Swapping of transmembrane domains in the epithelial calcium channel TRPV6.
Publication Type:Journal Article
Source:Sci Rep, Volume 7, Issue 1, p.10669 (2017)
<p>Tetrameric ion channels have either swapped or non-swapped arrangements of the S1-S4 and pore domains. Here we show that mutations in the transmembrane domain of TRPV6 can result in conversion from a domain-swapped to non-swapped fold. These results reveal structural determinants of domain swapping and raise the possibility that a single ion channel subtype can fold into either arrangement in vivo, affecting its function in normal or disease states.</p>