Publications
(2021) Fast Kinetics Reveals Rate-Limiting Oxidation and the Role of the Aromatic Cage in the Mechanism of the Nicotine-Degrading Enzyme NicA2. Biochemistry. 60, 259-273
(2016) Structural Analysis Provides Mechanistic Insight into Nicotine Oxidoreductase from Pseudomonas putida. Biochemistry. 55, 6595-6598
(2022) Structure of the Repurposed Fungal Terpene Cyclase FlvF Implicated in the C-N Bond-Forming Reaction of Flavunoidine Biosynthesis. Biochemistry. 10.1021/acs.biochem.2c00335
(2024) Dinickel enzyme evolved to metabolize the pharmaceutical metformin and its implications for wastewater and human microbiomes. Proc Natl Acad Sci U S A. 121, e2312652121
(2020) Discovery of an ultra-specific triuret hydrolase (TrtA) establishes the triuret biodegradation pathway. J Biol Chem. 10.1074/jbc.RA120.015631
(2017) The cytotoxic Staphylococcus aureus PSMα3 reveals a cross-α amyloid-like fibril.. Science. 355, 831-833
(2021) Inhibition of amyloid formation of the Nucleoprotein of SARS-CoV-2. bioRxiv. 10.1101/2021.03.05.434000
(2023) Low complexity domains of the nucleocapsid protein of SARS-CoV-2 form amyloid fibrils. Nat Commun. 14, 2379
(2015) Structural and Functional Characterization of the Enantiomers of the Antischistosomal Drug Oxamniquine. PLoS Negl Trop Dis. 9, e0004132
(2017) Structural and enzymatic insights into species-specific resistance to schistosome parasite drug therapy. J Biol Chem. 292, 11154-11164
(2016) Engineering an allosteric transcription factor to respond to new ligands. Nat Methods. 13, 177-83
(2023) Activity-based directed evolution of a membrane editor in mammalian cells. Nat Chem. 15, 1030-1039
(2021) Exploring Ligand-Directed -Acyl--alkylsulfonamide-Based Acylation Chemistry for Potential Targeted Degrader Development. ACS Med Chem Lett. 12, 1302-1307
(2012) Ribonuclease A suggests how proteins self-chaperone against amyloid fiber formation. Protein Sci. 21, 26-37
(2013) Structure-function studies of STAR family Quaking proteins bound to their in vivo RNA target sites. Genes Dev. 27, 928-40
(2008) Structural insights into RNA recognition by the alternative-splicing regulator muscleblind-like MBNL1. Nat Struct Mol Biol. 15, 1343-51
(2019) Crucial Roles of Two Hydrated Mg Ions in Reaction Catalysis of the Pistol Ribozyme. Angew Chem Int Ed Engl. 10.1002/anie.201912522
(2010) Structural insights into RNA recognition by the alternate-splicing regulator CUG-binding protein 1. Structure. 18, 1364-77
(2016) Structural basis underlying CAC RNA recognition by the RRM domain of dimeric RNA-binding protein RBPMS. Q Rev Biophys. 49, e1
(2025) Molecular glues that facilitate RAS binding to PI3Kα promote glucose uptake without insulin.. Science. 389, 402-408
(2018) Binding and Action of Amino Acid Analogs of Chloramphenicol upon the Bacterial Ribosome. J Mol Biol. 10.1016/j.jmb.2018.01.016
(2023) Cocrystallization of ubiquitin-deubiquitinase complexes through disulfide linkage. Acta Crystallogr D Struct Biol. 79, 1044-1055
(2023) Structural and functional validation of a highly specific Smurf2 inhibitor. Protein Sci. 10.1002/pro.4885
(2019) Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15. Structure. 27, 590-605.e5

