NECAT Beamline

The Northeastern Collaborative Access Team (NE-CAT) facility at the Advanced Photon Source at Argonne National Laboratory is managed by Cornell University and consists of seven member institutions:

  • Columbia University
  • Cornell University
  • Harvard University
  • Memorial Sloan-Kettering Cancer Center
  • Massachusetts Institute of Technology
  • Rockefeller University
  • Yale University.

    Primary funding for this project comes from the National Institute of General Medical Sciences (NIGMS) , a division of the National Institutes of Health (NIH). Additional financial support for NE-CAT comes from the member institutions.

    NIGMS at a Glance.

    Supported by:

    National Institutes of Health
    National Institute of General Medical Sciences

    Glycogen Synthase Kinase 3

    APOBEC3F Catalytic Domain

    Aristolochene Synthase

    Extracellular Signal-Regulated Kinase 2

    Elongation Factor 4

    Fullerene Organizing Protein Complex

    Group II Intron Maturase

    SARS PLpro

    Rat Phenylalanine Hydroxylase

    Mouse Cadherin/Protocadherin

    EGFR 696-1022

    S31N Influenza M2 Proton Channel

    Group II Intron Maturase


    Burkholderia glumae ToxA

    PPP-Phosphatase PP5C

    70S Ribosome/Cisplatin

    Human Serotonin Transporter

    Oncogenic Phosphatase SHP2

    HSV-1 Tegument Protein UL21

    E3 Ligase COP1

    ASC-Binding Nanobody

    Poxvirus Resolvase

    Human Adenosine Deaminase

    Human Adenosine Deaminase


    HIV gp120

    Dodecahedral Nanocage

    Complexes of the 70S Ribosome

    HECT E3 Ligase

    Human Primosome

    Set8 Histone Transferase

    σS-transcription Initiation Complex

    Cytosolic O-Glycosyl Transferase


    Thiazole Synthase

    FIS DNA Complexes

    Staphylococcus aureus thioredoxin

    ABICC1 SAM Domain

    Bcr-Abl Kinase

    Retinol Binding Protein 1

    Rous Sarcoma Virus Intasome

    Aminoarabinose Transferase ArnT

    E. coli CASCADE

    Dead Box Protein 5

    Human ATG5 E122D-ATG16L1

    Human Histone Deacetylase 8

    Janus Kinase 3

    LIM Kinase

    Histidine Acid Phosphatase

    BICC1 SAM Domain

    Factor Inhibiting HIF

    Streptomyces sahachiroi AziG


    Ribonucleotide Reductase

    Fusicoccadiene Synthase

    Agrobacterium tumefaciens ClpS2

    Isotope Labeled Insulin

    Tier 2 Neutralizing Antibody

    Superfolder Green Fluorescent Protein

    EMG1 N1-Specific Pseudouridine Methyl Transferase

    Human Carbonic Anhydrase II

    Budding Yeast Hrr25

    Amyloid-Forming Segment from p53

    Mmi1 YTH Domain

    OSCAR Ligand-Binding Domain

    Glutamine Riboswitch

    Oxalate Oxidoreductase

    Junin Virus Subunit

    Nipah Virus Fusion Glycoprotein

    IAPP Amyloidogenic Segments

    Parallel-Stranded d(YGA) Motif

    Lac Repressor

    Mcg Immunoglobulin

    TTC7B/Hyccin Complex

    Mouse Unkempt Zinc Fingers

    Protein Arginine Methyltransferase

    Human OSCAR Ligand-Binding Domain


    Nuclear Egress Complex

    Geosmin Synthase

    Human Ribonucleotide Reductase 1

    Plastid Division Protein ARC6

    BRD4a/DB-2-190 Complex

    Dna2 Nuclease-Helicase

    Activated Opsin

    Phosphatidylinositolphosphate Synthase

    PRV Nuclear Egress Complex

    14mer DNA Lattice

    Cytomegalovirus Glycoprotein B

    IAg7–RLGL–WE14 Complex


    Synechocystis Apocarotenoid Oxygenase

    Tetrahymena Telomerase

    Oryza sativa SWEET Transporter

    Protocadherin Isoforms

    Monoclonal Antibody 8H9

    Human Transthyretin

    ARD-FERM Interface

    Nick-Sealing RNA Ligase

    Extracellular Cadherin Domains

    Group II Intron Domain 1

    sErbB3-Fab3379 Complex

    70S Ribosome

    Human AF10 Protein

    Varkud Satellite Ribozyme

    DNA Deaminase APOBEC3B

    Hammerhead Ribozyme

    Mycobacterium tuberculosis

    Rv1816 Transcriptional Regulator


    Ornithine N5-Monooxygenase

    Toxoplasma gondii

    Schistosoma mansoni Sulfotransferase

    Lactobacillus kefir Ketoreductase

    Thermus thermophilus CarH

    Rv3249c Transcriptional Regulator

    RGG Motif of FMRP

    Transcription Initiation Complex

    Human RBPMS

    Human Argonaute2

    ELIC-GLIC Chimera

    Camponotus floridanus BRCC36-KIAA0157

    Danio rerio BRCC36

    Chaperone EspG3

    Acyl CoA Mutases

    Anti-sigma Factor PupR

    Anti-autophagy Effector RavZ

    Deinococcus radiodurans HucR

    Bovine Arp2/3 Complex

    YidC-like Protein

    USP7 Complexed with UHRF1

    SAT Domain

    Thermosinus carboxydivorans pfl Riboswitch

    Aldehyde Dehydrogenase 7A1

    Catalytic Core of SAMHD1

    Botulinum Neurotoxin Complex

    Fusion Protein with Linker

    Calmodulin-Domain Protein Kinase 1

    Lipopolysaccharide Assembly Complex LptD-LptE

    Toxic Core of α-Synuclein

     Hypothetical Bromodomain Tb427.10.7420

    Notch3 Negative Regulatory Region

    Zn-Transporter ZnuD

    Bud6 Flank Domain

    Guanine Riboswitch

    Aeromonas hydrophila Hexameric Shell Protein

    Mycobacterium smegmatis EccB1

    Periplasmic Binding Protein AfuA

    Acetylpolyamine Amidohydrolase

    ABC Transporter PCAT1

    eIF4E Complex

    Synaptotagmin-1 SNARE Complex

    PLK-1 Polo-Box Domain

    Escherichia coli BipA/TypA


    Self-Assembling Tetrahedral Cage T33-31

    Histone 3/4 Tetramer

    Human JMJD5 JMJ-C Domain


    ABC Transporter PCAT1

    Stearoyl-CoA Desaturase


    Human Paxillin

    Oxalate Oxidoreductase

    Trypanosoma cruzi Glucokinase

    Plk4 Kinase Domain Complex

    Scc2/Scc4 Complex

    Bardet-Biedl Syndrome 9 Protein

    Drosophila Dopamine Transporter

    Pox Virus DNA Glycosylase

    Human MCM2 HBD and ASF1b

    Self-Assembled DNA

    Human Antibody 641 I-9 /Influenza Hemagglutinin H1


    Geobacillus stearothermophilus MutY


    16 nm Cage, Quadruple Mutant

    Rab14/Rab-Coupling Protein

    Retinoid Isomerase RPE65

    DM Domain of Human DMRT1

    Thermus thermophilus 70S Ribosome

    Mycobacterium tuberculosis LpqH (Rv3763)

    DNMT3a ADD Domain

    KDM2A-H3K36ME-NO Complex

    Engyodontium album
    Proteinase K

    Drosophila Dopamine Transporter

    Metal-Organic Framework, MOF-2000

    Uracil DNA Glyco sylase

    Metal Bound Calprotectin

    3´,3´-cGAMP Riboswitch

    Pol α CTD-B Subunit Complex

    Alcanivorax borkumensis
    YdaH Transporter

    CARDS Toxin

    Neisseria gonorrhoeae MtrF

    APC3-APC16 Complex

    APCCDH1–UBCH10-Ub-Substrate Intermediate

    Amyloid Forming Peptide GNLVS

    Arabidopsis thaliana HMP-P synthase

    ABL2/ARG Kinase

    Y Complex Hub of the Nuclear Core

    Mib Repeat Domain of Mind Bomb 1

    MZM-REP Domains of Mind Bomb 1

    Rv1738 (Mycobacterium tuberculosis, Form-II)

    Guided Entry of TA (GET) Protein

    Split Full Length GFP Mutant

    CTD Phosphatase Fcp1-R271A

    Pro-bone Morphogenetic Protein 9

    Migration Inhibitory Factor

    Murine Cyclooxygenase-2

    Autophagic SNARE Complex

    Isobutyryl-CoA Mutase

    Intercalation-Locked DNA Tetraplex

    CS Domain of Human Shq1

    Haemophilus influenzae Biotin Carboxylase

    Type VII Secretion ATPase EccC

    Dickerson Drew Dodecamer

    Plasmodium falciparum Thioredoxin-2

    Bsg25A Binding with DNA

    Human Primase

    C-Terminal Domain of p100/NF-kB2

    Transmembrane Zn2+ Transporting Four-Helix Bundle


    APC3-APC16 Complex

    Human FAN1 Dimer

    Competence Protein ComFB


    HIV-1 Capsid

    Purine 2'-Deoxyribosyltransferase

    Human TRAAK K+ channel

    UDP-Galactopyranose Mutase

    Matrix Metalloproteinase-13

    Human W61 Peptide-Ca2+-S100B

    HORMA Domain Proteins

    Human DNA Polymerase Alpha

    Human FAN1 Nuclease

    Twister Ribozyme

    Iodo-Phenylalanyl-tRNA Synthetase

    Methanofuran/Methanopterin Biosynthetic Enzyme MJ1099


    Pct1 RNA Triphosphatase

    Myxovirus Resistance Protein 2

    Human BRD4


    PRC1 Ubiquitylation Module/Ribosome

    Ionotropic Glutamate Receptor

    APC11 RING Domain

    HRASLS3/LRAT Chimeric Protein

    Yeast DEAD-Box Splicing Factor Prp28

    Peptolide 12C/Bacterial Ribosome

    NEAT Domain of Lysterial Hbp2


    Resorufin Ligase

    Peptolide 12C/Bacterial Ribosome

    Bestrophin 1

    Mycobacterium tuberculosis ClpP1P2

    Glyceraldehyde-3-phosphate Dehydrogenase

    Human Epoxide Hydrolase

    CmeC Outer Membrane Channel


    Eukaryotic Group II Intron Lariat


    Ornithine N-Hydroxylase

    Bovin Eye GAPDH


    Human STING


    T-box Stem I RNA

    Teicoplanin A-2

    Atpase Domain of Tap1

    Twister Ribozyme

    Lamina-Associated Polypeptide 1

    Anaerobic Ribonucleotide Reductase

    Intron Debranching Enzyme Dbr1

    Yeast Sac1/Vps74 Complex

    Mcg Variable Domain

    IRE1 Endoribonuclease Inhibitor

    Rhino Chromodomain–H3K9me3 Complex

    Degradation Machine Cas3

    AMPA Ligand Binding Domain

    Extracellular Signal-Regulated Kinase 2

    Eukaryotic Translation Initiation Factor eIF4E

    Thermoanaerobacter tengcongensis ydaO Riboswitch

    Thermus thermophilus 70S Ribosome

    GroEL-GroES2-(ADPBeFx)14 Complex

    Neisseria gonorrhoeae MtrE

    Thermovirga lienii


    Glutamate-Gated Chloride Channel


    tRNA Proline

    Frameshift Suppressor tRNA SufA6

    Neisseria gonorrhoeae MtrE

    Spinach RNA Aptamer

    Cb GrpU Microcompartment Shell Protein

    Pw GrpU Microcompartment Shell Protein


    T Cell Recognition

    Human ANKS3 SAM Domain

    Anks3-SAM/Anks6-SAM Heterodimer

    Archaeoglobus fulgidus UbiA Homolog

    30S Ribosomal Subunit

    RBX1-UBC12~NEDD8-CUL1-DCN1 Complex

    [Leu-5]-Enkephalin Mutants

    Glycogen Synthase


    E-cadherin with Botulinum Neurotoxin

    Triple-Helical Stability Element of MALAT1

    Serine/Threonine-Protein Kinase RIO1

    Chicken Netrin-1

    RNA Aptamer

    PCE1 Guanylyltransferase


    Transhydrogenase Domain II Dimer

    Periplasmic Iron Siderophore Binding Protein

    Thermostabilized RebH

    Species from from CH103 Lineage

    Progenitor Toxin Complex

    Nicotiana tabacum Methyltransferase

    DinJ-YafQ Toxin-Antitoxin Complex

    Insect Muscle Myosin

    Amycolatopsis orientalis BexX-CysO

    Clathrin Adaptor Protein Complex 1

    Two-Component Self-Assembling Cage

    TPP Riboswitch Complex

    Extended-Synaptotagmin 2

    PduA K26A Mutant

    Membrane Protein

    Branched Intermediate in Protein Splicing

    Synthetic Tyrosine-Protein Phosphatase

    E. coli YfbU


    Chemokine Ser-CCL1

    HIV-1 Tat

    Transcriptional Regulator Rv0678


    Intracellular B30.2 Domain of Butyrophilin 3A1

    Human αB Crystallin Core Domain

    Triarylamide Foldamer

    Malarial Secretion System

    NaV C-Terminal Domain

    70S Ribosome

    Candida albicans Superoxide Dismutase 5

    Nogo Receptor 2

    Aminoglycoside Resistance Methyltransferase NpmA

    Toxoplasma Gliding Motility Adhesin

    Apocarotenoid Oxygenase

    C1QTNF5 Globular Domain


    Human Cathepsin A

    Streptomyces erythraeus Trypsin

    G-Segment Invertase

    Aeropyrum pernix UbiA Homolog

    Yeast ALDH4A1

    hRXR-α/hLXR-β Heterodimer

    Dicer Platform-PAZ-Connector Helix Cassette

    Legionella pneumophila
    Effector Protein SidC

    Transcriptional Regulator Rv1219c

    Zebrafish ALKBH5

    Dihydromethanopterin Reductase

    Human ALDH4A1

    Polysaccharide Deacetylase BA0150

    RB69 DNA Polymerase Ternary Complex 4

    Vitamin K Epoxide Reductase

    E. coli LptB

    Thermus thermophilus Argonaute

    Voltage Sensing Domain of Ci-VSP

    Sortase B-Substrate Complex

    Human 15-Lipoxygenase-2

    Plasma Protein Scaffold YPP1

    Z-DNA Dodecamer

    Murine Cyclooxygenase-2

    Epidermal Growth Factor Receptor

    QueE from Burkholderia multivorans

    Human MHF1-MHF2 Complex

    Serine-Specific Kinase PAK4

    Accelerated Cell Death 11

    Human ENPP4

    Uranyl Binding Protein

    Ankarin Repeat LIM Domain

    Epi-isozizaene Synthase

    Cdc34-Ubiquitin-CC0651 Complex

    P. vulgaris

    S-Glutathionylated PFKFB3

    Uracil DNA Glycosylas

    NS2B-NS3 Protease

    Human Superoxide Dismutase

    Human GABAB Receptor

    SspH1 LRR Domain

    G. kaustophilus tRNA-Gly

    E. coli Holoenzyme/Gp2 Complex

    SpyTag/SpyCatcher Complex

    Lipomide Dehydrogenase

    SAMHD1 Catalytic Core

    OmpF Porin

    DNA dC→ dU-Editing Enzyme APOBEC-3F

    30S Ribosomal Subunit

    ROP18 Kinase Domain

    Human Anion Exchanger 1

    Toxin MazF

    Botulinum Neurotoxin Complex

    LeuBAT Δ13 Mutant

    Human Autoimmune TCR

    Human BRCA1 BRCT

    EphA4 Ectodomain

    Biosynthetic Enzyme BtrN

    Mouse Cyclooxygenase-2

    Saccharomyces cerevisiae Iml

    Membrane Protein CusC

    Epidermal Growth Factor Receptor

    Dopamine Transporter

    Helicase Binding Domain

    Clostridium botulinum Thiaminase I

    Jak1 Pseudokinase Domain

    Pterin Dehydratase-Like Protein

    Thermus thermophilus IF2

    PAK6 Kinase Domain

    Styrene Monooxygenase Flavin Reductase

    Human Signaling Protein Sting

    Monobody NSa1/SHP2 N-SH2 Domain Complex

    Proline Dehydrogenase Domain

    Xenopus tropicalis Lgr4

    HECT E3

    ShK Toxin

    NSGC Target OR404

    Chaperonin GroEL

    NSGC Target OR398

    NSGC Target OR288

    Bovine Trypsin

    T-box Riboswitch Stem I Domain

    Human Argonaute1

    Mouse p202 HIN2

    Middle East Respiratory Syndrome Coronavirus

    Protein Regulator of Cytokinesis 1

    Ceramide-1-Phosphate Transfer Protein

    Rabbit 40S Ribosomal Subunit

    Triple-Mutant 16 nm Protein Cage

    Dpo4 Binary Complexes

    Nuclear Protein 188

    AML1-ETO NHR2 Domain

    LSR-DNA Complex

    30S Ribosomal Subunit

    Deubiquitinase Gumby

    Immunodominant Antigen Pgp3

    Proteus mirabilis

    B-Raf Kinase

    HHARI, a Ubiquitin Ligase

    HIV-1 gp120 H375S Core

    Mammalian Lectin LMAN1

    Rous Sarcoma Virus Integrase


    Human B Type Phosphoglycerate Mutase

    SIVmac239 Capsid N-terminal Domain

    Clostridium botulinum

    Nucleotide-Bound ClpX Hexamer

    Heterochromatin Protein Sir3

    Cyclic GMP-AMP Synthase

    Anaerobic Sulfatase Maturating Enzyme

    Yeast Qri7 Homodimer

    Angiopoietin-2 Fibrinogen

    Saccharomyces cerevisiae

    mTOR Kinase

    DNA-Binding Protein Fis

    SHH1 SAWADEE domain

    STAR Domain of Quaking Protein

    Adhesive Tip Pilin

    Bacterial Ribosome RAM Mutations

    Archeaoglobus fulgidus Rio1

    GrpN Pentameric Microcompartment Shell Protein

    Biotin Carboxyl Carrier Protein-Biotin Carboxylase Complex

    NSGC Target OR258

    Clostridium perfringens EutL


    TANK-Binding Kinase 1

    p11-AnxA2 Peptide Cassette

    Serine Hydrolase, OSH55.4_H1.2

    QsrR-Menadione Complex

    Glycoprotein E2 from Bovine Viral Diarrhea Virus

    30S Ribosomal Subunit

    Escherichia coli YjiA

    Human Prion Fragment

    Protelomerase TelA

    RNA Polymerase Paused Elongation Complexes

    DKP Ester Insulin

    MutM Mutations with DNA

    σA Domain 4 Complex

    Monoclonal Antibody 3F8 FAB Fragment

    Ubiquitin Activating Enzyme

    Heavy Metal Transporter CusBA

    Glycoprotein C from Rift Valley Fever Virus

    DUB-Inhibitor Complexes

    NSGC Target OR288

    Human MAdCAM-1 D1D2

    dsRNA Receptor MDA5

    HLA-DM–HLA-DR1 Complex

    Staphylococcus epidermidis

    Mycobacterum abscessus ESXEF

    Human Soluble Epoxide Hydrolase

    Klebsiella pneumoniae HpxO


    Human DNA Polymerase Iota

    β-Sheet Amyloid Mimics

    OmpF Porin

    RB69 DNA Polymerase Complexes

    Human DNA Ligase IV

    Bovine Trypsin

    SHP1 Catalytic Domain

    Proton-Gated Urea Channel

    Dengue Envelope Protein

    Influenza Antigen-Binding Site

    Replication Protein A

    Phosphoglycerate Mutase 1

    RAC1 F28L Mutant

    Summary Group II Intron

    Thermus thermophilus RuvC Dimer

    DCNL Complex-NEDD8 E2 Peptide

    G-Segment Invertase

    Globular Domain of C1QTNF5

    Human Serum Albumin

    30S Ribosomal Subunit

    Proline Dehydrogenase

    Caenorhabditis elegans Tdp2

    Zebrafish Tdp2

    AIIGLMV Segment from Alzheimer's Amyloid-β

    Homodimeric E1 Enzyme Complexes

    Rio2 Kinase 


    DNA Helicase

    Mouse Cadherin 23

    Human SMN YG-Dimer

    UDP Galactopyrannose

    Porcine Aminopeptidase-N

    Bovine Coronavirus Spike Protein

    DAXX Chaperone with H3.3/H4 Dimer

    Pseudouridine Monophosphate Glycosidase

    Pseudo-GlycosylTransferase VldE


    Transcriptional Regulator MOSR (Rv1049)

    DNA Cytosine-5 Methyltransferase

    5' Tri-Phosphorylated RNA Duplex

    Zea mays ZMET2

    CRISPR-Associated Protein Cas5d

    H37RV ESXOP (RV2346C-RV2347C) Complex

    Scaffold Nucleoporin

    RPE65 Isomerase

    Yeast Irc6p

    Rab25 Protein in Complex with Fip2 Ras


    Actin Complex with Gelsolin Segment

    Rab GTPase Complexes

    Ulster Paramyxovirus Hemagglutinin-Neuraminidase

    Calmodulin Binding to TRPV1 Channel

    RNA-Polymerase Sigma-Subunit Fragment


    RNA-Splicing Ligase RTCB


    Human PAK4

    Acid-Sensing Ion Channel– Spider Toxin Complex

    Indolocarbazole Biosynthetic Enzyme RebC

    Manganese Superoxide Dismutase

    Human GALNS

    1-Pyrroline-5-Carboxylate Dehydrogenase

    Severe Acute Respiratory Syndrome Coronavirus

    Transcriptional Regulator Rv3066 of Mycobacterium tuberculosis

    Human Nectin-1

    Yeast Monopolin Complex

    Surface Layer of the Methanogenic Archaean Methanosarcina acetivorans

    Wild Type RAC1

    Mouse JMJD3

    HIV-1 Nef

    Designed 16-nm Cage

    NaV C-Terminal Domain

    Human TRPV4 Ankyrin Repeat Domain

    UDP-Galactopyranose Mutase

    PutA Peripheral Membrane Flavoenzyme

    Protelomerase TelA Mutant R255A

    E. coli Class Ia Ribonucleotide Reductase

    Human GABA(B) Receptor GBR2

    Yeast Argonaute with Guide RNA

    Yeast Polyamine Oxidase Fms1

    Tetrahymena Telomerase Protein p65

    Self-Assembling Tetrahedron Protein, T3-10

    Human SUN2

    Arabidopsis IDN2 XS Domain

    Conformationally Restrained Methanocarba-2'-Deoxyadenosine

    RB69 DNA Polymerase

    Rap1 in complex with KRIT

    Self-Assembling Octahedral Cage Protein, O3-33

    Human ALKBH2

    Archaeoglobus fulgidus
    Rio1 Kinase

    Fluoride Riboswitch

    TGF-beta Receptor Type 1

    Self-Assembling Tetrahedron Protein, T310

    RGD Finger of Del-1

    Chimeric Glutamate Dehydrogenase

    D-alanine-D-alanine Ligase B


    Mouse Δ1-Pyrroline-5-Carboxylate Dehydrogenase 

    MutM, a Bacterial DNA-Glycosylase

    Agrin LRP Complex

    KcsA Potassium Channel Mutant Y82C


    Human HRASLS

    Human Argonaute2

    Circumsporozoite Protein aTSR Domain

    Human 5-Lipoxygenase Mutants

    Calcium-Dependent 11R-Lipoxygenase

    ATP-Gated P2X4 Ion Channel

    Human Δ1-Pyrroline-5-Carboxylate Dehydrogenase 

    PFKFB3 in Complex with PPi

    Candida albicans THI5

    Yeast Ribonucleotide Reductase 1

    Glutamine-Dependent NAD+ Synthetase

    Extracellular Domain BT3049

    Botulinum Neurotoxin

    Amyloid-related Segment of AlphaB-crystallin

    Group II Intron

    S. cerevisiae Proliferating Cell Nuclear Antigen

    Mouse ORC1 BAH Domain

    Ctf19-Mcm21 Kinetochore Heterodimer


    Transferrin Binding Protein B

    Mouse DNMT1 (731-1602)

    Mus musculus Iodotyrosine Deiodinase

    Ctf19-Mcm21 Kinetochore Heterodimer

    PFKFB3 in Complex with PPi

    Human Thymine DNA Glycosylase

    Adenosine Phosphorylase

    Mammalian Tetrahedral Aspartyl Aminopeptidase

    Human Survivin

    Novel Topological Analogue of Crambin

    UDP Galactopyranose Mutase

    Human OTUB1/UbcH5b~Ub/Ub

    LeuT in Space Group C2

    MutM Slanted Complex

    RB69 DNA Polymerase

    UvrA-UvrB DNA Damage Sensor

    Monobody SH13/Abl1 Sh2 Domain Complex

    Determinants of SUMO1 Specificity

    LeuT in Complex with FAB

    TcdA GlucosylTransferase Domain

    Kluyveromyces lactis

    ARC4 from Human Tankyrase 2

    Extracellular Signal-Regulated Kinase 2 

    TRIM33 PHD-Bromo

    Protein Ms6760 from Mycobacterium smegmatis

    Atg7 - Distinctive E1-E2 Architecture

    GG9a-like Protein SET Domain

    Caskin1 Tandem SAMs

    Mouse Lin28A

    Sir3 BAH Domain

    Full-length Drosophila Cryptochrome

    RNA-Polymerase σ Subunit Domain 2

    Adaptive Response Protein AidB


    RB69 Y567A-DNA Polymerase

    Monobody 7c12/Abl1 Sh2 Domain Complex

    LeuT mutant I359Q

    Human Liprin-β2 Coiled-Coil


    Nuclear Pore Channel (Nup62-2,Nup54-2)

    Chikungunya Virus nsP2 Protease


    G Protein-gated Inward Rectifier K+ Channel GIRK2

    "Covalent Dimer" HIV-1 Protease

    Yeast Actin Nucleation Cofactor Bud6

    Fungal Blue-Light Photoreceptor Vivid

    Maltose Binding Protein

    B Family RB69 DNA Polymerase

    Actinomyces Fimbrial Adhesin FimA

    Class I Ligase Ribozyme-Substrate Preligation Complex

    Human Spermidine Synthase

    T4 Lysozyme

    Human DNMT1 Complex with Sinefungin

    Saccharomyces cerevisiae

    Streptococcus agalactiae
    Sortase A

    THF Riboswitch

    Vascular Endothelial Growth Factor

    RNase III Domain of Dicer Mutant

    Toluene/O-Xylene Monooxygenase Hydroxylase


    Lys-48-Linked Diubiquitin

    Haemophilus influenzae e(P4) Acid Phosphatase

    UHRF1 PHD Finger

    Influenza Hemagglutinin

    GxGD Membrane Protease FlaK

    Human Arginase

    FANCI-FANCD2 Complex

    Truncated SNARE Complex with Complexin

    Mammalian Capping Enzyme and Pol II CTD

    Klebsiella pneumoniae
    5-Hydroxyisourate Hydrolase

    P. falciparum Arginase

    RING E3-Substrate Complex

    Streptococcus pyogenes
    Uridine Phosphorylase

    Human RRP6 Catalytic Domain

    Bacillus anthracis

    Spire KIND Domain

    AT2G44920 from Thylakoid Lumen

    Designed Redox-Controlled Caspase

    Human Cdc34 E2


    Dpo4 Extension

    Bacteria Ribosome

    Amyloid Forming Peptide

    GGVLVN Segment from Human Prostatic Acid Phosphatase

    Glutamate Gated Channel

    BPTF Bromo Histone H4K16ac Complex

    Mouse Coronavirus Receptor-Binding Domain

    ATRX ADD Domain

    Centromere-Specific Histone Cse4

    Macrocyclic β-Sheet Mimics

    α-Synuclein Fused to Maltose-Binding Protein

    Ent-copalyl Diphosphate Synthase

    Leishmania donovani
    OMP Decarboxylase

    Synthesized [allo-Ile50/50']HIV-1 Protease Molecule

    Glutamine Synthetase

    Aquifex aeolicus
    Peptidoglycan Glycosyltransferase

    Prohead RNA

    Streptococcus mutans
    Antigen I/II carboxy-terminus

    Klebsiella  pneumoniae Allantoin Racemase

    Leishmania donovani
    UMP Synthase

    4Fe-4S Cluster Domain of Human DNA Primase Large Subunit

    MPP8 Chromodomain Interaction

    Human Insulin in Complex with Cucurbit[7]uril

    κB Kinase β

    T Cell Receptor β Chain

    Mycobacterium tuberculosis

    Glycine Riboswitch

    Protein Phosphatase Subunit: Alpha4

    EPEC Effector, EspG

    DCC - A Netrin-1 Receptor

    Human ROCK I

    Polyamine Amidohydrolase (APAH)

    Putative Flagellar Hook-Associated Protein

    Salmonella typhimurium Phosphoglucomutase

    CusBA Heavy-Metal Efflux Complex

    Human DNA Polymerase Iota

    Human 5-Lipoxygenase

    DegP Dodecamer

    PWWP Domain of Human Hepatoma-Derived Growth Factor 2

    Potassium Transporter TrkH



    Mycobacterium smegmatis
    EsxGH complex

    Human Hiwi1 PAZ Domain

    Metal-Dependent Deacetylase LpxC

    Potassium Channel KcsA

    RB69 DNA Polymerase Ternary Complex

    Calcineurin in Complex with AKAP79 Peptide

    TRIM 24 PHD-Bromo

    Archaeoglobus fulgidus

    PHF2 Jumonji-NOG-Ni(II)

    Nucleosome Core Particle


    Toxoflavin Lyase

    DNMT1-DNA Complex

    CRISPR Associated Protein Cas2

    Tomato Chloroplast Superoxide Dismutase

    CelA from Thermotoga maritima

    HIV-1 Primary Receptor CD4

    Benzimidazole-2-pyrazole HIF Prolyl 4-Hydroxylase 3oui

    Notch Transcription Complex Trimers on HES1 DNA

    Candida glabrata

    Nep1/Emg1 N1-specific Pseudouridine Methyltransferase

    Cluster II Fab 1281 with HIV-1 gp41 Ectodomain

    Haemophilus influenzae
    Class C Acid Phosphatase


    Human Prethrombin-1

    Human 8-Oxoguanine DNA
    Glycosylase hOGG1

    Eukaryotic CLC Transporter

    DcR3-TL1A Complex

    Odorant-binding Protein from the Southern House Mosquito

    Transcription-Repair Coupling Factor/RNA Polymerase

    Bacillus halodurans

    KsgA Mutant of Thermus thermophilus (HB8)

    Fas-FADD Death Domain Complex

    PduA from Salmonella enterica Typhimurium

    Cullin Neddylation Protein 1/Cell Division Control Protein 53

    Streptococcus pneumoniae Nicotinamidase

    PduT C38S Mutant from PduA from Salmonella enterica Typhimurium

    Heavy Metal Transporter CusA

    Escherichia coli

    Vps53 Subunit of GARP

    PTEN-like Region of Auxilin

    Telomere Length Regulation Protein TEL2

    Monopolin Complex


    Alka Undamaged DNA Complex

    Mouse-Human Sod1 Chimera

    Sec13-Sec16 Edge Element

    Ets1 Complex with Stromelysin-1 Promoter DNA


    Chromatin Factor RCC1

    Truncated Zebrafish AlphaA Crystallin

    Bacteriophage P1 Phd-Doc

    H37Rv EsxOP Complex Mycobacterium tuberculosis

    N-terminal Domain of Plasmodium falciparum Hsp90

    Polymerase Core of TRAMP

    Urea Transporter from Desulfovibrio vulgaris

    PRC1 (Conserved Non-motor Microtubule Binding Protein)

    Complex of Dishevlled2 and Clathrin Adaptor AP-2

    Coatomer Cage Proteins

    Human 8-OxoGuanine Glycosylase 1

    GYVLGS Segment 127-132 from Human Prion with V129


    EphA2 Ectodomain

    DiGeorge Critical Region 8 Dimerization Domain

    Human DNA Ligase III

    MLL1 PHD3-Bromo Cassette


    DNA Polymerase η

    Arginase from Plasmodium falciparum

    Conserved Herpesvirus Fusion Regulator Complex gH-gL

    CmeR-Bile Acid Complexes

    Dpo4 in Complex with DNA

    HIV-1 Tat complexed with human P-TEFb

    Klebsiella pneumoniae HpxJ

    Human Histone Deacetylase 8

    Intracellular Domain of Prokaryote FeoB

    PODANSg2158 from Podospora anserina

    Human BK Channel Ca2+-Activation Apparatus

    Glycopeptide Sulfotransferase Teg12

    Concatenated HAMP Domains

    AlphaA and AlphaB Crystallins

    Dph2 from Pyrococcus

    2ouf-2x, a Designed Knotted Protein

    Mouse Cadherin-23 EC1

    Allophanate Hydrolase Complex

    Kinase-Endonuclease IRE1

    -Galactosidase A

    MmoQ Response Regulator

    Bovine Uridine Phosphorylase

    Bacterial Nucleoid-Associated Protein Fis

    Mitogen-and Stress-Activated Protein Kinase

    Machupo Virus GP1

    A3VP1 of Antigen I/II

    Bovine trypsin

    Shigella flexneri
    Cytosine-Specific Methyltransferase

    Mycobacterial Lipoamide Dehydrogenase

    ParD-ParE Toxin-Antitoxin Complex

    Coiled-Coil Pair SYNZIP5:SYNZIP6

    Probable D-Alanine-Poly(Phosphoribitol) Ligase

    Bacterial Homologue of Vitamin K Epoxide Reductase

    Epi-Isozizaene Synthase

    C2 protein (HET-C2)

    70S Ribosome

    Mouse Elf3 C-terminal DNA-binding Domain

    K+ channel Kir2.2

    Y-family polymerase Dpo4

    Ethanolamine Utilization Microcompartment Shell Subunit

    Enzyme 2-(Acetamidomethylene)succinate Hydrolase

    ymzC Precursor from Bacillus subtilis

    UbcH5B~Ubiquitin-HECTNEDD4L Complex

    Type-I Restriction-Modification System Methylation Subunit

    Oceanobacillus Iheyensis
    Group II Intron

    Human Arginase I

    Avian Thymic Hormone

    Thioredoxin System from Deinococcus radiodurans

    HUWE1 HECT Domain

    Saporin-L1 in Complex with Dinucleotide Inhibitor

    Plasmodium Falciparum UCHL3

    N-terminal Kinase Domain of p90 Rbosomal S6 Kinase 2

    PF-8 from Kaposi's Sarcoma-Associated Herpesvirus

    Catalytic Core of an RNA Polymerase Ribozyme

    Cryptosporidium parvum
    Inosine-5'-Monophosphate Dehydrogenase

    Protein Rv0674 from Mycobacterium tuberculosis

    Sequence-matched MutM Interrogation Complex 5 (IC5)

    E. coli
    70S ribosome

    ClpX Hexamer

    MutY bound to its inhibitor DNA

    Nup84-Nup145C-Sec13 Edge Element

    Simvastatin Synthase (LovD)

    Urea Transporter from Desulfovibrio Vulgaris

    Histidine Acid Phosphatase

    Rru_A2000 from Rhodospirillum rubrum: A cupin-2 domain

    SPOP-Substrate Complexes

    CHK2 DNA-Damage Checkpoint Kinase

    P. aeruginonsa

    Human SepSecS-tRNASec complex

    T. thermophilus Argonaute E

    Mms21 and Smc5 Complex

    Inhibitor Bound to Cathepsin S


    Apo CAP

    SUMO E3 Ligase SIZ1

    Mutant Bacteriorhodopsins

    Human Nucleoporins Nup170 and 133

    CBC-Importin Alpha Complex

    Adenosine Deaminase from Plasmodial vivax

    Carboxysome Small Shell Protein CsoS1C

    Thermotoga maritima Soluble Receptor (Tm14)

    Ran-Binding Zinc Finger Domain

    Membrane Fusion Protein CusB

    Anaphase Promoting Complex TPR Subdomain Assembly

    Acyl-CoA Thioesterase (ACOT2)

    Rv3019c-Rv3020c (Mycobacterium tuberculosis)

    Nucleoporin Nup120

    ATP-gated P2X4 Ion Channel

    EPHA2 Ligand-Binding Domain

    Cytidine Deaminase

    Mus musculus Iodotyrosine Deiodinase

    Dpo4 Extension Ternary Complex

    Human Ubiquitin-Activating Enzyme 5

    Rv0301 Rv0300 Toxin Antitoxin Complex from Mycobacterium tuberculosis

    Vascular Protein von Willebrand Factor A2 Domain

    Islet Amyloid Segments
    JARID1A-PHD3 Complexed with H3(1-9)K4me3 Peptide
    Tomato Aspermy Virus 2b in Complex with siRNA


    Pyridoxal Phosphate Biosynthetic Protein (Burkholderi Pseudomallei)

    Glyceraldehyde-3-Phosphate Dehydrogenase

    2-Methyl-3-hydroxypyridine-5-carboxylic acid Oxygenase

    Shigella VirA

    Binary Complex of Citryl Dethia COA and Citrate Synthase

    SMK Box Riboswitch

    Protein-Translocation Complex (SecY Channel/SecA ATPase)

    Putative Methyltransferase-MM_2633 from Methanosarcina mazei

    Thermotoga maritima Lysine Riboswitch

    Human SENP7 Catalytic Domain

    IsocitrateLyase from Brucella melitensis

    Guide-Strand-Containing Argonaute Silencing Complex

    DegS-deltaPDZ q191A

    Sulfur Carrying Protein Complex

    SAM-dependent methyltransferase from Bacteroides vulgatus ATCC 8482

    Quinolinate synthase from Pyrococcus furiosus

    AlkA Host/Guest Complex

    Rotavirus SA11 VP1 / RNA Complexes


    Thermotoga maritima

    TRAPP Subassembly Activating the Rab Ypt1p

    Nipah G Attachment Glycoprotein

    Peptidoglycan Glycosyltransferase Domain from Aquifex aeolicus

    Putative Transglycosylase from Caulobacter crescentus


    VapBC-5 from Mycobacterium tuberculosis

    NF-κB Inhibitor A20

    B-subunit of the DNA gyrase from Myxococcus xanthus


    HIV Vif BC-box in Complex with Human ElonginB and ElonginC

    Platinum-DNA Adduct Bound to Deoxyguanosine

    Human Factor VIII

    PCNA12 Dimer from Sulfolobus solfataricus

    Anisomycin resistant 50S Ribosomal Subunit

    Prosubtilisin Substrate Complex of Subtilisin

    Pyruvate Kinase M2

    Receptor complex

    Self-spliced Group II Intron

    Hepatitis C Virus IRES Subdomain IIa

    CNK/HYP Dimer

    Thiamin Monophosphate Kinase
    Aquifex aeolicus

    L7/L12 stalk of 50S Large Ribosomal Subunit

    PDCD4 MA3 Domains

    Ankyrin Repeat Domain of TRPV6

    Oligogalacturonate lyase (VPA0088) from Vibrio Parahaemolyticus

    DR_0571 Protein from Deinococcus radiodurans

    HTH-type Transcriptional Regulator AcrR

    EGFR - Kinase Domain

    Thiamin Binding Protein

    S. cerevisiae Dcn1

    Metal Binding Domain of NikR

    Human BPTF PHD Finger

    PCNA123 Heterotrimer

    Violacein Biosynthetic Enzyme VioE

    Bacillus stearothermophilus

    Methanocaldococcus jannaschii PurP

    Pyrococcus furiosusPurP

    C-Terminal Kinase Domain of P90 2 Ribosomal S6 Kinase 2

    DegS, a PDZ Protease

    Human Intrinsic factor: Cobalamin complex

    DnaB Helicase

    HMPD Decarboxylase

    Inner Kinetochore Subunit Cep3p

    Rebeccamycin Biosynthetic Enzyme RebC

    Nucleoporin Nic96

    |Rad4 Nucleotide Excision Repair Protein

    AMP-activated Protein Kinase

    Pyrrolysyl-tRNA Synthetase

    ADH Synthase

    Lowe Syndrome Protein OCRL

    C. crescentus SspB Ortholog

    Yeast Sec13/31 Vertex Element

    Yeast Fatty Acid Synthase

    Minimal Pluripotent DNA Ligase

    Phi29 DNA Polymerase

    At1g77540-Coenzyme A Complex

    Human MCL-1

    SCFCdc4 Dimer

    Focal Adhesion Kinase

    Non-covalent Complex Between Human SUMO-1 and Human Ubc9

    Fbw7-Skp1-Cyclin E Complex

    FH2 domain of Daam1

    DNA Ligase Bound to Nicked DNA-Adenylate

    Herpesvirus-encoded Cysteine Protease

    Monobody MBP-74/Maltose Binding Protein Fusion Complex

    Lung Cancer-Derived EGFR

    Death Domain Containing Protein CRADD

    Inosine 5'-monophosphate cyclohydrolase
    Methanobacterium thermoautotrophicum

    Rab GTPase Sec4p

    Peptidoglycan Glycosyltransferase


    Q7WAF1 BORPA from Bordetella parapertussis

    4-Hydroxybutyrate Coenzyme A Transferase

    Q9HYQ7 PSEAE from Pseudomonas aeruginosa

    Escherichia coli N5-carboxyaminoimidazole Ribonucleotide Mutase

    Aromatic Amine Dehydrogenase

    Synthetic Human Lysozyme

    Eurkaryotic RNA Exosome

    Hydroxylase-Regulatory Protein Complex

    T4 RNA Ligase 2


    Thermotoga maritima Formylglycinamide Ribonucleotide Amidotransferase

    Human Senp2 in Complex with PreSUMO-2

    Bacterial Antitoxin HigA from Escherichia coli

    FeeM, an N-Acyl Amino Acid Synthase

    RNAase II

    Arabidopsis thaliana Double Bond Reductase (at5G16970)

    DNA polymerase III alpha subunit
    Thermus aquaticus

    Glycoprotein B from Herpes Simplex virus 1

    P52G Mutant of Amicyanin

    Self-inhibited Thrombin

    Active Chimera of (S)-Mandelate Dehydrogenase

    Ankyrin Repeat Domain - TRPV2 Ion Channel

    BMP2-induced 3-kb Gene Protein

    tRNA Splicing Endonuclease

    Mouse Pyrimidine 5'-Nucleotidase Type 1

    Arabidopsis thaliana At1g77540

    DNA Glycosylase

    BPTF PHD Finger of NURF

    Cbf5-Nop10-Gar1 Complex

    Rb C-terminal Domain bound to E2F1-DP1

    5'-Deoxy-5'-Methylthioadenosine Phosphorylase II

    Ubiquitin-Conjugating Enzyme E2

    RNAase A

    Exocyst Subunit Exo70p

    Escherichia coli ThiFS

    Arsenical Resistance Protein

    Human Deoxycytidine Kinase

    Type IIA DNA Topoisomerase

    Fe(II) HppE

    Skp1-Skp2-Cks1-p27Kip1 Complex

    pH Domain of SKAP55

    Eschrichia coli Uridine Phosphorylase

    Succinylglutamate Desuccinylase
    Escherichia coli

    Toxoplasma gondii Adenosine Kinase


    Chromatin-Remodeling Domain


    Sspb Heterodimer

    Ubiquitin Hydrolase UCH-L3

    Bacillus subtilis TenI

    Bacillus subtilis TenA

    Trichomonas vaginalis
    Purine Nucleoside Phosphorylase

    Hypothetical Protein (Tm1631)
    Thermotoga Maritima

    Permutated Arc Repressor

    Sspb-Rsea Complex

    Human Tub Protein (Isoform A)

    Protein-primed DNA Polymerase
    of Bacteriophage Phi29

    Bacterial Nucleoside Transporter Tsx

    Sspb Disulfide

    Hypothetical Protein Vc1974 from Vibrio Cholerae

    Cytochrome c and
    Cytochrome c Peroxidase

    Achaeoglobus fulgidus tRNA Nucleotidyltransferase

    Ytnj from Bacillus subtilis

    Phage Twort Group I
    Ribozyme Product Complex

    Long-Chain Fatty Acid Transporter FadL

    Thiazole Synthase/Sulfur Carrier Protein Complex from Bacillus subtilis

    Aminoimidazole Riboside Kinase from Salmonella enterica


    T. maritima S-adenosylmethionine Decarboxylase

    Bni1p Formin Homology-2 domain

    α/β Serine Hydrolase (Ydr428C)

    B. subtilis PurS

    Protein Conducting Channel

    Purine 2'-deoxyribosyltransferase

    E. coli AMP Nucleosidase

    Nogo-66 Receptor (NgR)

    Nickel-Responsive Transcription Factor NikR

    Semaphorin-3A Receptor binding Module

    Human phosphopantothenoylcysteine (PPC) Decarboxylase


    Pvl ArgDC


    Human Phosphopantothenoylcysteine Synthetase

    Large ribosomal E site Complexes