Publications
A widespread family of serine/threonine protein phosphatases shares a common regulatory switch with proteasomal proteases. Elife. 10.7554/eLife.26111
(2017) Structures in multiple conformations reveal distinct transition metal and proton pathways in an Nramp transporter. Elife. 10.7554/eLife.41124
(2019) Structure of the ubiquitin hydrolase UCH-L3 complexed with a suicide substrate. J Biol Chem. 280, 1512-20
(2005) Structure of the N-terminal ankyrin repeat domain of the TRPV2 ion channel. J Biol Chem. 281, 25006-10
(2006) Structure of a herpesvirus-encoded cysteine protease reveals a unique class of deubiquitinating enzymes. Mol Cell. 25, 677-87
(2007) Structure of a force-conveying cadherin bond essential for inner-ear mechanotransduction. Nature. 492, 128-32
(2012) Structure and Sequence Analyses of Clustered Protocadherins Reveal Antiparallel Interactions that Mediate Homophilic Specificity. Structure. 23, 2087-98
(2015) (2010) Structural characterization of the late competence protein ComFB from Bacillus subtilis. Biosci Rep. 10.1042/BSR20140174
(2015) Structural basis of colibactin activation by the ClbP peptidase. Nat Chem Biol. 10.1038/s41589-022-01142-z
(2022) Structural and biochemical consequences of disease-causing mutations in the ankyrin repeat domain of the human TRPV4 channel. Biochemistry. 51, 6195-206
(2012) Structural analyses of the ankyrin repeat domain of TRPV6 and related TRPV ion channels. Biochemistry. 47, 2476-84
(2008) A Partial Calcium-Free Linker Confers Flexibility to Inner-Ear Protocadherin-15. Structure. 25, 482-495
(2017) Mechanistic determinants of the directionality and energetics of active export by a heterodimeric ABC transporter. Nat Commun. 5, 5419
(2014) Interaction specificity of clustered protocadherins inferred from sequence covariation and structural analysis. Proc Natl Acad Sci U S A. 116, 17825-17830
(2019) High-resolution structures with bound Mn and Cd map the metal import pathway in an Nramp transporter. Elife. 10.7554/eLife.84006
(2023) High-Affinity Alkynyl Bisubstrate Inhibitors of Nicotinamide -Methyltransferase (NNMT). J Med Chem. 10.1021/acs.jmedchem.9b01238
(2019) Distinct properties of Ca2+-calmodulin binding to N- and C-terminal regulatory regions of the TRPV1 channel. J Gen Physiol. 140, 541-55
(2012) (2016) Crystal Structure and Conformational Change Mechanism of a Bacterial Nramp-Family Divalent Metal Transporter. Structure. 24, 2102-2114
(2016) Characterization and structural studies of the Plasmodium falciparum ubiquitin and Nedd8 hydrolase UCHL3. J Biol Chem. 285, 6857-66
(2010) (2016)