Glucose-neopentyl glycol (GNG) amphiphiles for membrane protein study.
Publication Type:Journal Article
Source:Chem Commun (Camb), Volume 49, Issue 23, p.2287-9 (2013)
Keywords:Detergents, Glucose, Glycols, Membrane Proteins, Protein Stability, Rhodobacter capsulatus
<p>The development of a new class of surfactants for membrane protein manipulation, "GNG amphiphiles", is reported. These amphiphiles display promising behavior for membrane proteins, as demonstrated recently by the high resolution structure of a sodium-pumping pyrophosphatase reported by Kellosalo et al. (Science, 2012, 337, 473).</p>