Publications
Validating fragment-based drug discovery for biological RNAs: lead fragments bind and remodel the TPP riboswitch specifically. Chem Biol. 21, 591-5
(2014) Structure-Guided Engineering of the Homodimeric Mango-IV Fluorescence Turn-on Aptamer Yields an RNA FRET Pair. Structure. 10.1016/j.str.2020.04.007
(2020) Structure and functional reselection of the Mango-III fluorogenic RNA aptamer. Nat Chem Biol. 15, 472-479
(2019) Structural basis for high-affinity fluorophore binding and activation by RNA Mango. Nat Chem Biol. 13, 807-813
(2017) Structural basis for activity of highly efficient RNA mimics of green fluorescent protein. Nat Struct Mol Biol. 21, 658-63
(2014) (2015) Parallel Discovery Strategies Provide a Basis for Riboswitch Ligand Design. Cell Chem Biol. 10.1016/j.chembiol.2020.07.021
(2020) (2023) (2023) A homodimer interface without base pairs in an RNA mimic of red fluorescent protein. Nat Chem Biol. 13, 1195-1201
(2017) Fluorogenic aptamers resolve the flexibility of RNA junctions using orientation-dependent FRET. RNA. 27, 433-444
(2021) The fluorescent aptamer Squash extensively repurposes the adenine riboswitch fold. Nat Chem Biol. 10.1038/s41589-021-00931-2
(2021) Dramatic improvement of crystals of large RNAs by cation replacement and dehydration. Structure. 22, 1363-71
(2014) (2016) Crystallographic analysis of TPP riboswitch binding by small-molecule ligands discovered through fragment-based drug discovery approaches. Methods Enzymol. 549, 221-33
(2014) Crystal Structures of the Mango-II RNA Aptamer Reveal Heterogeneous Fluorophore Binding and Guide Engineering of Variants with Improved Selectivity and Brightness. Biochemistry. 57, 3544-3548
(2018) Crystal structure of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) frameshifting pseudoknot. RNA. 10.1261/rna.078825.121
(2022) Co-crystal structures of the fluorogenic aptamer Beetroot show that close homology may not predict similar RNA architecture. Nat Commun. 14, 2969
(2023) Co-crystal structure of a T-box riboswitch stem I domain in complex with its cognate tRNA. Nature. 500, 363-6
(2013) Binding between G Quadruplexes at the Homodimer Interface of the Corn RNA Aptamer Strongly Activates Thioflavin T Fluorescence. Cell Chem Biol. 26, 1159-1168.e4
(2019)