Publications

Found 11 results
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Pecic, S., Pakhomova, S., Newcomer, M. E., Morisseau, C., Hammock, B. D., Zhu, Z., Rinderspacher, A., and Deng, S. - X. (2013) Synthesis and structure-activity relationship of piperidine-derived non-urea soluble epoxide hydrolase inhibitors. Bioorg Med Chem Lett. 23, 417-21
Gilbert, N. C., Bartlett, S. G., Waight, M. T., Neau, D. B., Boeglin, W. E., Brash, A. R., and Newcomer, M. E. (2011) The structure of human 5-lipoxygenase. Science. 331, 217-9
Kobe, M. J., Neau, D. B., Mitchell, C. E., Bartlett, S. G., and Newcomer, M. E. (2014) The structure of human 15-lipoxygenase-2 with a substrate mimic. J Biol Chem. 289, 8562-9
Eek, P., Järving, R., Järving, I., Gilbert, N. C., Newcomer, M. E., and Samel, N. (2012) Structure of a calcium-dependent 11R-lipoxygenase suggests a mechanism for Ca2+ regulation. J Biol Chem. 287, 22377-86
Gilbert, N. C., Gerstmeier, J., Schexnaydre, E. E., Börner, F., Garscha, U., Neau, D. B., Werz, O., and Newcomer, M. E. (2020) Structural and mechanistic insights into 5-lipoxygenase inhibition by natural products. Nat Chem Biol. 10.1038/s41589-020-0544-7
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Lee, K. Sing Steph, Liu, J. - Y., Wagner, K. M., Pakhomova, S., Dong, H., Morisseau, C., Fu, S. H., Yang, J., Wang, P., Ulu, A., Mate, C. A., Nguyen, L. V., Hwang, S. Hee, Edin, M. L., Mara, A. A., Wulff, H., Newcomer, M. E., Zeldin, D. C., and Hammock, B. D. (2014) Optimized inhibitors of soluble epoxide hydrolase improve in vitro target residence time and in vivo efficacy. J Med Chem. 57, 7016-30
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Gallegos, E. M., Reed, T. D., Mathes, F. A., Guevara, N. V., Neau, D. B., Huang, W., Newcomer, M. E., and Gilbert, N. C. (2022) Helical remodeling augments 5-lipoxygenase activity in the synthesis of pro-inflammatory mediators. J Biol Chem. 10.1016/j.jbc.2022.102282
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Gilbert, N. C., Neau, D. B., and Newcomer, M. E. (2018) Expression of an 8R-Lipoxygenase From the Coral Plexaura homomalla. Methods Enzymol. 605, 33-49
Pakhomova, S., Boeglin, W. E., Neau, D. B., Bartlett, S. G., Brash, A. R., and Newcomer, M. E. (2019) An ensemble of lipoxygenase structures reveals novel conformations of the Fe coordination sphere. Protein Sci. 10.1002/pro.3602
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Neau, D. B., Bender, G., Boeglin, W. E., Bartlett, S. G., Brash, A. R., and Newcomer, M. E. (2014) Crystal structure of a lipoxygenase in complex with substrate: the arachidonic acid-binding site of 8R-lipoxygenase. J Biol Chem. 289, 31905-13
Gilbert, N. C., Rui, Z., Neau, D. B., Waight, M. T., Bartlett, S. G., Boeglin, W. E., Brash, A. R., and Newcomer, M. E. (2012) Conversion of human 5-lipoxygenase to a 15-lipoxygenase by a point mutation to mimic phosphorylation at Serine-663. FASEB J. 26, 3222-9