COVID-19 Research

NECAT is giving priority to COVID-19 research while accepting all GUP beamtime requests.

Advances in COVID-19 Prevention and Treatment Enabled by Structural Biology Research

The emergence of the novel Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) -- the etiologic agent responsible for the current outbreak of COVID-19 -- mobilized research communities around the world to investigate the virus and the disease at unprecedented speed. To deliver information suitable for the development of vaccines, therapeutics, and diagnostics, researchers representing multiple disciplines and institutions quickly initiated broad collaborations, while DOE user facilities provided unlimited access to resources necessary for this research.

COVID-19 Research

Novel Coronavirus

On June 15, 2020, Argonne and the Advanced Photon Source started a phased, coordinated process to return to normal operations. The first phase of the transition is from minimum safe operations – the state APS was in starting March 21 – to a stage known as limited operations.

Potent SARS-CoV-2 neutralizing antibodies directed against spike N-terminal domain target a single supersite.

Modular basis for potent SARS-CoV-2 neutralization by a prevalent VH1-2-derived antibody class.

Speakers at Current and Future Trends in Macromolecular Crystallography Experiments

Malcolm Capel and Frank Murphy will be speaking at "Current and Future Trends in Macromolecular Crystallography Experiments." This workshop is hosted by NSLS-II and will be held virtually March 16-18, 2021. The workshop will be from 12pm - 6pm EST each day.

Malcolm will be speaking in Session I (March 16, 2021).  His talk is entitled, "New endstations at NE-CAT:  MD3UP microdiffractometer and 30 puck ALS-style loader."

Office Hours


....Answers Provided.


Zoom-based office hours to answer questions regarding using NE-CAT, data processing, structure solution or anything else x-ray crystallography-related available weekly.

Thursday, 1:00 - 3:00 PM Central Time

Request the Zoom link via email.

Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti-COVID-19 drug design.

Rapid Access Beamtime for COVID-19 Research

On February 18, 2020, in support of the COVID-19 outbreak, NE-CAT provided rapid access beamtime to researchers from the Walter Reed Army Institute of Research working on the the SARS-CoV-2 S glycoprotein receptor-binding-domain. The novel coronavirus's surface Spike (S) glycoprotein mediates cell entry via the human ACE-2 receptor, and is the principal target for the development of vaccines and immunotherapeutics.

Rapid Access Beamtime is available for all research projects related to COVID-19.