Mature Synchotron Resource
NE-CAT is an x-ray crystallographic research facility designed to address the most demanding and complex diffraction problems in structural biology. As a Mature Synchrotron Resource for Structural Biology, we offer biomedical researchers state-of-the-art X-ray beamlines, hands-on user support, and expert training to generate and analyze structural biology data. Our operation is driven by the requirements of our user community.
Beamtime is available on a first-come, first-serve basis to anyone with an active General User Proposal and to our member institutions.
What’s New
From fresh results to facility updates, keep up with everything happening at the beamlines.
Changes Coming to C Line
All the changes that are coming to C Line, summarized here.
Scientists hypothesize new mechanism for destroying cancer-causing protein
RAS proteins function as on/off switches in pathways controlling cell growth and proliferation. Mutated RASs keep the pathways permanently activated, leading to conditions such as cancer and Noonan syndrome. A protein called Leucine Zipper-like Transcription Regulator 1 (LZTR1) regulates cellular levels of RAS by promoting RAS’s destruction. However, LTZR1 is itself prone to mutations, disrupting its ability to bind and degrade RAS and causing diseases such as Noonan syndrome and Schwannomatosis.
Graeme Winter, New Deputy Director
We're very happy to announce that Graeme Winter [...]
NAS Award in Molecular Biology recognizes work on innate immunity
The lab of Philip Kranzusch, Professor of Microbiology at Harvard Medical School and the Dana-Farber Cancer Institute, regularly uses beamtime at NE-CAT to examine the question of innate immunity.
Sulfur is the key ingredient for the π
Lincosamides are naturally occurring antibiotics that are effective against a variety of different types of bacterial infections. However, they possess a sulfur atom at a key location that makes them vulnerable to rapid metabolism in both animals and humans, reducing their usefulness in the clinic. Efforts to make a synthetic version without the sulfur atom have failed to generate a new antibiotic that is both long-lived and effective, and all the synthetic versions that do work still have the key sulfur.
Inside the awe-inspiring ‘Aurora’ supercomputer at Argonne National Lab
Read the story at WGN or watch to find one of the NE-CAT staff members.
Science
Publications which used NE-CAT or the NE-CAT BAG at NSLS-II.
Upcoming Workshops
Learn the principles of macromolecular x-ray crystallography from data collection to structure solution from leaders in the field.
Members
The Northeastern Collaborative Access Team (NE-CAT) facility at the Advanced Photon Source at Argonne National Laboratory is managed by Cornell University and consists of eight member institutions:
- Columbia University
- Cornell University
- Genentech
- Harvard University
- Massachusetts Institute of Technology
- Memorial Sloan-Kettering Cancer Center
- Rockefeller University
- Yale University
Request Beamtime
Beamtime at NE-CAT is available through the Universal Proposal System.