Publications
An Allosteric Interaction Links USP7 to Deubiquitination and Chromatin Targeting of UHRF1. Cell Rep. 12, 1400-6
(2015) The BAH domain of ORC1 links H4K20me2 to DNA replication licensing and Meier-Gorlin syndrome. Nature. 484, 115-9
(2012) DNA sequence-dependent activity and base flipping mechanisms of DNMT1 regulate genome-wide DNA methylation. Nat Commun. 11, 3723
(2020) (2021) The FAM86 domain of FAM86A confers substrate specificity to promote EEF2-Lys525 methylation. J Biol Chem. 299, 104842
(2023) Haematopoietic malignancies caused by dysregulation of a chromatin-binding PHD finger. Nature. 459, 847-51
(2009) (2022) Pro isomerization in MLL1 PHD3-bromo cassette connects H3K4me readout to CyP33 and HDAC-mediated repression. Cell. 141, 1183-94
(2010) (2018) (2019) Structural insights into RNA recognition by the alternate-splicing regulator CUG-binding protein 1. Structure. 18, 1364-77
(2010) Structure of DNMT1-DNA complex reveals a role for autoinhibition in maintenance DNA methylation. Science. 331, 1036-40
(2011) Structure of DNMT3B homo-oligomer reveals vulnerability to impairment by ICF mutations. Nat Commun. 13, 4249
(2022) Structure-based mechanistic insights into DNMT1-mediated maintenance DNA methylation. Science. 335, 709-12
(2012) Substrate deformation regulates DRM2-mediated DNA methylation in plants. Sci Adv. 10.1126/sciadv.abd9224
(2021) (2023)