Publications

Found 35 results
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Journal Article
Hitosugi, T., Zhou, L., Fan, J., Elf, S., Zhang, L., Xie, J., Wang, Y., Gu, T. - L., Alečković, M., LeRoy, G., Kang, Y., Kang, H. - B., Seo, J. - H., Shan, C., Jin, P., Gong, W., Lonial, S., Arellano, M. L., Khoury, H. J., Chen, G. Z., Shin, D. M., Khuri, F. R., Boggon, T. J., Kang, S., He, C., and Chen, J. (2013) Tyr26 phosphorylation of PGAM1 provides a metabolic advantage to tumours by stabilizing the active conformation. Nat Commun. 4, 1790
Ha, B. Hak, Davis, M. J., Chen, C., Lou, H. Jane, Gao, J., Zhang, R., Krauthammer, M., Halaban, R., Schlessinger, J., Turk, B. E., and Boggon, T. J. (2012) Type II p21-activated kinases (PAKs) are regulated by an autoinhibitory pseudosubstrate. Proc Natl Acad Sci U S A. 109, 16107-12
Simon, B., Lou, H. Jane, Huet-Calderwood, C., Shi, G., Boggon, T. J., Turk, B. E., and Calderwood, D. A. (2022) Tousled-like kinase 2 targets ASF1 histone chaperones through client mimicry. Nat Commun. 13, 749
Stiegler, A. L., Vish, K. J., and Boggon, T. J. (2022) Tandem engagement of phosphotyrosines by the dual SH2 domains of p120RasGAP. Structure. 30, 1603-1614.e5
Gao, J., Ha, B. Hak, Lou, H. Jane, Morse, E. M., Zhang, R., Calderwood, D. A., Turk, B. E., and Boggon, T. J. (2013) Substrate and inhibitor specificity of the type II p21-activated kinase, PAK6. PLoS One. 8, e77818
Yun, C. -hong, Boggon, T. J., Li, Y., Woo, M. S., Greulich, H., Meyerson, M., and Eck, M. J. (2007) Structures of lung cancer-derived EGFR mutants and inhibitor complexes: mechanism of activation and insights into differential inhibitor sensitivity. Cancer Cell. 11, 217-27
Alicea-Velázquez, N. L., Jakoncic, J., and Boggon, T. J. (2013) Structure-guided studies of the SHP-1/JAK1 interaction provide new insights into phosphatase catalytic domain substrate recognition. J Struct Biol. 181, 243-51
Ha, B. Hak, Simpson, M. Adam, Koleske, A. J., and Boggon, T. J. (2015) Structure of the ABL2/ARG kinase in complex with dasatinib. Acta Crystallogr F Struct Biol Commun. 71, 443-8
Fisher, O. S., Deng, H., Liu, D., Zhang, Y., Wei, R., Deng, Y., Zhang, F., Louvi, A., Turk, B. E., Boggon, T. J., and Su, B. (2015) Structure and vascular function of MEKK3-cerebral cavernous malformations 2 complex. Nat Commun. 6, 7937
Fisher, O. S., Zhang, R., Li, X., Murphy, J. W., Demeler, B., and Boggon, T. J. (2013) Structural studies of cerebral cavernous malformations 2 (CCM2) reveal a folded helical domain at its C-terminus. FEBS Lett. 587, 272-7
Stiegler, A. L., Zhang, R., Liu, W., and Boggon, T. J. (2014) Structural determinants for binding of sorting nexin 17 (SNX17) to the cytoplasmic adaptor protein Krev interaction trapped 1 (KRIT1). J Biol Chem. 289, 25362-73
Fisher, O. S., Liu, W., Zhang, R., Stiegler, A. L., Ghedia, S., Weber, J. L., and Boggon, T. J. (2015) Structural basis for the disruption of the cerebral cavernous malformations 2 (CCM2) interaction with Krev interaction trapped 1 (KRIT1) by disease-associated mutations. J Biol Chem. 290, 2842-53
Li, X., Zhang, R., Draheim, K. M., Liu, W., Calderwood, D. A., and Boggon, T. J. (2012) Structural basis for small G protein effector interaction of Ras-related protein 1 (Rap1) and adaptor protein Krev interaction trapped 1 (KRIT1). J Biol Chem. 287, 22317-27
Hamill, S., Lou, H. Jane, Turk, B. E., and Boggon, T. J. (2016) Structural Basis for Noncanonical Substrate Recognition of Cofilin/ADF Proteins by LIM Kinases. Mol Cell. 62, 397-408
Zhang, R., Li, X., and Boggon, T. J. (2015) Structural analysis of the KRIT1 ankyrin repeat and FERM domains reveals a conformationally stable ARD-FERM interface. J Struct Biol. 192, 449-56
Chau, J. E., Vish, K. J., Boggon, T. J., and Stiegler, A. L. (2022) SH3 domain regulation of RhoGAP activity: Crosstalk between p120RasGAP and DLC1 RhoGAP. Nat Commun. 13, 4788
Chetty, A. K., Sexton, J. A., Ha, B. Hak, Turk, B. E., and Boggon, T. J. (2020) Recognition of physiological phosphorylation sites by p21-activated kinase 4. J Struct Biol. 211, 107553
Davis, M. J., Ha, B. Hak, Holman, E. C., Halaban, R., Schlessinger, J., and Boggon, T. J. (2013) RAC1P29S is a spontaneously activating cancer-associated GTPase. Proc Natl Acad Sci U S A. 110, 912-7
Hitosugi, T., Zhou, L., Elf, S., Fan, J., Kang, H. - B., Seo, J. Ho, Shan, C., Dai, Q., Zhang, L., Xie, J., Gu, T. - L., Jin, P., Alečković, M., LeRoy, G., Kang, Y., Sudderth, J. A., DeBerardinis, R. J., Luan, C. - H., Chen, G. Z., Muller, S., Shin, D. M., Owonikoko, T. K., Lonial, S., Arellano, M. L., Khoury, H. J., Khuri, F. R., Lee, B. H., Ye, K., Boggon, T. J., Kang, S., He, C., and Chen, J. (2012) Phosphoglycerate mutase 1 coordinates glycolysis and biosynthesis to promote tumor growth. Cancer Cell. 22, 585-600
Zhang, E. Y., Ha, B. Hak, and Boggon, T. J. (2017) PAK4 crystal structures suggest unusual kinase conformational movements. Biochim Biophys Acta. 10.1016/j.bbapap.2017.10.004
Stiegler, A. L., and Boggon, T. J. (2017) p190RhoGAP proteins contain pseudoGTPase domains. Nat Commun. 8, 506
Stiegler, A. L., and Boggon, T. J. (2018) The N-Terminal GTPase Domain of p190RhoGAP Proteins Is a PseudoGTPase. Structure. 10.1016/j.str.2018.07.015
Ha, B. Hak, Yigit, S., Natarajan, N., Morse, E. M., Calderwood, D. A., and Boggon, T. J. (2022) Molecular basis for integrin adhesion receptor binding to p21-activated kinase 4 (PAK4). Commun Biol. 5, 1257
Liu, W., Draheim, K. M., Zhang, R., Calderwood, D. A., and Boggon, T. J. (2013) Mechanism for KRIT1 release of ICAP1-mediated suppression of integrin activation. Mol Cell. 49, 719-29
Chen, C., Ha, B. Hak, Thévenin, A. F., Lou, H. Jane, Zhang, R., Yip, K. Y., Peterson, J. R., Gerstein, M., Kim, P. M., Filippakopoulos, P., Knapp, S., Boggon, T. J., and Turk, B. E. (2014) Identification of a major determinant for serine-threonine kinase phosphoacceptor specificity. Mol Cell. 53, 140-7

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