Publications

Found 93 results
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Journal Article
Huang, H., Strømme, C. B., Saredi, G., Hödl, M., Strandsby, A., González-Aguilera, C., Chen, S., Groth, A., and Patel, D. J. (2015) A unique binding mode enables MCM2 to chaperone histones H3-H4 at replication forks. Nat Struct Mol Biol. 22, 618-26
Gao, P., Yang, H., Rajashankar, K. R., Huang, Z., and Patel, D. J. (2016) Type V CRISPR-Cas Cpf1 endonuclease employs a unique mechanism for crRNA-mediated target DNA recognition. Cell Res. 26, 901-13
Tsai, W. - W., Wang, Z., Yiu, T. T., Akdemir, K. C., Xia, W., Winter, S., Tsai, C. - Y., Shi, X., Schwarzer, D., Plunkett, W., Aronow, B., Gozani, O., Fischle, W., Hung, M. - C., Patel, D. J., and Barton, M. Craig (2010) TRIM24 links a non-canonical histone signature to breast cancer. Nature. 468, 927-32
Teplova, M., Hafner, M., Teplov, D., Essig, K., Tuschl, T., and Patel, D. J. (2013) Structure-function studies of STAR family Quaking proteins bound to their in vivo RNA target sites. Genes Dev. 27, 928-40
Chen, S., Rufiange, A., Huang, H., Rajashankar, K. R., Nourani, A., and Patel, D. J. (2015) Structure-function studies of histone H3/H4 tetramer maintenance during transcription by chaperone Spt2. Genes Dev. 29, 1326-40
Jia, N., Xie, W., M de la Cruz, J., Eng, E. T., and Patel, D. J. (2020) Structure-function insights into the initial step of DNA integration by a CRISPR-Cas-Transposon complex. Cell Res. 10.1038/s41422-019-0272-2
Gao, P., Ascano, M., Zillinger, T., Wang, W., Dai, P., Serganov, A. A., Gaffney, B. L., Shuman, S., Jones, R. A., Deng, L., Hartmann, G., Barchet, W., Tuschl, T., and Patel, D. J. (2013) Structure-function analysis of STING activation by c[G(2',5')pA(3',5')p] and targeting by antiviral DMXAA. Cell. 154, 748-62
Xie, W., Sowemimo, I., Hayashi, R., Wang, J., Burkard, T. R., Brennecke, J., Ameres, S. L., and Patel, D. J. (2020) Structure-function analysis of microRNA 3'-end trimming by Nibbler. Proc Natl Acad Sci U S A. 10.1073/pnas.2018156117
Xie, W., Sowemimo, I., Hayashi, R., Wang, J., Burkard, T. R., Brennecke, J., Ameres, S. L., and Patel, D. J. (2020) Structure-function analysis of microRNA 3'-end trimming by Nibbler. Proc Natl Acad Sci U S A. 10.1073/pnas.2018156117
Sheng, G., Gogakos, T., Wang, J., Zhao, H., Serganov, A., Juranek, S., Tuschl, T., Patel, D. J., and Wang, Y. (2017) Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes. Nucleic Acids Res. 45, 9149-9163
Song, J., Teplova, M., Ishibe-Murakami, S., and Patel, D. J. (2012) Structure-based mechanistic insights into DNMT1-mediated maintenance DNA methylation. Science. 335, 709-12
Sheng, G., Zhao, H., Wang, J., Rao, Y., Tian, W., Swarts, D. C., van der Oost, J., Patel, D. J., and Wang, Y. (2014) Structure-based cleavage mechanism of Thermus thermophilus Argonaute DNA guide strand-mediated DNA target cleavage. Proc Natl Acad Sci U S A. 111, 652-7
Nakanishi, K., Weinberg, D. E., Bartel, D. P., and Patel, D. J. (2012) Structure of yeast Argonaute with guide RNA. Nature. 486, 368-74
Wang, Y., Sheng, G., Juranek, S., Tuschl, T., and Patel, D. J. (2008) Structure of the guide-strand-containing argonaute silencing complex. Nature. 456, 209-13
Song, J., Rechkoblit, O., Bestor, T. H., and Patel, D. J. (2011) Structure of DNMT1-DNA complex reveals a role for autoinhibition in maintenance DNA methylation. Science. 331, 1036-40
Wang, Y., Juranek, S., Li, H., Sheng, G., Tuschl, T., and Patel, D. J. (2008) Structure of an argonaute silencing complex with a seed-containing guide DNA and target RNA duplex. Nature. 456, 921-6
Teplova, M., and Patel, D. J. (2008) Structural insights into RNA recognition by the alternative-splicing regulator muscleblind-like MBNL1. Nat Struct Mol Biol. 15, 1343-51
Teplova, M., Song, J., Gaw, H. Yan, Teplov, A., and Patel, D. J. (2010) Structural insights into RNA recognition by the alternate-splicing regulator CUG-binding protein 1. Structure. 18, 1364-77
Serganov, A., Huang, L., and Patel, D. J. (2008) Structural insights into amino acid binding and gene control by a lysine riboswitch. Nature. 455, 1263-7
Kenoth, R., Simanshu, D. K., Kamlekar, R. Kanth, Pike, H. M., Molotkovsky, J. G., Benson, L. M., H Bergen, R., Prendergast, F. G., Malinina, L., Venyaminov, S. Y., Patel, D. J., and Brown, R. E. (2010) Structural determination and tryptophan fluorescence of heterokaryon incompatibility C2 protein (HET-C2), a fungal glycolipid transfer protein (GLTP), provide novel insights into glycolipid specificity and membrane interaction by the GLTP fold. J Biol Chem. 285, 13066-78
Huang, H., Deng, Z., Vladimirova, O., Wiedmer, A., Lu, F., Lieberman, P. M., and Patel, D. J. (2016) Structural basis underlying viral hijacking of a histone chaperone complex. Nat Commun. 7, 12707
Teplova, M., Farazi, T. A., Tuschl, T., and Patel, D. J. (2016) Structural basis underlying CAC RNA recognition by the RRM domain of dimeric RNA-binding protein RBPMS. Q Rev Biophys. 49, e1
Hirano, Y., Gao, Y. - G., Stephenson, D. J., Vu, N. T., Malinina, L., Simanshu, D. K., Chalfant, C. E., Patel, D. J., and Brown, R. E. (2019) Structural basis of phosphatidylcholine recognition by the C2-domain of cytosolic phospholipase Aα.. Elife. 10.7554/eLife.44760
Simanshu, D. K., Yamaguchi, Y., Park, J. - H., Inouye, M., and Patel, D. J. (2013) Structural basis of mRNA recognition and cleavage by toxin MazF and its regulation by antitoxin MazE in Bacillus subtilis. Mol Cell. 52, 447-58
Du, J., Kelly, A. E., Funabiki, H., and Patel, D. J. (2012) Structural basis for recognition of H3T3ph and Smac/DIABLO N-terminal peptides by human Survivin. Structure. 20, 185-95

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