda, D. M., Olszewski, J. L., Tron, A. E., Hammel, M., Lambert, L. J., Waddell, M. B., Mittag, T., Decaprio, J. A., and Schulman, B. A. (2012) Structure of a Glomulin-RBX1-CUL1 Complex: Inhibition of a RING E3 Ligase through Masking of Its E2-Binding Surface, Mol. Cell. 47, 371-382. PubMed

    Durer, Z. A., Kudryashov, D. S., Sawaya, M. R., Altenbach, C., Hubbell, W., and Reisler, E. (2012) Structural States and dynamics of the d-loop in actin, Biophys. J. 103, 930-939. PubMed

    Eek, P., Jarving, R., Jarving, I., Gilbert, N. C., Newcomer, M. E., and Samel, N. (2012) Structure of a calcium-dependent 11R-lipoxygenase suggests a mechanism for Ca2+-regulation, J. Biol. Chem. 287, 22377–22386. PubMed

    Ekworomadu, M. T., Poor, C. B., Owens, C. P., Balderas, M. A., Fabian, M., Olson, J. S., Murphy, F., Balkabasi, E., Honsa, E. S., He, C., Goulding, C. W., and Maresso, A. W. (2012) Differential Function of Lip Residues in the Mechanism and Biology of an Anthrax Hemophore. PLoS Pathog. 8, e1002559. PubMed

    Elsasser, S. J., Huang, H., Lewis, P. W., Chin, J. W., Allis, C. D., and Patel, D. J. (2012) DAXX envelops a histone H3.3-H4 dimer for H3.3-specific recognition, Nature 491, 560-565. PubMed

    Englert, M., Xia, S., Okada, C., Nakamura, A., Tanavde, V., Yao, M., Eom, S. H., Konigsberg, W. H., Soll, D., and Wang, J. (2012) Structural and mechanistic insights into guanylylation of RNA-splicing ligase RtcB joining RNA between 3'-terminal phosphate and 5'-OH, Proc. Natl. Acad. Sci. U. S. A. 109, 15235–15240. PubMed

    Fan, J., and Pavletich, N. P. (2012) Structure and conformational change of a replication protein A heterotrimer bound to ssDNA, Genes Dev. 26, 2337-2347. PubMed

    Ferreira-Cerca, S., Sagar, V., Schafer, T., Diop, M., Wesseling, A. M., Lu, H., Chai, E., Hurt, E., and Laronde-Leblanc, N. (2012) ATPase-dependent role of the atypical kinase Rio2 on the evolving pre-40S ribosomal subunit, Nat. Struct. Mol. Biol. 19, 1316-1323. PubMed

    Gagnon, M. G., Seetharaman, S. V., Bulkley, D., and Steitz, T. A. (2012) Structural basis for the rescue of stalled ribosomes: structure of YaeJ bound to the ribosome, Science 335, 1370-1372. PubMed

    Gareau, J. R., Reverter, D., and Lima, C. D. (2012) Determinants of SUMO1 specificity, E3 ligase and SUMO-RanGAP1 binding activities of the nucleoporin RanBP2, J. Biol. Chem. 287, 4740-4751. PubMed

    Geng, Y., Xiong, D., Mosyak, L., Malito, D. L., Kniazeff, J., Chen, Y., Burmakina, S., Quick, M., Bush, M., Javitch, J. A., Pin, J. P., and Fan, Q. R. (2012) Structure and functional interaction of the extracellular domain of human GABAB receptor GBR2, Nat. Neurosci. 15, 970-978. PubMed

    Gilbert, N. C., Rui, Z., Neau, D. B., Waight, M. T., Bartlett, S. G., Boeglin, W. E., Brash, A. R., and Newcomer, M. E. (2012) Conversion of human 5-lipoxygenase to a 15-lipoxygenase by a point mutation to mimic phosphorylation at Serine-663, FASEB J. 26,3222-3229. PubMed

    Golczak, M., Kiser, P. D., Sears, A. E., Lodowski, D. T., Blaner, W. S., and Palczewski, K. (2012) Structural basis for the acyltransferase activity of lecithin:retinol acyltransferase-like proteins, J. Biol. Chem. 287, 23790–23807. PubMed

    Goldman, P. J., Ryan, K. S., Hamill, M. J., Howard-Jones, A. R., Walsh, C. T., Elliott, S. J., and Drennan, C. L. (2012) An Unusual Role for a Mobile Flavin in StaC-like Indolocarbazole Biosynthetic Enzymes, Chem. Biol. 19, 855-865. PubMed

    Gorynia, S., Lorenz, T. C., Costaguta, G., Daboussi, L., Cascio, D., and Payne, G. S. (2012) Yeast Irc6p is a novel type of conserved clathrin coat accessory factor related to small G proteins, Mol. Biol. Cell 23, 4416-4429. PubMed

    Grossmann, T. N., Yeh, J. T., Bowman, B. R., Chu, Q., Moellering, R. E., and Verdine, G. L. (2012) Inhibition of oncogenic Wnt signaling through direct targeting of β-catenin, Proc. Natl. Acad. Sci. U. S. A. 109, 17942–17947. PubMed

    Gu, S., Rumpel, S., Zhou, J., Strotmeier, J., Bigalke, H., Perry, K., Shoemaker, C. B., Rummel, A., and Jin, R. (2012) Botulinum Neurotoxin Is Shielded by NTNHA in an Interlocked Complex, Science 335, 977-981. PubMed

    Ha, B. H., Davis, M. J., Chen, C., Lou, H. J., Gao, J., Zhang, R., Krauthammer, M., Halaban, R., Schlessinger, J., Turk, B. E., and Boggon, T. J. (2012) Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate, Proc. Natl. Acad. Sci. U. S. A. 109, 16107-16112. PubMed

    Harrison, O. J., Vendome, J., Brasch, J., Jin, X., Hong, S., Katsamba, P. S., Ahlsen, G., Troyanovsky, R. B., Troyanovsky, S. M., Honig, B., and Shapiro, L. (2012) Nectin ectodomain structures reveal a canonical adhesive interface, Nat. Struct. Mol. Biol. 19, 906-915. PubMed

    Hattori, M., and Gouaux, E. (2012) Molecular mechanism of ATP binding and ion channel activation in P2X receptors, Nature 485, 207-212. PubMed

    Hitosugi, T., Zhou, L., Elf, S., Fan, J., Kang, H. B., Seo, J. H., Shan, C., Dai, Q., Zhang, L., Xie, J., Gu, T. L., Jin, P., Aleckovic, M., Leroy, G., Kang, Y., Sudderth, J. A., Deberardinis, R. J., Luan, C. H., Chen, G. Z., Muller, S., Shin, D. M., Owonikoko, T. K., Lonial, S., Arellano, M. L., Khoury, H. J., Khuri, F. R., Lee, B. H., Ye, K., Boggon, T. J., Kang, S., He, C., and Chen, J. (2012) Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth, Cancer Cell 22, 585-600. PubMed

    Hmadeh, M., Lu, Z., Liu, Z., Gándara, F., Furukawa, H., Wan, S., Augustyn, V., Cheng, R., Liao, L., Zhou, F., Perre, E., Ozolins, V., Duan, X., Dunn, B., Yamamoto, Y., Terasaki, O., and Yaghi, O. M. (2012) New porous crystals of extended metal-catecholates, Chem. Mater 24, 3511-3513. DOI

    Huang, W. M., Dagloria, J., Fox, H., Ruan, Q., Tillou, J., Shi, K., Aihara, H., Aron, J., and Casjens, S. (2012) Linear chromosome generating system of Agrobacterium tumefaciens C58: Protelomerase generates and protects hairpin ends, J. Biol. Chem. 287, 25551–25563. PubMed

    Huang, S., Mahanta, N., Begley, T. P., and Ealick, S. E. (2012) Pseudouridine Monophosphate Glycosidase: A New Glycosidase Mechanism, Biochemistry 51, 9245-9255. PubMed

    Inada, H., Procko, E., Sotomayor, M., and Gaudet, R. (2012) Structural and biochemical consequences of disease-causing mutations in the ankyrin repeat domain of the human TRPV4 channel, Biochemistry 51, 6195−6206. PubMed

    Itsathitphaisarn, O., Wing, R. A., Eliason, W. K., Wang, J., and Steitz, T. A. (2012) The Hexameric Helicase DnaB Adopts a Nonplanar Conformation during Translocation, Cel1 151, 267-277. PubMed

    Jia, X., Singh, R., Homann, S., Yang, H., Guatelli, J., and Xiong, Y. (2012) Structural basis of evasion of cellular adaptive immunity by HIV-1 Nef, Nat. Struct. Mol. Biol. 19, 701-706. PubMed

    Johnson, Z. L., Cheong, C.-G., and Lee, S.-Y. (2012) Crystal structure of a concentrative nucleoside transporter from Vibrio cholerae at 2.4 Å, Nature 483, 489-493. PubMed

    Juang, Y. C., Landry, M. C., Sanches, M., Vittal, V., Leung, C. C., Ceccarelli, D. F., Mateo, A. R., Pruneda, J. N., Mao, D. Y., Szilard, R. K., Orlicky, S., Munro, M., Brzovic, P. S., Klevit, R. E., Sicheri, F., and Durocher, D. (2012) OTUB1 Co-opts Lys48-Linked Ubiquitin Recognition to Suppress E2 Enzyme Function, Mol. Cell. 45, 384-397. PubMed

    Kaiser, S. E., Mao, K., Taherbhoy, A. M., Yu, S., Olszewski, J. L., Duda, D. M., Kurinov, I., Deng, A., Fenn, T. D., Klionsky, D. J., and Schulman, B. A. (2012) Noncanonical E2 recruitment by the autophagy E1 revealed by Atg7-Atg3 and Atg7-Atg10 structures, Nat. Struct. Mol. Biol. 19, 1242-1249. PubMed

    Ketkar, A., Zafar, M. K., Banerjee, S., Marquez, V. E., Egli, M., and Eoff, R. L. (2012) A nucleotide analogue induced gain of function corrects the error-prone nature of human DNA polymerase iota, J. Am. Chem. Soc. 134, 10698–10705. PubMed

    Ketkar, A., Zafar, M. K., Marquez, V. E., Banerjee, S., Egli, M., and Eoff, R. L. (2012) Differential furanose selection in the active sites of archaeal DNA polymerases probed by fixed-conformation nucleotide analogues, Biochemistry 51, 9234−9244. PubMed

    Kiburu, I. N., and Laronde-Leblanc, N. (2012) Interaction of rio1 kinase with toyocamycin reveals a conformational switch that controls oligomeric state and catalytic activity, PLoS One 7, e37371. PubMed

    King, N. P., Sheffler, W., Sawaya, M. R., Vollmar, B. S., Sumida, J. P., Andre, I., Gonen, T., Yeates, T. O., and Baker, D. (2012) Computational design of self-assembling protein nanomaterials with atomic level accuracy, Science 336, 1171-1174. PubMed

    Kiser, P. D., Farquhar, E. R., Shi, W., Sui, X., Chance, M. R., and Palczewski, K. (2012) Structure of RPE65 isomerase in a lipidic matrix reveals roles for phospholipids and iron in catalysis, Proc. Natl. Acad. Sci. U. S. A. 109, E2747-2756. PubMed

    Koide, A., Wojcik, J., Gilbreth, R. N., Hoey, R. J., and Koide, S. (2012) Teaching an old scaffold new tricks: Monobodies constructed using alternative surfaces of the FN3 scaffold, J. Mol. Biol. 415, 393-405. PubMed

    Krauthammer, M., Kong, Y., Ha, B. H., Evans, P., Bacchiocchi, A., McCusker, J. P., Cheng, E., Davis, M. J., Goh, G., Choi, M., Ariyan, S., Narayan, D., Dutton-Regester, K., Capatana, A., Holman, E. C., Bosenberg, M., Sznol, M., Kluger, H. M., Brash, D. E., Stern, D. F., Materin, M. A., Lo, R. S., Mane, S., Ma, S., Kidd, K. K., Hayward, N. K., Lifton, R. P., Schlessinger, J., Boggon, T. J., and Halaban, R. (2012) Exome sequencing identifies recurrent somatic RAC1 mutations in melanoma, Nat. Genet. 44, 1006-1014. PubMed

    Krishnamurthy, H., and Gouaux, E. (2012) X-ray structures of LeuT in substrate-free outward-open and apo inward-open states, Nature 481, 469-474. PubMed

    Kruidenier, L., Chung, C. W., Cheng, Z., Liddle, J., Che, K., Joberty, G., Bantscheff, M., Bountra, C., Bridges, A., Diallo, H., Eberhard, D., Hutchinson, S., Jones, E., Katso, R., Leveridge, M., Mander, P. K., Mosley, J., Ramirez-Molina, C., Rowland, P., Schofield, C. J., Sheppard, R. J., Smith, J. E., Swales, C., Tanner, R., Thomas, P., Tumber, A., Drewes, G., Oppermann, U., Patel, D. J., Lee, K., and Wilson, D. M. (2012) A selective jumonji H3K27 demethylase inhibitor modulates the proinflammatory macrophage response, Nature 488, 404-408. PubMed

    Kung, Y., Ando, N., Doukov, T. I., Blasiak, L. C., Bender, G., Seravalli, J., Ragsdale, S. W., and Drennan, C. L. (2012) Visualizing molecular juggling within a B12-dependent methyltransferase complex, Nature 484, 265-269. PubMed

    Kuo, A. J., Song, J., Cheung, P., Ishibe-Murakami, S., Yamazoe, S., Chen, J. K., Patel, D. J., and Gozani, O. (2012) The BAH domain of ORC1 links H4K20me2 to DNA replication licensing and Meier-Gorlin syndrome, Nature 484, 115–119. PubMed

    Laganowsky, A., Liu, C., Sawaya, M. R., Whitelegge, J. P., Park, J., Zhao, M., Pensalfini, A., Soriaga, A. B., Landau, M., Teng, P. K., Cascio, D., Glabe, C., and Eisenberg, D. (2012) Atomic view of a toxic amyloid small oligomer, Science 335, 1228-1231. PubMed

    Lai, Y. T., Cascio, D., and Yeates, T. O. (2012) Structure of a 16-nm cage designed by using protein oligomers, Science 336, 1129. PubMed

    Lai, R. Y., Huang, S., Fenwick, M. K., Hazra, A. B., Zhang, Y., Rajashankar, K. R., Philmus, B., Kinsland, C., Sanders, J. M., Ealick, S. E., and Begley, T. P. (2012) Thiamin pyrimidine biosynthesis in Candida albicans: a remarkable reaction between histidine and pyridoxal phosphate, J. Am. Chem. Soc. 134, 9157−9159. PubMed

    Lai, M. Y., Zhang, D., Laronde-Leblanc, N., and Fushman, D. (2012) Structural and biochemical studies of the open state of Lys48-linked diubiquitin, Biochim. Biophys. Acta1823, 2046-2056. PubMed

    Lau, S. Y., Procko, E., and Gaudet, R. (2012) Distinct properties of Ca2+-calmodulin binding to N- and C-terminal regulatory regions of the TRPV1 channel, J. Gen. Physiol. 140, 541-555. PubMed

    Levin, E. J., Cao, Y., Enkavi, G., Quick, M., Pan, Y., Tajkhorshid, E., and Zhou, M. (2012) Structure and permeation mechanism of a mammalian urea transporter, Proc. Natl. Acad. Sci. U. S. A. 109, 11194–11199. PubMed

    Li, H., Pink, M. D., Murphy, J. G., Stein, A., Dell'acqua, M. L., and Hogan, P. G. (2012) Balanced interactions of calcineurin with AKAP79 regulate Ca2+-calcineurin-NFAT signaling, Nat. Struct. Mol. Biol. 19, 337-345. PubMed

    Li, J., Malakhova, M., Mottamal, M., Reddy, K., Kurinov, I., Carper, A., Langfald, A., Oi, N., Kim, M. O., Zhu, F., Sosa, C. P., Zhou, K., Bode, A. M., and Dong, Z. (2012) Norathyriol suppresses skin cancers induced by solar ultraviolet radiation by targeting ERK kinases, Cancer Res.72, 260-270. PubMed

    Li, X., Zhang, R., Draheim, K. M., Liu, W., Calderwood, D. A., and Boggon, T. J. (2012) Structural basis for the small G-protein-effector interaction of Ras-related protein 1 (Rap1) and the adaptor protein Krev interaction trapped 1 (KRIT1), J. Biol. Chem. 287, 22317–22327. PubMed

    Liu, C., Zhao, M., Jiang, L., Cheng, P. N., Park, J., Sawaya, M. R., Pensalfini, A., Gou, D., Berk, A. J., Glabe, C. G., Nowick, J., and Eisenberg, D. (2012) Out-of-register β-sheets suggest a pathway to toxic amyloid aggregates, Proc. Natl. Acad. Sci. U. S. A. 109, 20913–20918. PubMed

    Logsdon, N. J., Allen, C. E., Rajashankar, K. R., and Walter, M. R. (2012) Purification, crystallization and preliminary X-ray diffraction analysis of the IL-20-IL-20R1-IL-20R2 complex, Acta Crystallogr. F 68, 89-92. PubMed

    Logsdon, N. J., Deshpande, A., Harris, B. D., Rajashankar, K. R., and Walter, M. R. (2012) Structural basis for receptor sharing and activation by interleukin-20 receptor-2 (IL-20R2) binding cytokines, Proc. Natl. Acad. Sci. U. S. A. 109, 12704-12709. PubMed

    Luo, D., Kohlway, A., Vela, A., and Pyle, A. M. (2012) Visualizing the Determinants of Viral RNA Recognition by Innate Immune Sensor RIG-I, Structure 20, 1983-1988. PubMed

    Luo, M., Arentson, B. W., Srivastava, D., Becker, D. F., and Tanner, J. J. (2012) Crystal Structures and Kinetics of Monofunctional Proline Dehydrogenase Provide Insight into Substrate Recognition and Conformational Changes Associated With Flavin Reduction and Product Release, Biochemistry 51, 10099−10108. PubMed

    Mandal, K., Pentelute, B. L., Bang, D., Gates, Z. P., Torbeev, V. Y., and Kent, S. B. (2011) Design, Total Chemical Synthesis, and X-Ray Structure of a Protein Having a Novel Linear-Loop Polypeptide Chain Topology, Angew. Chem. Int. Ed. Engl. 51, 1481-1486. PubMed

    Mandal, K., Uppalapati, M., Ault-Riche, D., Kenney, J., Lowitz, J., Sidhu, S. S., and Kent, S. B. (2012) Chemical synthesis and X-ray structure of a heterochiral {D-protein antagonist plus vascular endothelial growth factor} protein complex by racemic crystallography, Proc. Natl. Acad. Sci. U. S. A. 109, 14779-14784. PubMed

    Marcia, M., and Pyle, A. M. (2012) Visualizing Group II Intron Catalysis through the Stages of Splicing, Cell 151, 497-507. PubMed

    Martin, R., Gupta, K., Ninan, N. S., Perry, K., and Van Duyne, G. D. (2012) The Survival Motor Neuron Protein Forms Soluble Glycine Zipper Oligomers, Structure. 20, 1929–1939. PubMed

    Meisner, J., Maehigashi, T., Andre, I., Dunham, C. M., and Moran, C. P., Jr. (2012) Structure of the basal components of a bacterial transporter, Proc. Natl. Acad. Sci. U.S. A.109, 5446–5451. PubMed

    Min, A. B., Miallau, L., Sawaya, M. R., Habel, J., Cascio, D., and Eisenberg, D. (2012) The crystal structure of the Rv0301-Rv0300 VapBC-3 toxin-antitoxin complex from M. tuberculosis reveals a Mg2+ ion in the active site and a putative RNA-binding site, Protein Sci. 21, 1754-1767. PubMed

    Morris, W., Volosskiy, B., Demir, S., Gándara, F., McGrier, P. L., Furukawa, H., Cascio, D., Stoddart, J. F., and Yaghi, O. M. (2012) Synthesis, structure, and metalation of two new highly porous zirconium metal-organic frameworks, Inorg. Chem. 51, 6443-6445. PubMed

    Nakanishi, K., Weinberg, D. E., Bartel, D. P., and Patel, D. J. (2012) Structure of yeast Argonaute with guide RNA, Nature 486, 368-374. PubMed

    Nam, K. H., Haitjema, C., Liu, X., Ding, F., Wang, H., DeLisa, M. P., and Ke, A. Cas5d Protein Processes Pre-crRNA and Assembles into a Cascade-like Interference Complex in Subtype I-C/Dvulg CRISPR-Cas System, Structure 20, 1574–1584. PubMed

    Ogunjimi, A. A., Zeqiraj, E., Ceccarelli, D., Sicheri, F., Wrana, J. L., and David, L. (2012) Structural basis for specificity of TGFb family receptor small molecule inhibitors, Cell. Signalling 24, 476-483. PubMed

    Osmundson, J., Montero-Diez, C., Westblade, L. F., Hochschild, A., and Darst, S. A. (2012) Promoter-Specific Transcription Inhibition in Staphylococcus aureus by a Phage Protein, Cell 151, 1005-1016. PubMed

    Padayatti, P., Palczewska, G., Sun, W., Palczewski, K., and Salom, D. (2012) Imaging of protein crystals with two-photon microscopy, Biochemistry 51, 1625-1637. PubMed

    Pakotiprapha, D., Samuels, M., Shen, K., Hu, J. H., and Jeruzalmi, D. (2012) Structure and mechanism of the UvrA-UvrB DNA damage sensor, Nat. Struct. Mol. Biol. 19, 292-298. PubMed

    Pemberton, T. A., Still, B. R., Christensen, E. M., Singh, H., Srivastava, D., and Tanner, J. J. (2012) Proline: Mother Nature's cryoprotectant applied to protein crystallography, Acta Crystallogr. D 68, 1010-1018. PubMed

    Peng, G., Xu, L., Lin, Y. L., Chen, L., Pasquarella, J. R., Holmes, K. V., and Li, F. (2012) Crystal structure of bovine coronavirus spike protein lectin domain, J. Biol. Chem. 287, 41931–41938. PubMed

    Piscitelli, C. L., and Gouaux, E. (2012) Insights into transport mechanism from LeuT engineered to transport tryptophan, EMBO J. 31, 228-235. PubMed

    Polikanov, Y. S., Blaha, G. M., and Steitz, T. A. (2012) How hibernation factors RMF, HPF, and YfiA turn off protein synthesis, Science 336, 915-91. PubMed

    Pos, W., Sethi, D. K., Call, M., Schulze, M.-S., Anders, A.-K., Pyrdol, J., and Wucherpfennig, K. (2012) Crystal Structure of the HLA-DM-HLA-DR1 Complex Defines Mechanisms for Rapid Peptide Selection, Cell 151, 1557-1568. PubMed

    Pruitt, R. N., Chumbler, N. M., Rutherford, S. A., Farrow, M. A., Friedman, D. B., Spiller, B., and Lacy, D. B. (2012) Structural determinants of the Clostridium difficile toxin A glucosyltransferase activity, J. Biol. Chem. 287, 8013-8020. PubMed

    Qi, Y., Nam, K., Spong, M. C., Banerjee, A., Sung, R.-J., Zhang, M., Karplus, M., and Verdine, G. L. (2012) Strandwise translocation of a DNA glycosylase on undamaged DNA, Proc. Natl. Acad. Sci. U. S. A. 109, 1086-1091. PubMed

    Raghuraman, H., Cordero-Morales, J. F., Jogini, V., Pan, A. C., Kollewe, A., Roux, B., and Perozo, E. (2012) Mechanism of Cd2+ Coordination during Slow Inactivation in Potassium Channels, Structure 20, 1332–1342. PubMed.

    Ren, A., Rajashankar, K. R., and Patel, D. J. (2012) Fluoride ion encapsulation by Mg2+ ions and phosphates in a fluoride riboswitch, Nature 486, 85-89. PubMed

    Rivera-Colón, Y., Schutsky, E. K., Kita, A. Z., and Garman, S. C. The structure of human GALNS reveals the molecular basis for mucopolysaccharidosis IV A, J. Mol. Biol. 423, 736-751. PubMed

    Schirle, N. T., and Macrae, I. J. (2012) The Crystal Structure of Human Argonaute2, Science 336, 1037-1040. PubMed

    Schmitzberger, F., and Harrison, S. C. (2012) RWD domain: a recurring module in kinetochore architecture shown by a Ctf19-Mcm21 complex structure, EMBO Rep. 13, 216-22. PubMed

    Schurpf, T., Chen, Q., Liu, J. H., Wang, R., Springer, T. A., and Wang, J. H. (2012) The RGD finger of Del-1 is a unique structural feature critical for integrin binding, FASEB J. 26, 3412-3420. PubMed

    Sheng, Y., Butler Gralla, E., Schumacher, M., Cascio, D., Cabelli, D. E., and Selverstone Valentine, J. (2012) Six-coordinate manganese(3+) in catalysis by yeast manganese superoxide dismutase, Proc. Natl. Acad. Sci. U. S. A. 109, 14314–14319. PubMed

    Shi, K., Kurahashi, K., Gao, R., Tsutakawa, S. E., Tainer, J. A., Pommier, Y., and Aihara, H. (2012) Structural basis for recognition of 5'-phosphotyrosine adducts by Tdp2, Nat. Struct. Mol. Biol. 19, 1372-1377. PubMed

    Singh, M., Wang, Z., Koo, B. K., Patel, A., Cascio, D., Collins, K., and Feigon, J. (2012) Structural Basis for Telomerase RNA Recognition and RNP Assembly by the Holoenzyme La Family Protein p65, Mol. Cell. 47, 16-26. PubMed

    Song, J., Teplova, M., Ishibe-Murakami, S., and Patel, D. J. (2012) Structure-based mechanistic insights into DNMT1-mediated maintenance DNA methylation, Science 335, 709-712. PubMed

    Sosa, B. A., Rothballer, A., Kutay, U., and Schwartz, T. U. (2012) LINC Complexes Form by Binding of Three KASH Peptides to Domain Interfaces of Trimeric SUN Proteins, Cell 149, 1035-1047. PubMed

    Sotomayor, M., Weihofen, W. A., Gaudet, R., and Corey, D. P. (2012) Structure of a force-conveying cadherin bond essential for inner-ear mechanotransduction, Nature 492, 128-132.. PubMed

    Srivastava, D., Singh, R. K., Moxley, M. A., Henzl, M. T., Becker, D. F., and Tanner, J. J. (2012) The Three-Dimensional Structural Basis of Type II Hyperprolinemia, J. Mol. Biol .420, 176-189. PubMed

    Stokes-Rees, I., Levesque, I., Murphy, F. V. t., Yang, W., Deacon, A., and Sliz, P. (2012) Adapting federated cyberinfrastructure for shared data collection facilities in structural biology, J. Synchrotron Radiat. 19, 462-467. PubMed

    Su, C. C., Long, F., Lei, H. T., Bolla, J. R., Do, S. V., Rajashankar, K. R., and Yu, E. W. (2012) Charged Amino Acids (R83, E567, D617, E625, R669, and K678) of CusA Are Required for Metal Ion Transport in the Cus Efflux System, J. Mol. Biol. 422, 429–441. PubMed

    Sung, R. J., Zhang, M., Qi, Y., and Verdine, G. L. (2012) Sequence-Dependent Structural Variation in DNA Undergoing Intrahelical Inspection by MutM, J. Biol. Chem. 287, 18044-18054. PubMed

    Teng, P. K., Anderson, N. J., Goldschmidt, L., Sawaya, M. R., Sambashivan, S., and Eisenberg, D. (2012) Ribonuclease A suggests how proteins self-chaperone against amyloid fiber formation, Protein Sci. 21, 26-37. PubMed

    Tu, D., Graziano, B. R., Park, E., Zheng, W., Li, Y., Goode, B. L., and Eck, M. J. (2012) Structure of the formin-interaction domain of the actin nucleation-promoting factor Bud6, Proc. Natl. Acad. Sci. U. S. A. 109, E3424–E3433. PubMed

    Tu, X., and Palczewski, K. Crystal structure of the globular domain of C1QTNF5: Implications for late-onset retinal macular degeneration, J. Struct. Biol. 180, 439–446. PubMed

    Vendeix, F. A., Murphy, F. V. t., Cantara, W. A., Leszczynska, G., Gustilo, E. M., Sproat, B., Malkiewicz, A., and Agris, P. F. (2012) Human tRNA(Lys3)(UUU) Is Pre-Structured by Natural Modifications for Cognate and Wobble Codon Binding through Keto-Enol Tautomerism, J. Mol. Biol. 416, 467-485 PubMed

    Wang, C., Chung, B. C., Yan, H., Lee, S. Y., and Pitt, G. S. (2012) Crystal Structure of the Ternary Complex of a NaV C-Terminal Domain, a Fibroblast Growth Factor Homologous Factor, and Calmodulin, Structure 20, 1167-1176. PubMed

    Wang, H., Elferich, J., and Gouaux, E. (2012) Structures of LeuT in bicelles define conformation and substrate binding in a membrane-like context, Nat. Struct. Mol. Biol. 19, 212-219. PubMed

    Wang, H., and Gouaux, E. (2012) Substrate binds in the S1 site of the F253A mutant of LeuT, a neurotransmitter sodium symporter homologue, EMBO Rep.13, 861-866. PubMed

    Windsor, M. A., Hermanson, D. J., Kingsley, P. J., Xu, S., Crews, B. C., Ho, W., Keenan, C. M., Banerjee, S., Sharkey, K. A., and Marnett, L. J. (2012) Substrate-Selective Inhibition of Cyclooxygenase-2: Development and Evaluation of Achiral Profen Probes, ACS Med. Chem. Lett. 3, 759–763. PubMed

    Wu, K., Peng, G., Wilken, M., Geraghty, R. J., and Li, F. (2012) Mechanisms of host receptor adaptation by SARS coronavirus, J. Biol. Chem. 287, 8904-8911. PubMed

    Xia, S., Beckman, J., Wang, J., and Konigsberg, W. H. (2012) Using a Fluorescent Cytosine Analogue tC° To Probe the Effect of the Y567 to Ala Substitution on the Preinsertion Steps of dNMP Incorporation by RB69 DNA Polymerase, Biochemistry 51, 4609−4617. PubMed

    Xia, S., Christian, T. D., Wang, J., and Konigsberg, W. H. (2012) Probing Minor Groove Hydrogen Bonding Interactions between RB69 DNA Polymerase and DNA, Biochemistry 51, 4343-4353. PubMed

    Xia, S., Eom, S. H., Konigsberg, W. H., and Wang, J. (2012) Bidendate and tridendate metal-ion coordination states within ternary complexes of RB69 DNA polymerase, Protein Sci. 2, 447-451. PubMed

    Xia, S., Eom, S. H., Konigsberg, W. H., and Wang, J. (2012) Structural Basis for Differential Insertion Kinetics of dNMPs Opposite a Difluorotoluene Nucleotide Residue, Biochemistry 51, 1476-1485. PubMed

    Xia, S., Vashishtha, A. K., Bulkley, D., Eom, S. H., Wang, J., and Konigsberg, W. H. (2012) Contribution of Partial Charge Interactions and Base-Stacking to the Efficiency of Primer-Extension at and beyond Abasic Sites in DNA, Biochemistry 51, 4922–4931. PubMed

    Xu, K., Chan, Y. P., Rajashankar, K. R., Khetawat, D., Yan, L., Kolev, M. V., Broder, C. C., and Nikolov, D. B. (2012) New insights into the hendra virus attachment and entry process from structures of the virus g glycoprotein and its complex with ephrin-β2, PLoS One 7, e48742. PubMed

    Yang, H., Ji, X., Zhao, G., Ning, J., Zhao, Q., Aiken, C., Gronenborn, A. M., Zhang, P., and Xiong, Y. (2012) Structural insight into HIV-1 capsid recognition by rhesus TRIMα5, Proc. Natl. Acad. Sci. U. S. A.109, 18372–18377. PubMed

    Yi, C., Chen, B., Qi, B., Zhang, W., Jia, G., Zhang, L., Li, C. J., Dinner, A. R., Yang, C. G., and He, C. (2012) Duplex interrogation by a direct DNA repair protein in search of base damage, Nat. Struct. Mol. Biol. 19, 671-676. PubMed

    Yuan, P., Paterson, R. G., Leser, G. P., Lamb, R. A., and Jardetzky, T. S. (2012) Structure of the ulster strain newcastle disease virus hemagglutinin-neuraminidase reveals auto-inhibitory interactions associated with low virulence, PLoS Pathog. 8, e1002855. PubMed

    Zhang, L., Lu, X., Lu, J., Liang, H., Dai, Q., Xu, G. L., Luo, C., Jiang, H., and He, C. (2012) Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA, Nat. Chem. Biol. 8, 328-330. PubMed

    Zimanyi, C. M., Ando, N., Brignole, E. J., Asturias, F. J., Stubbe, J., and Drennan, C. L. (2012) Tangled Up in Knots: Structures of Inactivated Forms of E. coli Class Ia Ribonucleotide Reductase, Structure 20, 1374–1383. P PubMed

    Zong, Y., Zhang, B., Gu, S., Lee, K., Zhou, J., Yao, G., Figueiredo, D., Perry, K., Mei, L., and Jin, R. (2012) Structural basis of agrin-LRP4-MuSK signaling, Genes Dev. 26, 247-258. PubMed

    2011

    Agarkar, V. B., Babayeva, N. D., Pavlov, Y. I., and Tahirov, T. H. (2011) Crystal structure of the C-terminal domain of human DNA primase large subunit: Implications for the mechanism of the primase - polymerase alpha switch, Cell Cycle 10, 926-931. PubMed

    Armache, K. J., Garlick, J. D., Canzio, D., Narlikar, G. J., and Kingston, R. E. (2011) Structural basis of silencing: Sir3 BAH domain in complex with a nucleosome at 3.0 Å resolution, Science 334, 977-982. PubMed

    Brzezinski, K., Brzuszkiewicz, A., Dauter, M., Kubicki, M., Jaskolski, M., and Dauter, Z. (2011) High regularity of Z-DNA revealed by ultra high-resolution crystal structure at 0.55 Å, Nucleic Acids Res. 39, 6238-6248. PubMed

    Brzezinski, K., Dauter, Z., Baj, A., Walejko, P., and Witkowski, S. (2011) rac-6-Hy-droxy-2,5,7,8-tetra-methyl-chroman-2-carboxamide from synchrotron data, Acta Crystallogr. E 67, o503-504. PubMed

    Brzezinski, K., Walejko, P., Baj, A., Witkowski, S., and Dauter, Z. (2011) 2,2,5,7,8-Penta-methyl-chroman-6-yl 2,3,4,6-tetra-O-acetyl-α-D-glucopyran-oside from synchrotron data, Acta Crystallogr. E 67, o718. PubMed

    Butler, E. B., Xiong, Y., Wang, J., and Strobel, S. A. (2011) Structural basis of cooperative ligand binding by the glycine riboswitch, Chem. Biol. 18, 293-298. PubMed

    Calabrese, M. F., Scott, D. C., Duda, D. M., Grace, C. R., Kurinov, I., Kriwacki, R. W., and Schulman, B. A. (2011) A RING E3-substrate complex poised for ubiquitin-like protein transfer: structural insights into cullin-RING ligases, Nat. Struct. Mol. Biol. 14, 947-949. PubMed

    Callahan, S. J., Morgan, R. D., Jain, R., Townson, S. A., Wilson, G. G., Roberts, R. J., and Aggarwal, A. K. (2011) Crystallization and preliminary crystallographic analysis of the type IIL restriction enzyme MmeI in complex with DNA, Acta Crystallogr. F 67, 1262-1265. PubMed

    Cao, Y., Jin, X., Levin, E. J., Huang, H., Zong, Y., Quick, M., Weng, J., Pan, Y., Love, J., Punta, M., Rost, B., Hendrickson, W. A., Javitch, J. A., Rajashankar, K. R., and Zhou, M. (2011) Crystal structure of a phosphorylation-coupled saccharide transporter, Nature 473, 50-54. PubMed

    Cao, Y., Jin, X., Huang, H., Derebe, M. G., Levin, E. J., Kabaleeswaran, V., Pan, Y., Punta, M., Love, J., Weng, J., Quick, M., Ye, S., Kloss, B., Bruni, R., Martinez-Hackert, E., Hendrickson, W. A., Rost, B., Javitch, J. A., Rajashankar, K. R., Jiang, Y., and Zhou, M. (2011) Crystal structure of a potassium ion transporter, TrkH, Nature 471, 336-340. PubMed

    Ceccarelli, D. F., Tang, X., Pelletier, B., Orlicky, S., Xie, W., Plantevin, V., Neculai, D., Chou, Y. C., Ogunjimi, A., Al-Hakim, A., Varelas, X., Koszela, J., Wasney, G. A., Vedadi, M., Dhe-Paganon, S., Cox, S., Xu, S., Lopez-Girona, A., Mercurio, F., Wrana, J., Durocher, D., Meloche, S., Webb, D. R., Tyers, M., and Sicheri, F. (2011) An allosteric inhibitor of the human cdc34 ubiquitin-conjugating enzyme, Cell 145, 1075-1087. PubMed

    Chang, Y., Horton, J. R., Bedford, M. T., Zhang, X., and Cheng, X. (2011) Structural insights for MPP8 chromodomain interaction with histone H3 lysine 9, potential effect of phosphorylation on methyl-lysine binding, J. Mol. Biol. 408, 807-814. PubMed

    Chang, Y., Sun, L., Kokura, K., Horton, J. R., Fukuda, M., Espejo, A., Izumi, V., Koomen, J. M., Bedford, M. T., Zhang, X., Shinkai, Y., Fang, J., and Cheng, X. (2011) MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a, Nat. Commun. 2, 533. PubMed

    Chaptal, V., Kwon, S., Sawaya, M. R., Guan, L., Kaback, H. R., and Abramson, J. (2011) Crystal structure of lactose permease in complex with an affinity inactivator yields unique insight into sugar recognition, Proc. Natl. Acad. Sci. U. S. A. 108, 9361-9366. PubMed

    Chinai, J. M., Taylor, A. B., Ryno, L. M., Hargreaves, N. D., Morris, C. A., Hart, P. J., and Urbach, A. R. (2011) Molecular Recognition of Insulin by a Synthetic Receptor, J. Am. Chem. Soc. 133, 8810-8813. PubMed

    Cho, U. S., and Harrison, S. C. (2011) Recognition of the centromere-specific histone Cse4 by the chaperone Scm3, Proc. Natl. Acad. Sci. U. S. A. 108, 9367-9371. PubMed

    Choi, M., Sukumar, N., Mathews, F. S., Liu, A., and Davidson, V. L. (2011) Proline 96 of the Copper Ligand Loop of Amicyanin Regulates Electron Transfer from Methylamine Dehydrogenase by Positioning Other Residues at the Protein-Protein Interface, Biochemistry 50, 1265-1273. PubMed

    Chou, C. Y., and Tong, L. (2011) Structural and biochemical studies on the regulation of biotin carboxylase by substrate inhibition and dimerization, J. Biol. Chem. 286, 24417-24425. PubMed

    Cole, K. E., Gattis, S. G., Angell, H. D., Fierke, C. A., and Christianson, D. W. (2011) Structure of the Metal-Dependent Deacetylase LpxC from Yersinia enterocolitica Complexed with the Potent Inhibitor CHIR-090, Biochemistry 50, 258-265. PubMed

    Colletier, J. P., Laganowsky, A., Landau, M., Zhao, M., Soriaga, A. B., Goldschmidt, L., Flot, D., Cascio, D., Sawaya, M. R., and Eisenberg, D. (2011) Molecular basis for amyloid-β polymorphism, Proc. Natl. Acad. Sci. U. S. A. 108, 16938–16943. PubMed

    Di Paolo, J. A., Huang, T., Balazs, M., Barbosa, J., Barck, K. H., Bravo, B. J., Carano, R. A., Darrow, J., Davies, D. R., DeForge, L. E., Diehl, L., Ferrando, R., Gallion, S. L., Giannetti, A. M., Gribling, P., Hurez, V., Hymowitz, S. G., Jones, R., Kropf, J. E., Lee, W. P., Maciejewski, P. M., Mitchell, S. A., Rong, H., Staker, B. L., Whitney, J. A., Yeh, S., Young, W. B., Yu, C., Zhang, J., Reif, K., and Currie, K. S. (2011) Specific Btk inhibition suppresses B cell- and myeloid cell-mediated arthritis, Nat. Chem. Biol. 7, 41-50. PubMed

    Ding, F., Lu, C., Zhao, W., Rajashankar, K. R., Anderson, D. L., Jardine, P. J., Grimes, S., and Ke, A. (2011) Structure and assembly of the essential RNA ring component of a viral DNA packaging motor, Proc. Natl. Acad. Sci. U. S. A. 108, 7357-7362. PubMed

    Duggan, K. C., Hermanson, D. J., Musee, J., Prusakiewicz, J. J., Scheib, J. L., Carter, B. D., Banerjee, S., Oates, J. A., and Marnett, L. J. (2011) (R)-Profens are substrate-selective inhibitors of endocannabinoid oxygenation by COX-2, Nat. Chem. Biol. 7, 803-809. PubMed

    Dunkle, J. A., Wang, L., Feldman, M. B., Pulk, A., Chen, V. B., Kapral, G. J., Noeske, J., Richardson, J. S., Blanchard, S. C., and Cate, J. H. (2011) Structures of the bacterial ribosome in classical and hybrid states of tRNA binding, Science 332, 981-984. PubMed

    Fairman, J. W., Wijerathna, S. R., Ahmad, M. F., Xu, H., Nakano, R., Jha, S., Prendergast, J., Welin, R. M., Flodin, S., Roos, A., Nordlund, P., Li, Z., Walz, T., and Dealwis, C. G. (2011) Structural basis for allosteric regulation of human ribonucleotide reductase by nucleotide-induced oligomerization, Nat. Struct. Mol. Biol. 18, 316-322. PubMed

    Feklistov, A., and Darst, S. A. (2011) Structural Basis for Promoter -10 Element Recognition by the Bacterial RNA Polymerase σ Subunit, Cell 147, 1257-1269. PubMed

    Fenwick, M. K., Philmus, B., Begley, T. P., and Ealick, S. E. (2011) Toxoflavin Lyase Requires a Novel 1-His-2-Carboxylate Facial Triad, Biochemistry 50, 1091-1100. PubMed

    Fernandes, H., Franklin, E., and Khan, A. R. (2011) Crystallization of an engineered RUN domain of Rab6-interacting protein 1/DENND5, Acta Cryst. F 67, 556-560. PubMed

    Forse, G. J., Ram, N., Banatao, D. R., Cascio, D., Sawaya, M. R., Klock, H. E., Lesley, S. A., and Yeates, T. O. (2011) Synthetic symmetrization in the crystallization and structure determination of CelA from Thermotoga maritima, Protein Sci. 20, 168-178. PubMed

    French, J. B., Begley, T. P., and ealick, S. E. (2011) Structure of trifunctional THI20 from yeast, Acta Cryst. D 67, 784-791. PubMed

    French, J. B., and Ealick, S. E. (2011) Structural and kinetic insights into the mechanism of 5-hydroxyisourate hydrolase from Klebsiella pneumoniae, Acta Crystallogr. D 67, 671-677. PubMed

    French, J. B., Neau, D. B., and Ealick, S. E. (2011) Characterization of the Structure and Function of Klebsiella pneumoniae Allantoin Racemase, J. Mol. Biol. 410, 447-460. PubMed

    French, J. B., Yates, P. A., Soysa, D. R., Boitz, J. M., Carter, N. S., Chang, B., Ullman, B., and Ealick, S. E. (2011) The Leishmania donovani UMP synthase is essential for promastigote viability and has an unusual tetrameric structure that exhibits substrate-controlled oligomerization, J. Biol. Chem. 286, 20930-20941. PubMed

    Germane, K. L., and Spiller, B. W. (2011) Structural and functional studies indicate that the EPEC effector, EspG, directly binds p21 activated kinase, Biochemistry 50, 917-919. PubMed

    Ghosh, A., Shuman, S., and Lima, C. D. (2011) Structural Insights to How Mammalian Capping Enzyme Reads the CTD Code, Mol.Cell 43, 299–310. PubMed

    Gilbert, N. C., Bartlett, S. G., Waight, M. T., Neau, D. B., Boeglin, W. E., Brash, A. R., and Newcomer, M. E. (2011) The structure of human 5-lipoxygenase, Science 331, 217-219. PubMed

    Grebien, F., Hantschel, O., Wojcik, J., Kaupe, I., Kovacic, B., Wyrzucki, A. M., Gish, G. D., Cerny-Reiterer, S., Koide, A., Beug, H., Pawson, T., Valent, P., Koide, S., and Superti-Furga, G. (2011) Targeting the SH2-Kinase Interface in Bcr-Abl Inhibits Leukemogenesis, Cell 147, 306-319. PubMed

    Guettler, S., LaRose, J., Petsalaki, E., Gish, G., Scotter, A., Pawson, T., Rottapel, R., and Sicheri, F. (2011) Structural Basis and Sequence Rules for Substrate Recognition by Tankyrase Explain the Basis for Cherubism Disease, Cell 147, 1340-1354. PubMed

    Hamill, M. J., Jost, M., Wong, C., Elliott, S. J., and Drennan, C. L. (2011) Flavin-induced oligomerization in Escherichia coli adaptive response protein AidB, Biochemistry 50, 10159−10169. PubMed

    Hausmann, J., Kamtekar, S., Christodoulou, E., Day, J. E., Wu, T., Fulkerson, Z., Albers, H. M., van Meeteren, L. A., Houben, A. J., van Zeijl, L., Jansen, S., Andries, M., Hall, T., Pegg, L. E., Benson, T. E., Kasiem, M., Harlos, K., Kooi, C. W., Smyth, S. S., Ovaa, H., Bollen, M., Morris, A. J., Moolenaar, W. H., and Perrakis, A. (2011) Structural basis of substrate discrimination and integrin binding by autotaxin, Nat. Struct. Mol. Biol. 18, 198-204. PubMed

    Hibbs, R. E., and Gouaux, E. (2011) Principles of activation and permeation in an anion-selective Cys-loop receptor, Nature 474, 54-60. PubMed

    Horton, J. R., Upadhyay, A. K., Hashimoto, H., Zhang, X., and Cheng, X. (2011) Structural Basis for Human PHF2 Jumonji Domain Interaction with Metal Ions, J. Mol. Biol. 406, 1-8. PubMed

    Hu, J., Xue, Y., Lee, S., and Ha, Y. (2011) The crystal structure of GXGD membrane protease FlaK, Nature 475, 528-531. PubMed

    Huang, L., Ishibe-Murakami, S., Patel, D. J., and Serganov, A. (2011) Long-range pseudoknot interactions dictate the regulatory response in the tetrahydrofolate riboswitch, Proc. Natl. Acad. Sci. U. S. A. 108, 14801-14806. PubMed

    Ilies, M., Di Costanzo, L., Dowling, D. P., Thorn, K. J., and Christianson, D. W. (2011) Binding of α,α-Disubstituted Amino Acids to Arginase Suggests New Avenues for Inhibitor Design, J. Med. Chem. 54, 5432-5443. PubMed

    Iwase, S., Xiang, B., Ghosh, S., Ren, T., Lewis, P. W., Cochrane, J. C., Allis, C. D., Picketts, D. J., Patel, D. J., Li, H., and Shi, Y. (2011) ATRX ADD domain links an atypical histone methylation recognition mechanism to human mental-retardation syndrome, Nat. Struct. Mol. Biol. 18, 769-776. PubMed

    Januszyk, K., Liu, Q., and Lima, C. D. (2011) Activities of human RRP6 and structure of the human RRP6 catalytic domain, RNA 17, 1566-1577. PubMed

    Joo, W., Xu, G., Persky, N. S., Smogorzewska, A., Rudge, D. G., Buzovetsky, O., Elledge, S. J., and Pavletich, N. P. (2011) Structure of the FANCI-FANCD2 complex: insights into the Fanconi anemia DNA repair pathway, Science 333, 312-316. PubMed

    Khare, B., Krishnan, V., Rajashankar, K. R., I-Hsiu, H., Xin, M., Ton-That, H., and Narayana, S. V. (2011) Structural Differences between the Streptococcus agalactiae Housekeeping and Pilus-Specific Sortases: SrtA and SrtC1, PLoS One 6, e22995. PubMed

    Kim, S., Grant, R. A., and Sauer, R. (2011) Covalent Linkage of Distinct Substrate Degrons Controls Assembly and Disassembly of DegP Proteolytic Cages, Cell 145, 67-78. PubMed

    Kirouac, K. N., and Ling, H. (2011) Unique active site promotes error-free replication opposite an 8-oxo-guanine lesion by human DNA polymerase iota, Proc. Natl. Acad. Sci. U. S. A. 108, 3210-3215. PubMed

    Koksal, M., Hu, H., Coates, R. M., Peters, R. J., and Christianson, D. W. (2011) Structure and mechanism of the diterpene cyclase ent-copalyl diphosphate synthase, Nat. Chem. Biol. 7, 431–433. PubMed

    Kucera, K., Harrison, L. M., Cappello, M., and Modis, Y. (2011) Ancylostoma ceylanicum Excretory-Secretory Protein 2 Adopts a Netrin-Like Fold and Defines a Novel Family of Nematode Proteins, J. Mol. Biol. 408, 9-17. PubMed

    Kümmel, D., Krishnakumar, S. S., Radoff, D. T., Li, F., Giraudo, C. G., Pincet, F., Rothman, J. E., and Reinisch, K. M. (2011) Complexin cross-links prefusion SNAREs into a zigzag array, Nat. Struct. Mol. Biol. 18, 927-933. PubMed

    Laganowsky, A., Zhao, M., Soriaga, A. B., Sawaya, M. R., Cascio, D., and Yeates, T. O. (2011) An approach to crystallizing proteins by metal-mediated synthetic symmetrization, Protein Sci. 20, 1876-1890. PubMed

    Landau, M., Sawaya, M. R., Faull, K. F., Laganowsky, A., Jiang, L., Sievers, S. A., Liu, J., Barrio, J. R., and Eisenberg, D. (2011) Towards a Pharmacophore for Amyloid, PLoS Biol 9, e1001080. PubMed

    Larson, M. R., Rajashankar, K. R., Crowley, P. J., Kelly, C., Mitchell, T. J., Brady, L. J., and Deivanayagam, C. (2011) Crystal structure of the C-terminus of Streptococcus mutans antigen I/II and characterization of salivary agglutinin adherence domains, J. Biol. Chem. (286, 21657-21666. PubMed

    Lazarus, M. B., Nam, Y., Jiang, J., Sliz, P., and Walker, S. (2011) Structure of human O-GlcNAc transferase and its complex with a peptide substrate, Nature 469, 564-567. PubMed

    Lei, H. T., Shen, Z., Surana, P., Routh, M. D., Su, C. C., Zhang, Q., and Yu, E. W. (2011) Crystal structures of CmeR-bile acid complexes from Campylobacter jejuni, Protein Sci. 20, 712-723. PubMed

    LeNoue-Newton, M., Watkins, G. R., Zhou, P., Germane, K. L., McCorvey, L. R., Wadzinski, B. E., and Spiller, B. W. (2011) The E3 ubiquitin ligase and protein phosphatase 2A (PP2A) binding domains of Alpha4 are both required for Alpha4 to inhibit PP2A degradation, J. Biol. Chem. 286, 17665-17671. PubMed

    Liu, C., Sawaya, M. R., Cheng, P. N., Zheng, J., Nowick, J. S., and Eisenberg, D. (2011) Characteristics of Amyloid-Related Oligomers Revealed by Crystal Structures of Macrocyclic β-Sheet Mimics, J. Am. Chem. Soc.133, 6736-6744. PubMed

    Liu, C., Sawaya, M. R., and Eisenberg, D. (2011) β2-microglobulin forms three-dimensional domain-swapped amyloid fibrils with disulfide linkages, Nat. Struct. Mol. Biol. 18, 49-55. PubMed

    Lombardi, P. M., Angell, H. D., Whittington, D. A., Flynn, E. F., Rajashankar, K. R., and Christianson, D. W. (2011) Structure of Prokaryotic Polyamine Deacetylase Reveals Evolutionary Functional Relationships with Eukaryotic Histone Deacetylases, Biochemistry 50, 1808-1817. PubMed

    Luo, D., Ding, S. C., Vela, A., Kohlway, A., Lindenbach, B. D., and Pyle, A. M. (2011) Structural Insights into RNA Recognition by RIG-I, Cell 147, 409-422. PubMed

    Mandal, K., and Kent, S. B. (2011) Total Chemical Synthesis of Biologically Active Vascular Endothelial Growth Factor, Angew. Chem. Int. Ed. Engl. 50, 8029-8033. PubMed

    Mehra-Chaudhary, R., Mick, J., Tanner, J. J., Henzl, M. T., and Beamer, L. J. (2011) Crystal structure of a bacterial phosphoglucomutase, an enzyme involved in the virulence of multiple human pathogens, Proteins 79, 1215-1229. PubMed

    Mishra, A., Devarajan, B., Reardon, M. E., Dwivedi, P., Krishnan, V., Cisar, J. O., Das, A., Narayana, S. V., and Ton-That, H. (2011) Two Autonomous Structural Modules in the Fimbrial Shaft Adhesin FimA Mediate Actinomyces Interactions with Streptococci and Host Cells during Oral Biofilm Development, Mol. Microbiol. 81, 1205–1220. PubMed

    Nam, K. H., Kurinov, I., and Ke, A. (2011) Crystal Structure of Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-associated Csn2 Protein Revealed Ca2+-dependent Double-stranded DNA-binding Activity, J. Biol. Chem. 286, 30759-30768. PubMed

    Nam, Y., Chen, C., Gregory, R. I., Chou, J. J., and Sliz, P. (2011) Molecular Basis for Interaction of let-7 MicroRNAs with Lin28, Cell 147, 1080–1091. PubMed

    Nelersa, C. M., Schmier, B. J., and Malhotra, A. (2011) Purification and crystallization of Bacillus subtilis NrnA, a novel enzyme involved in nanoRNA degradation, Acta Crystallogr. F 67, 1235-1238. PubMed

    Ni, S., McGookey, M. E., Tinch, S. L., Jones, A. N., Jayaraman, S., Tong, L., and Kennedy, M. A. (2011) The 1.7 Å resolution structure of At2g44920, a pentapeptide-repeat protein in the thylakoid lumen of Arabidopsis thaliana, Acta Crystallogr. F 67, 1480-1484. PubMed

    Peng, G., Sun, D., Rajashankar, K. R., Qian, Z., Holmes, K. V., and Li, F. (2011) Crystal structure of mouse coronavirus receptor-binding domain complexed with its murine receptor, Proc. Natl. Acad. Sci. U. S. A. 108, 10696-10701. PubMed

    Pickens, L. B., Sawaya, M. R., Rasool, H., Pashkov, I., Yeates, T. O., and Tang, Y. (2011) Structural and biochemical characterizations of the salicylyl-acyltranferase SSFX3 from a tetracycline biosynthetic pathway, J. Biol. Chem. 286, 41539–41551. PubMed

    Rajakumara, E., Law, J. A., Simanshu, D. K., Voigt, P., Johnson, L. M., Reinberg, D., Patel, D. J., and Jacobsen, S. E. (2011) A dual flip-out mechanism for 5mC recognition by the Arabidopsis SUVH5 SRA domain and its impact on DNA methylation and H3K9 dimethylation in vivo, Genes Dev. 25, 137-152. PubMed

    Rajakumara, E., Wang, Z., Ma, H., Hu, L., Chen, H., Lin, Y., Guo, R., Wu, F., Li, H., Lan, F., Shi, Y. G., Xu, Y., Patel, D. J., and Shi, Y. (2011) PHD Finger Recognition of Unmodified Histone H3R2 Links UHRF1 to Regulation of Euchromatic Gene Expression, Mol. Cell 43, 275-284. PubMed

    Rechkoblit, O., Delaney, J. C., Essigmann, J. M., and Patel, D. J. (2011) Implications for Damage Recognition during Dpo4-Mediated Mutagenic Bypass of m1G and m3C Lesions, Structure 19, 821-832. PubMed

    Reha-Krantz, L. J., Hariharan, C., Subuddhi, U., Xia, S., Zhao, C., Beckman, J., Christian, T. D., and Konigsberg, W. H. (2011) Structure of the 2-Aminopurine-Cytosine Base Pair Formed in the Polymerase Active Site of the RB69 Y567A-DNA Polymerase, Biochemistry 50, 10136-10149. PubMed

    Ruthenburg, A. J., Li, H., Milne, T. A., Dewell, S., McGinty, R. K., Yuen, M., Ueberheide, B., Dou, Y., Muir, T. W., Patel, D. J., and Allis, C. D. (2011) Recognition of a Mononucleosomal Histone Modification Pattern by BPTF via Multivalent Interactions, Cell 145, 692-706. PubMed

    Scott, D. C., Monda, J. K., Bennett, E. J., Harper, J. W., and Schulman, B. A. (2011) N-Terminal Acetylation Acts as an Avidity Enhancer Within an Interconnected Multiprotein Complex, Science 334, 674-678. PubMed

    Seckute, J., McCloskey, D. E., Thomas, J. H., Secrist III, J. A., Pegg, A. E., and Ealick, S. E. (2011) Binding and Inhibition of Human Spermidine Synthase by Decarboxylated S-adenosylhomocysteine. Protein Sci. 20,1836-1844. PubMed

    Seo, M., Kim, J. D., Neau, D., Sehgal, I., and Lee, Y. H. (2011) Structure-Based Development of Small Molecule PFKFB3 Inhibitors: A Framework for Potential Cancer Therapeutic Agents Targeting the Warburg Effect, PLoS One 6, e24179. PubMed

    Shechner, D. M., and Bartel, D. P. (2011) The structural basis of RNA-catalyzed RNA polymerization, Nat. Struct. Mol. Biol. 18, 1036-1042. PubMed

    Semavina, M., Saha, N., Kolev, M. V., Goldgur, Y., Giger, R. J., Himanen, J. P., and Nikolov, D. (2011) Crystal structure of the Nogo-receptor-2, Protein Sci. 20, 684 - 689. PubMed

    Sievers, S. A., Karanicolas, J., Chang, H. W., Zhao, A., Jiang, L., Zirafi, O., Stevens, J. T., Munch, J., Baker, D., and Eisenberg, D. (2011) Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation, Nature 475, 96-100. PubMed

    Singh, H., Reilly, T. J., and Tanner, J. J. (2011) Structural Basis of the Inhibition of Class C Acid Phosphatases by Adenosine 5'-phosphorothioate, FEBS J. 278, 4374-4381. PubMed

    Solmaz, S. R., Chauhan, R., Blobel, G., and Melcak, I. (2011) Molecular Architecture of the Transport Channel of the Nuclear Pore Complex, Cell 147, 590-602. PubMed

    Song, W. J., Gucinski, G., Sazinsky, M. H., and Lippard, S. J. (2011) Tracking a defined route for O2 migration in a dioxygen-activating diiron enzyme, Proc. Natl. Acad. Sci. U. S. A. 108, 14795-14800. PubMed

    Song, J., Rechkoblit, O., Bestor, T. H., and Patel, D. J. (2011) Structure of DNMT1-DNA Complex Reveals a Role for Autoinhibition in Maintenance DNA Methylation, Science 331, 1036-1040. PubMed

    Stafford, R. L., Hinde, E., Knight, M. J., Pennella, M. A., Ear, J., Digman, M. A., Gratton, E., and Bowie, J. U. (2011) Tandem SAM Domain Structure of Human Caskin1: A Presynaptic, Self-Assembling Scaffold for CASK, Structure 19, 1826-1836. PubMed

    Stafford, R. L., Tang, M. Y., Sawaya, M. R., Phillips, M. L., and Bowie, J. U. (2011) Crystal structure of the central coiled-coil domain from human liprin-β2, Biochemistry 50, 3807-3815. PubMed

    Su, C. C., Long, F., and Yu, E. W. (2011) The Cus efflux system removes toxic ions via a methionine shuttle, Protein Sci. 20, 6-18. PubMed

    Su, C.-C., Long, F., Zimmermann, M. T., Rajashankar, K. R., Jernigan, R. L., and Yu, E. W. (2011) Crystal structure of the CusBA heavy-metal efflux complex of Escherichia coli, Nature 470, 558-562. PubMed

    Sukumar, N., Choi, M., and Davidson, V. L. Replacement of the axial copper ligand methionine with lysine in amicyanin converts it to a zinc-binding protein that no longer binds copper, J. Inorg. Biochem. 105, 1638-1644. PubMed

    Taherbhoy, A. M., Tait, S. W., Kaiser, S. E., Williams, A. H., Deng, A., Nourse, A., Hammel, M., Kurinov, I., Rock, C. O., Green, D. R., and Schulman, B. A. (2011) Atg8 transfer from Atg7 to Atg3: a distinctive E1-E2 architecture and mechanism in the autophagy pathway, Mol. Cell 44, 451-461. PubMed

    Thomas, S. R., Keller, C. A., Szyk, A., Cannon, J. R., and Laronde-Leblanc, N. A. (2011) Structural insight into the functional mechanism of Nep1/Emg1 N1-specific pseudouridine methyltransferase in ribosome biogenesis, Nucleic Acids Res. 39, 2445-2457. PubMed

    Tian, Y., Simanshu, D. K., Ma, J. B., and Patel, D. J. (2011) Inaugural Article: Structural basis for piRNA 2'-O-methylated 3'-end recognition by Piwi PAZ (Piwi/Argonaute/Zwille) domains, Proc. Natl. Acad. Sci. U. S. A.108, 903-910. PubMed

    Tian, Y., Simanshu, D. K., Ascano, M., Diaz-Avalos, R., Park, A. Y., Juranek, S. A., Rice, W. J., Yin, Q., Robinson, C. V., Tuschl, T., and Patel, D. J. (2011) Multimeric assembly and biochemical characterization of the Trax-translin endonuclease complex, Nat. Struct. Mol. Biol. 18, 658-664. PubMed

    Torbeev, V. Y., Raghuraman, H., Hamelberg, D., Tonelli, M., Westler, W. M., Perozo, E., and Kent, S. B. (2011) Protein conformational dynamics in the mechanism of HIV-1 protease catalysis, Proc. Natl. Acad. Sci. U. S. A. 108, 20982-20987. PubMed

    Tran, T. H., Christoffersen, S., Allan, P. W., Parker, W. B., Piskur, J., Serra, I., Terreni, M., and Ealick, S. E. (2011) The Crystal Structure of Streptococcus pyogenes Uridine Phosphorylase Reveals a Distinct Subfamily of Nucleoside Phosphorylases, Biochemistry 50, 6549–6558. PubMed

    Tu, D., Li, Y., Song, H. K., Toms, A. V., Gould, C. J., Ficarro, S. B., Marto, J. A., Goode, B. L., and Eck, M. J. (2011) Crystal Structure of a Coiled-Coil Domain from Human ROCK I, PLoS One 6, e18080. PubMed

    Uysal, S., Cuello, L. G., Cortes, D. M., Koide, S., Kossiakoff, A. A., and Perozo, E. (2011) Mechanism of activation gating in the full-length KcsA K+ channel, Proc. Natl. Acad. Sci. U. S. A. 108, 11896-11899. PubMed

    Vaidya, A. T., Chen, C. H., Dunlap, J. C., Loros, J. J., and Crane, B. R. (2011) Structure of a Light-Activated LOV Protein Dimer That Regulates Transcription, Sci. Signal 4, ra50. PubMed

    Vizcarra, C. L., Kreutz, B., Rodal, A. A., Toms, A. V., Lu, J., Zheng, W., Quinlan, M. E., and Eck, M. J. (2011) Structure and function of the interacting domains of Spire and Fmn-family formins, Proc. Natl. Acad. Sci. U. S. A. 108, 11884–11889. PubMed

    Wan, Q., Ahmad, m., Fairman, J., Gorzelle, B., de la Fuente, M., Dealwis, C., and Maguire, M. (2011) X-Ray Crystallography and Isothermal Titration Calorimetry Studies of the Salmonella Zinc Transporter ZntB, Structure 19, 700-710. PubMed

    Wang, M., Xia, S., Blaha, G., Steitz, T. A., Konigsberg, W. H., and Wang, J. (2011) Insights into Base Selectivity from the 1.8 Å Resolution Structure of an RB69 DNA Polymerase Ternary Complex, Biochemistry 50, 581-590. PubMed

    Weinberg, D. E., Nakanishi, K., Patel, D. J., and Bartel, D. P. (2011) The inside-out mechanism of dicers from budding yeasts, Cell 146, 262-276. PubMed

    Whittle, J. R., Zhang, R., Khurana, S., King, L. R., Manischewitz, J., Golding, H., Dormitzer, P. R., Haynes, B. F., Walter, E. B., Moody, M. A., Kepler, T. B., Liao, H. X., and Harrison, S. C. (2011) Broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza virus hemagglutinin, Proc. Natl. Acad. Sci. U. S. A. 108, 14216–14221. PubMed

    Whorton, M. R., and MacKinnon, R. (2011) Crystal Structure of the Mammalian GIRK2 K+ Channel and Gating Regulation by G Proteins, PIP2, and Sodium, Cell 147, 199-208. PubMed

    Witkowski, W. A., and Hardy, J. A. (2011) A designed redox-controlled caspase, Protein Sci. 20, 1421-1431. PubMed

    Wu, H., Zeng, H., Lam, R., Tempel, W., Amaya, M. F., Xu, C., Dombrovski, L., Qiu, W., Wang, Y., and Min, J. (2011) Structural and histone binding ability characterizations of human PWWP domains, PloS One 6, e18919. PubMed

    Xi, Q., Wang, Z., Zaromytidou, A. I., Zhang, X. H., Chow-Tsang, L. F., Liu, J. X., Kim, H., Barlas, A., Manova-Todorova, K., Kaartinen, V., Studer, L., Mark, W., Patel, D. J., and Massague, J. (2011) A Poised Chromatin Platform for TGF-β Access to Master Regulators, Cell 147, 1511-1524. PubMed

    Xia, S., Konigsberg, W. H., and Wang, J. (2011) Hydrogen-Bonding Capability of a Templating Difluorotoluene Nucleotide Residue in an RB69 DNA Polymerase Ternary Complex, J. Am.Chem. Soc. 133, 10003-1000. PubMed

    Xia, S., Wang, M., Blaha, G., Konigsberg, W. H., and Wang, J. (2011) Structural Insights into Complete Metal Ion Coordination from Ternary Complexes of B Family RB69 DNA Polymerase, Biochemistry 50, 9114-9124. PubMed

    Xia, S., Wang, M., Lee, H. R., Sinha, A., Blaha, G., Christian, T., Wang, J., and Konigsberg, W. (2011) Variation in Mutation Rates Caused by RB69pol Fidelity Mutants Can Be Rationalized on the Basis of Their Kinetic Behavior and Crystal Structures, J. Mol. Biol. 406, 558-570. PubMed

    Xu, G., Lo, Y.-C., Li, Q., Napolitano, G., Wu, X., Jiang, X., Dreano, M., Karin, M., and Wu, H. (2011) Crystal structure of inhibitor of κB kinase β, Nature 472, 325-330. PubMed

    Yun, D., Dey, M., Higgins, L. J., Yan, F., Liu, H. W., and Drennan, C. L. (2011) Structural Basis of Regiospecificity of a Mononuclear Iron Enzyme in Antibiotic Fosfomycin Biosynthesis, J. Am. Chem. Soc.133, 11262-11269. PubMed

    Zhan, C., Patskovsky, Y., Yan, Q., Li, Z., Ramagopal, U., Cheng, H., Brenowitz, M., Hui, X., Nathenson, S. G., and Almo, S. C. (2011) Decoy Strategies: The Structure of TL1A:DcR3 Complex, Structure 19, 162-171. PubMed

    Zhan, X., Gimenez, L. E., Gurevich, V. V., and Spiller, B. W. (2011) Crystal structure of arrestin-3 reveals the basis of the difference in receptor binding between two non-visual subtypes, J. Mol. Biol. 406, 467-478. PubMed

    Zhao, M., Cascio, D., Sawaya, M. R., and Eisenberg, D. (2011) Structures of segments of α-synuclein fused to maltose-binding protein suggest intermediate states during amyloid formation, Protein Sci. 20, 996-1004. PubMed

    Zhou, B., Chen, Q., Mallis, R., Zhang, H., Liu, J.-h., Reinherz, E. L., and Wang, J.-H. (2011) A conserved hydrophobic patch on Vβ domains revealed by TCRβ chain crystal structures: implications for pre-TCR dimerization.Front. Immunol. 2, 5. PubMed

    Beamline: 24-ID-E

    Zoltowski, B. D., Vaidya, A. T., Top, D., Widom, J., Young, M. W., and Crane, B. R. (2011) Structure of full-length Drosophila cryptochrome, Nature 480, 396-399. PubMed

    2010

    Aaron, J. A., Lin, X., Cane, D. E., and Christianson, D. W. (2010) Structure of Epi-Isozizaene Synthase from Streptomyces coelicolor A3(2), a Platform for New Terpenoid Cyclization Templates, Biochemistry 49, 1787-1797. PubMed

    Abraham, J., Corbett, K. D., Farzan, M., Choe, H., and Harrison, S. C. (2010) Structural basis for receptor recognition by New World hemorrhagic fever arenaviruses, Nat. Struct. Mol. Biol. 17, 438-444. PubMed

    Agarkar, V. B., Babayeva, N. D., Wilder, P. J., Rizzino, A., and Tahirov, T. H. (2010) Crystal Structure of Mouse Elf3 C-terminal DNA-binding Domain in Complex with Type II TGF-β Receptor Promoter DNA, J. Mol. Biol. 397, 278-289. PubMed

    Airola, M. V., Watts, K. J., Bilwes, A. M., and Crane, B. R. (2010) Structure of Concatenated HAMP Domains Provides a Mechanism for Signal Transduction, Structure 18, 436-448. PubMed

    Apostol, M. I., Sawaya, M. R., Cascio, D., and Eisenberg, D. (2010) Crystallographic studies of prion protein (PrP) segments suggest how structural changes encoded by polymorphism at residue 129 modulate susceptibility to human prion disease, J. Biol. Chem. 285, 29671-29675. PubMed

    Arbing, M. A., Handelman, S. K., Kuzin, A. P., Verdon, G., Wang, C., Su, M., Rothenbacher, F. P., Abashidze, M., Liu, M., Hurley, J. M., Xiao, R., Acton, T., Inouye, M., Montelione, G. T., Woychik, N. A., and Hunt, J. F. (2010) Crystal Structures of Phd-Doc, HigA, and YeeU Establish Multiple Evolutionary Links between Microbial Growth-Regulating Toxin-Antitoxin Systems, Structure 18, 996-1010. PubMed

    Arbing, M. A., Kaufmann, M., Phan, T., Chan, S., Cascio, D., and Eisenberg, D. (2010) The crystal structure of the Mycobacterium tuberculosis Rv3019c-Rv3020c ESX complex reveals a domain-swapped heterotetramer, Protein Sci. 19, 1692-1703. PubMed

    Arnett, K. L., Hass, M., McArthur, D. G., Ilagan, M. X., Aster, J. C., Kopan, R., and Blacklow, S. C. (2010) Structural and mechanistic insights into cooperative assembly of dimeric Notch transcription complexes, Nat. Struct. Mol. Biol. 17, 1312-1317. PubMed

    Artavanis-Tsakonas, K., Weihofen, W. A., Antos, J. M., Coleman, B. I., Comeaux, C. A., Duraisingh, M. T., Gaudet, R., and Ploegh, H. L. (2010) Characterization and structural studies of the Plasmodium falciparum ubiquitin and Nedd8 hydrolase UCHL3. J. Biol. Chem. 285, 6857-6866. PubMed

    Babayeva, N. D., Wilder, P. J., Shiina, M., Mino, K., Desler, M., Ogata, K., Rizzino, A., and Tahirov, T. H. (2010) Structural basis of Ets1 cooperative binding to palindromic sequences on stromelysin-1 promoter DNA, Cell Cycle 9, 3054-3062. PubMed

    Bacik, J. P., Walker, J. R., Ali, M., Schimmer, A. D., and Dhe-Paganon, S. (2010) Crystal structure of the human ubiquitin-activating enzyme 5 (UBA5) bound to ATP: mechanistic insights into a minimalistic E1 enzyme, J. Biol. Chem. 285, 20273-20280. PubMed

    Bale S, Baba K, McCloskey DE, and Ealick SE. (2010) Complexes of Thermotoga maritima S-Adenosylmethionine Decarboxylase Provide Insights into Substrate Specificity. Acta Crystallogr. D 66, 181-189. PubMed.

    Bale, S., Rajashankar, K. R., Perry, K., Begley, T. P., and Ealick, S. E. (2010) HMP Binding Protein ThiY and HMP-P Synthase THI5 are Structural Homologues, Biochemistry 49, 8929-8936. PubMed

    Banigan, J. R., Mandal, K., Sawaya, M. R., Thammavongsa, V., Hendrickx, A. P., Schneewind, O., Yeates, T. O., and Kent, S. B. (2010) Determination of the X-ray structure of the snake venom protein omwaprin by total chemical synthesis and racemic protein crystallography,Protein Sci. 19, 1840-1849. PubMed

    Bick, M. J., Banik, J. J., Darst, S. A., and Brady, S. F. (2010) Crystal Structures of the Glycopeptide Sulfotransferase Teg12 Complexed with the Teicoplanin Aglycone, Biochemistry 49, 4159-4168. PubMed

    Bowman, B. R., Lee, S., Wang, S., and Verdine, G. L. (2010) Structure of Escherichia coli AlkA in complex with undamaged DNA, J. Biol. Chem. 285, 35783-35791. PubMed

    Bryk, R., Arango, N., Venugopal, A., Warren, J. D., Park, Y. H., Patel, M. S., Lima, C. D., and Nathan, C. (2010) Triazaspirodimethoxybenzoyls as Selective Inhibitors of Mycobacterial Lipoamide Dehydrogenase, Biochemistry 49, 1616-1627. PubMed

    Bulkley, D., Innis, C. A., Blaha, G., and Steitz, T. A. (2010) Revisiting the structures of several antibiotics bound to the bacterial ribosome, Proc. Natl. Acad. Sci. U. S. A. 107, 17158-17163. PubMed

    Chen, Z., Pelc, L. A., and Di Cera, E. (2010) Crystal structure of prethrombin-1, Proc. Natl. Acad. Sci. U. S. A. 107, 19278-19283. PubMed

    Chowdary, T. K., Cairns, T. M., Atanasiu, D., Cohen, G. H., Eisenberg, R. J., and Heldwein, E. E. (2010) Crystal structure of the conserved herpesvirus fusion regulator complex gH-gL, Nat. Struct. Mol. Biol. 17, 882-888. PubMed

    Corbett, K. D., and Berger, J. M. (2010) Structure of the ATP-binding domain of Plasmodium falciparum Hsp90, Proteins 78, 2738-2744. PubMed

    Corbett, K. D., Yip, C. K., Ee, L. S., Walz, T., Amon, A., and Harrison, S. C. (2010) The Monopolin Complex Crosslinks Kinetochore Components to Regulate Chromosome-Microtubule Attachments, Cell 142, 556-567. PubMed

    Cotner-Gohara, E., Kim, I.-K., Hammel, M., Tainer, J. A., Tomkinson, A. E., and Ellenberger, T. (2010) Human DNA Ligase III Recognizes DNA Ends by Dynamic Switching Between Two DNA Bound States, Biochemistry 49, 6165-6176. PubMed

    Crowley, C. S., Cascio, D., Sawaya, M. R., Kopstein, J. S., Bobik, T. A., and Yeates, T. O. (2010) Structural insights into the mechanisms of transport across the Salmonella enterica Pdu microcompartment shell, J. Biol. Chem. 285, 37838-37846. PubMed

    Cuello, L. G., Jogini, V., Cortes, D. M., and Perozo, E. (2010) Structural mechanism of C-type inactivation in K+ channels, Nature 466, 203-208. PubMed

    Cuello, L. G., Jogini, V., Cortes, D. M., Pan, A. C., Gagnon, D. G., Dalmas, O., Cordero-Morales, J. F., Chakrapani, S., Roux, B., and Perozo, E. (2010) Structural basis for the coupling between activation and inactivation gates in K+ channels, Nature 466, 272-275. PubMed

    Dalton, K. M., and Crosson, S. (2010) A conserved mode of protein recognition and binding in a ParD-ParE toxin-antitoxin complex, Biochemistry 49, 2205-2215. PubMed

    Day, J. E., Hall, T., Pegg, L. E., Benson, T. E., Hausmann, J., and Kamtekar, S. (2010) Crystallization and preliminary X-ray diffraction analysis of rat autotaxin, Acta Crystallogr. F 66, 1127-1129. PubMed

    Demirci, H., Murphy, F. V. IV, Belardinelli, R., Kelley, A. C., Ramakrishnan, V., Gregory, S. T., Dahlberg, A. E., and Jogl, G. (2010) Modification of 16S ribosomal RNA by the KsgA methyltransferase restructures the 30S subunit to optimize ribosome function, RNA 16, 2319-2324. PubMed

    Di Costanzo, L., Ilies, M., Thorn, K. J., and Christianson, D. W. (2010) Inhibition of Human Arginase I by Substrate and Product Analogues, Arch. Biochem. Biophys. 496, 101-108. PubMed

    Dowling, D. P., Gattis, S. G., Fierke, C. A., and Christianson, D. W. (2010) Structures of Metal-Substituted Human Histone Deacetylase 8 Provide Mechanistic Inferences on Biological Function, Biochemistry 49, 5048–5056. PubMed

    Dowling, D. P., Ilies, M., Olszewski, K. L., Portugal, S., Mota, M. M., Llinas, M., and Christianson, D. W. (2010) Crystal Structure of Arginase from Plasmodium falciparum and Implications for L-Arginine Depletion in Malarial Infection, Biochemistry 49, 5600-5608. PubMed

    Dutta, S., Gulla, S., Chen, T. S., Fire, E., Grant, R. A., and Keating, A. E. (2010) Determinants of BH3 binding specificity for Mcl-1 vs. Bcl-xL. J. Mol. Biol. 398, 747-762. PubMed

    Feng, L., Campbell, E. B., Hsiung, Y., and MacKinnon, R. (2010) Structure of a Eukaryotic CLC Transporter Defines an Intermediate State in the Transport Cycle, Science 330, 635-641. PubMed

    Fire, E., Gulla, S. V., Grant, R. A., and Keating, A. E. (2010) Mcl-1-Bim complexes accommodate surprising point mutations via minor structural changes, Protein Sci. 19, 507-519. PubMed

    Freeman, M. M., Seaman, M. S., Rits-Volloch, S., Hong, X., Kao, C. Y., Ho, D. D., and Chen, B. (2010) Crystal structure of HIV-1 primary receptor CD4 in complex with a potent antiviral antibody, Structure 18, 1632-1641. PubMed

    French JB, Cen Y, Sauve AA, and Ealick SE. High Resolution Crystal Structures of Streptococcus pneumoniae Nicotinamidase with Trapped Intermediates Provide Insights into Catalytic Mechanism and Inhibition by Aldehydes. Biochemistry 49, 8803-8812. PubMed

    French, J. B., and Ealick, S. E. (2010) Biochemical and Structural Characterization of a Ureidoglycine Aminotransferase in the Klebsiella pneumoniae Ureide Catabolic Pathway, Biochemistry 49, 5975-5977. PubMed

    French, J. B., and Ealick, S. E. (2010) Structural and Mechanistic Studies on Klebsiella pneumoniae 2-Oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline Decarboxylase, J. Biol. Chem. 285, 35446-35454. PubMed

    Frey, G., Chen, J., Rits-Volloch, S., Freeman, M. M., Zolla-Pazner, S., and Chen, B. (2010) Distinct conformational states of HIV-1 gp41 are recognized by neutralizing and non-neutralizing antibodies, Nat. Struct. Mol. Biol. 17, 1486-1491. PubMed

    Fuse, S., Tsukamoto, H., Yuan, Y., Wang, T. S., Zhang, Y., Bolla, M., Walker, S., Sliz, P., and Kahne, D. (2010) Functional and Structural Analysis of a Key Region of the Cell Wall Inhibitor Moenomycin, ACS Chem. Biol. 5, 701-711. PubMed

    Guan, R., Han, D., Harrison, S. C., and Kirchhausen, T. (2010) Structure of the PTEN-like Region of Auxilin, a Detector of Clathrin-Coated Vesicle Budding, Structure 18, 1191-1198. PubMed

    Hamill, S., Wolin, S. L., and Reinisch, K. M. (2010) Structure and function of the polymerase core of TRAMP, a RNA surveillance complex, Proc. Natl. Acad. Sci. U. S. A. 107, 15045-15050. PubMed

    Himanen, J. P., Yermekbayeva, L., Janes, P. W., Walker, J. R., Xu, K., Atapattu, L., Rajashankar, K. R., Mensinga, A., Lackmann, M., Nikolov, D. B., and Dhe-Paganon, S. (2010) Architecture of Eph receptor clusters, Proc. Natl. Acad. Sci. U. S. A. 107, 10860-10865. PubMed

    Hung, K. W., Chang, Y. W., Eng, E. T., Chen, J. H., Chen, Y. C., Sun, Y. J., Hsiao, C. D., Dong, G., Spasov, K. A., Unger, V. M., and Huang, T. H. (2010) Structural fold, conservation and Fe(II) binding of the intracellular domain of prokaryote FeoB, J. Struct. Biol. 170, 501-512. PubMed

    Kenoth, R., Simanshu, D. K., Kamlekar, R. K., Pike, H. M., Molotkovsky, J. G., Benson, L. M., Bergen, H. R., 3rd, Prendergast, F. G., Malinina, L., Venyaminov, S. Y., Patel, D. J., and Brown, R. E. (2010) Structural determination and tryptophan fluorescence of heterokaryon incompatibility C2 protein (HET-C2), a fungal glycolipid transfer protein (GLTP), provide novel insights into glycolipid specificity and membrane interaction by the GLTP fold, J. Biol. Chem. 285, 13066-13078. PubMed

    Khare, B., Samal, A., Vengadesan, K., Rajashankar, K. R., Ma, X., Huang, I. H., Ton-That, H., and Narayana, S. V. (2010) Preliminary crystallographic study of the Streptococcus agalactiae sortases, sortase A and sortase C1, Acta Crystallogr. F 66, 1096-1100. PubMed

    King, N. P., Jacobitz, A. W., Sawaya, M. R., Goldschmidt, L., and Yeates, T. O. (2010) Structure and folding of a designed knotted protein, Proc. Natl. Acad. Sci. U. S. A. 107, 20732-20737. PubMed

    Kovalevsky, A. Y., Fisher, S. Z., Seaver, S., Mustyakimov, M., Sukumar, N., Langan, P., Mueser, T. C., and Hanson, B. L. (2010) Preliminary neutron and X-ray crystallographic studies of equine cyanomethemoglobin, Acta Crystallogr. F 66, 474-477. PubMed

    Kucera, K., Koblansky, A. A., Saunders, L. P., Frederick, K. B., De La Cruz, E. M., Ghosh, S., and Modis, Y. Structure-Based Analysis of Toxoplasma gondii Profilin: A Parasite-Specific Motif is Required for Recognition by Toll-like Receptor 11, J. Mol. Biol. 403, 616-629. PubMed

    Laganowsky, A., Benesch, J. L., Landau, M., Ding, L., Sawaya, M. R., Cascio, D., Huang, Q., Robinson, C. V., Horwitz, J., and Eisenberg, D. (2010) Crystal structures of truncated alphaA and alphaB crystallins reveal structural mechanisms of polydispersity important for eye lens function, Protein Sci. 19, 1031-1043. PubMed

    Laganowsky, A., and Eisenberg, D. (2010) Non-3D domain swapped crystal structure of truncated zebrafish alphaA crystallin, Protein Sci. 19, 1978-1984. PubMed

    Larson, M. R., Rajashankar, K. R., Patel, M. H., Robinette, R. A., Crowley, P. J., Michalek, S., Brady, L. J., and Deivanayagam, C. (2010) Elongated fibrillar structure of a streptococcal adhesin assembled by the high-affinity association of α- and PPII-helices, Proc. Natl. Acad. Sci. U. S. A. 107, 5983-5988. PubMed

    Lee, C., and Goldberg, J. (2010) Structure of Coatomer Cage Proteins and the Relationship among COPI, COPII, and Clathrin Vesicle Coats, Cell. 142, 123-132. PubMed

    Li, W., Schulman, S., Dutton, R. J., Boyd, D., Beckwith, J., and Rapoport, T. A. (2010) Structure of a bacterial homologue of vitamin K epoxide reductase, Nature 463, 507-512. PubMed

    Lin, S. C., Lo, Y. C., and Wu, H. (2010) Helical assembly in the MyD88-IRAK4-IRAK2 complex in TLR/IL-1R signalling, Nature 465, 885-890. PubMed

    Long, F., Su, C.-C., Zimmermann, M. T., Boyken, S. E., Rajashankar, K. R., Jernigan, R. L., and Yu, E. W. (2010) Crystal structures of the CusA efflux pump suggest methionine-mediated metal transport, Nature 467, 484-488. PubMed

    Macpherson, I. S., Kirubakaran, S., Gorla, S. K., Riera, T. V., D'Aquino, J. A., Zhang, M., Cuny, G. D., and Hedstrom, L. (2010) The structural basis of Cryptosporidium-specific IMP dehydrogenase inhibitor selectivity, J. Am. Chem. Soc. 132, 1230-1231. PubMed

    Makde, R. D., England, J. R., Yennawar, H. P., and Tan, S. (2010) Structure of RCC1 chromatin factor bound to the nucleosome core particle, Nature 467, 562-566. PubMed

    Malakhova, M., D'Angelo, I., Kim, H. G., Kurinov, I., Bode, A. M., and Dong, Z. (2010) The crystal structure of the active form of the C-terminal kinase domain of mitogen-and stress-activated protein kinase 1. J. Mol. Biol. 399, 41-52. PubMed

    Mao, Y., Xu, X., Xu, W., Ishida, Y., Leal, W. S., Ames, J. B., and Clardy, J. (2010) Crystal and solution structures of an odorant-binding protein from the southern house mosquito complexed with an oviposition pheromone, Proc. Natl. Acad. Sci. U. S. A. 107, 19102-19107. PubMed

    Matsuura, H., Kirschner, A. N., Longnecker, R., and Jardetzky, T. S. (2010) Crystal structure of the Epstein-Barr virus (EBV) glycoprotein H/glycoprotein L (gH/gL) complex, Proc. Natl. Acad. Sci. U. S. A. 107, 22641-22646. PubMed

    McCulloch KM, Mukherjee T, Begley TP, and Ealick SE. (2010) Structure Determination and Characterization of the Vitamin B6 Degradative Enzyme (E)-2-(Acetamidomethylene)Succinate Hydrolase. Biochemistry 49, 1226-1235. PubMed.

    Mehboob, S., Mulhearn, D. C., Truong, K., Johnson, M. E., and Santarsiero, B. D. (2010) Structure of dihydroorotase from Bacillus anthracis at 2.6 Å resolution, Acta Crystallogr. F 66, 1432-1435. PubMed

    Mehboob, S., Song, Y., Witek, M., Long, F., Santarsiero, B. D., Johnson, M. E., and Fung, L. W. (2010) Crystal structure of the non-erythroid α-spectrin tetramerization site reveals differences between erythroid and non-erythroid spectrin tetramer formation, J. Biol. Chem. 285, 14572-14584. PubMed

    Mueser, T. C., Griffith, W. P., Kovalevsky, A. Y., Guo, J., Seaver, S., Langan, P., and Hanson, B. L. (2010) Hemoglobin redux: combining neutron and X-ray diffraction with mass spectrometry to analyse the quaternary state of oxidized hemoglobins, Acta Crystallogr. D 66, 1249-1256. PubMed

    Mukherjee, T., Zhang, Y., Abdelwahed, S., Ealick, S. E., and Begley, T. P. (2010) Catalysis of a Flavoenzyme-Mediated Amide Hydrolysis, J. Am. Chem. Soc. 132, 1550-1551. PubMed

    Obiero, J., Pittet, V., Bonderoff, S. A., and Sanders, D. A. (2010) The Thioredoxin System from Deinococcus radiodurans, J. Bacteriol. 192, 494-501. PubMed

    Olsen, S. K., Capili, A. D., Lu, X., Tan, D. S., and Lima, C. D. (2010) Active site remodelling accompanies thioester bond formation in the SUMO E1, Nature 463, 906-912. PubMed

    Pandya, R. K., Partridge, J. R., Love, K. R., Schwartz, T. U., and Ploegh, H. L. (2010) A Structural Element within the HUWE1 HECT Domain Modulates Self-ubiquitination and Substrate Ubiquitination Activities, J. Biol. Chem. 285, 5664-5673. PubMed

    Paul, D., Chatterjee, A., Begley, T. P., and Ealick, S. E. (2010) Domain Organization in Candida glabrata THI6, a Bifunctional Enzyme Required for Thiamin Biosynthesis in Eukaryotes, Biochemistry 49, 9922-9934. PubMed

    Paul, D., O'Leary, S. E., Rajashankar, K., Bu, W., Toms, A., Settembre, E. C., Sanders, J. M., Begley, T. P., and Ealick, S. E. (2010) Glycal Formation in Crystals of Uridine Phosphorylase.  Biochemistry 49, 3499-3509. PubMed

    Rechkoblit, O., Kolbanovskiy, A., Malinina, L., Geacintov, N. E., Broyde, S., and Patel, D. J. (2010) Mechanism of error-free and semitargeted mutagenic bypass of an aromatic amine lesion by Y-family polymerase Dpo4, Nat. Struct. Mol. Biol. 17, 379-388. PubMed

    Reinke, A. W., Grant, R. A., and Keating, A. E. (2010) A Synthetic Coiled-Coil Interactome Provides Heterospecific Modules for Molecular Engineering, J. Am. Chem. Soc. 132, 6025-6031. PubMed

    Rosen, M. D., Venkatesan, H., Peltier, H. M., Bembenek, S. D., Kanelakis, K. C., Zhao, L. X., Leonard, B. E., Hocutt, F. M., Wu, X., Palomino, H. L., Brondstetter, T. I., Haugh, P. V., Cagnon, L., Yan, W., Liotta, L. A., Young, A., Mirzadegan, T., Shankley, N. P., Barrett, T. D., and Rabinowitz, M. H. (2010) Benzimidazole-2-pyrazole HIF Prolyl 4-Hydroxylase Inhibitors as Oral Erythropoietin Secretagogues, ACS Med. Chem. Lett. 1, 526-529. URL

    Samai, P., Smith, P., and Shuman, S. (2010) Structure of a CRISPR-associated protein Cas2 from Desulfovibrio vulgaris, Acta Crystallogr. F 66, 1552-1556. PubMed

    Schoeffler, A. J., May, A. P., and Berger, J. M. (2010) A domain insertion in Escherichia coli GyrB adopts a novel fold that plays a critical role in gyrase function, Nucleic Acids Res. 38, 7830-7844. PubMed

    Schuermann, J. P., Tan, A., Tanner, J. J., and Henzl, M. T. (2010) Structure of Avian Thymic Hormone, a High-affinity Avian β-parvalbumin, in the Ca2+-free and Ca2+-bound States, J. Mol. Biol. 397, 991-1002. PubMed

    Scott, D. C., Monda, J. K., Grace, C. R., Duda, D. M., Kriwacki, R. W., Kurz, T., and Schulman, B. A. (2010) A Dual E3 mechanism for Rub1 Ligation to Cdc53, Mol Cell. 39, 784-796. PubMed

    Seetharaman, S. V., Taylor, A. B., Holloway, S., and Hart, P. J. (2010) Structures of Mouse SOD1 and Human/Mouse SOD1 Chimeras, Arch Biochem. Biophys. 503, 183-190. PubMed

    Senturia, R., Faller, M., Yin, S., Loo, J. A., Cascio, D., Sawaya, M. R., Hwang, D., Clubb, R. T., and Guo, F. (2010) Structure of the dimerization domain of DiGeorge critical region 8, Protein Sci. 19, 1354-1365. PubMed

    Silverstein, T. D., Jain, R., Johnson, R. E., Prakash, L., Prakash, S., and Aggarwal, A. K. (2010) Structural Basis for Error-free Replication of Oxidatively Damaged DNA by Yeast DNA Polymerase η, Structure 18, 1463-1470. PubMed

    Silverstein, T. D., Johnson, R. E., Jain, R., Prakash, L., Prakash, S., and Aggarwal, A. K. (2010) Structural basis for the suppression of skin cancers by DNA polymerase η, Nature 465, 1039-1043. PubMed

    Singh, H., Schuermann, J. P., Reilly, T. J., Calcutt, M. J., and Tanner, J. J. (2010) Recognition of Nucleoside Monophosphate Substrates by Haemophilus influenzae Class C Acid Phosphatase, J. Mol. Biol. 404, 639-649. PubMed

    Singla, N., Goldgur, Y., Xu, K., Paavilainen, S., Nikolov, D. B., and Himanen, J. P. (2010) Crystal Structure of the ligand-binding domain of the promiscuous EphA4 receptor reveals two distinct conformations, Biochem. Biophys. Res. Commun. 399, 555-559. PubMed

    Sohn, J., Grant, R. A., and Sauer, R. T. (2010) Allostery is an intrinsic property of the protease domain of DegS: implications for enzyme function and evolution, J. Biol. Chem. 285, 34039-34047. PubMed

    Sotomayor, M., Weihofen, W. A., Gaudet, R., and Corey, D. P. (2010) Structural Determinants of Cadherin-23 Function in Hearing and Deafness, Neuron 66, 85-100. PubMed

    Stanley, R. E., Blaha, G., Grodzicki, R. L., Strickler, M. D., and Steitz, T. A. (2010) The structures of the anti-tuberculosis antibiotics viomycin and capreomycin bound to the 70S ribosome, Nat. Struct. Mol. Biol.17, 289-293. PubMed

    Stella, S., Cascio, D., and Johnson, R. C. (2010) The shape of the DNA minor groove directs binding by the DNA-bending protein Fis, Genes Dev. 24, 814-826. PubMed

    Stewart, M. L., Fire, E., Keating, A. E., and Walensky, L. D. (2010) The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer, Nat. Chem. Biol. 6, 595-601. PubMed

    Subramanian, R., Wilson-Kubalek, E. M., Arthur, C. P., Bick, M. J., Campbell, E. A., Darst, S. A., Milligan, R. A., and Kapoor, T. M. (2010) Insights into Antiparallel Microtubule Crosslinking by PRC1, a Conserved Nonmotor Microtubule Binding Protein, Cell 142, 433-443. PubMed

    Sukumar, N., Mathews, F. S., Langan, P., and Davidson, V. L. (2010) A joint x-ray and neutron study on amicyanin reveals the role of protein dynamics in electron transfer, Proc. Natl. Acad. Sci. U. S. A. 107, 6817-6822. PubMed

    Tahirov, T. H., Babayeva, N. D., Varzavand, K., Cooper, J. J., Sedore, S. C., and Price, D. H. (2010) Crystal structure of HIV-1 Tat complexed with human P-TEFb, Nature 465, 747-751. PubMed

    Takai, H., Xie, Y., de Lange, T., and Pavletich, N. P. (2010) Tel2 structure and function in the Hsp90-dependent maturation of mTOR and ATR complexes, Genes Dev. 24, 2019-2030. PubMed

    Tanaka, S., Sawaya, M. R., and Yeates, T. O. (2010) Structure and mechanisms of a protein-based organelle in Escherichia coli, Science 327, 81-84. PubMed

    Teplova, M., Song, J., Gaw, H. Y., Teplov, A., and Patel, D. J. (2010) Structural insights into RNA recognition by the alternate-splicing regulator CUG-binding protein 1, Structure 18, 1364-1377. PubMed

    Todd, R. C., and Lippard, S. J. (2010) Consequences of cisplatin binding on nucleosome structure and dynamics, Chem. Biol. 17, 1334-1343. PubMed

    Tomasic, I. B., Metcalf, M. C., Guce, A. I., Clark, N. E., and Garman, S. C. (2010) Interconversion of the specificities of human lysosomal enzymes associated with Fabry and Schindler diseases, J. Biol. Chem. 285, 21560-21566. PubMed

    Toor, N., Keating, K. S., Fedorova, O., Rajashankar, K., Wang, J., and Pyle, A. M. (2010) Tertiary architecture of the Oceanobacillus iheyensis group II intron, RNA16, 57-69. PubMed

    Tormos, J. R., Taylor, A. B., Daubner, S. C., Hart, P. J., and Fitzpatrick, P. F. (2010) Identification of a Hypothetical Protein from Podospora anserina as a Nitroalkane Oxidase, Biochemistry 49, 5035-5041. PubMed

    Tsai, W. W., Wang, Z., Yiu, T. T., Akdemir, K. C., Xia, W., Winter, S., Tsai, C. Y., Shi, X., Schwarzer, D., Plunkett, W., Aronow, B., Gozani, O., Fischle, W., Hung, M. C., Patel, D. J., and Barton, M. C. (2010) TRIM24 links a non-canonical histone signature to breast cancer, Nature 468, 927-932. PubMed

    Vasan, N., Hutagalung, A., Novick, P., and Reinisch, K. M. (2010) Structure of a C-terminal fragment of its Vps53 subunit suggests similarity of Golgi-associated retrograde protein (GARP) complex to a family of tethering complexes, Proc. Natl. Acad. Sci. U S. A. 107, 14176-14181. PubMed

    Wang, Z., Song, J., Milne, T. A., Wang, G. G., Li, H., Allis, C. D., and Patel, D. J. (2010) Pro Isomerization in MLL1 PHD3-Bromo Cassette Connects H3K4me Readout to CyP33 and HDAC-Mediated Repression, Cell 141, 1183-1194. PubMed

    Wang, L., Yang, J. K., Kabaleeswaran, V., Rice, A. J., Cruz, A. C., Park, A. Y., Yin, Q., Damko, E., Jang, S. B., Raunser, S., Robinson, C. V., Siegel, R. M., Walz, T., and Wu, H. (2010) The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations, Nat. Struct. Mol. Biol. 17, 1324-1329. PubMed

    Westblade, L. F., Campbell, E. A., Pukhrambam, C., Padovan, J. C., Nickels, B. E., Lamour, V., and Darst, S. A. (2010) Structural basis for the bacterial transcription-repair coupling factor/RNA polymerase interaction, Nucleic Acids Res. 38, 8357–8369. PubMed

    Whittle, J. R., and Schwartz, T. U. (2010) Structure of the Sec13-Sec16 edge element, a template for assembly of the COPII vesicle coat, J. Cell. Biol. 190, 347-361. PubMed

    Wiseman, R. L., Zhang, Y., Lee, K. P. K., Harding, H. P., Haynes, C. M., Price, J., Sicheri, F., and Ron, D. (2010) Flavonol Activation Defines an Unanticipated Ligand-Binding Site in the Kinase-RNase Domain of IRE1, Mol. Cell 38, 291-304.  PubMed

    Wolfe, L. S., Calabrese, M. F., Nath, A., Blaho, D. V., Miranker, A. D., and Xiong, Y. (2010) Protein-induced photophysical changes to the amyloid indicator dye thioflavin T, Proc. Natl. Acad. Sci. U.S. A. 107, 16863–16868. PubMed

    Wong, J. H. Y., Brown, J. A., Suo, Z., Blum, P., Nohmi, T., and Ling, H. (2010) Structural insight into dynamic bypass of the major cisplatin-DNA adduct by Y-family polymerase Dpo4, EMBO J. 29, 2059-2069. PubMed

    Yang, H., Wang, J., Jia, X., McNatt, M. W., Zang, T., Pan, B., Meng, W., Wang, H. W., Bieniasz, P. D., and Xiong, Y. (2010) Structural insight into the mechanisms of enveloped virus tethering by tetherin, Proc. Natl. Acad. Sci. U S. A. 107, 18428-18432. PubMed

    Yu, A., Xing, Y., Harrison, S. C., and Kirchhausen, T. (2010) Structural Analysis of the Interaction between Dishevelled2 and Clathrin AP-2 Adaptor, A Critical Step in Noncanonical Wnt Signaling, Structure 18, 1311-1320. PubMed

    Yuan, P., Leonetti, M. D., Pico, A. R., Hsiung, Y., and MacKinnon, R. (2010) Structure of the Human BK Channel Ca2+-Activation Apparatus at 3.0 Å Resolution, Science 329, 182-186. PubMed

    Zhang, A., Jordan, J. L., Ivanova, M. I., Weiss, W. F., Roberts, C. J., and Fernandez, E. J. (2010) Molecular-level insights into thermally-induced α-chymotrypsinogen A amyloid aggregation mechanism and semi-flexible protofibril morphology, Biochemistry 49, 10553-10564. PubMed

    Zhang, Y., Zhu, X., Torelli, A. T., Lee, M., Dzikovski, B., Koralewski, R. M., Wang, E., Freed, J., Krebs, C., Ealick, S. E., and Lin, H. (2010) Diphthamide biosynthesis requires an organic radical generated by an iron-sulphur enzyme, Nature 465, 891-896. PubMed.

    2009

    Afshar, S., Sawaya, M. R., and Morrison, S. L. (2009) Structure of a mutant human purine nucleoside phosphorylase with the prodrug, 2-fluoro-2'-deoxyadenosine and the cytotoxic drug, 2-fluoroadenine, Protein Sci. 18, 1107-1114. PubMed

    Agarkar, V. B., Babyeva, N. D., Rizzino, A., and Tahirov, T. H. (2009) Preliminary crystallographic analysis of mouse Elf3 C-terminal DNA-binding domain in complex with type II TGF-β receptor promoter DNA, Acta Crystallogr. F 65, 1261-1263. PubMed

    Ameriks, M. K., Axe, F. U., Bembenek, S. D., Edwards, J. P., Gu, Y., Karlsson, L., Randal, M., Sun, S., Thurmond, R. L., and Zhu, J. (2009) Pyrazole-based cathepsin S inhibitors with arylalkynes as P1 binding elements, Bioorg. Med. Chem. Lett. 19, 6131-6134. PubMed

    Aoki, S. T., Settembre, E. C., Trask, S. D., Greenberg, H. B., Harrison, S. C., and Dormitzer, P. R. (2009) Structure of rotavirus outer-layer protein VP7 bound with a neutralizing Fab, Science 324, 1444-1447. PubMed

    Bale, S., Brooks, W., Hanes, J. W., Mahesan, A. M., Guida, W. C., and Ealick, S. E. (2009) Role of the Sulfonium Center in Determining the Ligand Specificity of Human S-Adenosylmethionine Decarboxylase, Biochemistry 48, 6423-6430. PubMed

    Baltz, J. L., Filman, D. J., Ciustea, M., Silverman, J. E., Lautenschlager, C. L., Coen, D. M., Ricciardi, R. P., and Hogle, J. M. (2009) The Crystal Structure of PF-8, the DNA Polymerase Accessory Subunit from Kaposi's Sarcoma-Associated Herpesvirus, J. Virol. 83, 12215-12228. PubMed

    Bick, M. J., Lamour, V., Rajashankar, K. R., Gordiyenko, Y., Robinson, C. V., and Darst, S. A. (2009) How to Switch Off a Histidine Kinase: Crystal Structure of Geobacillus stearothermophilus KinB with the inhibitor Sda, J. Mol. Biol. 386, 163-177. PubMed

    Blaha, G., Stanley, R. E., and Steitz, T. A. (2009) Formation of the first peptide bond: the structure of EF-P bound to the 70S ribosome, Science 325, 966-970. PubMed

    Brohawn, S. G., and Schwartz, T. U. (2009) Molecular architecture of the Nup84-Nup145C-Sec13 edge element in the nuclear pore complex lattice, Nat. Struct. Mol. Biol. 16, 1173-1177. PubMed

    Cai, Z., Chehab, N. H., and Pavletich, N. P. (2009) Structure and activation mechanism of the CHK2 DNA damage checkpoint kinase, Mol. Cell 35, 818-829. PubMed

    Choi, M., Sukumar, N., Liu, A., and Davidson, V. L. (2009) Defining the Role of the Axial Ligand of the Type 1 Copper Site in Amicyanin by Replacement of Methionine with Leucine, Biochemistry 48, 9174-9184. PubMed

    Dias, S. M., Wilson, K. F., Rojas, K. S., Ambrosio, A. L., and Cerione, R. A. (2009) The molecular basis for the regulation of the cap-binding complex by the importins, Nat. Struct. Mol. Biol. 16, 930-937. PubMed

    Dong, G., Wearsch, P. A., Peaper, D. R., Cresswell, P., and Reinisch, K. M. (2009) Insights into MHC class I peptide loading from the structure of the tapasin-ERp57 thiol oxidoreductase heterodimer, Immunity 30, 21-32. PubMed

    Duan, X., Sarangi, P., Liu, X., Rangi, G. K., Zhao, X., and Ye, H. (2009) Structural and functional insights into the roles of the Mms21 subunit of the Smc5/6 complex, Mol. Cell 35, 657-668. PubMed

    Duan, X., and Ye, H. (2009) Purification, crystallization and preliminary X-ray crystallographic studies of the complex between Smc5 and the SUMO E3 ligase Mms21, Acta Crystallogr. F 65, 849-852. PubMed

    Escobar-Alvarez, S., Goldgur, Y., Yang, G., Ouerfelli, O., Li, Y., and Scheinberg, D. A. (2009) Structure and Activity of Human Mitochondrial Peptide Deformylase, a Novel Cancer Target, J. Mol. Biol. 387 1211-1228. PubMed

    Gallagher, D. T., Ruan, B., London, M., Bryan, M. A., and Bryan, P. N. (2009) Structure of a switchable subtilisin complexed with substrate and with the activator azide, Biochemistry 48, 10389-10394. PubMed

    Gallagher, D. T., Smith, N., Kim, S. K., Robinson, H., and Reddy, P. T. (2009) Profound asymmetry in the structure of the cAMP-free cAMP Receptor Protein (CRP) from Mycobacterium tuberculosis, J. Biol. Chem. 284, 8228-8232. PubMed

    Gao, X., Xie, X., Pashkov, I., Sawaya, M. R., Laidman, J., Zhang, W., Cacho, R., Yeates, T. O., and Tang, Y. (2009) Directed evolution and structural characterization of a simvastatin synthase, Chem. Biol. 16, 1064-1074. PubMed

    Gennadios, H. A., Gonzalez, V., Di Costanzo, L., Li, A., Yu, F., Miller, D. J., Allemann, R. K., and Christianson, D. W. (2009) Crystal Structure of (+)-δ-Cadinene Synthase from Gossypium arboreum and Evolutionary Divergence of Metal Binding Motifs for Catalysis, Biochemistry 48, 6175-6183. PubMed

    Glynn, S. E., Martin, A., Nager, A. R., Baker, T. A., and Sauer, R. T. (2009) Structures of Asymmetric ClpX Hexamers Reveal Nucleotide-Dependent Motions in a AAA+ Protein-Unfolding Machine, Cell 139, 744-756. PubMed

    Gordon, W. R., Roy, M., Vardar-Ulu, D., Garfinkel, M., Mansour, M. R., Aster, J. C., and Blacklow, S. C. (2009) Structure of the Notch1 negative regulatory region: Implications for normal activation and pathogenic signaling in T-ALL, Blood 113, 4381-4390. PubMed

    Gordon, W. R., Vardar-Ulu, D., L'Heureux, S., Ashworth, T., Malecki, M. J., Sanchez-Irizarry, C., McArthur, D. G., Histen, G., Mitchell, J. L., Aster, J. C., and Blacklow, S. C. (2009) Effects of S1 cleavage on the structure, surface export, and signaling activity of human Notch1 and Notch2, PLoS One 4, e6613. PubMed

    Gurel, G., Blaha, G., Moore, P. B., and Steitz, T. A. (2009) U2504 Determines the Species Specificity of the A-site Cleft Antibiotics. The Structures of Tiamulin, Homoharringtonine and Bruceantin Bound to the Ribosome, J. Mol. Biol. 389, 146-156. PubMed

    Gurel, G., Blaha, G., Steitz, T. A., and Moore, P. B. (2009) The structures of Triacetyloleandomycin and Mycalamide A bound to the large ribosomal subunit of Haloarcula marismortui, Antimicrob. Agents Chemother. 53, 5010-5014. PubMed

    Himanen, J. P., Goldgur, Y., Miao, H., Myshkin, E., Guo, H., Buck, M., Nguyen, M., Rajashankar, K. R., Wang, B., and Nikolov, D. B. (2009) Ligand recognition by A-class Eph receptors: crystal structures of the EphA2 ligand-binding domain and the EphA2/ephrin-A1 complex, EMBO Rep. 10, 722-728. PubMed

    Ho, M. C., Cassera, M. B., Madrid, D. C., Ting, L. M., Tyler, P. C., Kim, K., Almo, S. C., and Schramm, V. L. (2009) Structural and metabolic specificity of methylthiocoformycin for malarial adenosine deaminases, Biochemistry 48, 9618-9626. PubMed

    Ho, M. C., Sturm, M. B., Almo, S. C., and Schramm, V. L. (2009) Transition state analogues in structures of ricin and saporin ribosome-inactivating proteins, Proc. Natl. Acad. Sci. U. S. A. 106, 20276-20281. PubMed

    Huang, D. T., Ayrault, O., Hunt, H. W., Taherbhoy, A. M., Duda, D. M., Scott, D. C., Borg, L. A., Neale, G., Murray, P. J., Roussel, M. F., and Schulman, B. A. (2009) E2-RING expansion of the NEDD8 cascade confers specificity to cullin modification, Mol. Cell. 33, 483-495. PubMed

    Huang, J., Makabe, K., Biancalana, M., Koide, A., and Koide, S. (2009) Structural basis for exquisite specificity of affinity clamps, synthetic binding proteins generated through directed domain-interface evolution, J. Mol. Biol. 392, 1221-1231. PubMed

    Ivanova, M. I., Sievers, S. A., Sawaya, M. R., Wall, J. S., and Eisenberg, D. (2009) Molecular basis for insulin fibril assembly, Proc. Natl. Acad. Sci. U. S. A. 106, 18990-18995. PubMed

    Jin, L., Wei, W., Jiang, Y., Peng, H., Cai, J., Mao, C., Dai, H., Choy, W., Bemis, J. E., Jirousek, M. R., Milne, J. C., Westphal, C. H., and Perni, R. B. (2009) Crystal structures of human SIRT3 displaying substrate-induced conformational changes, J. Biol. Chem. 284, 24394-24405. PubMed

    Jin, R., Singh, S. K., Gu, S., Furukawa, H., Sobolevsky, A. I., Zhou, J., Jin, Y., and Gouaux, E. (2009) Crystal structure and association behaviour of the GluR2 amino-terminal domain, EMBO J. 28, 1812-1823. PubMed

    Joh, N. H., Oberai, A., Yang, D., Whitelegge, J. P., and Bowie, J. U. (2009) Similar Energetic Contributions of Packing in the Core of Membrane and Water-Soluble Proteins, J. Am. Chem. Soc. 131, 10846-10847. PubMed

    Kamadurai, H. B., Souphron, J., Scott, D. C., Duda, D. M., Miller, D. J., Stringer, D., Piper, R. C., and Schulman, B. A. (2009) Insights into Ubiquitin Transfer Cascades from a Structure of a UbcH5B~Ubiquitin-HECTNEDD4L Complex, Mol. Cell 36, 1095-1102. PubMed

    Kapoor, N., Menon, S. T., Chauhan, R., Sachdev, P., and Sakmar, T. P. (2009) Structural Evidence for a Sequential Release Mechanism for Activation of Heterotrimeric G Proteins, J. Mol. Biol. 393, 882-897. PubMed

    Kawate, T., Michel, J. C., Birdsong, W. T., and Gouaux, E. (2009) Crystal structure of the ATP-gated P2X4 ion channel in the closed state, Nature 460, 592-598. PubMed

    Kirouac, K. N., and Ling, H. (2009) Structural basis of error-prone replication and stalling at a thymine base by human DNA polymerase iota, EMBO J. 28,1644-1654. PubMed

    Laronde-Leblanc, N., Resto, M., and Gerratana, B. (2009) Regulation of active site coupling in glutamine-dependent NAD+ synthetase, Nat. Struct. Mol. Biol. 16, 421-429. PubMed

    Lee, S., and Verdine, G. L. (2009) Atomic substitution reveals the structural basis for substrate adenine recognition and removal by adenine DNA glycosylase, Proc. Natl. Acad. Sci. U. S. A. 106, 18497-18502. PubMed

    Leksa, N. C., Brohawn, S. G., and Schwartz, T. U. (2009) The Structure of the Scaffold Nucleoporin Nup120 Reveals a New and Unexpected Domain Architecture, Structure 17, 1082-1091. PubMed

    Levin, E. J., Quick, M., and Zhou, M. (2009) Crystal structure of a bacterial homologue of the kidney urea transporter, Nature 462, 757-761. PubMed

    Lo, Y. C., Lin, S. C., Rospigliosi, C. C., Conze, D. B., Wu, C. J., Ashwell, J. D., Eliezer, D., and Wu, H. (2009) Structural Basis for Recognition of Diubiquitins by NEMO, Mol. Cell. 33, 602-615. PubMed

    Malakhova, M., Kurinov, I., Liu, K., Zheng, D., D'Angelo, I., Shim, J. H., Steinman, V., Bode, A. M., and Dong, Z. (2009) Structural diversity of the active N-terminal kinase domain of p90 ribosomal S6 kinase 2, PLoS One 4, e8044. PubMed

    Mandel, C. R., Tweel, B., and Tong, L. (2009) Crystal structure of human mitochondrial acyl-CoA thioesterase (ACOT2), Biochem. Biophys. Res. Commun. 385, 630-633. PubMed

    McCloskey, D. E., Bale, S., Secrist, J. A., Tiwari, A., Moss, T. H., Valiyaveettil, J., Brooks, W. H., Guida, W. C., Pegg, A. E., and Ealick, S. E. (2009) New Insights into the Design of Inhibitors of Human S-Adenosylmethionine Decarboxylase: Studies of Adenine C8 Substitution in Structural Analogues of S-Adenosylmethionine. J. Med. Chem. 52, 1388-1407. PubMed

    McCulloch, K., Mukherjee, T., Begley, T., and Ealick, S. (2009) Structure of the PLP Degradative Enzyme 2-Methyl-3-hydroxypyridine-5-carboxylic acid Oxygenase from Mesorhizobium loti MAFF303099 and its Mechanistic Implications, Biochemistry 48, 4139-4149. PubMed

    Miallau, L., Faller, M., Chiang, J., Arbing, M., Guo, F., Cascio, D., and Eisenberg, D. (2009) Structure and Proposed Activity of a Member of the VapBC Family of Toxin-Antitoxin Systems: VapBC-5 from Mycobacterium tuberculosis, J. Biol. Chem. 284, 276-283. PubMed

    Nayak, V., Dessau, M., Kucera, K., Anthony, K., Ledizet, M., and Modis, Y. (2009) Crystal structure of dengue virus type 1 envelope protein in the postfusion conformation and its implications for membrane fusion, J. Virol. 83, 4338-4344. PubMed

    Ostrander, E. L., Larson, J. D., Schuermann, J. P., and Tanner, J. J. (2009) A Conserved Active Site Tyrosine Residue of Proline Dehydrogenase Helps Enforce the Preference for Proline over Hydroxyproline as the Substrate Biochemistry 48, 951-959. PubMed

    Pakotiprapha, D., Liu, Y., Verdine, G. L., and Jeruzalmi, D. (2009) A structural model for the damage sensing complex in bacterial nucleotide excision repair, J. Biol. Chem. 284, 12837–12844. PubMed

    Palioura, S., Sherrer, R. L., Steitz, T. A., Soll, D., and Simonovic, M. (2009) The human SepSecS-tRNASec complex reveals the mechanism of selenocysteine formation, Science 325, 321-325. PubMed

    Partridge, J. R., and Schwartz, T. U. (2009) Crystallographic and Biochemical Analysis of the Ran-Binding Zinc Finger Domain, J. Mol. Biol. 391, 375-389. PubMed

    Pollard, A. M., Bilwes, A. M., and Crane, B. R. (2009) The structure of a soluble chemoreceptor suggests a mechanism for propagating conformational signals, Biochemistry 48, 1936-1944. PubMed

    Qi, Y., Spong, M. C., Nam, K., Banerjee, A., Jiralerspong, S., Karplus, M., and Verdine, G. L. (2009) Encounter and extrusion of an intrahelical lesion by a DNA repair enzyme, Nature 462, 762-766. PubMed

    Randau, L., Stanley, B. J., Kohlway, A., Mechta, S., Xiong, Y., and Soll, D. (2009) A cytidine deaminase edits C to U in transfer RNAs in Archaea, Science 324, 657-659. PubMed

    Rechkoblit, O., Malinina, L., Cheng, Y., Geacintov, N. E., Broyde, S., and Patel, D. J. (2009) Impact of Conformational Heterogeneity of OxoG Lesions and Their Pairing Partners on Bypass Fidelity by Y Family Polymerases Structure 17, 725-736. PubMed

    Regni, C. A., Roush, R. F., Miller, D. J., Nourse, A., Walsh, C. T., and Schulman, B. A. (2009) How the MccB bacterial ancestor of ubiquitin E1 initiates biosynthesis of the microcin C7 antibiotic, EMBO J. 23, 1953-1964. PubMed

    Roman-Hernandez, G., Grant, R. A., Sauer, R. T., and Baker, T. A. (2009) Molecular basis of substrate selection by the N-end rule adaptor protein ClpS, Proc. Natl. Acad. Sci. U. S. A. 106, 8888-8893. PubMed

    Samanta, U., Kirby, S. D., Srinivasan, P., Cerasoli, D. M., and Bahnson, B. J. (2009) Crystal Structures of Human Group-VIIA Phospholipase A2 Inhibited by Organophosphorus Nerve Agents Exhibit Non-aged Complexes, Biochem. Pharmacol. 78, 420-429. PubMed

    Shechner, D. M., Grant, R. A., Bagby, S. C., Koldobskaya, Y., Piccirilli, J. A., and Bartel, D. P. (2009) Crystal Structure of the Catalytic Core of an RNA-Polymerase Ribozyme, Science 326, 1271-1275. PubMed

    Serganov, A., Huang, L., and Patel, D. J. (2009) Coenzyme recognition and gene regulation by a flavin mononucleotide riboswitch, Nature 458, 233-237. PubMed

    Sharma, H., Yu, S., Kong, J., Wang, J., and Steitz, T. A. (2009) Structure of apo-CAP reveals that large conformational changes are necessary for DNA binding, Proc. Natl Acad. Sci. U. S. A. 106, 16604-16609. PubMed

    Shen, A., Higgins, D. E., and Panne, D. (2009) Recognition of AT-Rich DNA Binding Sites by the MogR Repressor, Structure 17, 769-777. PubMed

    Singh, H., Felts, R. L., Schuermann, J. P., Reilly, T. J., and Tanner, J. J. (2009) Crystal Structures of the Histidine Acid Phosphatase from Francisella tularensis Provide Insight into Substrate Recognition, J. Mol. Biol. 394, 893-904. PubMed

    Singh, M., Gonzales, F. A., Cascio, D., Heckmann, N., Chanfreau, G., and Feigon, J. (2009) Structure and Functional Studies of the CS Domain of the Essential H/ACA Ribonucleoparticle Assembly Protein SHQ1, J. Biol. Chem. 284, 1906-1916. PubMed

    Sobolevsky, A. I., Rosconi, M. P., and Gouaux, E. (2009) X-ray structure, symmetry and mechanism of an AMPA-subtype glutamate receptor, Nature 462, 745-756. PubMed

    Sohn, J., Grant, R. A., and Sauer, R. T. (2009) OMP peptides activate the DegS stress-sensor protease by a relief of inhibition mechanism, Structure 17, 1411-1421. PubMed

    Stabach, P. R., Simonovic, I., Ranieri, M. A., Aboodi, M. S., Steitz, T. A., Simonovic, M., and Morrow, J. S. (2009) The structure of the ankyrin-binding site of β-spectrin reveals how tandem spectrin-repeats generate unique ligand-binding properties, Blood 113, 5377-5384. PubMed

    Su, C.-C., Yang, F., Long, F., Reyon, D., Routh, M. D., Kuo, D. W., Mokhtari, A. K., Van Ornam, J. D., Rabe, K. L., Hoy, J. A., Lee, Y. J., Rajashankar, K. R., and Yu, E. W. Crystal structure of the membrane fusion protein CusB from Escherichia coli, J. Mol. Biol. 393, 342-355. PubMed

    Sukumar, N., Dewanti, A., Merli, A., Rossi, G. L., Mitra, B., and Mathews, F. S. (2009) Structures of the G81A mutant form of the active chimera of (S)-mandelate dehydrogenase and its complex with two of its substrates, Acta Crystallogr. D 65, 543-552. PubMed

    Sukumar, N., Mathews, F. S., Gordon, M. M., Ealick, S. E., and Alpers, D. H. (2009) Postcrystallization Analysis of the Irreproducibility of the Human Intrinsic Factor-Cobalamin Complex Crystals, Cryst. Growth Des. 9, 348-351. PubMed

    Tanaka, S., Sawaya, M. R., Phillips, M., and Yeates, T. O. (2009) Insights from multiple structures of the shell proteins from the beta-carboxysome, Protein Sci.18, 108-120. PubMed

    Tao, X., Avalos, J. L., Chen, J., and Mackinnon, R. (2009) Crystal structure of the eukaryotic strong inward-rectifier K+ channel Kir2.2 at 3.1 Å resolution, Science 326, 1668-1674. PubMed

    Thomas, S. R., McTamney, P. M., Adler, J. M., Laronde-Leblanc, N., and Rokita, S. E. (2009) Crystal Structure of Iodotyrosine Deiodinase, a Novel Flavoprotein Responsible for Iodide Salvage in Thyroid Glands, J. Biol. Chem. 284, 19659-19667. PubMed

    Tsai Y, Sawaya MR and Yeats TO. (2009) Analysis of lattice translocation disorder in the layered hexagonal structure of carboxysome shell protein CsoS1C. Acta Crystallogr. D. 65, 980-988. PubMed

    Wada, M., Heux, L., Nishiyama, Y., and Langan, P. (2009) X-ray Crystallographic, Scanning Microprobe X-ray Diffraction, and Cross-Polarized/Magic Angle Spinning 13C NMR Studies of the Structure of Cellulose III, Biomacromolecules 10, 302-309. URL

    Wang, G. G., Song, J., Wang, Z., Dormann, H. L., Casadio, F., Li, H., Luo, J. L., Patel, D. J., and Allis, C. D. (2009) Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger, Nature. 458, 847-851. PubMed

    Wang, J., Dye, B. T., Rajashankar, K. R., Kurinov, I., and Schulman, B. A. (2009) Insights into anaphase promoting complex TPR subdomain assembly from a CDC26-APC6 structure, Nat. Struct. Mol. Biol. 16, 987-989. PubMed

    Wang, Y., Juranek, S., Li, H., Sheng, G., Wardle, G. S., Tuschl, T., and Patel, D. J. (2009) Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes, Nature 461, 754-761. PubMed

    Wang, Q., Navarro, M. V., Peng, G., Molinelli, E., Shih, L. G., Judson, B. L., Rajashankar, K. R., and Sondermann, H. (2009) Molecular mechanism of membrane constriction and tubulation mediated by the F-BAR protein Pacsin/Syndapin, Proc. Natl. Acad. Sci. U. S. A. 106, 12700-12705. PubMed

    Whittle, J. R., and Schwartz, T. U. (2009) Architectural nucleoporins Nup157/170 and Nup133 are structurally related and descend from a second ancestral element, J. Biol. Chem. 284, 28442-28452. PubMed

    Wiltzius, J. J., Landau, M., Nelson, R., Sawaya, M. R., Apostol, M. I., Goldschmidt, L., Soriaga, A. B., Cascio, D., Rajashankar, K., and Eisenberg, D. (2009) Molecular mechanisms for protein-encoded inheritance, Nat. Struct. Mol. Biol. 16, 973-978. PubMed

    Wiltzius, J. J., Sievers, S. A., Sawaya, M. R., and Eisenberg, D. (2009) Atomic structures of IAPP (amylin) fusions suggest a mechanism for fibrillation and the role of insulin in the process, Protein Sci. 18, 1521-1530. PubMed

    Wong, C., Fujimori, D. G., Walsh, C. T., and Drennan, C. L. (2009) Structural Analysis of an Open Active Site Conformation of Nonheme Iron Halogenase CytC3, J. Am. Chem. Soc.J. Am. Chem. Soc. 131, 4872-4879. PubMed

    Yin, F. F., Bailey, S., Innis, C. A., Ciubotaru, M., Kamtekar, S., Steitz, T. A., and Schatz, D. G. (2009) Structure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsis, Nat. Struct. Mol. Biol. 6, 499-508. PubMed

    Yun, S. M., Moulaei, T., Lim, D., Bang, J. K., Park, J. E., Shenoy, S. R., Liu, F., Kang, Y. H., Liao, C., Soung, N. K., Lee, S., Yoon, D. Y., Lim, Y., Lee, D. H., Otaka, A., Appella, E., McMahon, J. B., Nicklaus, M. C., Burke Jr, T. R., Yaffe, M. B., Wlodawer, A., and Lee, K. S. (2009) Structural and functional analyses of minimal phosphopeptides targeting the polo-box domain of polo-like kinase 1,Nat. Struct. Mol. Biol. 16, 876-883. PubMed

    Yunus, A. A., and Lima, C. D. (2009) Structure of the Siz/PIAS SUMO E3 ligase Siz1 and determinants required for SUMO modification of PCNA, Mol. Cell. 35, 669-682. PubMed

    Zhang, H., Astrof, N. S., Liu, J. H., Wang, J. H., and Shimaoka, M. (2009) Crystal structure of isoflurane bound to integrin LFA-1 supports a unified mechanism of volatile anesthetic action in the immune and central nervous systems, FASEB J. 23, 2735-2740. PubMed

    Zhang, Q., Zhou, Y. F., Zhang, C. Z., Zhang, X., Lu, C., and Springer, T. A. (2009) Structural specializations of A2, a force-sensing domain in the ultralarge vascular protein von Willebrand factor, Proc. Natl. Acad. Sci. U. S. A. 106, 9226-9231. PubMed

    Zhang, W., Dunkle, J. A., and Cate, J. H. (2009) Structures of the Ribosome in Intermediate States of Ratcheting, Science 325, 1014-1017. PubMed

    Zheng, J., Sagar, V., Smolinsky, A., Bourke, C., LaRonde-LeBlanc, N., and Cropp, T. A. (2009) Structure and function of the macrolide biosensor protein, MphR(A), with and without erythromycin, J. Mol. Biol. 387, 1250-1260. PubMed

    Zhou, W., Ercan, D., Chen, L., Yun, C. H., Li, D., Capelletti, M., Cortot, A. B., Chirieac, L., Iacob, R. E., Padera, R., Engen, J. R., Wong, K. K., Eck, M. J., Gray, N. S., and Janne, P. A. (2009) Novel mutant-selective EGFR kinase inhibitors against EGFR T790M, Nature 462, 1070-1074. PubMed

    Zhuang, M., Calabrese, M. F., Liu, J., Waddell, M. B., Nourse, A., Hammel, M., Miller, D. J., Walden, H., Duda, D. M., Seyedin, S. N., Hoggard, T., Harper, J. W., White, K. P., and Schulman, B. A. (2009) Structures of SPOP-Substrate Complexes: Insights into Molecular Architectures of BTB-Cul3 Ubiquitin Ligases, Mol. Cell 36, 39-50. PubMed

    2008

    Aranda, R. t., Cai, H., Worley, C. E., Levin, E. J., Li, R., Olson, J. S., Phillips, G. N., Jr., and Richards, M. P. (2008) Structural analysis of fish versus mammalian hemoglobins: Effect of the heme pocket environment on autooxidation and hemin loss, Proteins 75, 217-230. PubMed

    Bale S, Lopez MM, Makhatadze G; Fang QI; Pegg AE, and Ealick SE. Structural Basis for Putrescine Activation of Human S-Adenosylmethionine Decarboxylase. Biochemistry 47, 13404-13417 (2008). PubMed

    Blaha, G., Gurel, G., Schroeder, S. J., Moore, P. B., and Steitz, T. A. (2008) Mutations outside the anisomycin-binding site can make ribosomes drug-resistant, J. Mol. Biol. 379, 505-519. PubMed

    Boehmer, T., Jeudy, S., Berke, I. C., and Schwartz, T. U. (2008) Structural and functional studies of Nup107/Nup133 interaction and its implications for the architecture of the nuclear pore complex, Mol. Cell 30, 721-731. PubMed

    Bowman, B. R., Lee, S., Wang, S., and Verdine, G. L. (2008) Structure of the E. coli DNA Glycosylase AlkA Bound to the Ends of Duplex DNA: A System for the Structure Determination of Lesion-Containing DNA, Structure 16, 1166-1174. PubMed

    Brohawn, S. G., Leksa, N. C., Spear, E. D., Rajashankar, K. R., and Schwartz, T. U. (2008) Structural Evidence for Common Ancestry of the Nuclear Pore Complex and Vesicle Coats, Science 322, 1369-1373. PubMed

    Cai, Y., Chin, H. F., Lazarova, D., Menon, S., Fu, C., Cai, H., Sclafani, A., Rodgers, D. W., De La Cruz, E. M., Ferro-Novick, S., and Reinisch, K. M. (2008) The structural basis for activation of the Rab Ypt1p by the TRAPP membrane-tethering complexes, Cell 133, 1202-1213. PubMed

    Chatterjee, A., Li, Y., Zhang, Y., Grove, T. L., Lee, M., Krebs, C., Booker, S. J., Begley, T. P., and Ealick, S. E. (2008) Reconstitution of ThiC in thiamine pyrimidine biosynthesis expands the radical SAM superfamily, Nat. Chem. Biol. 4, 758-765. PubMed

    Chen, Z., Yang, H., and Pavletich, N. P. (2008) Mechanism of homologous recombination from the RecA-ssDNA/dsDNA structures, Nature 453, 489-484. PubMed

    Christofk, H. R., Vander Heiden, M. G., Wu, N., Asara, J. M., and Cantley, L. C. (2008) Pyruvate kinase M2 is a phosphotyrosine-binding protein, Nature 452, 181-186. PubMed

    Debler, E. W., Ma, Y., Seo, H. S., Hsia, K. C., Noriega, T. R., Blobel, G., and Hoelz, A. (2008) A fence-like coat for the nuclear pore membrane, Mol. Cell 32, 815-826. PubMed

    Dowling, D. P., Gantt, S. L., Gattis, S. G., Fierke, C. A., and Christianson, D. W. (2008) Structural Studies of Human Histone Deacetylase 8 and Its Site-Specific Variants Complexed with Substrate and Inhibitors, Biochemistry 47, 13554-13563. PubMed

    Durniak, K. J., Bailey, S., and Steitz, T. A. (2008) The structure of a transcribing t7 RNA polymerase in transition from initiation to elongation, Science 322, 553-557. PubMed

    Evans, R. N., Blaha, G., Bailey, S., and Steitz, T. A. (2008) The structure of LepA, the ribosomal back translocase, Proc. Natl. Acad. Sci. U. S. A. 105, 4673-4678. PubMed

    Faham, S., Watanabe, A., Besserer, G. M., Cascio, D., Specht, A., Hirayama, B. A., Wright, E. M., and Abramson, J. (2008) The crystal structure of a sodium galactose transporter reveals mechanistic insights into Na+/sugar symport, Science 321, 810-814. PubMed

    Germane, K. L., Ohi, R., Goldberg, M. B., and Spiller, B. W. (2008) Structural and Functional Studies Indicate That Shigella VirA Is Not a Protease and Does Not Directly Destabilize Microtubules, Biochemistry 47, 10241-10243. PubMed

    Gerdts, C. J., Elliott, M., Lovell, S., Mixon, M. B., Napuli, A. J., Staker, B. L., Nollert, P., and Stewart, L. (2008) The plug-based nanovolume Microcapillary Protein Crystallization System (MPCS), Acta Crystallogr. D 64, 1116-1122. PubMed

    Ghosh, A., Shuman, S., and Lima, C. D. (2008) The Structure of Fcp1, an Essential RNA Polymerase II CTD Phosphatase, Mol. Cell 32, 478-490. PubMed

    Gu, R., Li, M., Su, S.-C., Long, F., Routh, M. D., Yang, F., McDermott, G., and Yu, E. W. (2008) Conformational change of the AcrR regulator reveals a possible mechanism of induction, Acta Crystallogr. F 64, 584-588. PubMed

    Hlinkova, V., Xing, G., Bauer, J., Shin, Y. J., Dionne, I., Rajashankar, K. R., Bell, S. D., and Ling, H. (2008) Structures of monomeric, dimeric and trimeric PCNA: PCNA-ring assembly and opening, Acta Crystallogr. D 64, 941-949. PubMed

    Huai, Q., Zhou, A., Lin, L., Mazar, A. P., Parry, G. C., Callahan, J., Shaw, D. E., Furie, B., Furie, B. C., and Huang, M. (2008) Crystal structures of two human vitronectin, urokinase and urokinase receptor complexes, Nat. Struct. Mol. Biol. 15, 422-423. PubMed

    Jenkins, A. L., Zhang, Y., Ealick, S. E., and Begley, T. P. (2008) Mutagenesis studies on TenA: A thiamin salvage enzyme from Bacillus subtilis, Bioorg. Chem. 36, 29-32. PubMed

    Jurgenson, C. T., Burns, K. E., Begley, T. P., and Ealick, S. E. (2008) Crystal Structure of a Sulfur Carrier Protein Complex Found in the Cysteine Biosynthetic Pathway of Mycobacterium tuberculosis, Biochemistry 47, 10354-10364. PubMed

    Kurz, T., Chou, Y. C., Willems, A. R., Meyer-Schaller, N., Hecht, M. L., Tyers, M., Peter, M., and Sicheri, F. (2008) Dcn1 functions as a scaffold-type E3 ligase for cullin neddylation, Mol. Cell 29, 23-35. PubMed

    Lee, S., Bowman, B. R., Ueno, Y., Wang, S., and Verdine, G. L. (2008) Synthesis and structure of duplex DNA containing the genotoxic nucleobase lesion N7-methylguanine, J. Am. Chem. Soc. 130, 11570-11571. PubMed

    Lima, C. D., and Reverter, D. (2008) Structure of the human SENP7 catalytic domain and poly-SUMO deconjugation activities for SENP6 and SENP7, J. Biol. Chem. 283, 32045-32055. PubMed

    Lin, S. C., Chung, J. Y., Lamothe, B., Rajashankar, K., Lu, M., Lo, Y. C., Lam, A. Y., Darnay, B. G., and Wu, H. (2008) Molecular Basis for the Unique Deubiquitinating Activity of the NF-kB Inhibitor A20, J. Mol. Biol. 376, 526-540. PubMed

    Lovejoy, K. S., Todd, R. C., Zhang, S., McCormick, M. S., D'Aquino, J. A., Reardon, J. T., Sancar, A., Giacomini, K. M., and Lippard, S. J. (2008) cis-Diammine(pyridine)chloroplatinum(II), a monofunctional platinum(II) antitumor agent: Uptake, structure, function, and prospects, Proc. Natl. Acad. Sci. U. S. A. 105, 8902-8907. PubMed

    Lu, X., McDonald, S. M., Tortorici, M. A., Tao, Y. J., Vasquez-Del Carpio, R., Nibert, M. L., Patton, J. T., and Harrison, S. C. (2008) Mechanism for Coordinated RNA Packaging and Genome Replication by Rotavirus Polymerase VP1, Structure 16, 1678-1688. PubMed

    Lu, C., Smith, A. M., Fuchs, R. T., Ding, F., Rajashankar, K., Henkin, T. M., and Ke, A. (2008) Crystal structures of the SAM-III/S(MK) riboswitch reveal the SAM-dependent translation inhibition mechanism, Nat. Struct. Mol. Biol. 15, 1076-1083. PubMed

    Malakhova, M., Tereshko, V., Lee, S. Y., Yao, K., Cho, Y. Y., Bode, A., and Dong, Z. (2008) Structural basis for activation of the autoinhibitory C-terminal kinase domain of p90 RSK2, Nat. Struct. Mol. Biol. 15, 112-113. PubMed

    Mancias, J. D., and Goldberg, J. (2008) Structural basis of cargo membrane protein discrimination by the human COPII coat machinery, EMBO J. 27, 2918-2928. PubMed

    Mao, D. Y., Neculai, D., Downey, M., Orlicky, S., Haffani, Y. Z., Ceccarelli, D. F., Ho, J. S., Szilard, R. K., Zhang, W., Ho, C. S., Wan, L., Fares, C., Rumpel, S., Kurinov, I., Arrowsmith, C. H., Durocher, D., and Sicheri, F. (2008) Atomic structure of the KEOPS complex: an ancient protein kinase-containing molecular machine, Mol. Cell 32, 259-275. PubMed

    McCulloch, K. M., Kinsland, C., Begley, T. P., and Ealick, S. E. (2008) Structural Studies of Thiamin Monophosphate Kinase in Complex with Substrates and Products, Biochemistry 47, 3810-3821. PubMed 

    Morar, M., Hoskins, A. A., Stubbe, J., and Ealick, S. E. (2008) Formylglycinamide Ribonucleotide Amidotransferase from Thermotoga maritima: Structural Insights into Complex Formation, Biochemistry 47, 7816-7830. PubMed

    Ngo, J. C., Huang, M., Roth, D. A., Furie, B. C., and Furie, B. (2008) Crystal Structure of Human Factor VIII: Implications for the Formation of the Factor IXa-Factor VIIIa Complex, Structure 16, 597-606. PubMed 

    Pakotiprapha, D., Inuzuka, Y., Bowman, B. R., Moolenaar, G. F., Goosen, N., Jeruzalmi, D., and Verdine, G. L. (2008) Crystal Structure of Bacillus stearothermophilus UvrA Provides Insight into ATP-Modulated Dimerization, UvrB Interaction, and DNA Binding, Mol. Cell 29, 122-133. PubMed

    Phelps, C. B., Huang, R. J., Lishko, P. V., Wang, R. R., and Gaudet, R. (2008) Structural Analyses of the Ankyrin Repeat Domain of TRPV6 and Related TRPV Ion Channels, Biochemistry 47, 2476-2484. PubMed

    Phillips, C. M., Schreiter, E. R., Guo, Y., Wang, S. C., Zamble, D. B., and Drennan, C. L. (2008) Structural Basis of the Metal Specificity for Nickel Regulatory Protein NikR, Biochemistry 47, 1938-1946. PubMed

    Rajakulendran, T., Sahmi, M., Kurinov, I., Tyers, M., Therrien, M., and Sicheri, F. (2008) CNK and HYP form a discrete dimer by their SAM domains to mediate RAF kinase signaling, Proc. Natl. Acad. Sci. U. S. A. 105, 2836-2841. PubMed

    Ruan, B., London, V., Fisher, K. E., Gallagher, D. T., and Bryan, P. N. (2008) Engineering Substrate Preference in Subtilisin: Structural and Kinetic Analysis of a Specificity Mutant, Biochemistry 47, 6628-6636. PubMed

    Ryan, K. S., Balibar, C. J., Turo, K. E., Walsh, C. T., and Drennan, C. L. (2008) The violacein biosynthetic enzyme VioE shares a fold with lipoprotein transporter proteins, J. Biol. Chem. 283, 6467-6475. PubMed

    Scrima, A., Konickova, R., Czyzewski, B. K., Kawasaki, Y., Jeffrey, P. D., Groisman, R., Nakatani, Y., Iwai, S., Pavletich, N. P., and Thoma, N. H. (2008) Structural basis of UV DNA-damage recognition by the DDB1-DDB2 complex, Cell 135, 1213-1223. PubMed

    Serganov, A., Huang, L., and Patel, D. J. (2008) Structural insights into amino acid binding and gene control by a lysine riboswitch, Nature 455, 1263-1267. PubMed

    Simonovic, M., and Steitz, T. A. (2008) Peptidyl-CCA deacylation on the ribosome promoted by induced fit and the O3'-hydroxyl group of A76 of the unacylated A-site tRNA, RNA 14, 2372-2378. PubMed

    Soriano, E. V., Rajashankar, K. R., Hanes, J. W., Bale, S., Begley, T. P., and Ealick, S. E. (2008) Structural Similarities between Thiamin-Binding Protein and Thiaminase-I Suggest a Common Ancestor, Biochemistry 47, 1346-1357. PubMed

    Stanley, B. J., Ehrlich, E. S., Short, L., Yu, Y., Xiao, Z., Yu, X. F., and Xiong, Y. (2008) Structural Insight into the HIV Vif SOCS Box and Its Role in Human E3 Ubiquitin Ligase Assembly, J. Virol. 82, 8656-8663. PubMed

    Su, C. C., Long, F., McDermott, G., Shafer, W. M., and Yu, E. W. (2008) Crystallization and preliminary X-ray diffraction analysis of the multidrug efflux transporter NorM from Neisseria gonorrhoeae, Acta Crystallogr. F 64, 289-292. PubMed

    Sudhamsu, J., Lee, G. I., Klessig, D. F., and Crane, B. R. (2008) The structure of YqeH: An AtNOS1/AtNOA1 ortholog that couples GTP hydrolysis to molecular recognition, J. Biol. Chem. 283, 32968-32976. PubMed

    Suzuki, C., Garces, R. G., Edmonds, K. A., Hiller, S., Hyberts, S. G., Marintchev, A., and Wagner, G. (2008) PDCD4 inhibits translation initiation by binding to eIF4A using both its MA3 domains, Proc. Natl. Acad. Sci. U. S. A. 105, 3274-3279. PubMed

    Teplova, M., and Patel, D. J. (2008) Structural insights into RNA recognition by the alternative-splicing regulator muscleblind-like MBNL1, Nat. Struct. Mol. Biol. 15,1343-1351. PubMed

    Toor, N., Keating, K. S., Taylor, S. D., and Pyle, A. M. (2008) Crystal structure of a self-spliced group II intron, Science 320, 77-82. PubMed

    Toor, N., Rajashankar, K., Keating, K. S., and Pyle, A. M. (2008) Structural basis for exon recognition by a group II intron, Nat. Struct. Mol. Biol. 15, 1221-1222. PubMed

    Ujwal, R., Cascio, D., Colletier, J. P., Faham, S., Zhang, J., Toro, L., Ping, P., and Abramson, J. (2008) The crystal structure of mouse VDAC1 at 2.3 Å resolution reveals mechanistic insights into metabolite gating, Proc. Natl. Acad. Sci. U. S. A. 105, 17742-17747. PubMed

    Van Straaten, K. E., Hoffort, A., Palmer, D. R., and Sanders, D. A. (2008) Purification, crystallization and preliminary X-ray analysis of inositol dehydrogenase (IDH) from Bacillus subtilis, Acta Crystallogr. F 64, 98-101. PubMed

    Wang, K. H., Roman-Hernandez, G., Grant, R. A., Sauer, R. T., and Baker, T. A. (2008) The Molecular Basis of N-End Rule Recognition, Mol. Cell 32, 406-414. PubMed

    Wang, Q., Kaan, H. Y., Hooda, R. N., Goh, S. L., and Sondermann, H. (2008) Structure and plasticity of Endophilin and Sorting Nexin 9, Structure 16, 1574-1587. PubMed

    Wang, Y., Juranek, S., Li, H., Sheng, G., Tuschl, T., and Patel, D. J. (2008) Structure of an argonaute silencing complex with a seed-containing guide DNA and target RNA duplex, Nature 456, 921-926. PubMed

    Wang, Y., Sheng, G., Juranek, S., Tuschl, T., and Patel, D. J. (2008) Structure of the guide-strand-containing argonaute silencing complex, Nature 456, 209-213. PubMed

    Wing, R. A., Bailey, S., and Steitz, T. A. (2008) Insights into the Replisome from the Structure of a Ternary Complex of the DNA Polymerase III α-Subunit, J. Mol. Biol. 382, 859-869. PubMed

    Wiltzius, J. J., Sievers, S. A., Sawaya, M. R., Cascio, D., Popov, D., Riekel, C., and Eisenberg, D. (2008) Atomic structure of the cross-beta spine of islet amyloid polypeptide (amylin), Protein Sci. 17, 1467-1474. PubMed

    Xu, K., Rajashankar, K. R., Chan, Y. P., Himanen, J. P., Broder, C. C., and Nikolov, D. B. (2008) Host cell recognition by the henipaviruses: crystal structures of the Nipah G attachment glycoprotein and its complex with ephrin-B3, Proc. Natl. Acad. Sci. U. S. A. 105, 9953-9958. PubMed

    Yuan, Y., Fuse, S., Ostash, B., Sliz, P., Kahne, D., and Walker, S. (2008) Structural analysis of the contacts anchoring moenomycin to peptidoglycan glycosyltransferases and implications for antibiotic design, ACS Chem. Biol. 3, 429-436. PubMed

    Yun, C. H., Mengwasser, K. E., Toms, A. V., Woo, M. S., Greulich, H., Wong, K. K., Meyerson, M., and Eck, M. J. (2008) The T790M mutation in EGFR kinase causes drug resistance by increasing the affinity for ATP, Proc. Natl. Acad. Sci. U. S. A. 105, 2070-2075. PubMed

    Zhang, Y., White, R. H., and Ealick, S. E. (2008) Crystal Structure and Function of 5-Formaminoimidazole-4-carboxamide Ribonucleotide Synthetase from Methanocaldococcus jannaschii, Biochemistry 47, 205-217. PubMed

    Zhao, Q., Han, Q., Kissinger, C. R., Hermann, T., and Thompson, P. A. (2008) Structure of hepatitis C virus IRES subdomain IIa, Acta Crystallogr. D 64, 436-443. PubMed

    Zimmer, J., Nam, Y., and Rapoport, T. A. (2008) Structure of a complex of the ATPase SecA and the protein-translocation channel, Nature 455, 936-943. PubMed

    2007

    Bailey, S., Eliason, W. K., and Steitz, T. A. (2007) Structure of hexameric DnaB helicase and its complex with a domain of DnaG primase, Science 318, 459-463. PubMed

    Bellizzi, J. J., 3rd, Sorger, P. K., and Harrison, S. C. (2007) Crystal structure of the yeast inner kinetochore subunit Cep3p, Structure 15, 1422-1430. PubMed

    Berman, A. J., Kamtekar, S., Goodman, J. L., Lazaro, J. M., de Vega, M., Blanco, L., Salas, M., and Steitz, T. A. (2007) Structures of phi29 DNA polymerase complexed with substrate: the mechanism of translocation in B-family polymerases, EMBO J. 26, 3494-3505. PubMed

    Blair, J. A., Rauh, D., Kung, C., Yun, C. H., Fan, Q. W., Rode, H., Zhang, C., Eck, M. J., Weiss, W. A., and Shokat, K. M. (2007) Structure-guided development of affinity probes for tyrosine kinases using chemical genetics, Nat. Chem. Biol. 3, 229-238. PubMed

    Boehmer, T., and Schwartz, T. U. (2007) Purification, crystallization and preliminary X-ray analysis of a Nup107-Nup133 heterodimeric nucleoporin complex, Acta Crystallogr. F 63, 816-818. PubMed

    Borovinskaya, M. A., Pai, R. D., Zhang, W., Schuwirth, B. S., Holton, J. M., Hirokawa, G., Kaji, H., Kaji, A., and Cate, J. H. (2007) Structural basis for aminoglycoside inhibition of bacterial ribosome recycling, Nat. Struct. Mol. Biol. 14, 727-732. PubMed

    Capili, A. D., and Lima, C. D. (2007) Structure and Analysis of a Complex between SUMO and Ubc9 Illustrates Features of a Conserved E2-Ubl Interaction, J. Mol. Biol. 369, 608-618. PubMed

    Carrell, C. J., Ma, J. K., Antholine, W. E., Hosler, J. P., Mathews, F. S., and Davidson, V. L. (2007) Generation of Novel Copper Sites by Mutation of the Axial Ligand of Amicyanin. Atomic Resolution Structures and Spectroscopic Properties, Biochemistry 46, 1900-1912. PubMed

    Chen, X., Kim, T. D., Carman, C. V., Mi, L. Z., Song, G., and Springer, T. A. (2007) Structural plasticity in Ig superfamily domain 4 of ICAM-1 mediates cell surface dimerization, Proc. Natl. Acad. Sci. U. S. A. 104, 15358-15363. PubMed

    Chien, P., Grant, R. A., Sauer, R. T., and Baker, T. A. (2007) Structure and Substrate Specificity of an SspB Ortholog: Design Implications for AAA+ Adaptors, Structure 15, 1296-1305. PubMed

    Dong, G., Medkova, M., Novick, P., and Reinisch, K. M. (2007) A Catalytic Coiled Coil: Structural Insights into the Activation of the Rab GTPase Sec4p by Sec2p, Mol. Cell 25, 455-462. PubMed

    Durek, T., Torbeev, V. Y., and Kent, S. B. (2007) Convergent chemical synthesis and high-resolution x-ray structure of human lysozyme, Proc. Natl. Acad. Sci. U. S. A. 104, 4846-4851. PubMed

    Erdmann, K. S., Mao, Y., McCrea, H. J., Zoncu, R., Lee, S., Paradise, S., Modregger, J., Biemesderfer, D., Toomre, D., and De Camilli, P. (2007) A role of the lowe syndrome protein OCRL in early steps of the endocytic pathway, Dev. Cell 13, 377-390. PubMed

    Fath, S., Mancias, J. D., Bi, X., and Goldberg, J. (2007) Structure and organization of coat proteins in the COPII cage, Cell 129, 1325-1336. PubMed

    Hao, B., Oehlmann, S., Sowa, M. E., Harper, J. W., and Pavletich, N. P. (2007) Structure of a Fbw7-Skp1-Cyclin E Complex: Multisite-Phosphorylated Substrate Recognition by SCF Ubiquitin Ligases, Mol. Cell 26, 131-143. PubMed

    Himanen, J. P., Saha, N., and Nikolov, D. B. (2007) Cell-cell signaling via Eph receptors and ephrins, Curr. Opin. Cell Biol. 19, 534-542. PubMed

    Hoskins, A. A., Morar, M., Kappock, T. J., Mathews, II, Zaugg, J. B., Barder, T. E., Peng, P., Okamoto, A., Ealick, S. E., and Stubbe, J. (2007) N5-CAIR Mutase: Role of a CO2 Binding Site and Substrate Movement in Catalysis, Biochemistry 46, 2842-2855. PubMed

    Jeudy, S., and Schwartz, T. U. (2007) Crystal structure of nucleoporin Nic96 reveals a novel, intricate helical domain architecture, J. Biol. Chem. 282, 34904-34912. PubMed

    Jin, X., Townley, R., and Shapiro, L. (2007) Structural Insight into AMPK Regulation: ADP Comes into Play, Structure 15, 1285-1295. PubMed

    Kamtekar, S., Hohn, M. J., Park, H. S., Schnitzbauer, M., Sauerwald, A., Soll, D., and Steitz, T. A. (2007) Toward understanding phosphoseryl-tRNACys formation: the crystal structure of Methanococcus maripaludis phosphoseryl-tRNA synthetase, Proc. Natl. Acad. Sci. U. S. A. 104, 2620-2625. PubMed

    Kang, Y.-N., Tran, A., White, R. H., and Ealick, S. E. (2007) A Novel Function for the NTN Hydrolase Fold Demonstrated by the Structure of an Archeal Inosine Monophosphate Cyclohydrolase, Biochemistry 46, 5050-5062. PubMed

    Kavran, J. M., Gundllapalli, S., O'Donoghue, P., Englert, M., Soll, D., and Steitz, T. A. (2007) Structure of pyrrolysyl-tRNA synthetase, an archaeal enzyme for genetic code innovation, Proc. Natl. Acad. Sci. U. S. A. 104, 11268-11273. PubMed

    Kavran, J. M., and Steitz, T. A. (2007) Structure of the Base of the L7/L12 Stalk of the Haloarcula marismortui Large Ribosomal Subunit: Analysis of L11 Movements, J. Mol. Biol. 371, 1047-1059. PubMed

    Koide, A., Gilbreth, R. N., Esaki, K., Tereshko, V., and Koide, S. (2007) High-affinity single-domain binding proteins with a binary-code interface, Proc. Natl. Acad. Sci. U. S. A. 104, 6632-6637. PubMed

    Levin, E. J., Kondrashov, D. A., Wesenberg, G. E., and Phillips, G. N., Jr. (2007) Ensemble refinement of protein crystal structures: validation and application, Structure 15, 1040-1052. PubMed

    Li, H., Fischle, W., Wang, W., Duncan, E. M., Liang, L., Murakami-Ishibe, S., Allis, C. D., and Patel, D. J. (2007) Structural Basis for Lower Lysine Methylation State-Specific Readout by MBT Repeats of L3MBTL1 and an Engineered PHD Finger, Mol Cell 28, 677-691. PubMed

    Li, X., Lee, H., Wu, J., and Breslow, E. (2007) Contributions of the interdomain loop, amino terminus, and subunit interface to the ligand-facilitated dimerization of neurophysin: Crystal structures and mutation studies of bovine neurophysin-I, Protein Sci. 16, 52-68. PubMed

    Lietha, D., Cai, X., Ceccarelli, D. F., Li, Y., Schaller, M. D., and Eck, M. J. (2007) Structural basis for the autoinhibition of focal adhesion kinase, Cell 129, 1177-1187. PubMed

    Liang, B., Xue, S., Terns, R. M., Terns, M. P., and Li, H. (2007) Substrate RNA positioning in the archaeal H/ACA ribonucleoprotein complex, Nat. Struct. Mol. Biol. 14, 1189-1195. PubMed

    Liu, H., Chen, X., Focia, P. J., and He, X. (2007) Structural basis for stem cell factor-KIT signaling and activation of class III receptor tyrosine kinases, EMBO J. 26, 891-901. PubMed

    Lomakin, I. B., Xiong, Y., and Steitz, T. A. (2007) The crystal structure of yeast fatty acid synthase, a cellular machine with eight active sites working together, Cell 129, 319-332. PubMed

    Lu, J., Meng, W., Poy, F., Maiti, S., Goode, B. L., and Eck, M. J. (2007) Structure of the FH2 Domain of Daam1: Implications for Formin Regulation of Actin Assembly, J. Mol. Biol. 369, 1258-1269. PubMed

    Mathews, F. S., Gordon, M. M., Chen, Z., Rajashankar, K. R., Ealick, S. E., Alpers, D. H., and Sukumar, N. (2007) Crystal structure of human intrinsic factor: Cobalamin complex at 2.6-A resolution, Proc. Natl. Acad. Sci. U. S. A. PubMed

    Min, J. H., and Pavletich, N. P. (2007) Recognition of DNA damage by the Rad4 nucleotide excision repair protein, Nature 449, 570-576. PubMed

    Morar, M., White, R. H., and Ealick, S. E. (2007) Structure of 2-Amino-3,7-dideoxy-d-threo-hept-6-ulosonic Acid Synthase, a Catalyst in the Archaeal Pathway for the Biosynthesis of Aromatic Amino Acids, Biochemistry 46, 10562-10571. PubMed

    Mukherjee, T., McCulloch, K. M., Ealick, S. E., and Begley, T. P. (2007) Gene Identification and Structural Characterization of the Pyridoxal 5'-Phosphate Degradative Protein 3-Hydroxy-2-methylpyridine-4,5-dicarboxylate Decarboxylase from Mesorhizobium loti MAFF303099, Biochemistry 46, 13606-13615. PubMed

    Nair, P. A., Nandakumar, J., Smith, P., Odell, M., Lima, C. D., and Shuman, S. (2007) Structural basis for nick recognition by a minimal pluripotent DNA ligase, Nat. Struct. Mol. Biol. 14, 770-778. PubMed

    Nandakumar, J., Nair, P. A., and Shuman, S. (2007) Last Stop on the Road to Repair: Structure of E. coli DNA Ligase Bound to Nicked DNA-Adenylate, Mol Cell 26, 257-271. PubMed

    Oruganti, S., Zhang, Y., Li, H., Robinson, H., Terns, M. P., Terns, R. M., Yang, W., and Li, H. (2007) Alternative Conformations of the Archaeal Nop56/58-Fibrillarin Complex Imply Flexibility in Box C/D RNPs, J. Mol. Biol. 371, 1141-1150. PubMed

    Park, H. H., Logette, E., Raunser, S., Cuenin, S., Walz, T., Tschopp, J., and Wu, H. (2007) Death Domain Assembly Mechanism Revealed by Crystal Structure of the Oligomeric PIDDosome Core Complex, Cell 128, 533-546. PubMed

    Park, H. H., and Wu, H. (2007) Crystallization and preliminary X-ray crystallographic studies of the oligomeric death-domain complex between PIDD and RAIDD, Acta Crystallogr. F 63, 229-232. PubMed

    Pradeep, L., Kurinov, I., Ealick, S. E., and Scheraga, H. A. (2007) Implementation of a k/k(0) Method to Identify Long-Range Structure in Transition States during Conformational Folding/Unfolding of Proteins, Structure 15, 1178-1189. PubMed

    Ryan, K. S., Howard-Jones, A. R., Hamill, M. J., Elliott, S. J., Walsh, C. T., and Drennan, C. L. (2007) Crystallographic trapping in the rebeccamycin biosynthetic enzyme RebC, Proc Natl Acad Sci U S A 104, 15311-15316. PubMed

    Schlieker, C., Weihofen, W. A., Frijns, E., Kattenhorn, L. M., Gaudet, R., and Ploegh, H. L. (2007) Structure of a herpesvirus-encoded cysteine protease reveals a unique class of deubiquitinating enzymes, Mol. Cell 25, 677-687. PubMed

    Sohn, J., Grant, R. A., and Sauer, R. T. (2007) Allosteric Activation of DegS, a Stress Sensor PDZ Protease, Cell 131, 572-583. PubMed

    Soriano, E. V., Clark, V. C., and Ealick, S. E. (2007) Structures of Human Deoxycytidine Kinase Product Complexes, Acta Crystallogr. D 63, 1201-1207. PubMed

    Tang, X., Orlicky, S., Lin, Z., Willems, A., Neculai, D., Ceccarelli, D., Mercurio, F., Shilton, B. H., Sicheri, F., and Tyers, M. (2007) Suprafacial Orientation of the SCF(Cdc4) Dimer Accommodates Multiple Geometries for Substrate Ubiquitination, Cell 129, 1165-1176. PubMed

    Vorontsov, II, Minasov, G., Brunzelle, J. S., Shuvalova, L., Kiryukhina, O., Collart, F. R., and Anderson, W. F. (2007) Crystal structure of an apo form of Shigella flexneri ArsH protein with an NADPH-dependent FMN reductase activity, Protein Sci 16, 2483-2490. PubMed

    Wang, J., Ogata, C., Yang, X., Sukumar, N., Kourinov, I., Capel, M., Lynch, A. E., Rajashankar, K., Withrow, J., and Ealick, S. (2007) NE-CAT upgrade of the bending magnet beamline 8BM at the APS, AIP Conference Proceedings 879, 832-835. URL

    Xing, G., Hlinkova, V., and Ling, H. (2007) Purification, Crystallization and Preliminary Diffraction Studies of the Sulfolobus solfataricus PCNA Proteins in Different Oligomeric Forms, Cryst. Growth Des. 7, 2202-2205. URL

    Yuan, Y., Barrett, D., Zhang, Y., Kahne, D., Sliz, P., and Walker, S. (2007) Crystal structure of a peptidoglycan glycosyltransferase suggests a model for processive glycan chain synthesis, Proc. Natl. Acad. Sci. U. S. A. 104, 5348-5353. PubMed

    Yun, C. H., Boggon, T. J., Li, Y., Woo, M. S., Greulich, H., Meyerson, M., and Eck, M. J. (2007) Structures of lung cancer-derived EGFR mutants and inhibitor complexes: mechanism of activation and insights into differential inhibitor sensitivity, Cancer Cell 11, 217-227. PubMed

    Zhang, Y., el Kouni, M. H., and Ealick, S. E. (2007) Substrate Analogs Induce an  Intermediate Conformational Change in Toxoplasma gondii Adenosine Kinase, Acta Crystallogr. D 63, 126-134. PubMed

    2006

    Bailey, S., Wing, R. A., and Steitz, T. A. (2006) The Structure of T. aquaticus DNA Polymerase III Is Distinct from Eukaryotic Replicative DNA Polymerases, Cell 126, 893-904. PubMed

    Banerjee, A., Santos, W. L., and Verdine, G. L. (2006) Structure of a DNA glycosylase searching for lesions, Science 311, 1153-1157. PubMed

    Barton, W. A., Tzvetkova-Robev, D., Miranda, E. P., Kolev, M. V., Rajashankar, K. R., Himanen, J. P., and Nikolov, D. B. (2006) Crystal structures of the Tie2 receptor ectodomain and the angiopoietin-2-Tie2 complex, Nat. Struct. Mol. Biol. 13, 524-532. PubMed

    Bitto, E., Bingman, C. A., Wesenberg, G. E., McCoy, J. G., and Phillips, G. N., Jr. (2006) Structure of pyrimidine 5'-nucleotidase type 1. Insight into mechanism of action and inhibition during lead poisoning, J. Biol. Chem. 281, 20521-20529. PubMed

    Heldwein, E. E., Lou, H., Bender, F. C., Cohen, G. H., Eisenberg, R. J., and Harrison, S. C. (2006) Crystal structure of glycoprotein B from herpes simplex virus 1, Science 313, 217-220. PubMed

    Jin, X., Touhey, J., and Gaudet, R. (2006) Structure of the N-terminal Ankyrin Repeat Domain of the TRPV2 Ion Channel, J. Biol. Chem. 281, 25006-25010. PubMed

    Kamtekar, S., Berman, A. J., Wang, J., Lazaro, J. M., de Vega, M., Blanco, L., Salas, M., and Steitz, T. A. (2006) The j29 DNA polymerase:protein-primer structure suggests a model for the initiation to elongation transition, EMBO J. 25, 1335-1343. PubMed

    Kamtekar, S., Ho, R. S., Cocco, M. J., Li, W., Wenwieser, S. V., Boocock, M. R., Grindley, N. D., and Steitz, T. A. (2006) Implications of structures of synaptic tetramers of gd resolvase for the mechanism of recombination, Proc. Natl. Acad. Sci. U. S. A. 103, 10642-10647. PubMed

    Kuznedelov, K., Lamour, V., Patikoglou, G., Chlenov, M., Darst, S. A., and Severinov, K. (2006) Recombinant Thermus aquaticus RNA Polymerase for Structural Studies, J. Mol. Biol. 359, 110-121. PubMed

    Lehmann, C., Begley, T. P., and Ealick, S. E. (2006) Structure of the Escherichia coli ThiS-ThiF complex, a key component of the sulfur transfer system in thiamin biosynthesis, Biochemistry 45, 11-19. PubMed

    Li, H., Ilin, S., Wang, W., Duncan, E. M., Wysocka, J., Allis, C. D., and Patel, D. J. (2006) Molecular basis for site-specific read-out of histone H3K4me3 by the BPTF PHD finger of NURF, Nature 442, 91-95. PubMed

    Liu, Q., Greimann, J. C., and Lima, C. D. (2006) Reconstitution, Activities, and Structure of the Eukaryotic RNA Exosome, Cell 127, 1223–1237. PubMed

    Ma, J. K., Carrell, C. J., Mathews, F. S., and Davidson, V. L. (2006) Site-directed mutagenesis of proline 52 to glycine in amicyanin converts a true electron transfer reaction into one that is conformationally gated, Biochemistry 45, 8284-8293. PubMed

    Morar, M., Anand, R., Hoskins, A. A., Stubbe, J., and Ealick, S. E. (2006) Complexed Structures of Formylglycinamide Ribonucleotide Amidotransferase from Thermotoga maritima Describe a Novel ATP Binding Protein Superfamily, Biochemistry 45, 14880-14895. PubMed

    Nandakumar, J., Shuman, S., and Lima, C. D. (2006) RNA Ligase Structures Reveal the Basis for RNA Specificity and Conformational Changes that Drive Ligation Forward, Cell 127, 71-84. PubMed

    Obiero, J., Bonderoff, S. A., Goertzen, M. M., and Sanders, D. A. (2006) Expression, purification, crystallization and preliminary X-ray crystallographic studies of Deinococcus radiodurans thioredoxin reductase, Acta Crystallogr. F 62, 757-760. PubMed

    Park, H. H., Tookes, H. E., and Wu, H. (2006) Crystallization and preliminary X-ray crystallographic studies of Drep-3, a DFF-related protein from Drosophila melanogaster, Acta Crystallogr. F 62, 597-599. PubMed

    Park, S. Y., Borbat, P. P., Gonzalez-Bonet, G., Bhatnagar, J., Pollard, A. M., Freed, J. H., Bilwes, A. M., and Crane, B. R. (2006) Reconstruction of the chemotaxis receptor-kinase assembly, Nat. Struct. Mol. Biol. 13, 400-407. PubMed

    Pineda, A. O., Chen, Z. W., Bah, A., Garvey, L. C., Mathews, F. S., and Di Cera, E. (2006) Crystal structure of thrombin in a self-inhibited conformation, J. Biol. Chem. 281, 32922-32928. PubMed

    Rashid, R., Liang, B., Baker, D. L., Youssef, O. A., He, Y., Phipps, K., Terns, R. M., Terns, M. P., and Li, H. (2006) Crystal Structure of a Cbf5-Nop10-Gar1 Complex and Implications in RNA-Guided Pseudouridylation and Dyskeratosis Congenita, Mol. Cell 21, 249-260. PubMed

    Reverter, D., and Lima, C. D. (2006) Structural basis for SENP2 protease interactions with SUMO precursors and conjugated substrates, Nat. Struct. Mol. Biol. 13, 1060-1068. PubMed

    Ruthenburg, A. J., Wang, W., Graybosch, D. M., Li, H., Allis, C. D., Patel, D. J., and Verdine, G. L. (2006) Histone H3 recognition and presentation by the WDR5 module of the MLL1 complex, Nat. Struct. Mol. Biol. 13, 704-712. PubMed

    Sazinsky, M. H., Dunten, P. W., McCormick, M. S., Didonato, A., and Lippard, S. J. (2006) X-ray Structure of a Hydroxylase-Regulatory Protein Complex from a Hydrocarbon-Oxidizing Multicomponent Monooxygenase, Pseudomonas sp. OX1 Phenol Hydroxylase, Biochemistry 45, 15392-15404. PubMed

    Sukumar, N., Chen, Z. W., Ferrari, D., Merli, A., Rossi, G. L., Bellamy, H. D., Chistoserdov, A., Davidson, V. L., and Mathews, F. S. (2006) Crystal Structure of an Electron Transfer Complex between Aromatic Amine Dehydrogenase and Azurin from Alcaligenes faecalis, Biochemistry 45, 13500-13510. PubMed

    Tyler, R. C., Bitto, E., Berndsen, C. E., Bingman, C. A., Singh, S., Lee, M. S., Wesenberg, G. E., Denu, J. M., Phillips, G. N., Jr., and Markley, J. L. (2006) Structure of Arabidopsis thaliana At1g77540 Protein, a Minimal Acetyltransferase from the COG2388 Family, Biochemistry 45, 14325-14336. PubMed

    Van Wagoner, R. M., and Clardy, J. (2006) FeeM, an N-Acyl Amino Acid Synthase from an Uncultured Soil Microbe: Structure, Mechanism, and Acyl Carrier Protein Binding, Structure 14, 1425-1435. PubMed

    Xu, G., Narayan, M., Kurinov, I., Ripoll, D. R., Welker, E., Khalili, M., Ealick, S. E., and Scheraga, H. A. (2006) A Localized Specific Interaction Alters the Unfolding Pathways of Structural Homologues, J. Am. Chem. Soc. 128, 1204-1213. PubMed

    Xu, H., Faber, C., Uchiki, T., Racca, J., and Dealwis, C. (2006) Structures of eukaryotic ribonucleotide reductase I define gemcitabine diphosphate binding and subunit assembly, Proc. Natl. Acad. Sci. U. S. A. 103, 4028-4033. PubMed

    Xue, S., Calvin, K., and Li, H. (2006) RNA recognition and cleavage by a splicing endonuclease, Science 312, 906-910. PubMed

    Youn, B., Kim, S. J., Moinuddin, S. G., Lee, C., Bedgar, D. L., Harper, A. R., Davin, L. B., Lewis, N. G., and Kang, C. (2006) Mechanistic and structural studies of apoform, binary, and ternary complexes of the Arabidopsis alkenal double bond reductase At5g16970, J. Biol. Chem. 281, 40076-40088. PubMed

    Yunus, A. A., and Lima, C. D. (2006) Lysine activation and functional analysis of E2-mediated conjugation in the SUMO pathway, Nat. Struct. Mol. Biol. 13, 491-499. PubMed

    Zein, F., Zhang, Y., Kang, Y. N., Burns, K., Begley, T. P., and Ealick, S. E. (2006) Structural Insights into the Mechanism of the PLP Synthase Holoenzyme from Thermotoga maritima, Biochemistry 45, 14609-14620. PubMed

    Zhang, Y., El Kouni, M. H., and Ealick, S. E. (2006) Structure of Toxoplasma gondii adenosine kinase in complex with an ATP analog at 1.1 Å resolution, Acta Crystallogr. D 62, 140-145. PubMed

    Zhang, Y., Porcelli, M., Cacciapuoti, G., and Ealick, S. E. (2006) The crystal structure of 5'-deoxy-5'-methylthioadenosine phosphorylase II from Sulfolobus solfataricus, a thermophilic enzyme stabilized by intramolecular disulfide bonds, J. Mol. Biol. 357, 252-262. PubMed

    Zhang, Y., Secrist, J. A., III, and Ealick, S. E. (2006) The structure of human deoxycytidine kinase in complex with clofarabine reveals key interactions for prodrug activation, Acta Crystallogr. D 62, 133-139. PubMed

    Zimmer, J., Li, W., and Rapoport, T. A. (2006) A Novel Dimer Interface and Conformational Changes Revealed by an X-ray Structure of B. subtilis SecA, J. Mol. Biol. 364, 259-265. PubMed

    Zuo, Y., Vincent, H. A., Zhang, J., Wang, Y., Deutscher, M. P., and Malhotra, A. (2006) Structural Basis for Processivity and Single-Strand Specificity of RNase II, Mol. Cell 24, 1-6. PubMed

    2005

    Arndt, J. W., Schwarzenbacher, R., Page, R., Abdubek, P., Ambing, E., Biorac, T., Canaves, J. M., Chiu, H. J., Dai, X., Deacon, A. M., Didonato, M., Elsliger, M. A., Godzik, A., Grittini, C., Grzechnik, S. K., Hale, J., Hampton, E., Han, G. W., Haugen, J., Hornsby, M., Klock, H. E., Koesema, E., Kreusch, A., Kuhn, P., Jaroszewski, L., Lesley, S. A., Levin, I., McMullan, D., McPhillips, T. M., Miller, M. D., Morse, A., Moy, K., Nigoghossian, E., Ouyang, J., Peti, W. S., Quijano, K., Reyes, R., Sims, E., Spraggon, G., Stevens, R. C., van den Bedem, H., Velasquez, J., Vincent, J., von Delft, F., Wang, X., West, B., White, A., Wolf, G., Xu, Q., Zagnitko, O., Hodgson, K. O., Wooley, J., and Wilson, I. A. (2005) Crystal structure of an alpha/beta serine hydrolase (YDR428C) from Saccharomyces cerevisiae at 1.85 Å resolution, Proteins 58, 755-758. PubMed

    Bolon, D. N., Grant, R. A., Baker, T. A., and Sauer, R. T. (2005) Specificity versus stability in computational protein design, Proc. Natl. Acad. Sci. U. S. A. 102, 12724-12729. PubMed

    Bu, W., Settembre, E. C., el Kouni, M. H., and Ealick, S. E. (2005) Structural basis for inhibition of Escherichia coli uridine phosphorylase by 5-substituted acyclouridines, Acta Crystallogr. D. 61, 863-872. PubMed

    Chase, E., and Golden, B. L. (2005) Crystallization and preliminary diffraction analysis of a group I ribozyme from bacteriophage Twort, Acta Crystallogr F. 61, 71-74. PubMed

    Deaconescu, A. M., and Darst, S. A. (2005) Crystallization and preliminary structure determination of Escherichia coli Mfd, the transcription-repair coupling factor, Acta Crystallograph. F 61, 1062-1064. PubMed

    Dong, G., Hutagalung, A. H., Fu, C., Novick, P., and Reinisch, K. M. (2005) The structures of exocyst subunit Exo70p and the Exo84p C-terminal domains reveal a common motif, Nat. Struct. Mol. Biol. 12, 1094-1100. PubMed

    Golden, B. L., Kim, H., and Chase, E. (2005) Crystal structure of a phage Twort group I ribozyme-product complex, Nat. Struct. Mol. Biol. 12, 82-89. PubMed

    Hao, B., Zheng, N., Schulman, B. A., Wu, G., Miller, J. J., Pagano, M., and Pavletich, N. P. (2005) Structural basis of the Cks1-dependent recognition of p27Kip1 by the SCFSkp2 ubiquitin ligase, Mol. Cell. 20, 9-19. PubMed

    Higgins, L. J., Yan, F., Liu, P., Liu, H. W., and Drennan, C. L. (2005) Structural insight into antibiotic fosfomycin biosynthesis by a mononuclear iron enzyme, Nature 437, 838-844. PubMed

    Langan, P., Sukumar, N., Nishiyama, Y., and Chanzy, H. (2005) Synchrotron X-ray structures of cellulose Ib and regenerated cellulose II at ambient temperature and 100 K, Cellulose (Dordrecht, Netherlands) 12, 551-562. URL

    Levchenko, I., Grant, R. A., Flynn, J. M., Sauer, R. T., and Baker, T. A. (2005) Versatile modes of peptide recognition by the AAA+ adaptor protein SspB, Nat. Struct. Mol. Biol. 12, 520-525. PubMed

    Misaghi, S., Galardy, P. J., Meester, W. J., Ovaa, H., Ploegh, H. L., and Gaudet, R. (2005) Structure of the Ubiquitin Hydrolase UCH-L3 Complexed with a Suicide Substrate, J. Biol. Chem. 280, 1512-1520. PubMed

    Rubin, S. M., Gall, A. L., Zheng, N., and Pavletich, N. P. (2005) Structure of the Rb C-terminal domain bound to E2F1-DP1: a mechanism for phosphorylation-induced E2F release, Cell 123, 1093-1106. PubMed

    Sukumar, N., Langan, P., Mathews, F. S., Jones, L. H., Thiyagarajan, P., Schoenborn, B. P., and Davidson, V. L. (2005) A preliminary time-of-flight neutron diffraction study on amicyanin from Paracoccus denitrificans, Acta Crystallogr. D. 61, 640-642. PubMed

    Tabtiang, R. K., Cezairliyan, B. O., Grant, R. A., Cochrane, J. C., and Sauer, R. T. (2005) Consolidating critical binding determinants by noncyclic rearrangement of protein secondary structure, Proc. Natl. Acad. Sci. U. S. A. 102, 2305-2309. PubMed

    Thoma, N. H., Czyzewski, B. K., Alexeev, A. A., Mazin, A. V., Kowalczykowski, S. C., and Pavletich, N. P. (2005) Structure of the SWI2/SNF2 chromatin-remodeling domain of eukaryotic Rad54, Nat. Struct. Mol. Biol. 12, 350-356. PubMed

    Toms, A. V., Haas, A. L., Park, J. H., Begley, T. P., and Ealick, S. E. (2005) Structural Characterization of the Regulatory Proteins TenA and TenI from Bacillus subtilis and Identification of TenA as a Thiaminase II, Biochemistry 44, 2319-2329. PubMed

    Wang, Y., Long, M. C., Ranganathan, S., Escuyer, V., Parker, W. B., and Li, R. (2005) Overexpression, purification and crystallographic analysis of a unique adenosine kinase from Mycobacterium tuberculosis, Acta Crystallogr. F 61, 553-557. PubMed

    Wei, H., Ruthenburg, A. J., Bechis, S. K., and Verdine, G. L. (2005) Nucleotide-dependent domain movement in the ATPase domain of a human type IIA DNA topoisomerase, J. Biol. Chem. 280, 37041-37047. PubMed

    Wilker, E. W., Grant, R. A., Artim, S. C., and Yaffe, M. B. (2005) A Structural Basis for 14-3-3 s Functional Specificity, J. Biol. Chem. 280, 18891-18898. PubMed

    Zhang, Y., Colabroy, K. L., Begley, T. P., and Ealick, S. E. (2005) Structural Studies on 3-Hydroxyanthranilate-3,4-dioxygenase: The Catalytic Mechanism of a Complex Oxidation Involved in NAD Biosynthesis, Biochemistry 44, 7632-7643. PubMed

    Zhang, Y., Wang, W. H., Wu, S. W., Ealick, S. E., and Wang, C. C. (2005) Identification of a Subversive Substrate of Trichomonas vaginalis Purine Nucleoside Phosphorylase and the Crystal Structure of the Enzyme-Substrate Complex, J. Biol. Chem. 280, 22318-22325. PubMed

    2004

    Anand, R., Hoskins, A. A., Bennett, E. M., Sintchak, M. D., Stubbe, J., and Ealick, S. E. (2004) A Model for the Bacillus subtilis Formylglycinamide Ribonucleotide Amidotransferase Multiprotein Complex, Biochemistry 43, 10343-10352. PubMed

    Anand, R., Kaminski, P. A., and Ealick, S. E. (2004) Structures of purine 2'-deoxyribosyltransferase, substrate complexes, and the ribosylated enzyme intermediate at 2.0 Å resolution, Biochemistry 43, 2384-2393. PubMed

    Bauer, J. A., Bennett, E. M., Begley, T. P., and Ealick, S. E. (2004) Three-dimensional Structure of YaaE from Bacillus subtilis, a Glutaminase Implicated in Pyridoxal-5'-phosphate Biosynthesis, J. Biol. Chem. 279, 2704-2711. PubMed

    Berkovitch, F., Behshad, E., Tang, K. H., Enns, E. A., Frey, P. A., and Drennan, C. L. (2004) A locking mechanism preventing radical damage in the absence of substrate, as revealed by the x-ray structure of lysine 5,6-aminomutase, Proc. Natl. Acad. Sci. U. S. A. 101, 15870-15875. PubMed

    Bolon, D. N., Grant, R. A., Baker, T. A., and Sauer, R. T. (2004) Nucleotide-Dependent Substrate Handoff from the SspB Adaptor to the AAA+ ClpXP Protease, Mol. Cell 16, 343-350. PubMed

    Kamtekar, S., Berman, A. J., Wang, J., Lazaro, J. M., de Vega, M., Blanco, L., Salas, M., and Steitz, T. A. (2004) Insights into strand displacement and processivity from the crystal structure of the protein-primed DNA polymerase of bacteriophage phi29, Mol. Cell 16, 609-618. PubMed

    Kang, S. A., Marjavaara, P. J., and Crane, B. R. (2004) Electron transfer between cytochrome c and cytochome c peroxidase in single crystals, J. Am. Chem. Soc. 126, 10836-10837. PubMed

    Ogawa, H., Qiu, Y., Ogata, C. M., and Misono, K. S. (2004) Crystal structure of hormone-bound atrial natriuretic peptide receptor extracellular domain: rotation mechanism for transmembrane signal transduction, J. Biol. Chem. 279, 28625-28631. PubMed

    Settembre, E. C., Dorrestein, P. C., Zhai, H., Chatterjee, A., McLafferty, F. W., Begley, T. P., and Ealick, S. E. (2004) Thiamin biosynthesis in Bacillus subtilis: structure of the thiazole synthase/sulfur carrier protein complex, Biochemistry 43, 11647-11657. PubMed

    Toms, A. V., Kinsland, C., McCloskey, D. E., Pegg, A. E., and Ealick, S. E. (2004) Evolutionary Links as Revealed by the Structure of Thermotoga maritima S-Adenosylmethionine Decarboxylase, J. Biol. Chem. 279, 33837-33846. PubMed

    van den Berg, B., Black, P. N., Clemons, W. M., Jr., and Rapoport, T. A. (2004) Crystal structure of the long-chain fatty acid transporter FadL, Science 304, 1506-1509. PubMed

    van den Berg, B., Clemons, W. M., Jr., Collinson, I., Modis, Y., Hartmann, E., Harrison, S. C., and Rapoport, T. A. (2004) X-ray structure of a protein-conducting channel, Nature 427, 36-44. PubMed

    Wang, J., and Ealick, S. E. (2004) Observation of time-resolved structural changes by linear interpolation of highly redundant X-ray diffraction data, Acta Crystallogr. D 60, 1579-1585. PubMed

    Xiao, T., Takagi, J., Coller, B. S., Wang, J. H., and Springer, T. A. (2004) Structural basis for allostery in integrins and binding to fibrinogen-mimetic therapeutics, Nature 432, 59-67. PubMed

    Xiong, Y., and Steitz, T. A. (2004) Mechanism of transfer RNA maturation by CCA-adding enzyme without using an oligonucleotide template, Nature 430, 640-645. PubMed

    Xu, Y., Moseley, J. B., Sagot, I., Poy, F., Pellman, D., Goode, B. L., and Eck, M. J. (2004) Crystal structures of a Formin Homology-2 domain reveal a tethered dimer architecture, Cell 116, 711-723. PubMed

    Ye, J., and Van Den Berg, B. (2004) Crystal structure of the bacterial nucleoside transporter Tsx, EMBO J. 23, 3187-3195. PubMed

    Zhang, Y., Cottet, S. E., and Ealick, S. E. (2004) Structure of Escherichia coli AMP Nucleosidase Reveals Similarity to Nucleoside Phosphorylases, Structure 12, 1383-1394. PubMed

    Zhang, Y., Dougherty, M., Downs, D. M., and Ealick, S. E. (2004) Crystal Structure of an Aminoimidazole Riboside Kinase from Salmonella enterica; Implications for the Evolution of the Ribokinase Superfamily, Structure 12, 1809-1821. PubMed

    2003

    Antipenko, A., Himanen, J. P., van Leyen, K., Nardi-Dei, V., Lesniak, J., Barton, W. A., Rajashankar, K. R., Lu, M., Hoemme, C., Puschel, A. W., and Nikolov, D. B. (2003) Structure of the semaphorin-3A receptor binding module, Neuron 39, 589-598. PubMed

    Barton, W. A., Liu, B. P., Tzvetkova, D., Jeffrey, P. D., Fournier, A. E., Sah, D., Cate, R., Strittmatter, S. M., and Nikolov, D. B. (2003) Structure and axon outgrowth inhibitor binding of the Nogo-66 receptor and related proteins, EMBO J. 22, 3291-3302. PubMed

    Manoj, N., and Ealick, S. E. (2003) Unusual space-group pseudosymmetry in crystals of human phosphopantothenoylcysteine decarboxylase, Acta Crystallogr. D. 59, 1762-1766. PubMed

    Manoj, N., Strauss, E., Begley, T. P., and Ealick, S. E. (2003) Structure of human phosphopantothenoylcysteine synthetase at 2.3 Å resolution, Structure 11, 927-936. PubMed

    Schmeing, T. M., Moore, P. B., and Steitz, T. A. (2003) Structures of deacylated tRNA mimics bound to the E site of the large ribosomal subunit, RNA 9, 1345-1352. PubMed

    Schreiter, E. R., Sintchak, M. D., Guo, Y., Chivers, P. T., Sauer, R. T., and Drennan, C. L. (2003) Crystal structure of the nickel-responsive transcription factor NikR, Nat. Struct. Biol. 10, 794-799. PubMed

    Settembre, E. C., Dorrestein, P. C., Park, J.-H., Augustine, A. M., Begley, T. P., and Ealick, S. E. (2003) Structural and Mechanistic Studies on ThiO, a Glycine Oxidase Essential for Thiamin Biosynthesis in Bacillus subtilis, Biochemistry 42, 2971-2981. PubMed

    Tolbert, W. D., Graham, D. E., White, R. H., and Ealick, S. E. (2003) Pyruvoyl-Dependent Arginine Decarboxylase from Methanococcus jannaschii. Crystal Structures of the Self-Cleaved and S53A Proenzyme Forms, Structure 11, 285-294. PubMed

    Wang, J., and Ealick, S. E. (2003) Evaluation of SnB for the location of anomalous scattering atoms in SAD/MAD phasing, J. Appl. Crystallogr. 36, 1397-1401. Journal