Publications

Found 19 results
Filters: Author is Sotomayor, Marcos  [Clear All Filters]
2010
Sotomayor, M., Weihofen, W. A., Gaudet, R., and Corey, D. P. (2010) Structural determinants of cadherin-23 function in hearing and deafness. Neuron. 66, 85-100
2012
Inada, H., Procko, E., Sotomayor, M., and Gaudet, R. (2012) Structural and biochemical consequences of disease-causing mutations in the ankyrin repeat domain of the human TRPV4 channel. Biochemistry. 51, 6195-206
Sotomayor, M., Weihofen, W. A., Gaudet, R., and Corey, D. P. (2012) Structure of a force-conveying cadherin bond essential for inner-ear mechanotransduction. Nature. 492, 128-32
2016
Araya-Secchi, R., Neel, B. L., and Sotomayor, M. (2016) An elastic element in the protocadherin-15 tip link of the inner ear. Nat Commun. 7, 13458
Cooper, S. R., Jontes, J. D., and Sotomayor, M. (2016) Structural determinants of adhesion by Protocadherin-19 and implications for its role in epilepsy. Elife. 10.7554/eLife.18529
2017
Powers, R. E., Gaudet, R., and Sotomayor, M. (2017) A Partial Calcium-Free Linker Confers Flexibility to Inner-Ear Protocadherin-15. Structure. 25, 482-495
2018
De-la-Torre, P., Choudhary, D., Araya-Secchi, R., Narui, Y., and Sotomayor, M. (2018) A Mechanically Weak Extracellular Membrane-Adjacent Domain Induces Dimerization of Protocadherin-15. Biophys J. 115, 2368-2385
Narui, Y., and Sotomayor, M. (2018) Tuning Inner-Ear Tip-Link Affinity Through Alternatively Spliced Variants of Protocadherin-15. Biochemistry. 10.1021/acs.biochem.7b01075
Jaiganesh, A., De-la-Torre, P., Patel, A. A., Termine, D. J., Velez-Cortes, F., Chen, C., and Sotomayor, M. (2018) Zooming in on Cadherin-23: Structural Diversity and Potential Mechanisms of Inherited Deafness. Structure. 10.1016/j.str.2018.06.003
2019
Modak, D., and Sotomayor, M. (2019) Identification of an adhesive interface for the non-clustered δ1 protocadherin-1 involved in respiratory diseases.. Commun Biol. 2, 354
Modak, D., and Sotomayor, M. (2019) Identification of an adhesive interface for the non-clustered δ1 protocadherin-1 involved in respiratory diseases.. Commun Biol. 2, 354
Nicoludis, J. M., Green, A. G., Walujkar, S., May, E. J., Sotomayor, M., Marks, D. S., and Gaudet, R. (2019) Interaction specificity of clustered protocadherins inferred from sequence covariation and structural analysis. Proc Natl Acad Sci U S A. 116, 17825-17830
Park, M. Seul, Araya-Secchi, R., Brackbill, J. A., Phan, H. - D., Kehling, A. C., El-Wahab, E. W. Abd, Dayeh, D. M., Sotomayor, M., and Nakanishi, K. (2019) Multidomain Convergence of Argonaute during RISC Assembly Correlates with the Formation of Internal Water Clusters. Mol Cell. 75, 725-740.e6
2020
Choudhary, D., Narui, Y., Neel, B. L., Wimalasena, L. N., Klanseck, C. F., De-la-Torre, P., Chen, C., Araya-Secchi, R., Tamilselvan, E., and Sotomayor, M. (2020) Structural determinants of protocadherin-15 mechanics and function in hearing and balance perception. Proc Natl Acad Sci U S A. 10.1073/pnas.1920444117
2021
Hudson, J. D., Tamilselvan, E., Sotomayor, M., and Cooper, S. R. (2021) A complete Protocadherin-19 ectodomain model for evaluating epilepsy-causing mutations and potential protein interaction sites. Structure. 29, 1128-1143.e4
Gray, M. E., and Sotomayor, M. (2021) Crystal structure of the nonclassical cadherin-17 N-terminus and implications for its adhesive binding mechanism. Acta Crystallogr F Struct Biol Commun. 77, 85-94
Gray, M. E., Johnson, Z. R., Modak, D., Tamilselvan, E., Tyska, M. J., and Sotomayor, M. (2021) Heterophilic and homophilic cadherin interactions in intestinal intermicrovillar links are species dependent. PLoS Biol. 19, e3001463
2023
Nisler, C. R., Narui, Y., Scheib, E., Choudhary, D., Bowman, J. D., Bharathi, H. Mandayam, Lynch, V. J., and Sotomayor, M. (2023) Interpreting the Evolutionary Echoes of a Protein Complex Essential for Inner-Ear Mechanosensation. Mol Biol Evol. 10.1093/molbev/msad057
2024
Tamilselvan, E., and Sotomayor, M. (2024) CELSR1, a core planar cell polarity protein, features a weakly adhesive and flexible cadherin ectodomain. Structure. 10.1016/j.str.2024.01.003