Research Highlights

Molecular basis for a germline-biased neutralizing antibody response to SARS-CoV-2. bioRxiv. 10.1101/2020.11.13.381533 (2020)

Biophysical and X-ray structural studies of the (GGGTT)3GGG G-quadruplex in complex with N-methyl mesoporphyrin IX. PLoS One. 15, e0241513 (2020)

Structural basis of antagonizing the vitamin K catalytic cycle for anticoagulation. Science. 10.1126/science.abc5667 (2020)

Activity profiling and crystal structures of inhibitor-bound SARS-CoV-2 papain-like protease: A framework for anti-COVID-19 drug design. Sci Adv. 10.1126/sciadv.abd4596 (2020)

Structural determinants of protocadherin-15 mechanics and function in hearing and balance perception. Proc Natl Acad Sci U S A. 10.1073/pnas.1920444117 (2020)

A defined structural unit enables de novo design of small-molecule-binding proteins. Science. 369, 1227-1233 (2020)

Architecture and self-assembly of the SARS-CoV-2 nucleocapsid protein. Protein Sci. 10.1002/pro.3909 (2020)
A Cryptic Site of Vulnerability on the Receptor Binding Domain of the SARS-CoV-2 Spike Glycoprotein. bioRxiv. 10.1101/2020.03.15.992883 (2020)

Crystal Structure of the LSD1/CoREST Histone Demethylase Bound to Its Nucleosome Substrate. Mol Cell. 10.1016/j.molcel.2020.04.019 (2020)

Structural basis of the UDP-diacylglucosamine pyrophosphohydrolase LpxH inhibition by sulfonyl piperazine antibiotics. Proc Natl Acad Sci U S A. 117, 4109-4116 (2020)
The human dimension in contemporary biological research. Nat Struct Mol Biol. 27, 107-108 (2020)

Mechanism of differential Zika and dengue virus neutralization by a public antibody lineage targeting the DIII lateral ridge. J Exp Med. 10.1084/jem.20191792 (2020)

HORMA Domain Proteins and a Trip13-like ATPase Regulate Bacterial cGAS-like Enzymes to Mediate Bacteriophage Immunity. Mol Cell. 10.1016/j.molcel.2019.12.009 (2019)

Structural basis for tRNA decoding and aminoacylation sensing by T-box riboregulators. Nat Struct Mol Biol. 26, 1106-1113 (2019)

Interaction specificity of clustered protocadherins inferred from sequence covariation and structural analysis. Proc Natl Acad Sci U S A. 116, 17825-17830 (2019)

Structures of a dimodular nonribosomal peptide synthetase reveal conformational flexibility. Science. 10.1126/science.aaw4388 (2019)

Multidomain Convergence of Argonaute during RISC Assembly Correlates with the Formation of Internal Water Clusters. Mol Cell. 75, 725-740.e6 (2019)

Structure of the full-length Clostridium difficile toxin B. Nat Struct Mol Biol. 10.1038/s41594-019-0268-0 (2019)

Antibodies to a Conserved Influenza Head Interface Epitope Protect by an IgG Subtype-Dependent Mechanism. Cell. 177, 1124-1135.e16 (2019)

Visualization of clustered protocadherin neuronal self-recognition complexes. Nature. 569, 280-283 (2019)

Bacterial cGAS-like enzymes synthesize diverse nucleotide signals. Nature. 10.1038/s41586-019-0953-5 (2019)
![Structure of VACV Poxin in post-reactive state with Gp[2'-5']Ap[3'] Structure of VACV Poxin in post-reactive state with Gp[2'-5']Ap[3']](https://necat.chem.cornell.edu/sites/default/files/styles/medium/public/6ea9.pdb1-500_0.jpg?itok=g_h_U9hi)
Viral and metazoan poxins are cGAMP-specific nucleases that restrict cGAS-STING signalling. Nature. 566, 259-263 (2019)

Crystal structure of the WD40 domain dimer of LRRK2. Proc Natl Acad Sci U S A. 10.1073/pnas.1817889116 (2019)

Structural basis of tubulin recruitment and assembly by microtubule polymerases with Tumor Overexpressed Gene (TOG) domain arrays. Elife. 10.7554/eLife.38922 (2018)

Redox-dependent rearrangements of the NiFeS cluster of carbon monoxide dehydrogenase. Elife. 10.7554/eLife.39451 (2018)

Structure of the Human cGAS-DNA Complex Reveals Enhanced Control of Immune Surveillance. Cell. 174, 300-311.e11 (2018)

Odilorhabdins, Antibacterial Agents that Cause Miscoding by Binding at a New Ribosomal Site. Mol Cell. 70, 83-94.e7 (2018)

Structural basis for recognition of diverse antidepressants by the human serotonin transporter. Nat Struct Mol Biol. 10.1038/s41594-018-0026-8 (2018)

Structures of β-klotho reveal a 'zip code'-like mechanism for endocrine FGF signalling.. Nature. 10.1038/nature25010 (2018)
Non-specific activities of the major herbicide-resistance gene BAR. Nat Plants. 3, 937-945 (2017)
Structural basis for methylphosphonate biosynthesis. Science. 358, 1336-1339 (2017)
How type II CRISPR-Cas establish immunity through Cas1-Cas2-mediated spacer integration. Nature. 550, 137-141 (2017)