Publications
A large-scale type I CBASS antiphage screen identifies the phage prohead protease as a key determinant of immune activation and evasion. Cell Host Microbe. 32, 1074-1088.e5
(2024) (2024) Bacterial SEAL domains undergo autoproteolysis and function in regulated intramembrane proteolysis. Proc Natl Acad Sci U S A. 120, e2310862120
(2023) cGLRs are a diverse family of pattern recognition receptors in innate immunity. Cell. 186, 3261-3276.e20
(2023) RNase L-activating 2'-5' oligoadenylates bind ABCF1, ABCF3 and Decr-1. J Gen Virol. 10.1099/jgv.0.001890
(2023) Structural basis of Gabija anti-phage defence and viral immune evasion. Nature. 10.1038/s41586-023-06855-2
(2023) Structural homology screens reveal host-derived poxvirus protein families impacting inflammasome activity. Cell Rep. 42, 112878
(2023) Structural homology screens reveal poxvirus-encoded proteins impacting inflammasome-mediated defenses. bioRxiv. 10.1101/2023.02.26.529821
(2023) (2022) (2022)
Phage anti-CBASS and anti-Pycsar nucleases subvert bacterial immunity. Nature. 10.1038/s41586-022-04716-y
(2022) (2022) (2022) cGAS phase separation inhibits TREX1-mediated DNA degradation and enhances cytosolic DNA sensing. Mol Cell. 81, 739-755.e7
(2021) cGAS-like receptors sense RNA and control 3'2'-cGAMP signaling in Drosophila. Nature. 10.1038/s41586-021-03743-5
(2021) (2021) Effector-mediated membrane disruption controls cell death in CBASS antiphage defense. Mol Cell. 10.1016/j.molcel.2021.10.020
(2021) (2021) CBASS Immunity Uses CARF-Related Effectors to Sense 3'-5'- and 2'-5'-Linked Cyclic Oligonucleotide Signals and Protect Bacteria from Phage Infection. Cell. 182, 38-49.e17
(2020) STING cyclic dinucleotide sensing originated in bacteria. Nature. 10.1038/s41586-020-2719-5
(2020) Structure and Mechanism of a Cyclic Trinucleotide-Activated Bacterial Endonuclease Mediating Bacteriophage Immunity. Mol Cell. 10.1016/j.molcel.2019.12.010
(2020) (2020) Bacterial cGAS-like enzymes synthesize diverse nucleotide signals. Nature. 10.1038/s41586-019-0953-5
(2019) Modular Architecture of the STING C-Terminal Tail Allows Interferon and NF-κB Signaling Adaptation.. Cell Rep. 27, 1165-1175.e5
(2019) (2019)