Publications
DNA repair. Mechanism of DNA interstrand cross-link processing by repair nuclease FAN1. Science. 346, 1127-30
(2014) DNA mismatch synthesis complexes provide insights into base selectivity of a B family DNA polymerase. J Am Chem Soc. 135, 193-202
(2013) A DNA G-quadruplex/i-motif hybrid. Nucleic Acids Res. 10.1093/nar/gkz1008
(2019) DNA asymmetry promotes SUMO modification of the single-stranded DNA-binding protein RPA. EMBO J. 10.15252/embj.2019103787
(2021) DNA aptamers against the DUX4 protein reveal novel therapeutic implications for FSHD. FASEB J. 34, 4573-4590
(2020) Diverse array of neutralizing antibodies elicited upon Spike Ferritin Nanoparticle vaccination in rhesus macaques. Nat Commun. 15, 200
(2024) Divalent cation and chloride ion sites of chicken acid sensing ion channel 1a elucidated by x-ray crystallography. PLoS One. 13, e0202134
(2018) A distributed residue network permits conformational binding specificity in a conserved family of actin remodelers. Elife. 10.7554/eLife.70601
(2021) Distinctive structural basis for DNA recognition by the fission yeast Zn2Cys6 transcription factor Pho7 and its role in phosphate homeostasis. Nucleic Acids Res. 10.1093/nar/gky827
(2018) Distinct tRNA Accommodation Intermediates Observed on the Ribosome with the Antibiotics Hygromycin A and A201A. Mol Cell. 58, 832-44
(2015) A distinct RNA recognition mechanism governs Np decapping by RppH. Proc Natl Acad Sci U S A. 10.1073/pnas.2117318119
(2022) Distinct regions that control ion selectivity and calcium-dependent activation in the bestrophin ion channel. Proc Natl Acad Sci U S A. 113, E7399-E7408
(2016) Distinct properties of Ca2+-calmodulin binding to N- and C-terminal regulatory regions of the TRPV1 channel. J Gen Physiol. 140, 541-55
(2012) (2022) (2016) Distinct conformational states of HIV-1 gp41 are recognized by neutralizing and non-neutralizing antibodies. Nat Struct Mol Biol. 17, 1486-91
(2010) Distal Amyloid β-Protein Fragments Template Amyloid Assembly.. Protein Sci. 10.1002/pro.3375
(2018) Dissection of the BCR-ABL signaling network using highly specific monobody inhibitors to the SHP2 SH2 domains. Proc Natl Acad Sci U S A. 110, 14924-9
(2013) Disruption of evolutionarily correlated tRNA elements impairs accurate decoding. Proc Natl Acad Sci U S A. 117, 16333-16338
(2020) Discovery of the First-in-Class G9a/GLP Covalent Inhibitors. J Med Chem. 10.1021/acs.jmedchem.2c00652
(2022) Discovery of the cryptic function of terpene cyclases as aromatic prenyltransferases. Nat Commun. 11, 3958
(2020) Discovery of Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase. J Med Chem. 60, 1876-1891
(2017) Discovery of Peptidomimetic Ligands of EED as Allosteric Inhibitors of PRC2. ACS Comb Sci. 19, 161-172
(2017) Discovery of Nonretinoid Inhibitors of CRBP1: Structural and Dynamic Insights for Ligand-Binding Mechanisms. ACS Chem Biol. 18, 2309-2323
(2023) Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhibitor and Degrader of Mutant PI3Kα.. J Med Chem. 10.1021/acs.jmedchem.2c01422
(2022)