Publications
Inhibitors of Glycogen Synthase Kinase 3 with Exquisite Kinome-Wide Selectivity and Their Functional Effects. ACS Chem Biol. 11, 1952-63
(2016) X-ray crystallography and isothermal titration calorimetry studies of the Salmonella zinc transporter ZntB. Structure. 19, 700-10
(2011) Reconstitution and characterization of eukaryotic N6-threonylcarbamoylation of tRNA using a minimal enzyme system. Nucleic Acids Res. 41, 6332-46
(2013) Molecular Basis for Control of Diverse Genome Stability Factors by the Multi-BRCT Scaffold Rtt107. Mol Cell. 75, 238-251.e5
(2019) Acute pharmacological degradation of Helios destabilizes regulatory T cells. Nat Chem Biol. 17, 711-717
(2021) (2008) Programming A Molecular Relay for Ultrasensitive Biodetection through (129)Xe NMR.. Angew Chem Int Ed Engl. 55, 1733-6
(2016) The Fas-FADD death domain complex structure reveals the basis of DISC assembly and disease mutations. Nat Struct Mol Biol. 17, 1324-9
(2010) Etesevimab in combination with JS026 neutralizing SARS-CoV-2 and its variants. Emerg Microbes Infect. 11, 548-551
(2022) Structural and Atropisomeric Factors Governing the Selectivity of Pyrimido-benzodiazipinones as Inhibitors of Kinases and Bromodomains. ACS Chem Biol. 10.1021/acschembio.7b00638
(2018) Observation of time-resolved structural changes by linear interpolation of highly redundant X-ray diffraction data. Acta Crystallogr D Biol Crystallogr. 60, 1579-85
(2004) Molecular mechanism of membrane constriction and tubulation mediated by the F-BAR protein Pacsin/Syndapin. Proc Natl Acad Sci U S A. 106, 12700-5
(2009) Intermediates in allosteric equilibria of DnaK-ATP interactions with substrate peptides. Acta Crystallogr D Struct Biol. 77, 606-617
(2021) Structural analyses of Ca²⁺/CaM interaction with NaV channel C-termini reveal mechanisms of calcium-dependent regulation.. Nat Commun. 5, 4896
(2014) Molecular and structural basis of olfactory sensory neuron axon coalescence by Kirrel receptors. Cell Rep. 37, 109940
(2021) Heterochromatin protein Sir3 induces contacts between the amino terminus of histone H4 and nucleosomal DNA. Proc Natl Acad Sci U S A. 110, 8495-500
(2013) Structural Basis for the Lesion-scanning Mechanism of the MutY DNA Glycosylase. J Biol Chem. 292, 5007-5017
(2017) Structural basis for activity of TRIC counter-ion channels in calcium release. Proc Natl Acad Sci U S A. 10.1073/pnas.1817271116
(2019) Identification of MRTX1133, a Noncovalent, Potent, and Selective KRAS Inhibitor. J Med Chem. 10.1021/acs.jmedchem.1c01688
(2021) A Combination of Human Broadly Neutralizing Antibodies against Hepatitis B Virus HBsAg with Distinct Epitopes Suppresses Escape Mutations. Cell Host Microbe. 28, 335-349.e6
(2020) C-terminal modification of the insulin B:11-23 peptide creates superagonists in mouse and human type 1 diabetes. Proc Natl Acad Sci U S A. 115, 162-167
(2018) Structural Basis for Avoidance of Promutagenic DNA Repair by MutY Adenine DNA Glycosylase. J Biol Chem. 290, 17096-105
(2015) (2008) ppGpp Coordinates Nucleotide and Amino-Acid Synthesis in E. coli During Starvation.. Mol Cell. 10.1016/j.molcel.2020.08.005
(2020) Structural Basis for tRNA Mimicry by a Bacterial Y RNA. Structure. 10.1016/j.str.2018.09.001
(2018)