Publications

Found 30 results
Filters: Author is Lima, Christopher D  [Clear All Filters]
Journal Article
Ginn, J., Jiang, X., Sun, S., Michino, M., Huggins, D. J., Mbambo, Z., Jansen, R., Rhee, K. Y., Arango, N., Lima, C. D., Liverton, N., Imaeda, T., Okamoto, R., Kuroita, T., Aso, K., Stamford, A., Foley, M., Meinke, P. T., Nathan, C., and Bryk, R. (2021) Whole Cell Active Inhibitors of Mycobacterial Lipoamide Dehydrogenase Afford Selectivity over the Human Enzyme through Tight Binding Interactions. ACS Infect Dis. 7, 435-444
Bryk, R., Arango, N., Venugopal, A., J Warren, D., Park, Y. - H., Patel, M. S., Lima, C. D., and Nathan, C. (2010) Triazaspirodimethoxybenzoyls as selective inhibitors of mycobacterial lipoamide dehydrogenase . Biochemistry. 49, 1616-27
Yunus, A. A., and Lima, C. D. (2009) Structure of the Siz/PIAS SUMO E3 ligase Siz1 and determinants required for SUMO modification of PCNA. Mol Cell. 35, 669-82
Lima, C. D., and Reverter, D. (2008) Structure of the human SENP7 catalytic domain and poly-SUMO deconjugation activities for SENP6 and SENP7. J Biol Chem. 283, 32045-55
Wasmuth, E. V., Januszyk, K., and Lima, C. D. (2014) Structure of an Rrp6-RNA exosome complex bound to poly(A) RNA. Nature. 511, 435-9
Olsen, S. K., and Lima, C. D. (2013) Structure of a ubiquitin E1-E2 complex: insights to E1-E2 thioester transfer. Mol Cell. 49, 884-96
Wasmuth, E. V., Zinder, J. C., Zattas, D., Das, M., and Lima, C. D. (2017) Structure and reconstitution of yeast Mpp6-nuclear exosome complexes reveals that Mpp6 stimulates RNA decay and recruits the Mtr4 helicase. Elife. 10.7554/eLife.29062
Doamekpor, S. K., Lee, J. - W., Hepowit, N. L., Wu, C., Charenton, C., Leonard, M., Bengtson, M. H., Rajashankar, K. R., Sachs, M. S., Lima, C. D., and Joazeiro, C. A. P. (2016) Structure and function of the yeast listerin (Ltn1) conserved N-terminal domain in binding to stalled 60S ribosomal subunits. Proc Natl Acad Sci U S A. 113, E4151-60
Capili, A. D., and Lima, C. D. (2007) Structure and analysis of a complex between SUMO and Ubc9 illustrates features of a conserved E2-Ubl interaction. J Mol Biol. 369, 608-18
Ghosh, A., Shuman, S., and Lima, C. D. (2011) Structural insights to how mammalian capping enzyme reads the CTD code. Mol Cell. 43, 299-310
Reverter, D., and Lima, C. D. (2006) Structural basis for SENP2 protease interactions with SUMO precursors and conjugated substrates. Nat Struct Mol Biol. 13, 1060-8
Nair, P. A., Nandakumar, J., Smith, P., Odell, M., Lima, C. D., and Shuman, S. (2007) Structural basis for nick recognition by a minimal pluripotent DNA ligase. Nat Struct Mol Biol. 14, 770-8
M Puno, R., and Lima, C. D. (2018) Structural basis for MTR4-ZCCHC8 interactions that stimulate the MTR4 helicase in the nuclear exosome-targeting complex. Proc Natl Acad Sci U S A. 10.1073/pnas.1803530115
Cappadocia, L., Pichler, A., and Lima, C. D. (2015) Structural basis for catalytic activation by the human ZNF451 SUMO E3 ligase. Nat Struct Mol Biol. 22, 968-75
Hann, Z. S., Ji, C., Olsen, S. K., Lu, X., Lux, M. C., Tan, D. S., and Lima, C. D. (2019) Structural basis for adenylation and thioester bond formation in the ubiquitin E1. Proc Natl Acad Sci U S A. 116, 15475-15484
Nandakumar, J., Shuman, S., and Lima, C. D. (2006) RNA ligase structures reveal the basis for RNA specificity and conformational changes that drive ligation forward. Cell. 127, 71-84
Armstrong, A. A., Mohideen, F., and Lima, C. D. (2012) Recognition of SUMO-modified PCNA requires tandem receptor motifs in Srs2. Nature. 483, 59-63
Békés, M., van Noort, G. J. van der, Ekkebus, R., Ovaa, H., Huang, T. T., and Lima, C. D. (2016) Recognition of Lys48-Linked Di-ubiquitin and Deubiquitinating Activities of the SARS Coronavirus Papain-like Protease. Mol Cell. 62, 572-85
Zinder, J. C., Wasmuth, E. V., and Lima, C. D. (2016) Nuclear RNA Exosome at 3.1 Å Reveals Substrate Specificities, RNA Paths, and Allosteric Inhibition of Rrp44/Dis3.. Mol Cell. 64, 734-745
Yunus, A. A., and Lima, C. D. (2006) Lysine activation and functional analysis of E2-mediated conjugation in the SUMO pathway. Nat Struct Mol Biol. 13, 491-9
Bryk, R., Arango, N., Maksymiuk, C., Balakrishnan, A., Wu, Y. - T., Wong, C. - H., Masquelin, T., Hipskind, P., Lima, C. D., and Nathan, C. (2013) Lipoamide channel-binding sulfonamides selectively inhibit mycobacterial lipoamide dehydrogenase. Biochemistry. 52, 9375-84
Doamekpor, S. K., Sanchez, A. M., Schwer, B., Shuman, S., and Lima, C. D. (2014) How an mRNA capping enzyme reads distinct RNA polymerase II and Spt5 CTD phosphorylation codes. Genes Dev. 28, 1323-36
Schwer, B., Ghosh, A., Sanchez, A. M., Lima, C. D., and Shuman, S. (2015) Genetic and structural analysis of the essential fission yeast RNA polymerase II CTD phosphatase Fcp1. RNA. 21, 1135-46
Doamekpor, S. K., Schwer, B., Sanchez, A. M., Shuman, S., and Lima, C. D. (2015) Fission yeast RNA triphosphatase reads an Spt5 CTD code. RNA. 21, 113-23
Lau, Y. - T. K., Baytshtok, V., Howard, T. A., Fiala, B. M., Johnson, J. L. M., Carter, L. P., Baker, D., Lima, C. D., and Bahl, C. D. (2018) Discovery and engineering of enhanced SUMO protease enzymes. J Biol Chem. 293, 13224-13233

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