Found 2590 results
Govande, A. A., Duncan-Lowey, B., Eaglesham, J. B., Whiteley, A. T., and Kranzusch, P. J. (2021) Molecular basis of CD-NTase nucleotide selection in CBASS anti-phage defense. Cell Rep. 35, 109206
Dawson, C. D., Irwin, S. M., Backman, L. R. F., Le, C., Wang, J. X., Vennelakanti, V., Yang, Z., Kulik, H. J., Drennan, C. L., and Balskus, E. P. (2021) Molecular basis of C-S bond cleavage in the glycyl radical enzyme isethionate sulfite-lyase. Cell Chem Biol. 10.1016/j.chembiol.2021.03.001
Borowska, M. T., Drees, C., Yarawsky, A. E., Viswanathan, M., Ryan, S. M., Bunker, J. J., Herr, A. B., Bendelac, A., and Adams, E. J. (2021) The molecular characterization of antibody binding to a superantigen-like protein from a commensal microbe. Proc Natl Acad Sci U S A. 10.1073/pnas.2023898118
Huang, F., Lu, X., Yu, C., Sliz, P., Wang, L., and Zhu, B. (2021) Molecular Dissection of the Primase and Polymerase Activities of Deep-Sea Phage NrS-1 Primase-Polymerase. Front Microbiol. 12, 766612
Xie, W., Wang, S., Wang, J., M de la Cruz, J., Xu, G., Scaltriti, M., and Patel, D. J. (2021) Molecular mechanisms of assembly and TRIP13-mediated remodeling of the human Shieldin complex. Proc Natl Acad Sci U S A. 10.1073/pnas.2024512118
Schnabl, J., Wang, J., Hohmann, U., Gehre, M., Batki, J., Andreev, V. I., Purkhauser, K., Fasching, N., Duchek, P., Novatchkova, M., Mechtler, K., Plaschka, C., Patel, D. J., and Brennecke, J. (2021) Molecular principles of Piwi-mediated cotranscriptional silencing through the dimeric SFiNX complex. Genes Dev. 35, 392-409
Patchett, S., Lv, Z., Rut, W., Békés, M., Drag, M., Olsen, S. K., and Huang, T. T. (2021) A molecular sensor determines the ubiquitin substrate specificity of SARS-CoV-2 papain-like protease. Cell Rep. 36, 109754
Tompkins, K. J., Houtti, M., Litzau, L. A., Aird, E. J., Everett, B. A., Nelson, A. T., Pornschloegl, L., Limón-Swanson, L. K., Evans, R. L., Evans, K., Shi, K., Aihara, H., and Gordon, W. R. (2021) Molecular underpinnings of ssDNA specificity by Rep HUH-endonucleases and implications for HUH-tag multiplexing and engineering. Nucleic Acids Res. 49, 1046-1064
Fenton, B. A., Tomberg, J., Sciandra, C. A., Nicholas, R. A., Davies, C., and Zhou, P. (2021) Mutations in PBP2 from Ceftriaxone-resistant Neisseria gonorrhoeae Alter the Dynamics of the β3-β4 Loop to Favor a Low-affinity Drug-binding State.. J Biol Chem. 10.1016/j.jbc.2021.101188
Zahid, H., Buchholz, C. R., Singh, M., Ciccone, M. F., Chan, A., Nithianantham, S., Shi, K., Aihara, H., Fischer, M., Schönbrunn, E., Santos, C. O. Dos, Landry, J. W., and Pomerantz, W. C. K. (2021) New Design Rules for Developing Potent Cell-Active Inhibitors of the Nucleosome Remodeling Factor (NURF) via BPTF Bromodomain Inhibition. J Med Chem. 64, 13902-13917
Capel, M. (2021) New endstations at NE-CAT: MD3UP microdiffractometer and 30 puck ALS-style loader. Current and Future Trends in Macromolecular Crystallography Experiments: Focus on Automation, High Data Rate Analysis and User Interfaces
Deng, Y., Deng, S., Ho, Y. - H., Gardner, S. M., Huang, Z., Marmorstein, R., and Huang, R. (2021) Novel Bisubstrate Inhibitors for Protein N-Terminal Acetyltransferase D. J Med Chem. 10.1021/acs.jmedchem.1c00141
Yu, C. H., Bhattacharya, A., Persaud, M., Taylor, A. B., Wang, Z., Bulnes-Ramos, A., Xu, J., Selyutina, A., Martinez-Lopez, A., Cano, K., Demeler, B., Kim, B., Hardies, S. C., Diaz-Griffero, F., and Ivanov, D. N. (2021) Nucleic acid binding by SAMHD1 contributes to the antiretroviral activity and is enhanced by the GpsN modification. Nat Commun. 12, 731
Zhang, C. - H., Spasov, K. A., Reilly, R. A., Hollander, K., Stone, E. A., Ippolito, J. A., Liosi, M. - E., Deshmukh, M. G., Tirado-Rives, J., Zhang, S., Liang, Z., Miller, S. J., Isaacs, F., Lindenbach, B. D., Anderson, K. S., and Jorgensen, W. L. (2021) Optimization of Triarylpyridinone Inhibitors of the Main Protease of SARS-CoV-2 to Low-Nanomolar Antiviral Potency. ACS Med Chem Lett. 12, 1325-1332
Sea, K. W., Taylor, A. B., Thomas, S. T., Liba, A., Bergman, I. B., Holloway, S. P., Cao, X., Gralla, E. B., Valentine, J. S., P Hart, J., and Galaleldeen, A. (2021) A pH Switch Controls Zinc Binding in Tomato Copper-Zinc Superoxide Dismutase. Biochemistry. 60, 1597-1608
Shah, M., Taylor, V. L., Bona, D., Tsao, Y., Stanley, S. Y., Pimentel-Elardo, S. M., McCallum, M., Bondy-Denomy, J., P Howell, L., Nodwell, J. R., Davidson, A. R., Moraes, T. F., and Maxwell, K. L. (2021) A phage-encoded anti-activator inhibits quorum sensing in Pseudomonas aeruginosa. Mol Cell. 81, 571-583.e6
Chen, S., Tjin, C. Chandra, Gao, X., Xue, Y., Jiao, H., Zhang, R., Wu, M., He, Z., Ellman, J., and Ha, Y. (2021) Pharmacological inhibition of PI5P4Kα/β disrupts cell energy metabolism and selectively kills p53-null tumor cells.. Proc Natl Acad Sci U S A. 10.1073/pnas.2002486118
Schwartz, J., Son, J., Brugger, C., and Deaconescu, A. M. (2021) Phospho-dependent signaling during the general stress response by the atypical response regulator and ClpXP adaptor RssB. Protein Sci. 10.1002/pro.4047
Campbell, A. C., Prater, A. R., Bogner, A. N., Quinn, T. P., Gates, K. S., Becker, D. F., and Tanner, J. J. (2021) Photoinduced Covalent Irreversible Inactivation of Proline Dehydrogenase by S-Heterocycles. ACS Chem Biol. 10.1021/acschembio.1c00427
Rietmeijer, R. A., Sorum, B., Li, B., and Brohawn, S. G. (2021) Physical basis for distinct basal and mechanically gated activity of the human K channel TRAAK. Neuron. 10.1016/j.neuron.2021.07.009
Landor, S. K. J., Santio, N. M., Eccleshall, W. B., Paramonov, V. M., Gagliani, E. K., Hall, D., Jin, S. - B., Dahlström, K. M., Salminen, T. A., Rivero-Müller, A., Lendahl, U., Kovall, R. A., Koskinen, P. J., and Sahlgren, C. (2021) PIM-induced phosphorylation of Notch3 promotes breast cancer tumorigenicity in a CSL-independent fashion. J Biol Chem. 10.1016/j.jbc.2021.100593
Zhang, C. - H., Stone, E. A., Deshmukh, M., Ippolito, J. A., Ghahremanpour, M. M., Tirado-Rives, J., Spasov, K. A., Zhang, S., Takeo, Y., Kudalkar, S. N., Liang, Z., Isaacs, F., Lindenbach, B., Miller, S. J., Anderson, K. S., and Jorgensen, W. L. (2021) Potent Noncovalent Inhibitors of the Main Protease of SARS-CoV-2 from Molecular Sculpting of the Drug Perampanel Guided by Free Energy Perturbation Calculations. ACS Cent Sci. 7, 467-475
Cerutti, G., Guo, Y., Zhou, T., Gorman, J., Lee, M., Rapp, M., Reddem, E. R., Yu, J., Bahna, F., Bimela, J., Huang, Y., Katsamba, P. S., Liu, L., Nair, M. S., Rawi, R., Olia, A. S., Wang, P., Zhang, B., Chuang, G. - Y., Ho, D. D., Sheng, Z., Kwong, P. D., and Shapiro, L. (2021) Potent SARS-CoV-2 neutralizing antibodies directed against spike N-terminal domain target a single supersite. Cell Host Microbe. 10.1016/j.chom.2021.03.005
McCarthy, K. R., Lee, J., Watanabe, A., Kuraoka, M., Robinson-McCarthy, L. R., Georgiou, G., Kelsoe, G., and Harrison, S. C. (2021) A Prevalent Focused Human Antibody Response to the Influenza Virus Hemagglutinin Head Interface. mBio. 12, e0114421
Murphy, F. (2021) RAPD data analysis at NE-CAT. Current and Future Trends in Macromolecular Crystallography Experiments: Focus on Automation, High Data Rate Analysis and User Interfaces