Publications
A Structure-Based Strategy for Engineering Selective Ubiquitin Variant Inhibitors of Skp1-Cul1-F-Box Ubiquitin Ligases. Structure. 10.1016/j.str.2018.06.004
(2018) (2023) Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL. Blood. 113, 4381-90
(2009) Effects of S1 cleavage on the structure, surface export, and signaling activity of human Notch1 and Notch2. PLoS One. 4, e6613
(2009) How clustered protocadherin binding specificity is tuned for neuronal self-/nonself-recognition. Elife. 10.7554/eLife.72416
(2022) Protocadherin cis-dimer architecture and recognition unit diversity. Proc Natl Acad Sci U S A. 10.1073/pnas.1713449114
(2017) γ-Protocadherin structural diversity and functional implications.. Elife. 10.7554/eLife.20930
(2016) Structural Basis of Diverse Homophilic Recognition by Clustered α- and β-Protocadherins.. Neuron. 90, 709-23
(2016) Dual cyclooxygenase-fatty acid amide hydrolase inhibitor exploits novel binding interactions in the cyclooxygenase active site. J Biol Chem. 10.1074/jbc.M117.802058
(2018) Molecular basis of sidekick-mediated cell-cell adhesion and specificity. Elife. 10.7554/eLife.19058
(2016) Crystal structure of LGR ligand α2/β5 from with implications for the evolution of glycoprotein hormones.. Proc Natl Acad Sci U S A. 120, e2218630120
(2023) X-ray analysis of butirosin biosynthetic enzyme BtrN redefines structural motifs for AdoMet radical chemistry. Proc Natl Acad Sci U S A. 110, 15949-54
(2013) An unusual role for a mobile flavin in StaC-like indolocarbazole biosynthetic enzymes. Chem Biol. 19, 855-65
(2012) X-ray structure of an AdoMet radical activase reveals an anaerobic solution for formylglycine posttranslational modification. Proc Natl Acad Sci U S A. 110, 8519-24
(2013) (2014) (2005) Structural basis for the acyltransferase activity of lecithin:retinol acyltransferase-like proteins. J Biol Chem. 287, 23790-807
(2012) LRAT-specific domain facilitates vitamin A metabolism by domain swapping in HRASLS3. Nat Chem Biol. 11, 26-32
(2015) (2016) High-resolution structures of a siderophore-producing cyclization domain from Yersinia pestis offer a refined proposal of substrate binding. J Biol Chem. 298, 102454
(2022) Candida albicans SOD5 represents the prototype of an unprecedented class of Cu-only superoxide dismutases required for pathogen defense. Proc Natl Acad Sci U S A. 111, 5866-71
(2014) Immunodominant surface epitopes power immune evasion in the African trypanosome. Cell Rep. 42, 112262
(2023) Multivalent Interactions by the Set8 Histone Methyltransferase With Its Nucleosome Substrate. J Mol Biol. 428, 1531-43
(2016) (2021) (2018)