Publications
Panel of Engineered Ubiquitin Variants Targeting the Family of Human Ubiquitin Interacting Motifs. ACS Chem Biol. 17, 941-956
(2022) Panoramix SUMOylation on chromatin connects the piRNA pathway to the cellular heterochromatin machinery. Nat Struct Mol Biol. 29, 130-142
(2022) The parallel-stranded d(CGA) duplex is a highly predictable structural motif with two conformationally distinct strands. Acta Crystallogr D Struct Biol. 78, 299-309
(2022) (2022) Phage anti-CBASS and anti-Pycsar nucleases subvert bacterial immunity. Nature. 10.1038/s41586-022-04716-y
(2022) Physicochemical Heuristics for Identifying High Fidelity, Near-Native Structural Models of Peptide/MHC Complexes. Front Immunol. 13, 887759
(2022) Potent monoclonal antibody-mediated neutralization of a divergent Hendra virus variant. Proc Natl Acad Sci U S A. 119, e2122769119
(2022) (2022) A pH Switch Controls Zinc Binding in Tomato Copper-Zinc Superoxide Dismutase. Biochemistry. 60, 1597-1608
(2021) A phage-encoded anti-activator inhibits quorum sensing in Pseudomonas aeruginosa. Mol Cell. 81, 571-583.e6
(2021) Pharmacological inhibition of PI5P4Kα/β disrupts cell energy metabolism and selectively kills p53-null tumor cells.. Proc Natl Acad Sci U S A. 10.1073/pnas.2002486118
(2021) Phospho-dependent signaling during the general stress response by the atypical response regulator and ClpXP adaptor RssB. Protein Sci. 10.1002/pro.4047
(2021) Photoinduced Covalent Irreversible Inactivation of Proline Dehydrogenase by S-Heterocycles. ACS Chem Biol. 10.1021/acschembio.1c00427
(2021) Physical basis for distinct basal and mechanically gated activity of the human K channel TRAAK. Neuron. 10.1016/j.neuron.2021.07.009
(2021) PIM-induced phosphorylation of Notch3 promotes breast cancer tumorigenicity in a CSL-independent fashion. J Biol Chem. 10.1016/j.jbc.2021.100593
(2021) Potent Noncovalent Inhibitors of the Main Protease of SARS-CoV-2 from Molecular Sculpting of the Drug Perampanel Guided by Free Energy Perturbation Calculations. ACS Cent Sci. 7, 467-475
(2021) Potent SARS-CoV-2 neutralizing antibodies directed against spike N-terminal domain target a single supersite. Cell Host Microbe. 10.1016/j.chom.2021.03.005
(2021) (2021) Parallel Discovery Strategies Provide a Basis for Riboswitch Ligand Design. Cell Chem Biol. 10.1016/j.chembiol.2020.07.021
(2020) Peptide inhibitors of bacterial protein synthesis with broad spectrum and SbmA-independent bactericidal activity against clinical pathogens. J Med Chem. 10.1021/acs.jmedchem.0c00665
(2020) Pharmacological inhibition of PRMT7 links arginine monomethylation to the cellular stress response. Nat Commun. 11, 2396
(2020) Polymerization in the actin ATPase clan regulates hexokinase activity in yeast. Science. 367, 1039-1042
(2020) Post-Catalytic Complexes with Emtricitabine or Stavudine and HIV-1 Reverse Transcriptase Reveal New Mechanistic Insights for Nucleotide Incorporation and Drug Resistance. Molecules. 10.3390/molecules25204868
(2020) Potent Zika and dengue cross-neutralizing antibodies induced by Zika vaccination in a dengue-experienced donor. Nat Med. 26, 228-235
(2020) ppGpp Coordinates Nucleotide and Amino-Acid Synthesis in E. coli During Starvation.. Mol Cell. 10.1016/j.molcel.2020.08.005
(2020)