Sub-ångström cryo-EM structure of a prion protofibril reveals a polar clasp.

Publication Type:

Journal Article

Source:

Nat Struct Mol Biol (2018)

Abstract:

<p>The atomic structure of the infectious, protease-resistant, β-sheet-rich and fibrillar mammalian prion remains unknown. Through the cryo-EM method MicroED, we reveal the sub-ångström-resolution structure of a protofibril formed by a wild-type segment from the β2-α2 loop of the bank vole prion protein. The structure of this protofibril reveals a stabilizing network of hydrogen bonds that link polar zippers within a sheet, producing motifs we have named &#39;polar clasps&#39;.</p>

PDB: 
6BTK
Detector: 
Q315
Beamline: 
24-ID-E