Publications

Found 176 results
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2014
Du, J., Johnson, L. M., Groth, M., Feng, S., Hale, C. J., Li, S., Vashisht, A. A., Wohlschlegel, J. A., Patel, D. J., and Jacobsen, S. E. (2014) Mechanism of DNA methylation-directed histone methylation by KRYPTONITE. Mol Cell. 55, 495-504
Brown, N. G., Watson, E. R., Weissmann, F., Jarvis, M. A., VanderLinden, R., Grace, C. R. R., Frye, J. J., Qiao, R., Dube, P., Petzold, G., Cho, S. Ei, Alsharif, O., Bao, J., Davidson, I. F., Zheng, J. J., Nourse, A., Kurinov, I., Peters, J. - M., Stark, H., and Schulman, B. A. (2014) Mechanism of polyubiquitination by human anaphase-promoting complex: RING repurposing for ubiquitin chain assembly. Mol Cell. 56, 246-260
Ruangprasert, A., Maehigashi, T., Miles, S. J., Giridharan, N., Liu, J. X., and Dunham, C. M. (2014) Mechanisms of toxin inhibition and transcriptional repression by Escherichia coli DinJ-YafQ. J Biol Chem. 289, 20559-69
Grossmann, N., Vakkasoglu, A. S., Hulpke, S., Abele, R., Gaudet, R., and Tampé, R. (2014) Mechanistic determinants of the directionality and energetics of active export by a heterodimeric ABC transporter. Nat Commun. 5, 5419
Xia, W., and Springer, T. A. (2014) Metal ion and ligand binding of integrin α5β1.. Proc Natl Acad Sci U S A. 111, 17863-8
Zhao, Q., Saro, D., Sachpatzidis, A., Singh, T. Ramsing, Schlingman, D., Zheng, X. - F., Mack, A., Tsai, M. - S., Mochrie, S., Regan, L., Meetei, A. Ruhikanta, Sung, P., and Xiong, Y. (2014) The MHF complex senses branched DNA by binding a pair of crossover DNA duplexes. Nat Commun. 5, 2987
Xia, S., and Konigsberg, W. H. (2014) Mispairs with Watson-Crick base-pair geometry observed in ternary complexes of an RB69 DNA polymerase variant. Protein Sci. 23, 508-13
Lee, K., Zhong, X., Gu, S., Kruel, A. Magdalena, Dorner, M. B., Perry, K., Rummel, A., Dong, M., and Jin, R. (2014) Molecular basis for disruption of E-cadherin adhesion by botulinum neurotoxin A complex. Science. 344, 1405-10
Albright, R. A., Ornstein, D. L., Cao, W., Chang, W. C., Robert, D., Tehan, M., Hoyer, D., Liu, L., Stabach, P., Yang, G., De La Cruz, E. M., and Braddock, D. T. (2014) Molecular basis of purinergic signal metabolism by ectonucleotide pyrophosphatase/phosphodiesterases 4 and 1 and implications in stroke. J Biol Chem. 289, 3294-306
Poor, C. B., Wegner, S. V., Li, H., Dlouhy, A. C., Schuermann, J. P., Sanishvili, R., Hinshaw, J. R., Riggs-Gelasco, P. J., Outten, C. E., and He, C. (2014) Molecular mechanism and structure of the Saccharomyces cerevisiae iron regulator Aft2. Proc Natl Acad Sci U S A. 111, 4043-8
Zhong, X., Du, J., Hale, C. J., Gallego-Bartolome, J., Feng, S., Vashisht, A. A., Chory, J., Wohlschlegel, J. A., Patel, D. J., and Jacobsen, S. E. (2014) Molecular mechanism of action of plant DRM de novo DNA methyltransferases. Cell. 157, 1050-60
Dunkle, J. A., Vinal, K., Desai, P. M., Zelinskaya, N., Savic, M., West, D. M., Conn, G. L., and Dunham, C. M. (2014) Molecular recognition and modification of the 30S ribosome by the aminoglycoside-resistance methyltransferase NpmA. Proc Natl Acad Sci U S A. 111, 6275-80
Cheng, Z., Cheung, P., Kuo, A. J., Yukl, E. T., Wilmot, C. M., Gozani, O., and Patel, D. J. (2014) A molecular threading mechanism underlies Jumonji lysine demethylase KDM2A regulation of methylated H3K36. Genes Dev. 28, 1758-71
2015
Gagnon, D. M., Brophy, M. Brunjes, Bowman, S. E. J., Stich, T. A., Drennan, C. L., R Britt, D., and Nolan, E. M. (2015) Manganese binding properties of human calprotectin under conditions of high and low calcium: X-ray crystallographic and advanced electron paramagnetic resonance spectroscopic analysis. J Am Chem Soc. 137, 3004-16
Roy, R. N., Lomakin, I. B., Gagnon, M. G., and Steitz, T. A. (2015) The mechanism of inhibition of protein synthesis by the proline-rich peptide oncocin. Nat Struct Mol Biol. 22, 466-9
Matarlo, J. S., Evans, C. E., Sharma, I., Lavaud, L. J., Ngo, S. C., Shek, R., Rajashankar, K. R., French, J. B., Tan, D. S., and Tonge, P. J. (2015) Mechanism of MenE inhibition by acyl-adenylate analogues and discovery of novel antibacterial agents. Biochemistry. 54, 6514-6524
Jensen, J. L., Balbo, A., Neau, D. B., Chakravarthy, S., Zhao, H., Sinha, S. C., and Colbert, C. L. (2015) Mechanistic Implications of the Unique Structural Features and Dimerization of the Cytoplasmic Domain of the Pseudomonas Sigma Regulator, PupR. Biochemistry. 54, 5867-77
Košutić, M., Neuner, S., Ren, A., Flür, S., Wunderlich, C., Mairhofer, E., Vušurović, N., Seikowski, J., Breuker, K., Höbartner, C., Patel, D. J., Kreutz, C., and Micura, R. (2015) A Mini-Twister Variant and Impact of Residues/Cations on the Phosphodiester Cleavage of this Ribozyme Class. Angew Chem Int Ed Engl. 54, 15128-15133
Price, I. R., Gaballa, A., Ding, F., Helmann, J. D., and Ke, A. (2015) Mn(2+)-sensing mechanisms of yybP-ykoY orphan riboswitches. Mol Cell. 57, 1110-1123
Mahmutovic, S., Clark, L., Levis, S. C., Briggiler, A. M., Enria, D. A., Harrison, S. C., and Abraham, J. (2015) Molecular Basis for Antibody-Mediated Neutralization of New World Hemorrhagic Fever Mammarenaviruses. Cell Host Microbe. 18, 705-13
Rubinstein, R., Thu, C. Aye, Goodman, K. Marie, Wolcott, H. Noelle, Bahna, F., Mannepalli, S., Ahlsen, G., Chevee, M., Halim, A., Clausen, H., Maniatis, T., Shapiro, L., and Honig, B. (2015) Molecular logic of neuronal self-recognition through protocadherin domain interactions. Cell. 163, 629-42
Sekiyama, N., Arthanari, H., Papadopoulos, E., Rodriguez-Mias, R. A., Wagner, G., and Léger-Abraham, M. (2015) Molecular mechanism of the dual activity of 4EGI-1: Dissociating eIF4G from eIF4E but stabilizing the binding of unphosphorylated 4E-BP1. Proc Natl Acad Sci U S A. 112, E4036-45
Calmettes, C., Ing, C., Buckwalter, C. M., Bakkouri, M. El, Lai, C. Chieh- Lin, Pogoutse, A., Gray-Owen, S. D., Pomès, R., and Moraes, T. F. (2015) The molecular mechanism of Zinc acquisition by the neisserial outer-membrane transporter ZnuD. Nat Commun. 6, 7996
Zhang, J., Kiser, P. D., Badiee, M., Palczewska, G., Dong, Z., Golczak, M., Tochtrop, G. P., and Palczewski, K. (2015) Molecular pharmacodynamics of emixustat in protection against retinal degeneration. J Clin Invest. 125, 2781-94
Garnham, C. P., Vemu, A., Wilson-Kubalek, E. M., Yu, I., Szyk, A., Lander, G. C., Milligan, R. A., and Roll-Mecak, A. (2015) Multivalent Microtubule Recognition by Tubulin Tyrosine Ligase-like Family Glutamylases. Cell. 161, 1112-1123

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