Lead compounds for the development of SARS-CoV-2 3CL protease inhibitors.
Publication Type:Journal Article
Source:Nat Commun, Volume 12, Issue 1, p.2016 (2021)
<p>We report the identification of three structurally diverse compounds - compound 4, GC376, and MAC-5576 - as inhibitors of the SARS-CoV-2 3CL protease. Structures of each of these compounds in complex with the protease revealed strategies for further development, as well as general principles for designing SARS-CoV-2 3CL protease inhibitors. These compounds may therefore serve as leads for the basis of building effective SARS-CoV-2 3CL protease inhibitors.</p>