A structure-based kinetic model of transcription.

Publication Type:

Journal Article

Authors:

Zuo, Yuhong; Steitz, Thomas A

Source:

Transcription, Volume 8, Issue 1, p.1-8 (2017)

Keywords:

DNA, DNA-Directed RNA Polymerases, Models, Molecular, Transcription, Genetic

Abstract:

<p>During transcription, RNA polymerase moves downstream along the DNA template and maintains a transcription bubble. Several recent structural studies of transcription complexes with a complete transcription bubble provide new insights into how RNAP couples the nucleotide addition reaction to its directional movement.</p>