Publications
Molecular Basis for the Selective Inhibition of Histone Deacetylase 6 by a Mercaptoacetamide Inhibitor. ACS Med Chem Lett. 9, 1301-1305
(2018) Crystal structure of the HLA-DM-HLA-DR1 complex defines mechanisms for rapid peptide selection. Cell. 151, 1557-68
(2012) Functional characterization of a PROTAC directed against BRAF mutant V600E. Nat Chem Biol. 10.1038/s41589-020-0609-7
(2020) Structure of human ADP-ribosyl-acceptor hydrolase 3 bound to ADP-ribose reveals a conformational switch that enables specific substrate recognition. J Biol Chem. 293, 12350-12359
(2018) Structural and biochemical analysis of human ADP-ribosyl-acceptor hydrolase 3 (ARH3) reveals the basis of metal selectivity and different roles for the two Mg ions. J Biol Chem. 10.1016/j.jbc.2021.100692
(2021) A Partial Calcium-Free Linker Confers Flexibility to Inner-Ear Protocadherin-15. Structure. 25, 482-495
(2017) Implementation of a k/k(0) method to identify long-range structure in transition states during conformational folding/unfolding of proteins. Structure. 15, 1178-89
(2007) Structural basis for defective membrane targeting of mutant enzyme in human VLCAD deficiency. Nat Commun. 13, 3669
(2022) (2015) Structural insights into the formation of repulsive netrin guidance complexes. Sci Adv. 10, eadj8083
(2024) (2019) Covalent and noncovalent strategies for targeting Lys102 in HIV-1 reverse transcriptase. Eur J Med Chem. 262, 115894
(2023) Structural determinants of Clostridium difficile toxin A glucosyltransferase activity. J Biol Chem. 287, 8013-20
(2012) Identification and Characterization of JAK2 Pseudokinase Domain Small Molecule Binders. ACS Med Chem Lett. 8, 618-621
(2017) Structural basis for MTR4-ZCCHC8 interactions that stimulate the MTR4 helicase in the nuclear exosome-targeting complex. Proc Natl Acad Sci U S A. 10.1073/pnas.1803530115
(2018) (2009)
Strandwise translocation of a DNA glycosylase on undamaged DNA. Proc Natl Acad Sci U S A. 109, 1086-91
(2012) Potent and selective antitumor activity of a T cell-engaging bispecific antibody targeting a membrane-proximal epitope of ROR1. Proc Natl Acad Sci U S A. 115, E5467-E5476
(2018) Neighbor-directed histidine N (τ)-alkylation: A route to imidazolium-containing phosphopeptide macrocycles.. Biopolymers. 104, 663-73
(2015) (2017) Vesiculoviral matrix (M) protein occupies nucleic acid binding site at nucleoporin pair (Rae1 • Nup98).. Proc Natl Acad Sci U S A. 111, 9127-32
(2014) KRAS G13D sensitivity to neurofibromin-mediated GTP hydrolysis. Proc Natl Acad Sci U S A. 116, 22122-22131
(2019) Structure-guided aminoacylation and assembly of chimeric RNAs. bioRxiv. 10.1101/2024.03.02.583109
(2024) Crystal structure of the transcriptional regulator Rv0678 of Mycobacterium tuberculosis. J Biol Chem. 289, 16526-40
(2014) Mechanism of Cd2+ coordination during slow inactivation in potassium channels. Structure. 20, 1332-42
(2012)