Publications
Discovery of an Orally Bioavailable and Selective PKMYT1 Inhibitor, RP-6306. J Med Chem. 10.1021/acs.jmedchem.2c00552
(2022) (2022) Panel of Engineered Ubiquitin Variants Targeting the Family of Human Ubiquitin Interacting Motifs. ACS Chem Biol. 17, 941-956
(2022) Bipartite binding of the N terminus of Skp2 to cyclin A. Structure. 10.1016/j.str.2021.04.011
(2021) (2021) Conformation-specific inhibitors of activated Ras GTPases reveal limited Ras dependency of patient-derived cancer organoids. J Biol Chem. 10.1074/jbc.RA119.011025
(2020) Functional characterization of a PROTAC directed against BRAF mutant V600E. Nat Chem Biol. 10.1038/s41589-020-0609-7
(2020) FAM105A/OTULINL Is a Pseudodebuiquitinase of the OTU-Class that Localizes to the ER Membrane. Structure. 10.1016/j.str.2019.03.022
(2019) Rigidification Dramatically Improves Inhibitor Selectivity for RAF Kinases. ACS Med Chem Lett. 10, 1074-1080
(2019) Structural and Functional Analysis of Ubiquitin-based inhibitors that Target the Backsides of E2 Enzymes. J Mol Biol. 10.1016/j.jmb.2019.09.024
(2019) Structural and Functional Characterization of Ubiquitin Variant Inhibitors of USP15. Structure. 27, 590-605.e5
(2019) (2018)
MEK drives BRAF activation through allosteric control of KSR proteins. Nature. 10.1038/nature25478
(2018) Structural Basis for Auto-Inhibition of the NDR1 Kinase Domain by an Atypically Long Activation Segment. Structure. 26, 1101-1115.e6
(2018) A Structure-Based Strategy for Engineering Selective Ubiquitin Variant Inhibitors of Skp1-Cul1-F-Box Ubiquitin Ligases. Structure. 10.1016/j.str.2018.06.004
(2018) MOB1 Mediated Phospho-recognition in the Core Mammalian Hippo Pathway. Mol Cell Proteomics. 16, 1098-1110
(2017) Regulation of Protein Interactions by Mps One Binder (MOB1) Phosphorylation. Mol Cell Proteomics. 16, 1111-1125
(2017) Inhibition of SCF ubiquitin ligases by engineered ubiquitin variants that target the Cul1 binding site on the Skp1-F-box interface. Proc Natl Acad Sci U S A. 113, 3527-32
(2016) (2015)
Dimeric structure of pseudokinase RNase L bound to 2-5A reveals a basis for interferon-induced antiviral activity. Mol Cell. 53, 221-34
(2014) E2 enzyme inhibition by stabilization of a low-affinity interface with ubiquitin. Nat Chem Biol. 10, 156-163
(2014) Structural basis for the recruitment of glycogen synthase by glycogenin. Proc Natl Acad Sci U S A. 111, E2831-40
(2014) (2014) (2014) Inhibitors that stabilize a closed RAF kinase domain conformation induce dimerization. Nat Chem Biol. 9, 428-36
(2013)