Publications

Found 34 results
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Unciuleac, M. - C., Goldgur, Y., and Shuman, S. (2017) Two-metal versus one-metal mechanisms of lysine adenylylation by ATP-dependent and NAD(+)-dependent polynucleotide ligases. Proc Natl Acad Sci U S A. 114, 2592-2597
Chatterjee, D., Sanchez, A. M., Goldgur, Y., Shuman, S., and Schwer, B. (2016) Transcription of lncRNA prt, clustered prt RNA sites for Mmi1 binding, and RNA polymerase II CTD phospho-sites govern the repression of pho1 gene expression under phosphate-replete conditions in fission yeast. RNA. 22, 1011-25
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Jacewicz, A., Dantuluri, S., and Shuman, S. (2022) Structures of RNA ligase RtcB in complexes with divalent cations and GTP. RNA. 10.1261/rna.079327.122
Benjamin, B., Goldgur, Y., Jork, N., Jessen, H. J., Schwer, B., and Shuman, S. (2022) Structures of Fission Yeast Inositol Pyrophosphate Kinase Asp1 in Ligand-Free, Substrate-Bound, and Product-Bound States. mBio. 10.1128/mbio.03087-22
Unciuleac, M. - C., Goldgur, Y., and Shuman, S. (2019) Structures of ATP-bound DNA ligase D in a closed domain conformation reveal a network of amino acid and metal contacts to the ATP phosphates. J Biol Chem. 10.1074/jbc.RA119.007445
Gao, P., Ascano, M., Zillinger, T., Wang, W., Dai, P., Serganov, A. A., Gaffney, B. L., Shuman, S., Jones, R. A., Deng, L., Hartmann, G., Barchet, W., Tuschl, T., and Patel, D. J. (2013) Structure-function analysis of STING activation by c[G(2',5')pA(3',5')p] and targeting by antiviral DMXAA. Cell. 154, 748-62
Banerjee, A., Munir, A., Abdullahu, L., Damha, M. J., Goldgur, Y., and Shuman, S. (2019) Structure of tRNA splicing enzyme Tpt1 illuminates the mechanism of RNA 2'-PO recognition and ADP-ribosylation. Nat Commun. 10, 218
Ejaz, A., Ordonez, H., Jacewicz, A., Ferrao, R., and Shuman, S. (2017) Structure of mycobacterial 3'-to-5' RNA:DNA helicase Lhr bound to a ssDNA tracking strand highlights distinctive features of a novel family of bacterial helicases. Nucleic Acids Res. 10.1093/nar/gkx1163
Garg, A., Goldgur, Y., Sanchez, A. M., Schwer, B., and Shuman, S. (2019) Structure of fission yeast transcription factor Pho7 bound to promoter DNA and effect of Pho7 mutations on DNA binding and phosphate homeostasis. Mol Cell Biol. 10.1128/MCB.00132-19
Samai, P., Smith, P., and Shuman, S. (2010) Structure of a CRISPR-associated protein Cas2 from Desulfovibrio vulgaris. Acta Crystallogr Sect F Struct Biol Cryst Commun. 66, 1552-6
Banerjee, A., Goldgur, Y., and Shuman, S. (2021) Structure of 3'-PO/5'-OH RNA ligase RtcB in complex with a 5'-OH oligonucleotide. RNA. 10.1261/rna.078692.121
Banerjee, A., Ghosh, S., Goldgur, Y., and Shuman, S. (2018) Structure and two-metal mechanism of fungal tRNA ligase. Nucleic Acids Res. 10.1093/nar/gky1275
Unciuleac, M. - C., Goldgur, Y., and Shuman, S. (2015) Structure and two-metal mechanism of a eukaryal nick-sealing RNA ligase. Proc Natl Acad Sci U S A. 112, 13868-73
Remus, B. S., Jacewicz, A., and Shuman, S. (2014) Structure and mechanism of E. coli RNA 2',3'-cyclic phosphodiesterase. RNA. 20, 1697-705
Ghosh, A., Shuman, S., and Lima, C. D. (2011) Structural insights to how mammalian capping enzyme reads the CTD code. Mol Cell. 43, 299-310
Jacewicz, A., Dantuluri, S., and Shuman, S. (2023) Structural basis for Tpt1-catalyzed 2'-PO transfer from RNA and NADP(H) to NAD. Proc Natl Acad Sci U S A. 120, e2312999120
Remus, B. S., Goldgur, Y., and Shuman, S. (2017) Structural basis for the GTP specificity of the RNA kinase domain of fungal tRNA ligase. Nucleic Acids Res. 10.1093/nar/gkx1159
Nair, P. A., Nandakumar, J., Smith, P., Odell, M., Lima, C. D., and Shuman, S. (2007) Structural basis for nick recognition by a minimal pluripotent DNA ligase. Nat Struct Mol Biol. 14, 770-8
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Nandakumar, J., Shuman, S., and Lima, C. D. (2006) RNA ligase structures reveal the basis for RNA specificity and conformational changes that drive ligation forward. Cell. 127, 71-84
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Ghosh, S., Goldgur, Y., and Shuman, S. (2020) Mycobacterial DNA polymerase I: activities and crystal structures of the POL domain as apoenzyme and in complex with a DNA primer-template and of the full-length FEN/EXO-POL enzyme. Nucleic Acids Res. 10.1093/nar/gkaa075
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Nandakumar, J., Nair, P. A., and Shuman, S. (2007) Last stop on the road to repair: structure of E. coli DNA ligase bound to nicked DNA-adenylate. Mol Cell. 26, 257-71
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Doamekpor, S. K., Sanchez, A. M., Schwer, B., Shuman, S., and Lima, C. D. (2014) How an mRNA capping enzyme reads distinct RNA polymerase II and Spt5 CTD phosphorylation codes. Genes Dev. 28, 1323-36
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Schwer, B., Garg, A., Jacewicz, A., and Shuman, S. (2021) Genetic screen for suppression of transcriptional interference identifies a gain-of-function mutation in Pol2 termination factor Seb1. Proc Natl Acad Sci U S A. 10.1073/pnas.2108105118
Schwer, B., Ghosh, A., Sanchez, A. M., Lima, C. D., and Shuman, S. (2015) Genetic and structural analysis of the essential fission yeast RNA polymerase II CTD phosphatase Fcp1. RNA. 21, 1135-46
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Doamekpor, S. K., Schwer, B., Sanchez, A. M., Shuman, S., and Lima, C. D. (2015) Fission yeast RNA triphosphatase reads an Spt5 CTD code. RNA. 21, 113-23

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