APS Enables Protein Design

(A and B) The crystal structure of CHD_r1 (gray; ligand not modeled because of partial ligand electron density) is very similar to the computational design model (colored). (C and D) The crystal structure and the binding interface of CHD_buttress (gray) is very similar to the computational design model (colored). (E) The key polar- and hydrogen-bonding networks at the designed interface. (F) Composite omit map of interface region; the 2mFo-DFc electron density map at 1 σ level for CHD_buttress matches the d

 

Work by David Baker's lab on protein design which used NE-CAT for structural verification and was published in Science, is now featured on the Argonne National Laboratory website.