Publications
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(2011) Structure of DNMT1-DNA complex reveals a role for autoinhibition in maintenance DNA methylation. Science. 331, 1036-40
(2022) Structure of DNMT3B homo-oligomer reveals vulnerability to impairment by ICF mutations. Nat Commun. 13, 4249
(2010) Structure of epi-isozizaene synthase from Streptomyces coelicolor A3(2), a platform for new terpenoid cyclization templates. Biochemistry. 49, 1787-97
(2021) Structure of Erm-modified 70S ribosome reveals the mechanism of macrolide resistance. Nat Chem Biol. 10.1038/s41589-020-00715-0
(2004) Structure of Escherichia coli AMP nucleosidase reveals similarity to nucleoside phosphorylases. Structure. 12, 1383-94
(2025) Structure of European robin cryptochrome 1 reveals a role in circadian rhythms, not magnetoreception. iScience. 28, 114015
(2019) Structure of fission yeast transcription factor Pho7 bound to promoter DNA and effect of Pho7 mutations on DNA binding and phosphate homeostasis. Mol Cell Biol. 10.1128/MCB.00132-19
(2023) The structure of fly Teneurin-m reveals an asymmetric self-assembly that allows expansion into zippers. EMBO Rep. 10.15252/embr.202256728
(2008) Structure of hepatitis C virus IRES subdomain IIa. Acta Crystallogr D Biol Crystallogr. 64, 436-43
(2007) Structure of hexameric DnaB helicase and its complex with a domain of DnaG primase. Science. 318, 459-63
(2013) Structure of HHARI, a RING-IBR-RING ubiquitin ligase: autoinhibition of an Ariadne-family E3 and insights into ligation mechanism. Structure. 21, 1030-41
(2018) Structure of human ADP-ribosyl-acceptor hydrolase 3 bound to ADP-ribose reveals a conformational switch that enables specific substrate recognition. J Biol Chem. 293, 12350-12359
(2006) The structure of human deoxycytidine kinase in complex with clofarabine reveals key interactions for prodrug activation. Acta Crystallogr D Biol Crystallogr. 62, 133-9
(2012) The structure of human GALNS reveals the molecular basis for mucopolysaccharidosis IV A. J Mol Biol. 423, 736-51
(2025) Structure of human MUTYH and functional profiling of cancer-associated variants reveal an allosteric network between its [4Fe-4S] cluster cofactor and active site required for DNA repair. Nat Commun. 16, 3596
(2018) Structure of Human NatA and Its Regulation by the Huntingtin Interacting Protein HYPK. Structure. 10.1016/j.str.2018.04.003
(2011) Structure of human O-GlcNAc transferase and its complex with a peptide substrate. Nature. 469, 564-7
(2003) Structure of human phosphopantothenoylcysteine synthetase at 2.3 A resolution. Structure. 11, 927-36
(2017) Structure of human POFUT1, its requirement in ligand-independent oncogenic Notch signaling, and functional effects of Dowling-Degos mutations. Glycobiology. 10.1093/glycob/cwx020

