Publications
(2025) Structural insights into isoform-specific RAS-PI3Kα interactions and the role of RAS in PI3Kα activation.. Nat Commun. 16, 525
(2025) Structure-guided discovery of viral proteins that inhibit host immunity. Cell. 10.1016/j.cell.2024.12.035
(2025) A Target Class Ligandability Evaluation of WD40 Repeat-Containing Proteins. J Med Chem. 68, 1092-1112
(2025) A Target Class Ligandability Evaluation of WD40 Repeat-Containing Proteins. J Med Chem. 68, 1092-1112
(2025) Why Sulfur is Important in Lincosamide Antibiotics. Chem. 10.1016/j.chempr.2025.102480
(2026) An allosteric network governs Tom70 conformational dynamics to coordinate mitochondrial import. Structure. 34, 273-283.e6
(2026) Discovery and Optimization of a Potent, Efficacious, and Brain-Penetrant Inhibitor of KRAS G12C. J Med Chem. 69, 5241-5258
(2026) Nucleotide signals coordinate activation and inhibition of bacterial immunity. Nature. 652, 978-985
(2026) Quantification and transcriptome profiling reveal abundant, dynamic and translatable dephospho-CoA-capped RNAs. Nat Biotechnol. 10.1038/s41587-026-03040-4
(2026) Small-molecule binding and sensing with a designed protein family. Nat Commun. 10.1038/s41467-026-70953-8
(2026) Structural and Positional Effects of Peptoid Residues on Triple Helix Stability. Biomacromolecules. 10.1021/acs.biomac.5c02232
(2026) Structural Basis for the Mechanism and Stability of the EEPD1 5' Endonuclease. J Biol Chem. 10.1016/j.jbc.2026.111432
(2026) Structure of SHOC2-KRAS-PP1C complex reveals RAS isoform-specific determinants and insights into targeting complex assembly by RAS inhibitors. Nat Commun. 10.1038/s41467-026-68319-1

