Publications

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Golani, L. K., Wallace-Povirk, A., Deis, S. M., Wong, J., Ke, J., Gu, X., Raghavan, S., Wilson, M. R., Li, X., Polin, L., de Waal, P. W., White, K., Kushner, J., O'Connor, C., Hou, Z., H Xu, E., Melcher, K., Dann, C. E., Matherly, L. H., and Gangjee, A. (2016) Tumor Targeting with Novel 6-Substituted Pyrrolo [2,3-d] Pyrimidine Antifolates with Heteroatom Bridge Substitutions via Cellular Uptake by Folate Receptor α and the Proton-Coupled Folate Transporter and Inhibition of de Novo Purine Nucleotide Biosynthes. J Med Chem. 59, 7856-76
Gnann, A. D., Xia, Y., Soule, J., Barthélemy, C., Mawani, J. S., Musoke, S. Nzikoba, Castellano, B. M., Brignole, E. J., Frueh, D. P., and Dowling, D. P. (2022) High-resolution structures of a siderophore-producing cyclization domain from Yersinia pestis offer a refined proposal of substrate binding. J Biol Chem. 298, 102454
Gleason, J. E., Galaleldeen, A., Peterson, R. L., Taylor, A. B., Holloway, S. P., Waninger-Saroni, J., Cormack, B. P., Cabelli, D. E., P Hart, J., and Culotta, V. Cizewski (2014) Candida albicans SOD5 represents the prototype of an unprecedented class of Cu-only superoxide dismutases required for pathogen defense. Proc Natl Acad Sci U S A. 111, 5866-71
Gkeka, A., Aresta-Branco, F., Triller, G., Vlachou, E. P., van Straaten, M., Lilic, M., Olinares, P. Dominic B., Perez, K., Chait, B. T., Blatnik, R., Ruppert, T., Verdi, J. P., C Stebbins, E., and F Papavasiliou, N. (2023) Immunodominant surface epitopes power immune evasion in the African trypanosome. Cell Rep. 42, 112262
Girish, T. S., McGinty, R. K., and Tan, S. (2016) Multivalent Interactions by the Set8 Histone Methyltransferase With Its Nucleosome Substrate. J Mol Biol. 428, 1531-43
Ginn, J., Jiang, X., Sun, S., Michino, M., Huggins, D. J., Mbambo, Z., Jansen, R., Rhee, K. Y., Arango, N., Lima, C. D., Liverton, N., Imaeda, T., Okamoto, R., Kuroita, T., Aso, K., Stamford, A., Foley, M., Meinke, P. T., Nathan, C., and Bryk, R. (2021) Whole Cell Active Inhibitors of Mycobacterial Lipoamide Dehydrogenase Afford Selectivity over the Human Enzyme through Tight Binding Interactions. ACS Infect Dis. 7, 435-444
Gilbert, N. C., Bartlett, S. G., Waight, M. T., Neau, D. B., Boeglin, W. E., Brash, A. R., and Newcomer, M. E. (2011) The structure of human 5-lipoxygenase. Science. 331, 217-9
Gilbert, N. C., Neau, D. B., and Newcomer, M. E. (2018) Expression of an 8R-Lipoxygenase From the Coral Plexaura homomalla. Methods Enzymol. 605, 33-49
Gilbert, N. C., Rui, Z., Neau, D. B., Waight, M. T., Bartlett, S. G., Boeglin, W. E., Brash, A. R., and Newcomer, M. E. (2012) Conversion of human 5-lipoxygenase to a 15-lipoxygenase by a point mutation to mimic phosphorylation at Serine-663. FASEB J. 26, 3222-9
Gilbert, N. C., Gerstmeier, J., Schexnaydre, E. E., Börner, F., Garscha, U., Neau, D. B., Werz, O., and Newcomer, M. E. (2020) Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products. Nat Chem Biol. 10.1038/s41589-020-0544-7
Gibson, M. I., Brignole, E. J., Pierce, E., Can, M., Ragsdale, S. W., and Drennan, C. L. (2015) The Structure of an Oxalate Oxidoreductase Provides Insight into Microbial 2-Oxoacid Metabolism. Biochemistry. 54, 4112-20
Gibson, M. I., Chen, P. Yang- Ting, Johnson, A. C., Pierce, E., Can, M., Ragsdale, S. W., and Drennan, C. L. (2016) One-carbon chemistry of oxalate oxidoreductase captured by X-ray crystallography. Proc Natl Acad Sci U S A. 113, 320-5
Gibson, M. I. (2015) Structures of Oxalate Oxidoreductase: C[2] Activation by a Microbial TPP-Dependent Ferredoxin Oxidoreductase. Ph.D. thesis, Massachusetts Institute of Technology, Cambridge, Massachusetts
Ghosh, S., Goldgur, Y., and Shuman, S. (2020) Mycobacterial DNA polymerase I: activities and crystal structures of the POL domain as apoenzyme and in complex with a DNA primer-template and of the full-length FEN/EXO-POL enzyme. Nucleic Acids Res. 10.1093/nar/gkaa075
Ghosh, A., Shuman, S., and Lima, C. D. (2011) Structural insights to how mammalian capping enzyme reads the CTD code. Mol Cell. 43, 299-310
Geronimo, I., Denning, C. A., W Rogers, E., Othman, T., Huxford, T., Heidary, D. K., Glazer, E. C., and Payne, C. M. (2016) Effect of Mutation and Substrate Binding on the Stability of Cytochrome P450BM3 Variants. Biochemistry. 55, 3594-606
Gero, T. W., Heppner, D. E., Beyett, T. S., To, C., Azevedo, S. C., Jang, J., Bunnell, T., Feru, F., Li, Z., Shin, B. Hee, Soroko, K. M., Gokhale, P. C., Gray, N. S., Jänne, P. A., Eck, M. J., and Scott, D. A. (2022) Quinazolinones as allosteric fourth-generation EGFR inhibitors for the treatment of NSCLC. Bioorg Med Chem Lett. 10.1016/j.bmcl.2022.128718
Germane, K. L., Ohi, R., Goldberg, M. B., and Spiller, B. W. (2008) Structural and functional studies indicate that Shigella VirA is not a protease and does not directly destabilize microtubules. Biochemistry. 47, 10241-3
Germane, K. L., and Spiller, B. W. (2011) Structural and functional studies indicate that the EPEC effector, EspG, directly binds p21-activated kinase. Biochemistry. 50, 917-9
Gerdts, C. J., Elliott, M., Lovell, S., Mixon, M. B., Napuli, A. J., Staker, B. L., Nollert, P., and Stewart, L. (2008) The plug-based nanovolume Microcapillary Protein Crystallization System (MPCS). Acta Crystallogr D Biol Crystallogr. 64, 1116-22
Gerben, S. R., Borst, A. J., Hicks, D. R., Moczygemba, I., Feldman, D., Coventry, B., Yang, W., Bera, A. K., Miranda, M., Kang, A., Nguyen, H., and Baker, D. (2023) Design of Diverse Asymmetric Pockets in Homo-oligomeric Proteins. Biochemistry. 62, 358-368
Gennadios, H. A., Gonzalez, V., Di Costanzo, L., Li, A., Yu, F., Miller, D. J., Allemann, R. K., and Christianson, D. W. (2009) Crystal structure of (+)-delta-cadinene synthase from Gossypium arboreum and evolutionary divergence of metal binding motifs for catalysis. Biochemistry. 48, 6175-83
Geng, Y., Mosyak, L., Kurinov, I., Zuo, H., Sturchler, E., Cheng, T. Cheung, Subramanyam, P., Brown, A. P., Brennan, S. C., Mun, H. - C., Bush, M., Chen, Y., Nguyen, T. X., Cao, B., Chang, D. D., Quick, M., Conigrave, A. D., Colecraft, H. M., McDonald, P., and Fan, Q. R. (2016) Structural mechanism of ligand activation in human calcium-sensing receptor. Elife. 10.7554/eLife.13662
Geng, Y., Bush, M., Mosyak, L., Wang, F., and Fan, Q. R. (2013) Structural mechanism of ligand activation in human GABA(B) receptor. Nature. 504, 254-9
Geng, Y., Xiong, D., Mosyak, L., Malito, D. L., Kniazeff, J., Chen, Y., Burmakina, S., Quick, M., Bush, M., Javitch, J. A., Pin, J. - P., and Fan, Q. R. (2012) Structure and functional interaction of the extracellular domain of human GABA(B) receptor GBR2. Nat Neurosci. 15, 970-8

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