Publications
A novel allosteric site employs a conserved inhibition mechanism in human kidney-type glutaminase. FEBS J. 10.1111/febs.16658
(2022) A novel HER2-selective kinase inhibitor is effective in HER2 mutant and amplified non-small cell lung cancer. Cancer Res. 10.1158/0008-5472.CAN-21-2693
(2022) The nuclear egress complex of Epstein-Barr virus buds membranes through an oligomerization-driven mechanism. PLoS Pathog. 18, e1010623
(2022) Oligomeric interactions maintain active-site structure in a noncooperative enzyme family. EMBO J. 10.15252/embj.2021108368
(2022) Panel of Engineered Ubiquitin Variants Targeting the Family of Human Ubiquitin Interacting Motifs. ACS Chem Biol. 17, 941-956
(2022) Panoramix SUMOylation on chromatin connects the piRNA pathway to the cellular heterochromatin machinery. Nat Struct Mol Biol. 29, 130-142
(2022) The parallel-stranded d(CGA) duplex is a highly predictable structural motif with two conformationally distinct strands. Acta Crystallogr D Struct Biol. 78, 299-309
(2022) Peptide Centric Vβ Specific Germline Contacts Shape a Specialist T Cell Response.. Front Immunol. 13, 847092
(2022) (2022) PH domain-mediated autoinhibition and oncogenic activation of Akt. Elife. 10.7554/eLife.80148
(2022) Phage anti-CBASS and anti-Pycsar nucleases subvert bacterial immunity. Nature. 10.1038/s41586-022-04716-y
(2022) Pharmacological inhibition of NT5C2 reverses genetic and non-genetic drivers of 6-MP resistance in acute lymphoblastic leukemia. Cancer Discov. 10.1158/2159-8290.CD-22-0010
(2022) Physicochemical Heuristics for Identifying High Fidelity, Near-Native Structural Models of Peptide/MHC Complexes. Front Immunol. 13, 887759
(2022) Polerovirus N-terminal readthrough domain structures reveal molecular strategies for mitigating virus transmission by aphids. Nat Commun. 13, 6368
(2022) Potent monoclonal antibody-mediated neutralization of a divergent Hendra virus variant. Proc Natl Acad Sci U S A. 119, e2122769119
(2022) Practical Course in Macromolecular Crystallography. 36th Annual Symposium of The Protein Society, July 7-10, 2022
(2022) Preclinical characterization of vadadustat (AKB-6548), an oral small molecule hypoxia inducible factor prolyl-4-hydroxylase inhibitor, for the potential treatment of renal anemia. J Pharmacol Exp Ther. 10.1124/jpet.122.001126
(2022) Probing the structure and function of the protease domain of botulinum neurotoxins using single-domain antibodies. PLoS Pathog. 18, e1010169
(2022) Quaternary structure independent folding of voltage-gated ion channel pore domain subunits. Nat Struct Mol Biol. 29, 537-548
(2022) Quinazolinones as allosteric fourth-generation EGFR inhibitors for the treatment of NSCLC. Bioorg Med Chem Lett. 10.1016/j.bmcl.2022.128718
(2022) Rationally designed immunogens enable immune focusing following SARS-CoV-2 spike imprinting. Cell Rep. 38, 110561
(2022) (2022) Retinol-binding protein 2 (RBP2): More than just dietary retinoid uptake. Biochim Biophys Acta Mol Cell Biol Lipids. 1867, 159179
(2022) The rippled β-sheet layer configuration-a novel supramolecular architecture based on predictions by Pauling and Corey.. Chem Sci. 13, 8947-8952
(2022) SH3 domain regulation of RhoGAP activity: Crosstalk between p120RasGAP and DLC1 RhoGAP. Nat Commun. 13, 4788
(2022)