Publications
Small-molecule allosteric inhibitors of GPX4. Cell Chem Biol. 10.1016/j.chembiol.2022.11.003
(2022) (2022) Structural basis for defective membrane targeting of mutant enzyme in human VLCAD deficiency. Nat Commun. 13, 3669
(2022) (2022) Structural Basis for Inhibition of Mutant EGFR with Lazertinib (YH25448). ACS Med Chem Lett. 13, 1856-1863
(2022) (2022) Structural basis for substrate binding and catalysis by a self-alkylating ribozyme. Nat Chem Biol. 10.1038/s41589-021-00950-z
(2022) Structural basis for the context-specific action of the classic peptidyl transferase inhibitor chloramphenicol. Nat Struct Mol Biol. 29, 152-161
(2022) Structural basis for the inability of chloramphenicol to inhibit peptide bond formation in the presence of A-site glycine. Nucleic Acids Res. 50, 7669-7679
(2022) (2022) Structural insights into GABA transport inhibition using an engineered neurotransmitter transporter. EMBO J. 41, e110735
(2022) Structure and conformational dynamics of toxin A. Life Sci Alliance. 10.26508/lsa.202201383
(2022) Structure and Function of a Dehydrating Condensation Domain in Nonribosomal Peptide Biosynthesis. J Am Chem Soc. 144, 14057-14070
(2022) Structure and Function of a Dehydrating Condensation Domain in Nonribosomal Peptide Biosynthesis. J Am Chem Soc. 144, 14057-14070
(2022) The structure, binding and function of a Notch transcription complex involving RBPJ and the epigenetic reader protein L3MBTL3.. Nucleic Acids Res. 50, 13083-13099
(2022) Structure of the glucosyltransferase domain of TcdA in complex with RhoA provides insights into substrate recognition. Sci Rep. 12, 9028
(2022) A Structure-based Design Approach for Generating High Affinity BRD4 D1-Selective Chemical Probes. J Med Chem. 10.1021/acs.jmedchem.1c01779
(2022) tRNA Fusion to Streamline RNA Structure Determination: Case Studies in Probing Aminoacyl-tRNA Sensing Mechanisms by the T-Box Riboswitch. doi:10.3390/cryst12050694
(2022) Unraveling Complex Local Protein Environments with 4-Cyano-l-phenylalanine. J Phys Chem B. 126, 8957-8969
(2022) Unraveling Complex Local Protein Environments with 4-Cyano-l-phenylalanine. J Phys Chem B. 126, 8957-8969
(2022) Unraveling Complex Local Protein Environments with 4-Cyano-l-phenylalanine. J Phys Chem B. 126, 8957-8969
(2022) (2022) (2023)
Allosteric Tuning of Caspase-7: Establishing the Nexus of Structure and Catalytic Power. Chemistry. 29, e202300872
(2023) Antibody targeting of conserved sites of vulnerability on the SARS-CoV-2 spike receptor-binding domain. Structure. 10.1016/j.str.2023.11.015
(2023)