Publications
Open conformation of tetraspanins shapes interaction partner networks on cell membranes. EMBO J. 39, e105246
(2020) (2023) Methods for Structural and Functional Analyses of Intramembrane Prenyltransferases in the UbiA Superfamily. Methods Enzymol. 584, 309-347
(2017) Structural insight into the mechanisms of enveloped virus tethering by tetherin. Proc Natl Acad Sci U S A. 107, 18428-32
(2010) Structure of a bacterial OapB protein with its OLE RNA target gives insights into the architecture of the OLE ribonucleoprotein complex. Proc Natl Acad Sci U S A. 10.1073/pnas.2020393118
(2021) Structural visualization of transcription activated by a multidrug-sensing MerR family regulator. Nat Commun. 12, 2702
(2021) Caffeic acid directly targets ERK1/2 to attenuate solar UV-induced skin carcinogenesis. Cancer Prev Res (Phila). 7, 1056-66
(2014) Structural basis for clonal diversity of the human T-cell response to a dominant influenza virus epitope. J Biol Chem. 292, 18618-18627
(2017) Structural basis of 7SK RNA 5'-γ-phosphate methylation and retention by MePCE.. Nat Chem Biol. 15, 132-140
(2019) Structural basis for potent and broad inhibition of HIV-1 RT by thiophene[3,2-]pyrimidine non-nucleoside inhibitors. Elife. 10.7554/eLife.36340
(2018) Inhibition Mechanism of an Anti-CRISPR Suppressor AcrIIA4 Targeting SpyCas9. Mol Cell. 10.1016/j.molcel.2017.05.024
(2017) (2013) PAM-Dependent Target DNA Recognition and Cleavage by C2c1 CRISPR-Cas Endonuclease. Cell. 167, 1814-1828.e12
(2016) (2017) Molecular basis for ubiquitin ligase CRL2-mediated recognition of C-degron. Nat Chem Biol. 10.1038/s41589-020-00703-4
(2021) Structural Insights into the SPRED1-Neurofibromin-KRAS Complex and Disruption of SPRED1-Neurofibromin Interaction by Oncogenic EGFR. Cell Rep. 32, 107909
(2020) Structure of an APC3-APC16 complex: insights into assembly of the anaphase-promoting complex/cyclosome. J Mol Biol. 427, 1748-64
(2015) (2006) (2013)
Neural migration. Structures of netrin-1 bound to two receptors provide insight into its axon guidance mechanism. Science. 344, 1275-9
(2014) The crystal structure of DR6 in complex with the amyloid precursor protein provides insight into death receptor activation. Genes Dev. 29, 785-90
(2015) New insights into the Hendra virus attachment and entry process from structures of the virus G glycoprotein and its complex with Ephrin-B2. PLoS One. 7, e48742
(2012) Structures of eukaryotic ribonucleotide reductase I define gemcitabine diphosphate binding and subunit assembly. Proc Natl Acad Sci U S A. 103, 4028-33
(2006) Insights into Eph receptor tyrosine kinase activation from crystal structures of the EphA4 ectodomain and its complex with ephrin-A5. Proc Natl Acad Sci U S A. 110, 14634-9
(2013) Fluorescent indomethacin-dansyl conjugates utilize the membrane-binding domain of cyclooxygenase-2 to block the opening to the active site. J Biol Chem. 10.1074/jbc.RA119.007405
(2019)