Structural basis for continued antibody evasion by the SARS-CoV-2 receptor binding domain.

Publication Type:

Journal Article

Authors:

Nabel, Katherine G; Clark, Sarah A; Shankar, Sundaresh; Pan, Junhua; Clark, Lars E; Yang, Pan; Coscia, Adrian; McKay, Lindsay G A; Varnum, Haley H; Brusic, Vesna; Tolan, Nicole V; Zhou, Guohai; Desjardins, Michaël; Turbett, Sarah E; Kanjilal, Sanjat; Sherman, Amy C; Dighe, Anand; LaRocque, Regina C; Ryan, Edward T; Tylek, Casey; Cohen-Solal, Joel F; Darcy, Anhdao T; Tavella, Davide; Clabbers, Anca; Fan, Yao; Griffiths, Anthony; Correia, Ivan R; Seagal, Jane; Baden, Lindsey R; Charles, Richelle C; Abraham, Jonathan

Source:

Science, p.eabl6251 (2021)

Abstract:

<p>[Figure: see text].</p>

PDB: 
Protein Data Bank (PBD) identification numbers for the day 146* RBD human ACE2 ectodomain complex,the unliganded C1C-A3 Fab, the C1C-A3 Fab SARS-CoV-2 spike protein ectodomain complex, and focusedrefinement of the C1C-A3 Fab/RBD region are 7SN0, 7SN1, 7SN3, and 7SN2, respectively.
Detector: 
PILATUS
Beamline: 
24-ID-C
Crystal structure of spike protein receptor binding domain of escape mutant SARS-CoV-2 from immunocompromised patient (d146*) in complex with human receptor ACE2