Publications
In silico driven redesign of a clinically relevant antibody for the treatment of GD2 positive tumors. PLoS One. 8, e63359
(2013) Role of arginine 293 and glutamine 288 in communication between catalytic and allosteric sites in yeast ribonucleotide reductase. J Mol Biol. 419, 315-29
(2012) Identification of Non-nucleoside Human Ribonucleotide Reductase Modulators. J Med Chem. 58, 9498-509
(2015) Potent competitive inhibition of human ribonucleotide reductase by a nonnucleoside small molecule. Proc Natl Acad Sci U S A. 114, 8241-8246
(2017) Discovery of a First-in-Class Small-Molecule Ligand for WDR91 Using DNA-Encoded Chemical Library Selection Followed by Machine Learning. J Med Chem. 66, 16051-16061
(2023) (2019) Evaluating the therapeutic potential of a non-natural nucleotide that inhibits human ribonucleotide reductase. Mol Cancer Ther. 11, 2077-86
(2012) Peptides from human BNIP5 and PXT1 and non-native binders of pro-apoptotic BAK can directly activate or inhibit BAK-mediated membrane permeabilization. Structure. 31, 265-281.e7
(2023) Crystal structure of the C-terminal domain of human DNA primase large subunit: implications for the mechanism of the primase-polymerase α switch.. Cell Cycle. 10, 926-31
(2011) Preliminary crystallographic analysis of mouse Elf3 C-terminal DNA-binding domain in complex with type II TGF-beta receptor promoter DNA. Acta Crystallogr Sect F Struct Biol Cryst Commun. 65, 1261-3
(2009) Crystal structure of mouse Elf3 C-terminal DNA-binding domain in complex with type II TGF-beta receptor promoter DNA. J Mol Biol. 397, 278-89
(2010) Structure of a mutant human purine nucleoside phosphorylase with the prodrug, 2-fluoro-2'-deoxyadenosine and the cytotoxic drug, 2-fluoroadenine. Protein Sci. 18, 1107-14
(2009) Structural and biochemical insights into lipid transport by VPS13 proteins. J Cell Biol. 10.1083/jcb.202202030
(2022) Development of a covalent inhibitor of gut bacterial bile salt hydrolases. Nat Chem Biol. 16, 318-326
(2020) Crystal structure of the potato leafroll virus coat protein and implications for viral assembly. J Struct Biol. 214, 107811
(2021) DNA sequence-dependent activity and base flipping mechanisms of DNMT1 regulate genome-wide DNA methylation. Nat Commun. 11, 3723
(2020) Oxidative rearrangement of tryptophan to indole nitrile by a single diiron enzyme. bioRxiv. 10.1101/2023.08.03.551874
(2023) Mechanistic and structural analyses of the roles of active site residues in yeast polyamine oxidase Fms1: characterization of the N195A and D94N enzymes. Biochemistry. 51, 8690-7
(2012) Mechanistic and structural analyses of the role of His67 in the yeast polyamine oxidase Fms1. Biochemistry. 51, 4888-97
(2012) Crystal structure of a conformational antibody that binds tau oligomers and inhibits pathological seeding by extracts from donors with Alzheimer's disease. J Biol Chem. 10.1074/jbc.RA120.013638
(2020) Structure-based design of nanobodies that inhibit seeding of Alzheimer's patient-extracted tau fibrils. Proc Natl Acad Sci U S A. 120, e2300258120
(2023) Structural basis for receptor recognition by New World hemorrhagic fever arenaviruses. Nat Struct Mol Biol. 17, 438-44
(2010) Helical and β-Turn Conformations in the Peptide Recognition Regions of the VIM1 PHD Finger Abrogate H3K4 Peptide Recognition.. Biochemistry. 10.1021/acs.biochem.1c00191
(2021) (2010)