Publications

Found 10 results
Filters: Author is Osko, Jeremy D  [Clear All Filters]
2021
Campiani, G., Cavella, C., Osko, J. D., Brindisi, M., Relitti, N., Brogi, S., A Saraswati, P., Federico, S., Chemi, G., Maramai, S., Carullo, G., Jaeger, B., Carleo, A., Benedetti, R., Sarno, F., Lamponi, S., Rottoli, P., Bargagli, E., Bertucci, C., Tedesco, D., Herp, D., Senger, J., Ruberti, G., Saccoccia, F., Saponara, S., Gorelli, B., Valoti, M., Kennedy, B., Sundaramurthi, H., Butini, S., Jung, M., Roach, K. M., Altucci, L., Bradding, P., Christianson, D. W., Gemma, S., and Prasse, A. (2021) Harnessing the Role of HDAC6 in Idiopathic Pulmonary Fibrosis: Design, Synthesis, Structural Analysis, and Biological Evaluation of Potent Inhibitors. J Med Chem. 64, 9960-9988
2020
Osko, J. D., and Christianson, D. W. (2020) Binding of inhibitors to active-site mutants of CD1, the enigmatic catalytic domain of histone deacetylase 6. Acta Crystallogr F Struct Biol Commun. 76, 428-437
Miller, A. Kern, Morgen, M., Steimbach, R. R., Géraldy, M., Hellweg, L., Sehr, P., Ridinger, J., Witt, O., Oehme, I., Herbst-Gervasoni, C. J., Osko, J. D., Porter, N. J., Christianson, D. W., and Gunkel, N. (2020) Design and Synthesis of Dihydroxamic Acids as HDAC6/8/10 Inhibitors. ChemMedChem. 10.1002/cmdc.202000149
Osko, J. D., Porter, N. J., Reddy, P. Adi Naraya, Xiao, Y. - C., Rokka, J., Jung, M., Hooker, J. M., Salvino, J. M., and Christianson, D. W. (2020) Exploring Structural Determinants of Inhibitor Affinity and Selectivity in Complexes with Histone Deacetylase 6. J Med Chem. 63, 295-308
Reßing, N., Sönnichsen, M., Osko, J. D., Schöler, A., Schliehe-Diecks, J., Skerhut, A., Borkhardt, A., Hauer, J., Kassack, M. U., Christianson, D. W., Bhatia, S., and Hansen, F. K. (2020) Multicomponent Synthesis, Binding Mode, and Structure-Activity Relationship of Selective Histone Deacetylase 6 (HDAC6) Inhibitors with Bifurcated Capping Groups. J Med Chem. 63, 10339-10351
A Saraswati, P., Relitti, N., Brindisi, M., Osko, J. D., Chemi, G., Federico, S., Grillo, A., Brogi, S., McCabe, N. H., Turkington, R. C., Ibrahim, O., O'Sullivan, J., Lamponi, S., Ghanim, M., Kelly, V. P., Zisterer, D., Amet, R., Barroeta, P. Hannon, Vanni, F., Ulivieri, C., Herp, D., Sarno, F., Di Costanzo, A., Saccoccia, F., Ruberti, G., Jung, M., Altucci, L., Gemma, S., Butini, S., Christianson, D. W., and Campiani, G. (2020) Spiroindoline-Capped Selective HDAC6 Inhibitors: Design, Synthesis, Structural Analysis, and Biological Evaluation. ACS Med Chem Lett. 11, 2268-2276
Osko, J. D., Porter, N. J., Decroos, C., Lee, M. S., Watson, P. R., Raible, S. E., Krantz, I. D., Deardorff, M. A., and Christianson, D. W. (2020) Structural analysis of histone deacetylase 8 mutants associated with Cornelia de Lange Syndrome spectrum disorders. J Struct Biol. 213, 107681
2019
Osko, J. D., and Christianson, D. W. (2019) Structural Basis of Catalysis and Inhibition of HDAC6 CD1, the Enigmatic Catalytic Domain of Histone Deacetylase 6. Biochemistry. 10.1021/acs.biochem.9b00934
Osko, J. D., Roose, B. W., Shinsky, S. A., and Christianson, D. W. (2019) Structure and Function of the Acetylpolyamine Amidohydrolase from the Deep Earth Halophile . Biochemistry. 58, 3755-3766
2018
Porter, N. J., Osko, J. D., Diedrich, D., Kurz, T., Hooker, J. M., Hansen, F. K., and Christianson, D. W. (2018) Histone Deacetylase 6-Selective Inhibitors and the Influence of Capping Groups on Hydroxamate-Zinc Denticity. J Med Chem. 10.1021/acs.jmedchem.8b01013