NECAT Beamline

The Northeastern Collaborative Access Team (NE-CAT) facility at the Advanced Photon Source at Argonne National Laboratory is managed by Cornell University and consists of seven member institutions:

  • Columbia University
  • Cornell University
  • Harvard University
  • Memorial Sloan-Kettering Cancer Center
  • Massachusetts Institute of Technology
  • Rockefeller University
  • Yale University.

    Primary funding for this project comes from the National Institute of General Medical Sciences (NIGMS) , a division of the National Institutes of Health (NIH). Additional financial support for NE-CAT comes from the member institutions.

    NIGMS at a Glance.

    Supported by:

    National Institutes of Health
    National Institute of General Medical Sciences

    Advances in Moderate to Low Resolution Phasing and Refinement

    Caspary Auditorium, Rockefeller University
    September 19, 2011



    Structural biology is now at a juncture where moderate-to-low resolution diffraction is more frequent and equally important. To address the challenges and solutions in this area, NE-CAT organized a one-day workshop on "Advances in moderate to low resolution phasing and refinement". This workshop was held at Rockefeller University in New York City on September 19, 2011. The workshop ran from 9 AM to 5 PM with a break for lunch. The workshop is now over. For interested parties who were unable to attend the workshop, presentations from the speakers have been made available in both powerpoint and video format.


    (Original Schedule of Events as PDF)

    Speaker Title of Talk Powerpoint Video Audio
    Steve Harrison Introduction PPT MP4 High-Res MP4 Low-Res Audio
    Tom Terwilliger "Improving Molecular Replacement with Morphing" PPT MP4 High-Res MP4 Low-Res
    Axel Brunger "DEN-refinement: Methods and Applications" PPT MP4 High-Res MP4 Low-Res
    Frank DiMiao "Structure Prediction Methods for Molecular Replacement and Low-Resolution Crystallographic Refinement" PPTX MP4 High-Res MP4 Low-Res Audio
    Randy Read "Using Molecular Replacement to Exploit Multiple Crystal Forms" PPT MP4 High-Res MP4 Low-Res
    Yong Xiong "Interplay Between EM and X-ray: Molecular Replacement and Electron Density Averaging" PPTX MP4 High-Res MP4 Low-Res Audio
    John Tainer "SAXS - its Genesis and Capacity to Meet the Challenges for Structural Systems Biology" MP4 High-Res MP4 Low-Res
    Malcolm Capel "Beamline Technologies and Data Collection Techniques Supporting Low Resolution Crystallography Experiments" PPTX MP4 High-Res MP4 Low-Res Audio
    Silvia Russi "Getting Better Data Diffraction: On-line Crystal Dehydration" PPSX MP4 High-Res MP4 Low-Res
    Steve Harrison Discussion MP4 High-Res MP4 Low-Res

    NOTE: High-Res videos are ~400 MB. Low-Res videos are ~200 MB.


    The workshop is free, but registration is required for entry (and a complimentary lunch). Participants will be responsible for their own transportation and lodging.


    Registration is now closed due to a large response. If space opens up, we will re-open registration.

    Lunch is not provided for local attendees who have not registered.

    Organizing Committee

    Seth Darst, Igor Kourinov, Kay Perry and Raj Rajashankar