Publications
Accurate computational design of three-dimensional protein crystals. Nat Mater. 10.1038/s41563-023-01683-1
(2023) Accurate de novo design of membrane-traversing macrocycles. Cell. 10.1016/j.cell.2022.07.019
(2022) Binding and sensing diverse small molecules using shape-complementary pseudocycles. Science. 385, 276-282
(2024) Crystal structures of Moorella thermoacetica cyanuric acid hydrolase reveal conformational flexibility and asymmetry important for catalysis. PLoS One. 14, e0216979
(2019) Cyclic peptide structure prediction and design using AlphaFold. bioRxiv. 10.1101/2023.02.25.529956
(2023) De novo design of high-affinity binders of bioactive helical peptides. Nature. 10.1038/s41586-023-06953-1
(2023) (2023) De novo design of transmembrane β barrels.. Science. 10.1126/science.abc8182
(2021) De novo designed ice-binding proteins from twist-constrained helices. Proc Natl Acad Sci U S A. 120, e2220380120
(2023) De novo protein design by deep network hallucination. Nature. 10.1038/s41586-021-04184-w
(2021) (2024) (2023) (2021) Design of protein binding proteins from target structure alone. Nature. 10.1038/s41586-022-04654-9
(2022) Directing polymorph specific calcium carbonate formation with de novo protein templates. Nat Commun. 14, 8191
(2023) Exploration of Structured Symmetric Cyclic Peptides as Ligands for Metal-Organic Frameworks. Chem Mater. 34, 9736-9744
(2022) Hallucination of closed repeat proteins containing central pockets. Nat Struct Mol Biol. 30, 1755-1760
(2023) Improving the secretion of designed protein assemblies through negative design of cryptic transmembrane domains. Proc Natl Acad Sci U S A. 120, e2214556120
(2023) Large-scale design and refinement of stable proteins using sequence-only models. PLoS One. 17, e0265020
(2022) Precisely patterned nanofibres made from extendable protein multiplexes. Nat Chem. 10.1038/s41557-023-01314-x
(2023) Preclinical proof of principle for orally delivered Th17 antagonist miniproteins. Cell. 187, 4305-4317.e18
(2024)