Structural basis for continued antibody evasion by the SARS-CoV-2 receptor binding domain.

Publication Type:

Journal Article

Source:

Science, p.eabl6251 (2021)

Abstract:

<p>[Figure: see text].</p>

PDB: 
Protein Data Bank (PBD) identification numbers for the day 146* RBD human ACE2 ectodomain complex,the unliganded C1C-A3 Fab, the C1C-A3 Fab SARS-CoV-2 spike protein ectodomain complex, and focusedrefinement of the C1C-A3 Fab/RBD region are 7SN0, 7SN1, 7SN3, and 7SN2, respectively.
Detector: 
PILATUS
Beamline: 
24-ID-C
Crystal structure of spike protein receptor binding domain of escape mutant SARS-CoV-2 from immunocompromised patient (d146*) in complex with human receptor ACE2