Publications

Found 38 results
Filters: Author is Polikanov, Yury S  [Clear All Filters]
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J Y Wu, K., Aleksandrova, E. V., Robinson, P. J., Benedetto, A. E., Yu, M., Tresco, B. I. C., N Y See, D., Jiang, T., Ramkissoon, A., Dunand, C. F., Svetlov, M. S., Lee, J., Polikanov, Y. S., and Myers, A. G. (2025) Why Sulfur is Important in Lincosamide Antibiotics. Chem. 10.1016/j.chempr.2025.102480
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Mitcheltree, M. J., Pisipati, A., Syroegin, E. A., Silvestre, K. J., Klepacki, D., Mason, J. D., Terwilliger, D. W., Testolin, G., Pote, A. R., J Y Wu, K., Ladley, R. Porter, Chatman, K., Mankin, A. S., Polikanov, Y. S., and Myers, A. G. (2021) A synthetic antibiotic class overcoming bacterial multidrug resistance. Nature. 10.1038/s41586-021-04045-6
Svetlov, M. S., Syroegin, E. A., Aleksandrova, E. V., Atkinson, G. C., Gregory, S. T., Mankin, A. S., and Polikanov, Y. S. (2021) Structure of Erm-modified 70S ribosome reveals the mechanism of macrolide resistance. Nat Chem Biol. 10.1038/s41589-020-00715-0
Khabibullina, N. F., Tereshchenkov, A. G., Komarova, E. S., Syroegin, E. A., Shiriaev, D. I., Paleskava, A., Kartsev, V. G., Bogdanov, A. A., Konevega, A. L., Dontsova, O. A., Sergiev, P. V., Osterman, I. A., and Polikanov, Y. S. (2019) Structure of dirithromycin bound to the bacterial ribosome suggests new ways for rational improvement of macrolides. Antimicrob Agents Chemother. 10.1128/AAC.02266-18
Polikanov, Y. S., Melnikov, S. V., Söll, D., and Steitz, T. A. (2015) Structural insights into the role of rRNA modifications in protein synthesis and ribosome assembly. Nat Struct Mol Biol. 22, 342-344
Chen, C. - W., Leimer, N., Syroegin, E. A., Dunand, C., Bulman, Z. P., Lewis, K., Polikanov, Y. S., and Svetlov, M. S. (2023) Structural insights into the mechanism of overcoming Erm-mediated resistance by macrolides acting together with hygromycin-A. Nat Commun. 14, 4196
Syroegin, E. A., Aleksandrova, E. V., Kruglov, A. A., Paranjpe, M. N., Svetlov, M. S., and Polikanov, Y. S. (2025) Structural insights into context-specific inhibition of bacterial translation by macrolides. Nat Commun. 16, 9685
Aleksandrova, E. V., J Y Wu, K., Tresco, B. I. C., Syroegin, E. A., Killeavy, E. E., Balasanyants, S. M., Svetlov, M. S., Gregory, S. T., Atkinson, G. C., Myers, A. G., and Polikanov, Y. S. (2024) Structural basis of Cfr-mediated antimicrobial resistance and mechanisms to evade it. Nat Chem Biol. 20, 867-876
Syroegin, E. A., Aleksandrova, E. V., and Polikanov, Y. S. (2022) Structural basis for the inability of chloramphenicol to inhibit peptide bond formation in the presence of A-site glycine. Nucleic Acids Res. 50, 7669-7679
Syroegin, E. A., Flemmich, L., Klepacki, D., Vázquez-Laslop, N., Micura, R., and Polikanov, Y. S. (2022) Structural basis for the context-specific action of the classic peptidyl transferase inhibitor chloramphenicol. Nat Struct Mol Biol. 29, 152-161
Batool, Z., Lomakin, I. B., Polikanov, Y. S., and Bunick, C. G. (2020) Sarecycline interferes with tRNA accommodation and tethers mRNA to the 70S ribosome. Proc Natl Acad Sci U S A. 10.1073/pnas.2008671117
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Eyler, D. E., Franco, M. K., Batool, Z., Wu, M. Z., Dubuke, M. L., Dobosz-Bartoszek, M., Jones, J. D., Polikanov, Y. S., Roy, B., and Koutmou, K. S. (2019) Pseudouridinylation of mRNA coding sequences alters translation. Proc Natl Acad Sci U S A. 116, 23068-23074
Polikanov, Y. S., Steitz, T. A., and C Innis, A. (2014) A proton wire to couple aminoacyl-tRNA accommodation and peptide-bond formation on the ribosome. Nat Struct Mol Biol. 21, 787-93
Thaler, J., Syroegin, E. A., Breuker, K., Polikanov, Y. S., and Micura, R. (2023) Practical Synthesis of -Formylmethionylated Peptidyl-tRNA Mimics. ACS Chem Biol. 10.1021/acschembio.3c00237
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Pantel, L., Florin, T., Dobosz-Bartoszek, M., Racine, E., Sarciaux, M., Serri, M., Houard, J., Campagne, J. - M., de Figueiredo, R. Marcia, Midrier, C., Gaudriault, S., Givaudan, A., Lanois, A., Forst, S., Aumelas, A., Cotteaux-Lautard, C., Bolla, J. - M., Lundberg, C. Vingsbo, Huseby, D. L., Hughes, D., Villain-Guillot, P., Mankin, A. S., Polikanov, Y. S., and Gualtieri, M. (2018) Odilorhabdins, Antibacterial Agents that Cause Miscoding by Binding at a New Ribosomal Site. Mol Cell. 70, 83-94.e7
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Polikanov, Y. S., Szal, T., Jiang, F., Gupta, P., Matsuda, R., Shiozuka, M., Steitz, T. A., Vázquez-Laslop, N., and Mankin, A. S. (2014) Negamycin interferes with decoding and translocation by simultaneous interaction with rRNA and tRNA. Mol Cell. 56, 541-50
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Melnikov, S. V., Khabibullina, N. F., Mairhofer, E., Vargas-Rodriguez, O., Reynolds, N. M., Micura, R., Söll, D., and Polikanov, Y. S. (2018) Mechanistic insights into the slow peptide bond formation with D-amino acids in the ribosomal active site. Nucleic Acids Res. 10.1093/nar/gky1211
Aleksandrova, E. V., Syroegin, E. A., Basu, R. S., Vassilevski, A. A., Gagnon, M. G., and Polikanov, Y. S. (2025) Mechanism of release factor-mediated peptidyl-tRNA hydrolysis on the ribosome. Science. 388, eads9030
Osterman, I. A., Khabibullina, N. F., Komarova, E. S., Kasatsky, P., Kartsev, V. G., Bogdanov, A. A., Dontsova, O. A., Konevega, A. L., Sergiev, P. V., and Polikanov, Y. S. (2017) Madumycin II inhibits peptide bond formation by forcing the peptidyl transferase center into an inactive state. Nucleic Acids Res. 10.1093/nar/gkx413
Aleksandrova, E. V., Ma, C. - X., Klepacki, D., Alizadeh, F., Vázquez-Laslop, N., Liang, J. - H., Polikanov, Y. S., and Mankin, A. S. (2024) Macrolones target bacterial ribosomes and DNA gyrase and can evade resistance mechanisms. Nat Chem Biol. 10.1038/s41589-024-01685-3
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Metelev, M., Osterman, I. A., Ghilarov, D., Khabibullina, N. F., Yakimov, A., Shabalin, K., Utkina, I., Travin, D. Y., Komarova, E. S., Serebryakova, M., Artamonova, T., Khodorkovskii, M., Konevega, A. L., Sergiev, P. V., Severinov, K., and Polikanov, Y. S. (2017) Klebsazolicin inhibits 70S ribosome by obstructing the peptide exit tunnel. Nat Chem Biol. 10.1038/nchembio.2462
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Syroegin, E. A., Aleksandrova, E. V., and Polikanov, Y. S. (2022) Insights into the ribosome function from the structures of non-arrested ribosome-nascent chain complexes. Nat Chem. 10.1038/s41557-022-01073-1
Paranjpe, M. N., Marina, V. I., Grachev, A. A., Maviza, T. P., Tolicheva, O. A., Paleskava, A., Osterman, I. A., Sergiev, P. V., Konevega, A. L., Polikanov, Y. S., and Gagnon, M. G. (2023) Insights into the molecular mechanism of translation inhibition by the ribosome-targeting antibiotic thermorubin.. Nucleic Acids Res. 51, 449-462
Melnikov, S. V., Söll, D., Steitz, T. A., and Polikanov, Y. S. (2016) Insights into RNA binding by the anticancer drug cisplatin from the crystal structure of cisplatin-modified ribosome. Nucleic Acids Res. 44, 4978-87
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Polikanov, Y. S., Blaha, G. M., and Steitz, T. A. (2012) How hibernation factors RMF, HPF, and YfiA turn off protein synthesis. Science. 336, 915-8

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